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Volumn 22, Issue 1, 2013, Pages 6-17

Treatment of refractory obstetric antiphospholipid syndrome: The state of the art and new trends in the therapeutic management

Author keywords

Antiphospholipid antibody; complement activation; obstetric antiphospholipid syndrome; obstetric morbidity; refractory; treatment

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ADALIMUMAB; ANTICOAGULANT AGENT; ANTIMALARIAL AGENT; ANTIVITAMIN K; BEMIPARIN; CORTICOSTEROID; DALTEPARIN; DIPYRIDAMOLE; ENOXAPARIN; ETANERCEPT; FONDAPARINUX; GLUCOCORTICOID; HEPARIN; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; INFLIXIMAB; LOW MOLECULAR WEIGHT HEPARIN; PENTOXIFYLLINE; PHOSPHOLIPID ANTIBODY; PREDNISOLONE; PREDNISONE; RECOMBINANT INTERLEUKIN 10; TINZAPARIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UBIDECARENONE; UNINDEXED DRUG; WARFARIN;

EID: 84871539112     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203312465782     Document Type: Review
Times cited : (66)

References (135)
  • 1
    • 38049023658 scopus 로고    scopus 로고
    • Excessive exposure to anionic surfaces maintains autoantibody response to B2-glycoprotein i in patients with antiphospholipid syndrome
    • Yamaguchi Y, Noriyuki N, Kaburaki J, et al. Excessive exposure to anionic surfaces maintains autoantibody response to B2-glycoprotein I in patients with antiphospholipid syndrome. Blood. 2007 ; 110: 4312-4318
    • (2007) Blood , vol.110 , pp. 4312-4318
    • Yamaguchi, Y.1    Noriyuki, N.2    Kaburaki, J.3
  • 2
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome
    • Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost. 2006 ; 4: 295-306
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3
  • 3
    • 23444440318 scopus 로고    scopus 로고
    • Towards the comprehension of the heterogeneity of clinical manifestations related with antiphospholipid antibodies
    • Alijotas-Reig J. Towards the comprehension of the heterogeneity of clinical manifestations related with antiphospholipid antibodies. Med Clin [Barc]. 2005 ; 125: 187-189
    • (2005) Med Clin [Barc] , vol.125 , pp. 187-189
    • Alijotas-Reig, J.1
  • 4
    • 67749101879 scopus 로고    scopus 로고
    • Laboratory criteria of the obstetrical antiphospholipid syndrome [APS]. Data from a multicentre prospective European women cohort
    • Boffa M-C, Boinot C, de Carolis S, et al. Laboratory criteria of the obstetrical antiphospholipid syndrome [APS]. Data from a multicentre prospective European women cohort. Thromb Haemost. 2009 ; 102: 25-28
    • (2009) Thromb Haemost , vol.102 , pp. 25-28
    • Boffa, M.-C.1    Boinot, C.2    De Carolis, S.3
  • 5
    • 84861550718 scopus 로고    scopus 로고
    • Obstetric and vascular APS: Same autoantibodies but different diseases?
    • Meroni P, Raschi E, Grossi C, et al. Obstetric and vascular APS: Same autoantibodies but different diseases?. Lupus. 2012 ; 21: 708-710
    • (2012) Lupus , vol.21 , pp. 708-710
    • Meroni, P.1    Raschi, E.2    Grossi, C.3
  • 6
    • 7044274078 scopus 로고    scopus 로고
    • Treatment of antiphospholipid syndrome in pregnancy-a systematic review of randomized therapeutic trials
    • Lassere M, Empson M. Treatment of antiphospholipid syndrome in pregnancy-a systematic review of randomized therapeutic trials. Thromb Res. 2004 ; 114: 419-426
    • (2004) Thromb Res , vol.114 , pp. 419-426
    • Lassere, M.1    Empson, M.2
  • 8
  • 9
    • 79955014016 scopus 로고    scopus 로고
    • Consultative hematology: The pregnant patient pregnancy loss
    • Bates SM. Consultative hematology: the pregnant patient pregnancy loss. Haematology Am Soc Hematol Educ Program. 2010 ; 2010: 166-172
    • (2010) Haematology Am Soc Hematol Educ Program , vol.2010 , pp. 166-172
    • Bates, S.M.1
  • 10
    • 81355123254 scopus 로고    scopus 로고
    • High positive antibody titers and adverse pregnancy outcome in women with antiphospholipid syndrome
