Efficacy of carbazole alkaloids, essential oil and extract of murraya koenigii in enhancing subcutaneous wound healing in rats

Molecules

Volumn 17, Issue 12, 2012, Pages 14449-14463

  Nagappan, Thilahgavani ^a   Segaran, Thirukanthan Chandra ^b   Wahid, Mohd Effendy Abdul ^b   Ramasamy, Perumal ^a   Vairappan, Charles S ^a  

^a UNIVERSITI MALAYSIA SABAH   (Malaysia)

^b UNIVERSITI MALAYSIA TERENGGANU   (Malaysia)

Author keywords

Collagen deposition; Extract; Mahanimbicine; Murraya koenigii; Wound healing

Indexed keywords

ALKALOID; CARBAZOLE; CARBAZOLE DERIVATIVE; ESSENTIAL OIL; FUSED HETEROCYCLIC RINGS; MAHANIMBINE; MAHANINE; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; FEMALE; KIDNEY; LIVER; MURRAYA; PATHOLOGY; PLANT LEAF; RAT; SKIN; SPRAGUE DAWLEY RAT; TRADITIONAL MEDICINE; WOUND HEALING;

ALKALOIDS; ANIMALS; CARBAZOLES; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; KIDNEY; LIVER; MEDICINE, TRADITIONAL; MURRAYA; OILS, VOLATILE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; SKIN; WOUND HEALING;

EID: 84871565811     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules171214449     Document Type: Article

References (31)

