Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride

Alcohol and Alcoholism

Volumn 48, Issue 1, 2013, Pages 28-38

  Milivojevic, Verica ^a   Covault, Jonathan ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; FINASTERIDE; PREGNENOLONE; STEROID;

ADOLESCENT; ADULTHOOD; ALCOHOL ABSTINENCE; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; MALE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; STEROID BLOOD LEVEL;

AGE FACTORS; ALCOHOL DRINKING; ANIMALS; ETHANOL; FEMALE; FINASTERIDE; MALE; PREGNANCY; RATS; RATS, WISTAR; TREATMENT OUTCOME;

RATTUS; RATTUS NORVEGICUS;

EID: 84871584853     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/ags105     Document Type: Article

References (61)

1. Adinoff B, Iranmanesh A, Veldhuis J et al. (1998) Disturbances of the stress response: the role of the HPA axis during alcohol withdrawal and abstinence. Alcohol Health Res World 22:67-72.
2. Akwa Y, Purdy RH, Koob GF et al. (1999) The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat. Behav Brain Res 106:119-25.
3. Belelli D, Lambert JJ. (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci 6:565-75.
4. Belelli D, Bolger MB, Gee KW. (1989) Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.Eur J Pharmacol 166:325-9.
5. Besheer J, Lindsay TG, O'Buckley TK et al. (2010) Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats. Alcohol Clin Exp Res 34:2044-52.
6. Bitran D, Hilvers RJ, Kellogg CK. (1991) Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor.Brain Res 561:157-61.
7. Boyd KN, Kumar S, O'Buckley TK et al. (2010) Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids:mechanisms and reversal by exogenous ACTH. J Neurochem 115:142-52.
8. Corpechot C, Collins BE, Carey MP et al. (1997) Brain neurosteroids during the mouse oestrous cycle. Brain Res 766:276-80.
9. Courant F, Aksglaede L, Antignac JP et al. (2010) Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method. J Clin Endocrinol Metab 95:82-92.
10. Covault J, Pond T, Feinn R et al. (2012) Effects of dutasteride on alcohol responses in a laboratory setting and on drinking in the natural environment. Alcohol Clin Exp Res 36:18a.
11. Crews FT, Braun CJ, Hoplight B et al. (2000) Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 24:1712-23.
12. De Bellis MD, Clark DB, Beers SR et al. (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 157:737-44.
13. Ellis FW. (1966) Effect of ethanol on plasma corticosterone levels. J Pharmacol Exp Ther 153:121-7.
14. Fadalti M, Petraglia F, Luisi S et al. (1999) Changes of serum allopregnanolone levels in the first 2 years of life and during pubertal development. Pediatr Res 46:323-7.
15. Ford MM, Nickel JD, Finn DA. (2005a) Treatment with and withdrawal from finasteride alter ethanol intake patterns in male
16. Ford MM, Nickel JD, Phillips TJ et al. (2005b) Neurosteroid modulators of GABA(A) receptors differentially modulate ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res 29:1630-40.
17. Ford MM, Beckley EH, Nickel JD et al. (2008a) Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis. Drug Alcohol Depend 97:73-85.
18. Ford MM, Yoneyama N, Strong MN et al. (2008b) Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of
19. Garcia-Burgos D, Gonzalez F, Manrique T et al. (2009) Patterns of ethanol intake in preadolescent, adolescent, and adult Wistar rats under acquisition, maintenance, and relapse-like conditions.Alcohol Clin Exp Res 33:722-8.
20. Grant BF, Dawson DA. (1997) Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey.J Subst Abuse 9:103-10.
21. Hirani K, Sharma AN, Jain NS et al. (2005) Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alphapregnane-
22. Janak PH, Michael Gill T. (2003) Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol selfadministration with and without concurrently available sucrose.Alcohol 30:1-7.
23. Janak PH, Redfern JE, Samson HH. (1998) The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone.Alcohol Clin Exp Res 22:1106-12.
24. Johnston LD, O'Malley PM, Bachman JG et al. (2006) Monitoring the Future: National Survey Results on Drug Use, 1975-2005,Vol 1: Secondary School Students. Bethesda, MD: National Institutes of Health. NIH Publication 06-5883.
25. Khisti RT, Chopde CT, Jain SP. (2000) Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test. Pharmacol Biochem Behav 67:137-43.
26. Khisti RT, VanDoren MJ, O'Buckley T et al. (2003) Neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats. Brain Res 980:255-65.
27. Kim YS, Zhang H, Kim HY. (2000) Profiling neurosteroids in cerebrospinal fluids and plasma by gas chromatography/electron capture negative chemical ionization mass spectrometry. Anal Biochem 277:187-95.
28. Korenbrot CC, Huhtaniemi IT, Weiner RI. (1977) Preputial separation as an external sign of pubertal development in the male rat. Biol Reprod 17:298-303.
29. Lephart ED, Ladle DR, Jacobson NA et al. (1996) Inhibition of brain 5 alpha-reductase in pregnant rats: effects on enzymatic and behavioral activity. Brain Res 739:356-60.