    • Simchen MJ, Dulitzki M, Rofe G, et al. High positive antibody titers and adverse pregnancy outcome in women with antiphospholipid syndrome. Acta Obstet Gynecol Scand. 2011 ; 90: 1428-1433
    • (2011) Acta Obstet Gynecol Scand , vol.90 , pp. 1428-1433
    • Simchen, M.J.1    Dulitzki, M.2    Rofe, G.3
  • 11
    • 84871563518 scopus 로고    scopus 로고
    • Antiphospholipid syndrome during pregnancy: The state of the art
    • Di Prima FAF, Valenti O, Hyseni E, et al. Antiphospholipid syndrome during pregnancy: the state of the art. J Perinatal Med. 2011 ; 5: 41-53
    • (2011) J Perinatal Med , vol.5 , pp. 41-53
    • Di Prima, F.A.F.1    Valenti, O.2    Hyseni, E.3
  • 12
    • 84861560222 scopus 로고    scopus 로고
    • The European Registry on Obstetric Antiphospholipid Syndrome [EUROAPS]: A preliminary first year report
    • Alijotas-Reig J, Ferrer-Oliveras R. The European Registry on Obstetric Antiphospholipid Syndrome [EUROAPS]: A preliminary first year report. Lupus. 2012 ; 21: 766-768
    • (2012) Lupus , vol.21 , pp. 766-768
    • Alijotas-Reig, J.1    Ferrer-Oliveras, R.2
  • 14
    • 77953943135 scopus 로고    scopus 로고
    • Diagnosis and management of antiphospholipid syndrome
    • Cohen D, Berger SP, Steup-Beekman MA, et al. Diagnosis and management of antiphospholipid syndrome. BMJ. 2010 ; 340: 1125-1132
    • (2010) BMJ , vol.340 , pp. 1125-1132
    • Cohen, D.1    Berger, S.P.2    Ma, S.3
  • 15
    • 0346688744 scopus 로고    scopus 로고
    • High impact of antiphospholipid syndrome on irreversible organ damage and survival of patients with systemic lupus erythematosus
    • Ruiz-Irastorza G, Egurbide MV, Ugalde J, et al. High impact of antiphospholipid syndrome on irreversible organ damage and survival of patients with systemic lupus erythematosus. Arch Intern Med. 2004 ; 164: 77-78
    • (2004) Arch Intern Med , vol.164 , pp. 77-78
    • Ruiz-Irastorza, G.1    Egurbide, M.V.2    Ugalde, J.3
  • 17
    • 0031850746 scopus 로고    scopus 로고
    • Mid-trimester loss-appraisal of a screening protocol
    • Drakeley AJ, Quenby S, Farquharson R. Mid-trimester loss-appraisal of a screening protocol. Hum Reprod. 1998 ; 13: 1975-1980
    • (1998) Hum Reprod , vol.13 , pp. 1975-1980
    • Drakeley, A.J.1    Quenby, S.2    Farquharson, R.3
  • 19
    • 0036228886 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: Clinical and immunologic manifestations and pattern of disease expression in a cohort of 1,000 patients
    • Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and pattern of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002 ; 46: 1019-1027
    • (2002) Arthritis Rheum , vol.46 , pp. 1019-1027
    • Cervera, R.1    Piette, J.C.2    Font, J.3
  • 20
    • 84856733763 scopus 로고    scopus 로고
    • Prevalence and clinical usefulness of antiphospholipid and anti-cofactor antibodies in different Spanish preeclampsia subsets
    • Ferrer-Oliveras R, Llurba E, Cabero-Roura L, et al. Prevalence and clinical usefulness of antiphospholipid and anti-cofactor antibodies in different Spanish preeclampsia subsets. Lupus. 2012 ; 21: 257-263
    • (2012) Lupus , vol.21 , pp. 257-263
    • Ferrer-Oliveras, R.1    Llurba, E.2    Cabero-Roura, L.3
  • 22
    • 57649162473 scopus 로고    scopus 로고
    • Endothelial cell perturbation by anti-phospholipid antibodies in systemic lupus erythematosus
    • Meroni PL. Endothelial cell perturbation by anti-phospholipid antibodies in systemic lupus erythematosus. Lupus. 2007 ; 16 (suppl). 17-19
    • (2007) Lupus , vol.16 , Issue.SUPPL. , pp. 17-19
    • Meroni, P.L.1
  • 23
    • 84855353256 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and cell activation
    • Koike T. Antiphospholipid antibodies and cell activation. Lupus. 2007 ; 16 (suppl). 17-17
    • (2007) Lupus , vol.16 , Issue.SUPPL. , pp. 17-17
    • Koike, T.1
  • 25
    • 28244446632 scopus 로고    scopus 로고
    • Diffuse alveolar haemorrhage: A non-thrombotic antiphospholipid lung syndrome?
