A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity

Psychopharmacology

Volumn 224, Issue 4, 2012, Pages 573-579

  Conzelmann, Annette ^a   Reif, Andreas ^a   Jacob, Christian ^a   Weyers, Peter ^a   Lesch, Klaus Peter ^a   Lutz, Beat ^b   Pauli, Paul ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Emotion; Endocannabinoid; FAAH; Genetics; Startle reflex

Indexed keywords

ENDOCANNABINOID; FATTY ACID AMIDASE;

ADULT; ARTICLE; EMOTION; FAAH GENE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HETEROZYGOTE; HUMAN; MALE; MOTIVATION; PRIORITY JOURNAL; STARTLE REFLEX; STIMULUS RESPONSE; VISUAL STIMULATION;

ADULT; AMIDOHYDROLASES; AROUSAL; EMOTIONS; ENDOCANNABINOIDS; FEMALE; HUMANS; MALE; MOTIVATION; POLYMORPHISM, GENETIC; STARTLE REACTION; YOUNG ADULT;

EID: 84871615252     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2785-y     Document Type: Article

References (51)

1. Basavarajappa BS, Yalamanchili R, Cravatt BF, Cooper TB, Hungund BL (2006) Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice. Neuropharmacology 50:834-844
2. Blumenthal TD, Cuthbert BN, Filion DL, Hackley S, Lipp OV, van Boxtel A (2005) Committee report: guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42:1-15
3. Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A et al (2007) Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biol Psychiatry 62:1103-1110
4. Canli T, Lesch KP (2007) Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci 10:1103-1109
5. Castellanos FX, Tannock R (2002) Neuroscience of attention-deficit/ hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 3:617-628
6. Chiang KP, Gerber AL, Sipe JC, Cravatt BF (2004) Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum Mol Genet 13:2113-2119
7. Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB (1996) Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384:83-87
8. Davis MP (2008) Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain. Expert Opin Investig Drugs 17:85-95
9. Dlugos AM, Hamidovic A, Hodgkinson CA, Goldman D, Palmer AA, de Wit H (2010) More aroused, less fatigue: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. Neuropsychopharmacology 35:613-622
10. Eysenck SBG, Pearson PR, Easting G, Allsopp JF (1985) Age norms for impulsiveness, venturesomeness and empathy in adults. Pers IndivDiffer 6:613-619
11. First MB (1996) Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV). American Psychiatric Press, Washington
12. First MB, Spitzer RL, Gibbon M, Williams JBW (1997) Structured Clinical Interview for DSM-IV Personality Disorders, (SCID-II). American Psychiatric Press, Washington
13. Grillon C, Baas J (2003) A review of the modulation of the startle reflex by affective states and its application in psychiatry. Clin Neurophysiol 114:1557-1579
14. Hall W, Solowij N (1998) Adverse effects of cannabis. Lancet 352:1611-1616
15. Hariri AR, Gorka A, Hyde LW, Kimak M, Halder I, Ducci F et al (2009) Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry 66:9-16
16. Justinova Z, Mangieri RA, Bortalato M, Chefer SI, Mukhin AG, Clapper JR et al (2008) Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biol Psychiatry 64:930-937
17. Kalant H (2004) Adverse effects of cannabis on health: an update of the literature since 1996. Prog Neuropsychopharmacol Biol 28:849-863
18. Kathuria S, Gaetani S, Fegley D, Valino F, Duranti A, Tontina A et al (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81
19. Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107-128
20. Lang PJ (1980) Behavioral treatment and bio-behavioral assessment: computer applications. In: Sidowski JB, Johnson JH, Williams TA (eds) Technology in mental health care delivery systems. Ablex, Norwood, pp 119-137
21. Lang PJ (1995) The emotion probe. Studies of motivation and attention. Am Psychol 50:372-385
22. Lang PJ, Bradley MM, Cuthbert BNF (2005) International affective picture system (IAPS): affective ratings of pictures and instruction manual. Technical Report A-6. University of Florida, Gainesville
23. Lehrl S (1989) Mehrfachwahl-Wortschatz-Intelligenztest MWT-B. Perimed, Erlangen
24. Lutz B (2009) Endocannabinoid signals in the control of emotion. Curr Opin Pharmacol 9:46-52
