An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action

Journal of Biomolecular Screening

Volumn 18, Issue 1, 2013, Pages 108-115

  Jin, Shan ^a,b   Sarkar, Kumar S ^a,b   Jin, Youngnam N ^a,b   Liu, Yan ^a,b   Kokel, David ^a,b   Van Ham, Tjakko J ^a,b,d   Roberts, Lee D ^a,b   Gerszten, Robert E ^a,b   MacRae, Calum A ^b,c   Peterson, Randall T ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

high content screening; in vivo screening; mass spectrometry; Xenopus; zebrafish

Indexed keywords

AMILORIDE; ANTIDOTE; ATROPINE; BUCLADESINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; EMETINE; GLYCOPYRRONIUM BROMIDE; HARMALINE; MEPHENESIN; METOCLOPRAMIDE; NADOLOL; NALIDIXIC ACID; NIFUROXAZIDE; NIPECOTIC ACID; ONDANSETRON; ORGANOPHOSPHATE; RIFAMPICIN; SALBUTAMOL; TELENZEPINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; EMBRYO; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; NONHUMAN; PHENOTYPE; PILOT STUDY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ZEBRA FISH;

ANIMALS; ANTIDOTES; ATROPINE; CELL LINE, TUMOR; CHOLINERGIC ANTAGONISTS; CHOLINESTERASE REACTIVATORS; DRUG EVALUATION, PRECLINICAL; EMETINE; GLYCOPYRROLATE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LETHAL DOSE 50; METOCLOPRAMIDE; NEOSTIGMINE; ORGANOPHOSPHATES; PARATHION; PIRENZEPINE; PRALIDOXIME COMPOUNDS; ZEBRAFISH;

DANIO RERIO;

EID: 84871560193     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112458153     Document Type: Article

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