    • Asherson RA, Cervera R, Wells AU. Diffuse alveolar haemorrhage: a non-thrombotic antiphospholipid lung syndrome?. Semin Arthritis Rheum. 2005 ; 35: 138-142
    • (2005) Semin Arthritis Rheum , vol.35 , pp. 138-142
    • Asherson, R.A.1    Cervera, R.2    Wells, A.U.3
  • 26
    • 33744777805 scopus 로고    scopus 로고
    • Non-thrombotic manifestations of the antiphospholipid syndrome: Away from thrombosis?
    • Asherson RA, Cervera R, Shepshelovich D, et al. Non-thrombotic manifestations of the antiphospholipid syndrome: away from thrombosis?. J Rheumatol. 2006 ; 33: 1038-1044
    • (2006) J Rheumatol , vol.33 , pp. 1038-1044
    • Asherson, R.A.1    Cervera, R.2    Shepshelovich, D.3
  • 27
    • 73949110131 scopus 로고    scopus 로고
    • Is obstetric antiphospholipid syndrome a primary nonthrombotic, proinflammatory, complement-mediated disorder related to antiphospholipid antibodies?
    • Alijotas-Reig J, Vilardell-Tarrés M. Is obstetric antiphospholipid syndrome a primary nonthrombotic, proinflammatory, complement-mediated disorder related to antiphospholipid antibodies?. Obstet Gynecol Surv. 2010 ; 65: 39-45
    • (2010) Obstet Gynecol Surv , vol.65 , pp. 39-45
    • Alijotas-Reig, J.1    Vilardell-Tarrés, M.2
  • 28
    • 0025823651 scopus 로고
    • Histopathological findings in placenta from patients with intra-uterine fetal death and antiphospholipid antibodies
    • Out HJ, Kooijman CD, Bruinse HW, et al. Histopathological findings in placenta from patients with intra-uterine fetal death and antiphospholipid antibodies. Eur J Obstet Gynaecol Reprod Biol. 1991 ; 195: 211-220
    • (1991) Eur J Obstet Gynaecol Reprod Biol , vol.195 , pp. 211-220
    • Out, H.J.1    Kooijman, C.D.2    Bruinse, H.W.3
  • 29
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid- induced fetal loss by inhibiting complement activation. Nature Med. 2004 ; 10: 1222-1226
    • (2004) Nature Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 30
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest. 2003 ; 112: 1644-1654
    • (2003) J Clin Invest , vol.112 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3
  • 31
    • 0037148520 scopus 로고    scopus 로고
    • Complement C3 activation is required for antiphospholipid antibody induced fetal loss
    • Holers VM, Girardi G, Mo L. Complement C3 activation is required for antiphospholipid antibody induced fetal loss. J Exp Med. 2002 ; 195: 211-220
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1    Girardi, G.2    Mo, L.3
  • 32
    • 4644311061 scopus 로고    scopus 로고
    • Antiphospholipid antibodies as cause of pregnancy loss
    • Meroni PL, di Simone N, Testoni C, et al. Antiphospholipid antibodies as cause of pregnancy loss. Lupus. 2004 ; 13: 649-652
    • (2004) Lupus , vol.13 , pp. 649-652
    • Meroni, P.L.1    Di Simone, N.2    Testoni, C.3
  • 33
    • 0031873355 scopus 로고    scopus 로고
    • Placental pathology in systemic lupus erythematosus: A prospective study
    • Magid MS, Kaplan C, Sammaritano LR, et al. Placental pathology in systemic lupus erythematosus: a prospective study. Am J Obstet Gynecol. 1998 ; 179: 226-234
    • (1998) Am J Obstet Gynecol , vol.179 , pp. 226-234
    • Magid, M.S.1    Kaplan, C.2    Sammaritano, L.R.3
  • 34
    • 0026463621 scopus 로고
    • Complement and pregnancy: New insights into the immunobiology of the fetal-maternal relationship
    • Holmes CH, Simpson KL. Complement and pregnancy: new insights into the immunobiology of the fetal-maternal relationship. Balliere's Clin Obstet Gynecol. 1992 ; 6: 439-459
    • (1992) Balliere's Clin Obstet Gynecol , vol.6 , pp. 439-459
    • Holmes, C.H.1    Simpson, K.L.2
  • 35
    • 0028887580 scopus 로고
    • Decay-accelerating factor protects human trophoblast from complement-mediated attack
    • Cunningham DS, Tichenor JR. Decay-accelerating factor protects human trophoblast from complement-mediated attack. Clin Immunol Immunopathol. 1995 ; 74: 156-161
    • (1995) Clin Immunol Immunopathol , vol.74 , pp. 156-161
