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Volumn 739, Issue 1-2, 1996, Pages 356-360

Inhibition of brain 5α-reductase in pregnant rats: Effects on enzymatic and behavioral activity

Author keywords

5 reductase; brain; finasteride (Proscar); neurosteroids; open field behavior; pregnancy; prenatal development; rodent

Indexed keywords

FINASTERIDE; PROGESTERONE; STEROID 5ALPHA REDUCTASE;

EID: 0030580392     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01068-2     Document Type: Article
Times cited : (40)

References (34)
  • 5
    • 0026603924 scopus 로고
    • The 5α-reductase in the brain: Molecular aspects and relation to brain function
    • [5] Celotti, F., Melcangi, R.C. and Martini, L., The 5α-reductase in the brain: Molecular aspects and relation to brain function, Front. Neuroendocrinol., 13 (1992) 163-215.
    • (1992) Front. Neuroendocrinol. , vol.13 , pp. 163-215
    • Celotti, F.1    Melcangi, R.C.2    Martini, L.3
  • 6
    • 0028335927 scopus 로고
    • Progesterone and the neural mechanisms of hamster sexual behavior
    • [6] DeBold, J.F. and Frye, C.A., Progesterone and the neural mechanisms of hamster sexual behavior, Psychoneuroendocrinology, 19 (1994) 1-17.
    • (1994) Psychoneuroendocrinology , vol.19 , pp. 1-17
    • DeBold, J.F.1    Frye, C.A.2
  • 7
    • 0025793550 scopus 로고
    • Hypothalamic opiatergic tone during pregnancy, parturition and lactation in the rat
    • [7] Dindi, D., Maggi, R., Panterai, A.E., Piva, F. and Limonia, P., Hypothalamic opiatergic tone during pregnancy, parturition and lactation in the rat, Neuroendocrinology, 53 (1991) 460-466.
    • (1991) Neuroendocrinology , vol.53 , pp. 460-466
    • Dindi, D.1    Maggi, R.2    Panterai, A.E.3    Piva, F.4    Limonia, P.5
  • 8
    • 0026751778 scopus 로고
    • Metabolism of dihydrotesterone to 3α-androstanediol in brain and plasma: Effect on behavioral activity in female rats
    • [8] Erskine, M.S., Hippensteil, M. and Kornberg, E., Metabolism of dihydrotesterone to 3α-androstanediol in brain and plasma: effect on behavioral activity in female rats, J. Endocrinol., 134 (1992) 183-195.
    • (1992) J. Endocrinol. , vol.134 , pp. 183-195
    • Erskine, M.S.1    Hippensteil, M.2    Kornberg, E.3
  • 9
    • 0028954029 scopus 로고
    • Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice
    • [9] Finn, D.A., Roberts, A.J. and Crabbe, J.C., Neuroactive steroid sensitivity in withdrawal seizure-prone and -resistant mice, Alcohol. Clin. Exp. Res., 19 (1995) 410-415.
    • (1995) Alcohol. Clin. Exp. Res. , vol.19 , pp. 410-415
    • Finn, D.A.1    Roberts, A.J.2    Crabbe, J.C.3
  • 10
    • 0028853687 scopus 로고
    • Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive
    • [10] Flood, J.F., Morley, J.E. and Roberts, E., Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive, Proc. Natl. Acad. Sci. USA, 92 (1995) 10806-10810.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 10806-10810
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 11
    • 0028329702 scopus 로고
    • A receptor complex, attenuate pain sensitivity in rats
    • A receptor complex, attenuate pain sensitivity in rats, Brain Res., 634 (1994) 194-203.
    • (1994) Brain Res. , vol.634 , pp. 194-203
    • Frye, C.A.1    Duncan, J.E.2
  • 12
    • 0028973110 scopus 로고
    • The neurosteroid 3α, 5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy
    • [12] Frye, C.A., The neurosteroid 3α, 5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy, Brain Res., 696 (1995) 113-120.
    • (1995) Brain Res. , vol.696 , pp. 113-120
    • Frye, C.A.1
  • 13
    • 0030020526 scopus 로고    scopus 로고
    • Analgesic effects of the neurosteroid 3α-androstanediol
    • [13] Frye, C.A., Van Keuren, K.R., Rao, P.N. and Erskine, M.S., Analgesic effects of the neurosteroid 3α-androstanediol, Brain Res., 709 (1996) 1-9.