30. Maldonado-Devincci AM, Alipour KK, Michael LA et al. (2010a)Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats. Pharmacol Biochem Behav 96:476-87.
31. Maldonado-Devincci AM, Badanich KA, Kirstein CL. (2010b) Alcohol during adolescence selectively alters immediate and long-term behavior and neurochemistry. Alcohol 44:57-66.
32. Mellon SH, Griffin LD. (2002) Neurosteroids: biochemistry and clinical significance. Trends Endocrinol Metab 13:35-43.
33. Milivojevic V, Kranzler HR, Gelernter J et al. (2011) Variation in genes encoding the neuroactive steroid synthetic enzymes 5alpha-reductase type 1 and 3alpha-reductase type 2 is associated with alcohol dependence. Alcohol Clin Exp Res 35:946-52.
34. Morrow AL, VanDoren MJ, Penland SN et al. (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res Brain Res Rev 37:98-109.
35. Morrow AL, Porcu P, Boyd KN et al. (2006) Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior. Dialogues Clin Neurosci 8:463-77.
36. Nadeson R, Goodchild CS. (2001) Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously,intraperitoneally, and intragastrically. Br J Anaesth 86:704-8.
37. Ostlund RE, Jr, Hsu FF, Bosner MS et al. (1996) Quantification of cholesterol tracers by gas chromatography-negative ion chemical ionization mass spectrometry. J Mass Spectrom 31:1291-6.
38. Pascual M, Boix J, Felipo V et al. (2009) Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem 108:920-31.
39. Paul SM, Purdy RH. (1992) Neuroactive steroids. FASEB J 6:2311-22.
40. Pierucci-Lagha A, Covault J, Feinn R et al. (2005) GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 30:1193-203.
41. Porcu P, O'Buckley TK, Alward SE et al. (2010) Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5- beta neuroactive steroids in mice, rats, cynomolgus monkeys,and humans. Alcohol Clin Exp Res 34:432-42.
42. Przybycien-Szymanska MM, Mott NN, Paul CR et al. (2011)Binge-pattern alcohol exposure during puberty induces longterm changes in HPA axis reactivity. PLoS One 6:e18350.
43. Sanna E, Talani G, Busonero F et al. (2004) Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J Neurosci 24:6521-30.
44. Schuckit MA.(1994) Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-9.
45. Siegmund S, Vengeliene V, Singer MV et al. (2005) Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcohol Clin Exp Res 29:1139-45.
46. Silveri MM, Spear LP. (1998) Decreased sensitivity to the hypnotic effects of ethanol early in ontogeny. Alcohol Clin Exp Res 22:670-6.
47. Sinnott RS, Phillips TJ, Finn DA. (2002) Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology (Berl) 162:438-47.
48. Slawecki CJ, Betancourt M. (2002) Effects of adolescent ethanol exposure on ethanol consumption in adult rats. Alcohol 26:23-30.
49. Spear LP. (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-63.
50. Squeglia LM, Jacobus J, Tapert SF. (2009) The influence of substance use on adolescent brain development. Clin EEG Neurosci 40:31-8.
51. Tambour S, Brown LL, Crabbe JC. (2008) Gender and age at drinking onset affect voluntary alcohol consumption but neither the alcohol deprivation effect nor the response to stress in mice.Alcohol Clin Exp Res 32:2100-6.
52. Tanner JM, Whitehouse RH. (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 51:170-9.
53. Torres JM, Ortega E. (2004) Alcohol intoxication increases allopregnanolone levels in male adolescent humans.Psychopharmacology (Berl) 172:352-5.
54. Uzunova V, Sampson L, Uzunov DP. (2006) Relevance of endogenous 3alpha-reduced neurosteroids to depression and antidepressant action. Psychopharmacology (Berl) 186:351-61.
55. Vallee M, Rivera JD, Koob GF et al. (2000) Quantification of neurosteroids in rat plasma and brain following swim stress and allopregnanolone administration using negative chemical ionization gas chromatography/mass spectrometry. Anal Biochem 287:153-66.
56. VanDoren MJ, Matthews DB, Janis GC et al. (2000) Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 20:1982-9.
57. Varlinskaya EI, Spear LP. (2004) Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female Sprague-Dawley rats. Alcohol Clin Exp Res 28:40-50.
58. Varlinskaya EI, Spear LP. (2006) Differences in the social consequences of ethanol emerge during the course of adolescence in rats: social facilitation, social inhibition, and anxiolysis. Dev Psychobiol 48:146-61.
59. Vetter CS, Doremus-Fitzwater TL, Spear LP. (2007) Time course of elevated ethanol intake in adolescent relative to adult rats under continuous, voluntary-access conditions. Alcohol Clin Exp Res 31:1159-68.
60. Walf AA, Sumida K, Frye CA. (2006) Inhibiting 5alpha-reductase in the amygdala attenuates antianxiety and antidepressive behavior of naturally receptive and hormone-primed ovariectomized rats. Psychopharmacology (Berl) 186:302-11.
61. Wieland S, Lan NC, Mirasedeghi S et al. (1991) Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o 1-20 one. Brain Res 565:263-8.