    • Cunningham, D.S.1    Tichenor, J.R.2
  • 36
    • 70350751567 scopus 로고    scopus 로고
    • The immunological puzzle of recurrent miscarriage
    • Alijotas-Reig J. The immunological puzzle of recurrent miscarriage. Curr Immunol Rev. 2009 ; 5: 175-186
    • (2009) Curr Immunol Rev , vol.5 , pp. 175-186
    • Alijotas-Reig, J.1
  • 37
    • 0032873588 scopus 로고    scopus 로고
    • Pre-implantation endometrial leukocytes in women with recurrent miscarriage
    • Quenby S, Bates M, Doig T, et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod. 1999 ; 14: 2386-2391
    • (1999) Hum Reprod , vol.14 , pp. 2386-2391
    • Quenby, S.1    Bates, M.2    Doig, T.3
  • 38
    • 34547799185 scopus 로고    scopus 로고
    • Prognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage
    • Tuckerman E, Laird S, Prakash A, et al. Prognostic value of the measurement of uterine natural killer cells in the endometrium of women with recurrent miscarriage. Hum Reprod. 2007 ; 22: 2208-2213
    • (2007) Hum Reprod , vol.22 , pp. 2208-2213
    • Tuckerman, E.1    Laird, S.2    Prakash, A.3
  • 39
    • 0029971226 scopus 로고    scopus 로고
    • The immunological pregnancy protective effect of progesterone is manifested via controlling cytokine production
    • Szekeres-Bartho J, Faust Z, Varga P, et al. The immunological pregnancy protective effect of progesterone is manifested via controlling cytokine production. Am J Reprod Immunol. 1996 ; 35: 348-351
    • (1996) Am J Reprod Immunol , vol.35 , pp. 348-351
    • Szekeres-Bartho, J.1    Faust, Z.2    Varga, P.3
  • 40
    • 34848906294 scopus 로고    scopus 로고
    • Recurrent spontaneous abortions in antiphospholipid syndrome: Natural killer cells-an additional mechanism in a multifactorial process
    • Carp HJA, Shoenfeld Y. Recurrent spontaneous abortions in antiphospholipid syndrome: natural killer cells-an additional mechanism in a multifactorial process. Rheumatology. 2007 ; 46: 1517-1519
    • (2007) Rheumatology , vol.46 , pp. 1517-1519
    • Carp, H.J.A.1    Shoenfeld, Y.2
  • 41
    • 70350756320 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation
    • Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999 ; 42: 71-75
    • (1999) N Engl J Med , vol.42 , pp. 71-75
    • Levi, M.1    Ten Cate, H.2
  • 42
    • 0022256487 scopus 로고
    • The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes of healthy pregnant women release a factor inhibiting cytotoxicity and prostaglandin synthesis
    • Szekeres-Bartho J, Kilar F, Falkay G, et al. The mechanism of the inhibitory effect of progesterone on lymphocyte cytotoxicity: I. Progesterone-treated lymphocytes of healthy pregnant women release a factor inhibiting cytotoxicity and prostaglandin synthesis. Am J Reprod Immunol Microbiol. 1985 ; 9: 15-19
    • (1985) Am J Reprod Immunol Microbiol , vol.9 , pp. 15-19
    • Szekeres-Bartho, J.1    Kilar, F.2    Falkay, G.3
  • 43
    • 0033170413 scopus 로고    scopus 로고
    • Progesterone induced blocking factor inhibits degranulation of NK cells
    • Faust Z, Laskarin G, Rukavina D, et al. Progesterone induced blocking factor inhibits degranulation of NK cells. Am J Reprod Immunol. 1999 ; 42: 71-75
    • (1999) Am J Reprod Immunol , vol.42 , pp. 71-75
    • Faust, Z.1    Laskarin, G.2    Rukavina, D.3
  • 44
    • 34848906294 scopus 로고    scopus 로고
    • Recurrent spontaneous abortions in antiphospholipid syndrome: Natural killer cells-an additional mechanism in a multifactorial process
    • Carp HJA, Shoenfeld Y. Recurrent spontaneous abortions in antiphospholipid syndrome: natural killer cells-an additional mechanism in a multifactorial process. Rheumatology. 2007 ; 46: 1517-1519
    • (2007) Rheumatology , vol.46 , pp. 1517-1519
    • Carp, H.J.A.1    Shoenfeld, Y.2
  • 45
    • 34848864591 scopus 로고    scopus 로고
    • High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: A potential new hypothesis