1. Adetutu, A.; Morgan, W.A.; Corcoran, O. Ethnopharmacological survey and in vitro evaluation of wound-healing plants used on South-western Nigeria. J. Ethnopharmacol. 2011, 137, 50-56.
2. Gurung, S.; Basnet, N.S. Wound healing properties of Carica papaya latex: In vivo evaluation in mice burn model. J. Ethanopharmacol. 2009, 121, 338-341.
3. Suntar, I.; Akkol, E.K.; Keles, H.; Oktem, A.; Baser, K.H.C.; Yesilada, E. A novel wound healing ointment: A formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge. J. Ethanopharmacol. 2011, 134, 89-96.
4. Chah, K.F.; Eze, C.A.; Esimone, C.O. Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. J. Ethnopharmacol. 2006, 104, 164-167.
5. Muthusamy, S.K.; Ramasamy, S.; Harinarayan, V.R.; Praveen, K.S. Wound healing potential of Cassia fistula on infected albino rat model. J. Surg. Res. 2006, 131, 283-298.
6. Balekar, N.; Katkam, N.G.; Nakpheng, T.; Jehtae, K.; Srichana, T. Evaluation of the wound healing potential of Wedelia trilobata (L.) leaves. J. Ethanopharmacol. 2012, 141, 817-824.
7. Kumar, B.; Viayakumar, M.; Govindarajan, G.; Pushpangadan, P. Ethanopharmacological approaches to wound healing-Exploring medicinal plants of India. J. Ethanopharmacol. 2007, 114, 103-113.
8. Shailajan, S.; Menon, S.; Pednekar, S.; Singh, A. Wound healing efficacy of Jatyadi Taila: In vivo evaluation in rat using excision wound model. J. Ethanopharmacol. 2011, 138, 99-104.
9. Basal, A.A.M. Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. J. Ethanopharmacol. 2010, 131, 443-450.
10. Annan, K.; Houghton, P.J. Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana. J. Pharmacol. 2008, 119, 141-144.
11. Csupor, D.; Blazso, G.; Balogh, A.; Hohmann, J. The traditional Hungarian medicinal plant Centaureas adleriana Janka accelerates wound healing in rats. J. Ethnopharmacol. 2010, 127, 193-195.
12. Maldini, M.; Sosa, S.; Montoro, P.; Giangaspero, A.; Balick, M.J.; Pizza, C.; Loggia, R.D. Screening of the topical anti-inflammatory activity of the bark of Acacia cornigera Willdenow, Brysonimacrassi folia Kunth, Sweetia panamensis Yakovlev and the leaves of Sphagneticola trilobata Hitchcock. J. Ethanopharmacol. 2009, 122, 430-433.
13. Khanum, F.; Anilakumar, K.R.; Krishna, K.R.S.; Viswanathan, K.R.; Santhanam, K. Anticarcinogenic effects of curry leaves in dimethylhydrazine- treated rats. Plant Foods Hum. Nutr. 2000, 55, 347-355.
14. Raina, V.K.; Lal, R.K.; Tripathi, S.; Khan, M.; Syamasundar, K.V.; Srivastava, S.K. Essential oil composition of genetically diverse stocks of Murraya koenigii from India. Flavour Fragr. J. 2002, 17, 144-146.
15. Adebajo, A.C.; Ayoola, O.F.; Iwalewa, E.O.; Akindahunsi, A.A.; Omisore, N.O.A.; Adewunmi, C.O.; Adenowo, T.K. Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole isolated from the leaves of Murraya koenigii growing in Nigeria. Phytomedicine 2006, 13, 246-254.
16. Arulselvan, P.; Subramanian, S.P. Beneficial effects of Murraya koenigii leaves on antioxidant defense and ultra structural changes of pancreatic β-cells in experimental diabetes in rats. Chem. Biol. Interact. 2007, 165, 155-164.
17. Chowdhury, J.U.; Bhuiyan, M.N.I.; Yusuf, M. Chemical composition of the essential oil of Murraya koenigii (L.) Spreng and Murraya paniculata (L.) Jack. Banglad. J. Pharmacol. 2008, 3, 59-63.
18. Bhattacharjee, S.K. Handbook of Medicinal Plants, 5th Revised & Enlarged ed.; Pointer Publishers: New Delhi, India, 2008.
19. Bhattacharya, K.; Samanta, S.K.; Tripathi, R.; Mallick, A.; Chandra, S.; Pal, B.C.; Shaha, C.; Mandal, C. Apototic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem. Pharmacol. 2010, 79, 361-372.
20. Mandal, S.; Nayak, A.; Kar, M.; Banerjee, S.K.; Das, A.; Upadhyay, S.N.; Singh, R.K.; Banerji, A.; Banerji, J. Antidiarrhoel activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia 2012, 81, 72-74.
21. Tang, T.; Yin, L.W.; Yang, J.; Shan, G. Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur. J. Pharmacol. 2007, 567, 177-185.
22. Silva, K.A.B.S.; Manjavachi, M.N.; Paszcuk, A.F.; Pivatto, M.; Bolzani, V.S.; Calixto, J.B. Plant derived alkaloids (-)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models. Neuropharmacology 2012, 62, 967-977.
23. Dasgupta, T.; Rao, A.R.; Yadava, P.K. Chemomodulatory action of curry leaf (Murraya koenigii) extract on hepatic and extrahepatic xenobiotic metabolizing enzymes, antioxidant levels, lipid peroxidation, skin and forestomachpapillomagenesis. Nutr. Res. 2003, 23, 1427-1446.
24. Kaushik, G.; Satya, S.; Khandelwal, R.K.; Naik, S.N. Commonly consumed Indian plant food materials in the management of diabetes mellitus. Diabetes Metab. Syndr. 2010, 4, 21-40.
25. Nayak, B.S.; Anderson, M.; Pereira Pinto, L.M. Evaluation of wound-healing potential of Catharanthusroseus leaf extract in rats. Fitoterapia 2007, 78, 540-544.
26. Deshmukh, P.T.; Fernandes, J.; Atul, A.; Toppo, E. Wound healing activity of Calotropis gigantean root bark in rats. J. Ethanopharmacol. 2009, 125, 178-181.
27. Ramsewak, R.S.; Nair, M.G.; Strasburg, G.M.; DeWitt, D.L.; Nitiss, J.L. Biologically active carbazole alkaloids from Murraya koenigii. J. Agric. Food Chem. 1999, 47, 444-447.
28. Ningappa, M.B.; Dinesha, R.; Srinivas, L. Antioxidant and free radical scavenging activities of polyphenol-enriched curry leaf (Murraya koenigii L.) extracts. Food Chem. 2008, 106, 720-728.
29. Tachibana, Y.; Kikuzaki, H.; Lajis, N.; Nakatani, N. Antioxidative activity of carbazoles from Murraya koenigii leaves. J. Agric. Food Chem. 2001, 49, 5589-5594.
30. Ningappa, M.B.; Dhananjaya, B.L.; Dinesha, R.; Harsha, R.; Srinivas, L. Potent antibacterial property of APC protein from curry leaves (Murraya koenigii L.). Food Chem. 2010, 118, 747-750.
31. Nagappan, T.; Ramasamy, P.; Abdul Wahid, M.E.; Chandrasegaran, T.; Vairappan, C.S. Biological activity of carbazole alkaloids and essential oil of Murraya koenigii against antibiotic resistant microbes and cancer cell lines. Molecules 2011, 16, 9651-9664.