25. Maccarrone M, Rossi S, Bari M, De Chiara V, Fezza F, Musella A et al (2008) Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci 11:152-159
26. Mackie K (2005) Distrubution of cannabinoid receptors in the central and peripheral nervous system. Handb Exp Pharmacol 168:299-325
27. Mahler SV, Smith KS, Berridge KC (2007) Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances 'liking' of a sweet reward. Neuropsychopharmacology 32:2267-2278
28. Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG et al (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534
29. Monteleone P, Bifulco M, Di Filippo C, Gazzerro P, Canestrelli B, Monteleone F et al (2009) Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. Genes Brain Behav 8:728-732
30. Moreira FA, Lutz B (2008) The endocannabinoid system: emotion, learning and addiction. Addict Biol 13:196-212
31. Moreira FA, Kaiser N, Monory K, Lutz B (2008) Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54:141-150
32. Moreira FA, Grieb M, Lutz B (2009) Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression. Best Pract Res Clin Endocrinol Metab 23:133-144
33. Morrison PD, Zois V, McKeown DA, Lee TD, Holt DW, Powell JF, Kapur S, Murray RM (2009) The acute effects of synthetic intravenous Delta9- tetrahydrocannabinol on psychosis, mood and cognitive functioning. Psychol Med 39:1607-1616
34. Pagotto U, Marsicano G, Cota D, Lutz B, Pasquali R (2006) The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 27:73-100
35. Parolaro D, Realini N, Vigano D, Guidali C, Rubino T (2010) The endocannabinoid system and psychiatric disorders. Exp Neurol 224:3-14
36. Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008) Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. J Neurosci 28:2313-2319
37. Rubino T, Sala M, Vigano D, Braida D, Castiglioni C, Limonta V et al (2007) Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral [Delta]9-tetrahydrocannabinol in rats. Neuropsychopharmacology 32:2036-2045
38. Rubino T, Guidali C, Vigano D, Realini N, Valenti M, Massi P et al (2008) CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour. Neuropharmacology 54:151-160
39. Ruehle S, Aparisi Rey A, Remmers F, Lutz B (2012) The endocannabinoid system in anxiety, fear memory and habituation. J Psychopharmacol 26(1):23-39
40. Sañudo-Peña MC, Tsou K, Delay ER, Hohman AG, Force M, Walker JM (1997) Endogenous cannabinoids as an aversive or counter-rewarding system in the rat. Neurosci Lett 223:125-128
41. Schacht JP, Selling RE, Hutchison KE (2009) Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology 203:511-517
42. Sipe JC, Chiang K, Gerber AL, Beutler E, Cravatt BF (2002) A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc Natl Acad Sci USA 99:8394-8399
43. Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D et al (2007) The endogenous cannabinoid anandamide produces delta-9- tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. J Pharmacol Exp Ther 321:370-380
44. Spielberger CD, Gorsuch RL, Lushene RE (1970) State-Trait Anxiety Inventory, Manual for the State-Trait Anxiety Inventory. Consulting Psychologist Press, Palo Alto
45. Tanda G, Goldberg SR (2003) Cannabinoids: reward, dependence, and underlying neurochemical mechanisms - a review of recent preclinical data. Psychopharmacology 169:115-134
46. Terzian AL, Aguiar DC, Guimaraes FS, Moreira FA (2009) Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray. Eur Neuropsychopharmacol 19:188-195
47. Trezza V, Vanderschuren LJMJ (2009) Divergent effects of anandamide transporter inhibitors with different target selectivity on social play behavior in adolescent rats. J Pharmacol Exp Ther 328:343-350
48. Viveros MP, Marco EM, File SE (2005) Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 81:331-342
49. Wieser MJ, McTeague LM, Keil A (2011) Sustained preferential processing of social threat cues in social anxiety - bias without competition. Jo CognNeurosci 23:1973-1986
50. Yim CY, Mogenson GJ (1982) Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine. Brain Res 239:401-415
51. Yim CY, Mogenson GJ (1989) Low doses of accumbens dopamine modulate amygdala suppression of spontaneous exploratory activity in rats. Brain Res 477:202-210