    • Perricone C, De Carolis C, Giaccomelli R, et al. High levels of NK cells in the peripheral blood of patients affected with anti-phospholipid syndrome and recurrent spontaneous abortion: a potential new hypothesis. Rheumatology. 2007 ; 46: 1574-1578
    • (2007) Rheumatology , vol.46 , pp. 1574-1578
    • Perricone, C.1    De Carolis, C.2    Giaccomelli, R.3
  • 46
    • 10844288801 scopus 로고    scopus 로고
    • TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss
    • Berman J, Girardi G, Salmon JE. TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol. 2005 ; 174: 1222-1226
    • (2005) J Immunol , vol.174 , pp. 1222-1226
    • Berman, J.1    Girardi, G.2    Salmon, J.E.3
  • 47
    • 79958086576 scopus 로고    scopus 로고
    • Pathogenesis of antiphospholipid syndrome: Understanding the antibodies
    • Meroni PL, Borghi MO, Raschi E, et al. Pathogenesis of antiphospholipid syndrome: understanding the antibodies. Nat Rev Rheumatol. 2011 ; 7: 330-339
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 330-339
    • Meroni, P.L.1    Borghi, M.O.2    Raschi, E.3
  • 48
    • 33847253520 scopus 로고    scopus 로고
    • Pathogenic role of anti-β2-glycoprotein i antibodies on human placenta: Functional effects related to implantation and roles of heparin
    • Di Simone N, Meroni PL, D'Asta M, et al. Pathogenic role of anti-β2-glycoprotein I antibodies on human placenta: functional effects related to implantation and roles of heparin. Hum Reprod Update. 2007 ; 13: 189-196
    • (2007) Hum Reprod Update , vol.13 , pp. 189-196
    • Di Simone, N.1    Meroni, P.L.2    D'Asta, M.3
  • 49
    • 77955343208 scopus 로고    scopus 로고
    • Antiphospholipid antibodies affect human endometrial angiogenesis
    • Di Simone N, Di Nicuolo F, D'Ippolito S, et al. Antiphospholipid antibodies affect human endometrial angiogenesis. Biol Reprod. 2010 ; 83: 212-219
    • (2010) Biol Reprod , vol.83 , pp. 212-219
    • Di Simone, N.1    Di Nicuolo, F.2    D'Ippolito, S.3
  • 50
    • 84855297285 scopus 로고    scopus 로고
    • Effect of low molecular weight heparins on antiphospholipid antibodies-mediated inhibition of endometrial angiogenesis
    • D'Ippolito S, Marana R, Di Nicuolo F, et al. Effect of low molecular weight heparins on antiphospholipid antibodies-mediated inhibition of endometrial angiogenesis. PLoS ONE. 2012 ; 7: e29660 - e29660
    • (2012) PLoS ONE , vol.7
    • D'Ippolito, S.1    Marana, R.2    Di Nicuolo, F.3
  • 51
    • 77951230873 scopus 로고    scopus 로고
    • Towards evidence-based treatment of thrombotic antiphospholipid syndrome
    • Derksen RH, de Groot PG. Towards evidence-based treatment of thrombotic antiphospholipid syndrome. Lupus. 2010 ; 19: 470-474
    • (2010) Lupus , vol.19 , pp. 470-474
    • Derksen, R.H.1    De Groot, P.G.2
  • 52
    • 79953305113 scopus 로고    scopus 로고
    • Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report to a Task Force at the 13th International Congress on Antiphospholipid Antibodies
    • Ruiz-Irastorza G, Cuadrado M, Ruiz-Arruza I, et al. Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report to a Task Force at the 13th International Congress on Antiphospholipid Antibodies. Lupus. 2011 ; 20: 206-218
    • (2011) Lupus , vol.20 , pp. 206-218
    • Ruiz-Irastorza, G.1    Cuadrado, M.2    Ruiz-Arruza, I.3
  • 53
    • 45949094478 scopus 로고    scopus 로고
    • Venous thromboembolism, thrombophilias, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [8th edn]
    • Bates SM, Greer IA, Pabinger I, et al. Venous thromboembolism, thrombophilias, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [8th edn]. Chest. 2008 ; 133 (6 Suppl): 844S - 886S
    • (2008) Chest , vol.1336
    • Bates, S.M.1    Greer, I.A.2    Pabinger, I.3
  • 54
    • 79955014016 scopus 로고    scopus 로고
    • Consultative hematology: The pregnant patient pregnancy loss
    • Bates SM. Consultative hematology: the pregnant patient pregnancy loss. Haematology Am Soc Hematol Educ Program. 2010 ; 2010: 166-172
    • (2010) Haematology Am Soc Hematol Educ Program , vol.2010 , pp. 166-172
    • Bates, S.M.1
  • 55
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholid antibodies
