Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility

Digestive Diseases and Sciences

Volumn 57, Issue 11, 2012, Pages 2826-2845

  Jakab, Robert L ^a   Collaco, Anne M ^a   Ameen, Nadia A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cystic fibrosis conductance regulator; Ion transporters; Membrane trafficking; Receptor signaling

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BICARBONATE SODIUM COTRANSPORTER; CYCLIC AMP DEPENDENT PROTEIN KINASE; LUBIPROSTONE; PROSTANOID; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG TARGETING; ELECTROLYTE TRANSPORT; EXOCYTOSIS; IN VIVO STUDY; INTERNALIZATION; INTESTINE CELL; INTESTINE LOOP; LAMINA PROPRIA; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ALPROSTADIL; ANALYSIS OF VARIANCE; ANIMALS; ANTIPORTERS; BIOPSY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EXOCYTOSIS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTESTINAL MUCOSA; ION TRANSPORT; MEMBRANE TRANSPORT PROTEINS; MUCUS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; ORGANIC ANION TRANSPORTERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA-BINDING PROTEINS; SODIUM-BICARBONATE SYMPORTERS; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84871615464     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2352-8     Document Type: Article

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