Prion protein participates in the regulation of classical and alternative activation of BV2 microglia

Journal of Neurochemistry

Volumn 124, Issue 2, 2013, Pages 168-174

  Shi, Fushan ^a   Yang, Lifeng ^a   Kouadir, Mohammed ^a   Yang, Yang ^a   Ding, Tianjian ^a   Wang, Jihong ^a   Zhou, Xiangmei ^a   Yin, Xiaomin ^a   Zhao, Deming ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

activation; microglia; prion protein; siRNA

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR ALPHA; MESSENGER RNA; NITRIC OXIDE; PRION PROTEIN; SMALL INTERFERING RNA; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE LOCATION; GENE SILENCING; MICROGLIA; MOUSE; NERVE CELL STIMULATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PRNP GENE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; CELL LINE; DOWN-REGULATION; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICROGLIA; NEURAL INHIBITION; NEUROPROTECTIVE AGENTS; PRIONS; RNA, SMALL INTERFERING;

EID: 84871607977     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12053     Document Type: Article

References (31)

1. Adams D. O., and, Hamilton T. A., (1984) The cell biology of macrophage activation. Annu. Rev. Immunol. 2, 283-318.
2. Aguzzi A., Sigurdson C., and, Heikenwaelder M., (2008) Molecular mechanisms of prion pathogenesis. Ann. Rev. Path. Mech. Dis. 3, 11-40.
3. Brodie C., Goldreich N., Haiman T., and, Kazimirsky G., (1998) Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion. J. Neuroimmunol. 81, 20-30.
4. Colton C. A., (2009) Heterogeneity of microglial activation in the innate immune response in the brain. J. Neuroimmune Pharmacol. 4, 399-418.
5. Colton C. A., Mott R. T., Sharpe H., Xu Q., Van Nostrand W. E., and, Vitek M. P., (2006) Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J. Neuroinflammation 3, 27.
6. Davis B. K., Wen H., and, Ting J. P. Y., (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu. Rev. Immunol. 29, 707-735.
7. Dohi K., Ohtaki H., Nakamachi T., Yofu S., Satoh K., Miyamoto K., Song D., Tsunawaki S., Shioda S., and, Aruga T., (2010) Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J. Neuroinflammation 7, 41.
8. Franchi L., Eigenbrod T., Muñoz-Planillo R., and, Nuñez G., (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 10, 241-247.
9. Garden G. A., and, Möller T., (2006) Microglia biology in health and disease. J. Neuroimmune Pharmacol. 1, 127-137.
10. Gordon S., (2003) Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35.
11. Henn A., Lund S., Hedtjärn M., Schrattenholz A., Pörzgen P., and, Leist M., (2009) The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. Altex 26, 83.
12. Hume D. A., Ross I. L., Himes S. R., Sasmono R. T., Wells C. A., and, Ravasi T., (2002) The mononuclear phagocyte system revisited. J. Leukocyte Biol. 72, 621-627.
13. Kitamura Y., Taniguchi T., Kimura H., Nomura Y., and, Gebicke-Haerter P., (2000) Interleukin-4-inhibited mRNA expression in mixed rat glial and in isolated microglial cultures. J. Neuroimmunol. 106, 95-104.
14. Latz E., (2010) The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 22, 28-33.
15. Linden R., Martins V. R., Prado M. A. M., Cammarota M., Izquierdo I., and, Brentani R. R., (2008) Physiology of the prion protein. Physiol. Rev. 88, 673-728.
16. Liu S. H., Yang C. N., Pan H. C., Sung Y. J., Liao K. K., Chen W. B., Lin W. Z., and, Sheu M. L., (2010) IL-13 downregulates PPAR-γ/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death. Cell. Mol. Life Sci. 67, 1465-1476.
17. Martinez F. O., Helming L., and, Gordon S., (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483.
18. Martinon F., Mayor A., and, Tschopp J., (2009) The inflammasomes: guardians of the body. Annu. Rev. Immunol. 27, 229-265.
19. Mosser D. M., (2003) The many faces of macrophage activation. J. Leukocyte Biol. 73, 209-212.
20. Nguyen M. D., Julien J. P., and, Rivest S., (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216-227.
21. Nimmerjahn A., Kirchhoff F., and, Helmchen F., (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318.
22. Odegaard J. I., Ricardo-Gonzalez R. R., Goforth M. H., Morel C. R., Subramanian V., Mukundan L., Eagle A. R., Vats D., Brombacher F., and, Ferrante A. W., (2007) Macrophage-specific PPAR&ggr; controls alternative activation and improves insulin resistance. Nature 447, 1116-1120.
23. Pietr M., Kozela E., Levy R., Rimmerman N., Lin Y. H., Stella N., Vogel Z., and, Juknat A., (2009) Differential changes in GPR55 during microglial cell activation. FEBS Lett. 583, 2071-2076.
24. Prusiner S. B., (1998) Prions. Proc. Natl Acad. Sci. USA 95, 13363.
25. Ransohoff R. M., and, Perry V. H., (2009) Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27, 119-145.
26. van Rossum D., Hilbert S., Straãenburg S., Hanisch U., and, Brück W., (2008) Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype. Glia 56, 271-283.
27. Schroder K., and, Tschopp J., (2010) The inflammasomes. Cell 140, 821-832.
28. Soria J. A., Arroyo D. S., Gaviglio E. A., Rodriguez-Galan M. C., Wang J. M., and, Iribarren P., (2011) Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism. Neurobiol. Dis. 43, 616-624.
29. Soulet D., and, Rivest S., (2008) Bone-marrow-derived microglia: myth or reality? Curr. Opin. Pharmacol. 8, 508-518.
30. Wong M. L., and, Medrano J. F., (2005) Real-time PCR for mRNA quantitation. Biotechniques 39, 75.
31. Wu G., Nakajima K., Takeyama N., Yukawa M., Taniuchi Y., Sakudo A., and, Onodera T., (2008) Species-specific anti-apoptotic activity of cellular prion protein in a mouse PrP-deficient neuronal cell line transfected with mouse, hamster, and bovine Prnp. Neurosci. Lett. 446, 11-15.