    • Espinosa RG, Pierangeli SS, Gharavi AE, et al. Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholid antibodies. Thromb Haemost. 2002 ; 87: 518-522
    • (2002) Thromb Haemost , vol.87 , pp. 518-522
    • Espinosa, R.G.1    Pierangeli, S.S.2    Gharavi, A.E.3
  • 56
    • 0031442025 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice
    • Edwards MH, Pierangeli SS, Liu X, et al. Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice. Circulation. 1997 ; 96: 4380-4384
    • (1997) Circulation , vol.96 , pp. 4380-4384
    • Edwards, M.H.1    Pierangeli, S.S.2    Liu, X.3
  • 57
    • 33646883947 scopus 로고    scopus 로고
    • Heparin prevents programmed cell death in human trophosblast
    • Hills FA, Abrahams VM, Gonzalez-Timón B, et al. Heparin prevents programmed cell death in human trophosblast. Mol Hum Reprod. 2006 ; 12: 237-243
    • (2006) Mol Hum Reprod , vol.12 , pp. 237-243
    • Hills, F.A.1    Abrahams, V.M.2    Gonzalez-Timón, B.3
  • 58
    • 77951665492 scopus 로고    scopus 로고
    • Low-molecular-weight heparin inhibition in classical complement activation pathway during pregnancy
    • Oberkersch R, Attoresi A, Calabrese GC. Low-molecular-weight heparin inhibition in classical complement activation pathway during pregnancy. Thromb Res. 2010 ; 125: e240-245
    • (2010) Thromb Res , vol.125 , pp. 240-245
    • Oberkersch, R.1    Attoresi, A.2    Calabrese, G.C.3
  • 59
    • 80051798819 scopus 로고    scopus 로고
    • Complement and the antiphospholipid syndrome
    • Lim W. Complement and the antiphospholipid syndrome. Curr Opinion Hematol. 2011 ; 18: 361-365
    • (2011) Curr Opinion Hematol , vol.18 , pp. 361-365
    • Lim, W.1
  • 60
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid- induced fetal loss by inhibiting complement activation. Nat Med. 2004 ; 10: 1226-1226
    • (2004) Nat Med , vol.10 , pp. 1226-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 61
    • 33846883533 scopus 로고    scopus 로고
    • Low molecular weight heparin suppresses tumor necrosis factor expression from deep vein thrombosis
    • Carr JA, Cho JS. Low molecular weight heparin suppresses tumor necrosis factor expression from deep vein thrombosis. Ann Vasc Surg. 2007 ; 21: 50-55
    • (2007) Ann Vasc Surg , vol.21 , pp. 50-55
    • Carr, J.A.1    Cho, J.S.2
  • 62
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med. 2004 ; 10: 1222-1226
    • (2004) Nat Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 63
    • 0037239007 scopus 로고    scopus 로고
    • Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide [fondaparinux]
    • Samama MM, Gerotziafas GT. Evaluation of the pharmacological properties and clinical results of the synthetic pentasaccharide [fondaparinux]. Thromb Res. 2003 ; 109: 1-11
    • (2003) Thromb Res , vol.109 , pp. 1-11
    • Samama, M.M.1    Gerotziafas, G.T.2
  • 64
    • 84861561957 scopus 로고    scopus 로고
    • Circulating B2glycoprotein I-IgG anti-B2glycoprotein i immunocomplexes in patients with definite antiphospholipid syndrome
    • Banzato A, Frasson R, Acqusaliente L, et al. Circulating B2glycoprotein I-IgG anti-B2glycoprotein I immunocomplexes in patients with definite antiphospholipid syndrome. Lupus. 2012 ; 21: 784-786
    • (2012) Lupus , vol.21 , pp. 784-786
    • Banzato, A.1    Frasson, R.2    Acqusaliente, L.3
  • 65
    • 78149477844 scopus 로고    scopus 로고
    • Molecular intercommunications between the complement and coagulation systems
    • Amara U, Fliert MA, Rittirsch D, et al. Molecular intercommunications between the complement and coagulation systems. J Immunol. 2010 ; 185: 5268-5236
    • (2010) J Immunol , vol.185 , pp. 5268-5236
    • Amara, U.1    Ma, F.2    Rittirsch, D.3
  • 66
    • 84865244127 scopus 로고    scopus 로고
    • Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes
    • Da Pozzo E, Barsoti MC, Benditelli S, et al. Differential effects of fondaparinux and bemiparin on angiogenic and vasculogenesis-like processes. Thromb Res 2012; 130: e113-122.