    • (1996) Brain Res. , vol.709 , pp. 1-9
    • Frye, C.A.1    Van Keuren, K.R.2    Rao, P.N.3    Erskine, M.S.4
  • 14
    • 0027230870 scopus 로고
    • 3α-Hydrox-5α-pregnan-20-one modulation of solubilized GABA/benzodiazepine receptor complex
    • [14] Giusti, L., Stefania Belfiore, M., Martini, L. and Lucacchini, A., 3α-Hydrox-5α-pregnan-20-one modulation of solubilized GABA/benzodiazepine receptor complex, J. Steroid Biochem. Mole. Biol., 45 (1993) 309-314.
    • (1993) J. Steroid Biochem. Mole. Biol. , vol.45 , pp. 309-314
    • Giusti, L.1    Stefania Belfiore, M.2    Martini, L.3    Lucacchini, A.4
  • 15
    • 0026329027 scopus 로고
    • Evidence that 3α-hydroxy-5α-pregnan-20-one is a physiologically relevant modulator of GABA-ergic neurotransmission
    • [15] Hiemke, C., Jussofie, A. and Juptner, M., Evidence that 3α-hydroxy-5α-pregnan-20-one is a physiologically relevant modulator of GABA-ergic neurotransmission, Psychoneuroendocrinology, 16 (1991) 517-523.
    • (1991) Psychoneuroendocrinology , vol.16 , pp. 517-523
    • Hiemke, C.1    Jussofie, A.2    Juptner, M.3
  • 16
    • 0027361769 scopus 로고
    • Regional and interspecies differences in brain progesterone metabolism
    • [16] Korneyev, A., Guidotti, A. and Costa, E., Regional and interspecies differences in brain progesterone metabolism, J. Neurochem., 61 (1993) 2041-2047.
    • (1993) J. Neurochem. , vol.61 , pp. 2041-2047
    • Korneyev, A.1    Guidotti, A.2    Costa, E.3
  • 17
    • 0025041509 scopus 로고
    • Expression of neural 5α-reductase messenger ribonucleic acid: Comparison to 5α-reductase activity during prenatal development in the rat
    • [17] Lephart, E.D., Andersson, S. and Simpson, E.R., Expression of neural 5α-reductase messenger ribonucleic acid: comparison to 5α-reductase activity during prenatal development in the rat, Endocrinology, 127 (1990) 1121-1128.
    • (1990) Endocrinology , vol.127 , pp. 1121-1128
    • Lephart, E.D.1    Andersson, S.2    Simpson, E.R.3
  • 18
    • 0025218008 scopus 로고
    • Hypothalamic aromatase activity in male and female rats during juvenile peripubertal development
    • [18] Lephart, E.D. and Ojeda, S.R., Hypothalamic aromatase activity in male and female rats during juvenile peripubertal development, Neuroendocrinology, 51 (1990) 385-393.
    • (1990) Neuroendocrinology , vol.51 , pp. 385-393
    • Lephart, E.D.1    Ojeda, S.R.2
  • 19
    • 0026063623 scopus 로고
    • Rat adrenal 5α-reductase mRNA content and enzyme activity are sex hormone dependent
    • [19] Lephart, E.D., Simpson, E.R. and Trzeciak, W.H., Rat adrenal 5α-reductase mRNA content and enzyme activity are sex hormone dependent, J. Mol. Endocrinol., 6 (1991) 163-170.
    • (1991) J. Mol. Endocrinol. , vol.6 , pp. 163-170
    • Lephart, E.D.1    Simpson, E.R.2    Trzeciak, W.H.3
  • 20
    • 0027332117 scopus 로고
    • Brain 5α-reductase: Cellular, enzymatic, and molecular perspective and implications for biological function
    • [20] Lephart, E.D., Brain 5α-reductase: Cellular, enzymatic, and molecular perspective and implications for biological function, Mol. Cell. Neurosci., 4 (1993) 473-484.
    • (1993) Mol. Cell. Neurosci. , vol.4 , pp. 473-484
    • Lephart, E.D.1
  • 21
    • 0027332124 scopus 로고
    • Pituitary and brain 5α-reductase messenger RNA levels in control, castrated and dihydrotestosterone treated rats
    • [21] Lephart, E.D., Pituitary and brain 5α-reductase messenger RNA levels in control, castrated and dihydrotestosterone treated rats, Mol. Cell. Neurosci., 4 (1993) 526-531.
    • (1993) Mol. Cell. Neurosci. , vol.4 , pp. 526-531
    • Lephart, E.D.1
  • 23
    • 0024533243 scopus 로고
    • A receptor sensitivity in maternal brain: An antecedent of post-partum 'blues'?
