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Volumn 57, Issue 11, 2012, Pages 2846-2855

Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2

Author keywords

FOXP3; Interleukin 17A; Th17; Treg

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 17; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

EID: 84871609277     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2292-3     Document Type: Article
Times cited : (44)

References (30)
  • 1
    • 79954486763 scopus 로고    scopus 로고
    • Regulatory T cells and Foxp3
    • Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev. 2011;241:260-268.
    • (2011) Immunol Rev , vol.241 , pp. 260-268
    • Rudensky, A.Y.1
  • 2
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 3
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 4
    • 0035141865 scopus 로고    scopus 로고
    • Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse
    • Patel DD. Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. J Clin Invest. 2001;107:155-157.
    • (2001) J Clin Invest , vol.107 , pp. 155-157
    • Patel, D.D.1
  • 5
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001;27:18-20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3
  • 6
    • 4344682025 scopus 로고    scopus 로고
    • CD4+ CD25bright T cells in human intestinal lamina propria as regulatory cells
    • Makita S, Kanai T, Oshima S, Uraushihara K, et al. CD4+ CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol. 2004;173:3119-3130.
    • (2004) J Immunol , vol.173 , pp. 3119-3130
    • Makita, S.1    Kanai, T.2    Oshima, S.3    Uraushihara, K.4
  • 7
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
    • Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology. 2005;128:1868-1878.
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3
  • 8
    • 36249014365 scopus 로고    scopus 로고
    • Characterization of FOXP3+ CD4+ regulatory T cells in Crohn's disease
    • Saruta M, Yu QT, Fleshner PR, et al. Characterization of FOXP3+ CD4+ regulatory T cells in Crohn's disease. Clin Immunol. 2007;125:281-290.
    • (2007) Clin Immunol , vol.125 , pp. 281-290
    • Saruta, M.1    Yu, Q.T.2    Fleshner, P.R.3
  • 9
    • 33750375612 scopus 로고    scopus 로고
    • Characterization of Foxp3+ CD4+ CD25+ and IL-10-secreting CD4+ CD25+ T cells during cure of colitis
    • Uhlig HH, Coombes J, Mottet C, et al. Characterization of Foxp3+ CD4+ CD25+ and IL-10-secreting CD4+ CD25+ T cells during cure of colitis. J Immunol. 2006;177:5852-5860.
    • (2006) J Immunol , vol.177 , pp. 5852-5860
    • Uhlig, H.H.1    Coombes, J.2    Mottet, C.3
  • 10
    • 27644449311 scopus 로고    scopus 로고
    • The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    • Allan SE, Passerini L, Bacchetta R, et al. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest. 2005;115:3276-3284.
    • (2005) J Clin Invest , vol.115 , pp. 3276-3284
    • Allan, S.E.1    Passerini, L.2    Bacchetta, R.3
  • 11
    • 67749130955 scopus 로고    scopus 로고
    • Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity
    • Mailer RK, Falk K, Rotzschke O. Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity. PLoS One. 2009;4:e6104.
    • (2009) PLoS One , vol.4
    • Mailer, R.K.1    Falk, K.2    Rotzschke, O.3
  • 12
    • 18244378309 scopus 로고    scopus 로고
    • Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)
    • Kobayashi I, Shiari R, Yamada M, et al. Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX). J Med Genet. 2001;38:874-876.
    • (2001) J Med Genet , vol.38 , pp. 874-876
    • Kobayashi, I.1    Shiari, R.2    Yamada, M.3
  • 13
    • 34948875308 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: Forkhead box protein 3 mutations and lack of regulatory T cells
    • Torgerson TR, Ochs HD. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol. 2007;120:744-750.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 744-750
    • Torgerson, T.R.1    Ochs, H.D.2
  • 14
    • 56749151293 scopus 로고    scopus 로고
    • Th17 cells in immunity and autoimmunity
    • Oukka M. Th17 cells in immunity and autoimmunity. Ann Rheum Dis. 2008;67:iii26-iii29.
    • (2008) Ann Rheum Dis , vol.67
    • Oukka, M.1
  • 15
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziata F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med. 2007;204:1849-1861.
    • (2007) J Exp Med , vol.204 , pp. 1849-1861
    • Annunziata, F.1    Cosmi, L.2    Santarlasci, V.3
  • 16
    • 1642369092 scopus 로고    scopus 로고
    • Interleukin-17: A mediator of inflammatory responses
    • Witowski J, Ksiazek K, Jorres A. Interleukin-17: a mediator of inflammatory responses. Cell Mol Life Sci. 2004;61:567-579.
    • (2004) Cell Mol Life Sci , vol.61 , pp. 567-579
    • Witowski, J.1    Ksiazek, K.2    Jorres, A.3
  • 17
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006;24:179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 18
    • 34249030920 scopus 로고    scopus 로고
    • IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease
    • Dubinsky MC, Wang D, Picornell Y, et al. IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. Inflamm Bowel Dis. 2007;13:511-515.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 511-515
    • Dubinsky, M.C.1    Wang, D.2    Picornell, Y.3
  • 19
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006;314:1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 20
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide metaanalysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, et al. Genome-wide metaanalysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 21
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008;135:1130-1141.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 22
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006;441:235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 23
    • 0027447515 scopus 로고
    • Cytokine mRNA expression in intestine from normal and inflammatory bowel disease patients
    • McCabe RP, Secrist H, Botney M, Egan M, Peters MG. Cytokine mRNA expression in intestine from normal and inflammatory bowel disease patients. Clin Immunol Immunopathol. 1993;66: 52-58.
    • (1993) Clin Immunol Immunopathol. , vol.66 , pp. 52-58
    • McCabe, R.P.1    Secrist, H.2    Botney, M.3    Egan, M.4    Peters, M.G.5
  • 24
    • 79952300978 scopus 로고    scopus 로고
    • Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
    • Hovhannisyan Z, Treatman J, Littman DR, Mayer L. Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology. 2011;140:957-965.
    • (2011) Gastroenterology , vol.140 , pp. 957-965
    • Hovhannisyan, Z.1    Treatman, J.2    Littman, D.R.3    Mayer, L.4
  • 25
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation programof proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation programof proinflammatory IL-17+ T helper cells. Cell. 2006;126:1121-1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 26
    • 47749124186 scopus 로고    scopus 로고
    • Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    • Ichiyama K, Yoshida H, Wakabayashi Y, et al. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem. 2008;283: 17003-17008.
    • (2008) J Biol Chem. , vol.283 , pp. 17003-17008
    • Ichiyama, K.1    Yoshida, H.2    Wakabayashi, Y.3
  • 27
    • 43449135305 scopus 로고    scopus 로고
    • TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    • Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature. 2008;453:236-240.
    • (2008) Nature , vol.453 , pp. 236-240
    • Zhou, L.1    Lopes, J.E.2    Chong, M.M.3
  • 28
    • 66649115650 scopus 로고    scopus 로고
    • Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    • Ayyoub M, Deknuydt F, Raimbaud I, et al. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci U S A. 2009;106:8635-8640.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 8635-8640
    • Ayyoub, M.1    Deknuydt, F.2    Raimbaud, I.3
  • 29
    • 63849183918 scopus 로고    scopus 로고
    • Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    • Voo KS, Wang YH, Santori FR, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009;106:4793-4798.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4793-4798
    • Voo, K.S.1    Wang, Y.H.2    Santori, F.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.