    • (2012) Thromb Res , vol.130
    • Da Pozzo, E.1    Barsoti, M.C.2    Benditelli, S.3
  • 67
    • 82955212870 scopus 로고    scopus 로고
    • IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation
    • Ben-Hadj-Khalifa S, Hézard N, Almawi WY, et al. IL-10 modulates fondaparinux inhibition of monocyte-induced thrombin generation. J Throm Thrombolysis. 2011 ; 32: 311-317
    • (2011) J Throm Thrombolysis , vol.32 , pp. 311-317
    • Ben-Hadj-Khalifa, S.1    Hézard, N.2    Almawi, W.Y.3
  • 68
    • 79955613224 scopus 로고    scopus 로고
    • Lupus and pregnancy: Integrating clues from the bench and bedside
    • Ruiz-Irastorza G, Khamashta MA. Lupus and pregnancy: integrating clues from the bench and bedside. Eur J Clin Invest. 2011 ; 41: 672-678
    • (2011) Eur J Clin Invest , vol.41 , pp. 672-678
    • Ruiz-Irastorza, G.1    Khamashta, M.A.2
  • 69
    • 33744823535 scopus 로고    scopus 로고
    • Chloroquine treatment influences proinflammatory cytokine level in systemic lupus erythematosus patients
    • Wozniacka A, Lesiak A, Narbutt JM, et al. Chloroquine treatment influences proinflammatory cytokine level in systemic lupus erythematosus patients. Lupus. 2006 ; 15: 268-275
    • (2006) Lupus , vol.15 , pp. 268-275
    • Wozniacka, A.1    Lesiak, A.2    Narbutt, J.M.3
  • 70
    • 7244254348 scopus 로고    scopus 로고
    • Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
    • Rand JH, Wu XX, Lapinski R, et al. Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. Blood. 2004 ; 104: 2783-2790
    • (2004) Blood , vol.104 , pp. 2783-2790
    • Rand, J.H.1    Wu, X.X.2    Lapinski, R.3
  • 71
    • 80255129699 scopus 로고    scopus 로고
    • Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome
    • Hunt BJ, Wu XX, de Laat B, et al. Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome. Am J Obstet Gynecol. 2011 ; 205: 485.e17-23.6
    • (2011) Am J Obstet Gynecol , vol.205
    • Hunt, B.J.1    Wu, X.X.2    De Laat, B.3
  • 72
    • 77950435764 scopus 로고    scopus 로고
    • Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: Evidence for a novel effect for an old antimalarial drug
    • Rand JH, Wu XX, Quinn AS, et al. Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug. Blood. 2010 ; 115: 2292-229
    • (2010) Blood , vol.115 , pp. 2292-3229
    • Rand, J.H.1    Wu, X.X.2    Quinn, A.S.3
  • 73
    • 0042925727 scopus 로고    scopus 로고
    • Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: Evidence from atomic force microscopy and functional assay
    • Rand JH, Wu XX, Quinn As , et al. Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. Am J Pathol. 2003 ; 163: 1193-1200
    • (2003) Am J Pathol , vol.163 , pp. 1193-1200
    • Rand, J.H.1    Wu, X.X.2    As, Q.3
  • 74
    • 77951217438 scopus 로고    scopus 로고
    • The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: Role in pregnancy losses and thrombosis
    • Rand J, Wu X, Quinn A, et al. The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis. Lupus. 2010 ; 19: 460-469
    • (2010) Lupus , vol.19 , pp. 460-469
    • Rand, J.1    Wu, X.2    Quinn, A.3
  • 75
    • 33646596912 scopus 로고    scopus 로고
    • Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin [ESPRIT]: Randomised controlled trial
    • ESPRIT Study Group