    • A receptor sensitivity in maternal brain: An antecedent of post-partum 'blues'?, Brain Res., 482 (1989) 397-401.
    • (1989) Brain Res. , vol.482 , pp. 397-401
    • Majewska, M.D.1    Force-Rice, F.2    Falkay, G.3
  • 24
    • 0026509649 scopus 로고
    • A receptor. Mechanism of action and physiological significance
    • A receptor. Mechanism of action and physiological significance, Prog. Neurobiol., 38 (1992) 379-395.
    • (1992) Prog. Neurobiol. , vol.38 , pp. 379-395
    • Majewska, M.D.1
  • 25
    • 0020470292 scopus 로고
    • The 5α-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications
    • [25] Martini, L., The 5α-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications, Endocrine Rev., 3 (1982) 1-25.
    • (1982) Endocrine Rev. , vol.3 , pp. 1-25
    • Martini, L.1
  • 26
    • 0025175750 scopus 로고
    • Modulation by estrogen and progesterone on the effect of muscimol on nociception in the spinal cord
    • [26] McCarthy, M.M., Caba, M., Komisurak, B.R. and Beyer, C., Modulation by estrogen and progesterone on the effect of muscimol on nociception in the spinal cord, Pharmacol. Biochem. Behav., 37 (1990) 123-128.
    • (1990) Pharmacol. Biochem. Behav. , vol.37 , pp. 123-128
    • McCarthy, M.M.1    Caba, M.2    Komisurak, B.R.3    Beyer, C.4
  • 27
    • 0014114802 scopus 로고
    • Relationship between the anesthetic and gestagenic action and estrous-inducing activity of different progestins
    • [27] Meyerson, B.J., Relationship between the anesthetic and gestagenic action and estrous-inducing activity of different progestins, Endocrinology, 81 (1967) 369-374.
    • (1967) Endocrinology , vol.81 , pp. 369-374
    • Meyerson, B.J.1
  • 28
    • 0015739589 scopus 로고
    • Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat
    • [28] Morishige, W.K., Pepe, G.J. and Rothchild, I., Serum luteinizing hormone, prolactin and progesterone levels during pregnancy in the rat, Endocrinology, 92 (1973) 1527-1530.
    • (1973) Endocrinology , vol.92 , pp. 1527-1530
    • Morishige, W.K.1    Pepe, G.J.2    Rothchild, I.3
  • 29
    • 0023238727 scopus 로고
    • The anesthetic potency of 5α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats
    • [29] Norberg, L., Wahlstrom, G. and Backström, T., The anesthetic potency of 5α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats, Pharmacol. Toxicol., 61 (1987) 42-47.
    • (1987) Pharmacol. Toxicol. , vol.61 , pp. 42-47
    • Norberg, L.1    Wahlstrom, G.2    Backström, T.3
  • 30
    • 0026579057 scopus 로고
    • Neuroactive steroids
    • [30] Paul, S.M. and Purdy, R.H., Neuroactive steroids, FASEB J., 6 (1992) 2310-2322.
    • (1992) FASEB J. , vol.6 , pp. 2310-2322
    • Paul, S.M.1    Purdy, R.H.2
  • 32
    • 0025689849 scopus 로고
    • The clinical development of a 5α-reductase inhibitor, finasteride
    • [32] Stoner, E., The clinical development of a 5α-reductase inhibitor, finasteride, J. Steroid Biochem., 37 (1990) 375-378.
    • (1990) J. Steroid Biochem. , vol.37 , pp. 375-378
    • Stoner, E.1
  • 33
    • 0020603472 scopus 로고
    • Brain β-endorphin during pregnancy, parturition, and the postpartum period
    • [33] Wardlaw, S.L. and Frantz, A.G., Brain β-endorphin during pregnancy, parturition, and the postpartum period, Endocrinology, 113 (1983) 1664-1668.
    • (1983) Endocrinology , vol.113 , pp. 1664-1668
    • Wardlaw, S.L.1    Frantz, A.G.2
  • 34
    • 0018921896 scopus 로고
    • Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring
    • [34] Weisz, J. and Ward, I.L., Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring, Endocrinology, 106 (1980) 306-316.
    • (1980) Endocrinology , vol.106 , pp. 306-316
    • Weisz, J.1    Ward, I.L.2


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