    • ESPRIT Study Group, Halkes PH, van Gijn J, Kappelle LJ, et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin [ESPRIT]: randomised controlled trial. Lancet. 2006 ; 367: 1665-1673
    • (2006) Lancet , vol.367 , pp. 1665-1673
    • Halkes, P.H.1    Van Gijn, J.2    Kappelle, L.J.3
  • 76
    • 0026605355 scopus 로고
    • Risk of recurrent thromboembolic events in patients with focal cerebral ischemia and antiphospholipid antibodies. The Antiphospholipid Antibodies in Stroke Study Group
    • Levine SR, Brey RL, Joseph CL, et al. Risk of recurrent thromboembolic events in patients with focal cerebral ischemia and antiphospholipid antibodies. The Antiphospholipid Antibodies in Stroke Study Group. Stroke. 1992 ; 23 (2 Suppl). 129-132
    • (1992) Stroke , vol.23 , Issue.SUPPL. 2 , pp. 129-132
    • Levine, S.R.1    Brey, R.L.2    Joseph, C.L.3
  • 77
    • 78649873524 scopus 로고    scopus 로고
    • Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic condition in rat placental villous explants
    • George EM, Cockrell K, Adair TH, et al. Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic condition in rat placental villous explants. Am J Physiol Regul Integr Comp Physiol. 2010 ; 299: R1629-1633
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.299 , pp. 1629-1633
    • George, E.M.1    Cockrell, K.2    Adair, T.H.3
  • 78
    • 34249034723 scopus 로고    scopus 로고
    • Antiplatelet agents for preventing pre-eclampsia and its complications
    • Duley L, Henderson-Smart DJ, Meher S, et al. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane database Syst Rev. 2007 ; 18: CD004659 - CD004659
    • (2007) Cochrane Database Syst Rev , vol.18
    • Duley, L.1    Henderson-Smart, D.J.2    Meher, S.3
  • 79
    • 0028319106 scopus 로고
    • A primitive catastrophic antiphospholipid syndrome
    • Vivaldi P, Andreotti C, Mazzoni C, et al. A primitive catastrophic antiphospholipid syndrome. Haematologica. 1994 ; 79: 173-176
    • (1994) Haematologica , vol.79 , pp. 173-176
    • Vivaldi, P.1    Andreotti, C.2    Mazzoni, C.3
  • 80
    • 0036732005 scopus 로고    scopus 로고
    • Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator
    • Burcoglu-O'Ral A, Erkan D, Asherson R. Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. J Rheumatol. 2002 ; 29: 2006-2011
    • (2002) J Rheumatol , vol.29 , pp. 2006-2011
    • Burcoglu-O'Ral, A.1    Erkan, D.2    Asherson, R.3
  • 81
    • 0020640457 scopus 로고
    • Fetal survival after prednisone suppression of maternal lupus anticoagulant
    • Lubbe W, Butler W, Palmer S, et al. Fetal survival after prednisone suppression of maternal lupus anticoagulant. Lancet. 1983 ; 1: 1361-1363
    • (1983) Lancet , vol.1 , pp. 1361-1363
    • Lubbe, W.1    Butler, W.2    Palmer, S.3
  • 82
    • 0013570260 scopus 로고
    • Glucocortiocoids
    • Kelley NK, Harris ED, Ruddy S, Sledge C (eds) 4th ed. Philadelphia, W.B. Saunders Co
    • Axelrod L. Glucocortiocoids. In: Kelley NK, Harris ED, Ruddy S, Sledge C (eds) Textbook of rheumatology. 4th ed. Philadelphia, W.B. Saunders Co, 1993, vol 1, pp.779-796.
    • (1993) Textbook of Rheumatology , vol.1 , pp. 779-796
    • Axelrod, L.1
  • 83
    • 84871601292 scopus 로고
    • Effects of corticosteroids on complement and the neutrophil polymorphonuclear leukocyte
    • Sneiderman C, Wilson J. Effects of corticosteroids on complement and the neutrophil polymorphonuclear leukocyte. Transplant Proc. 1975 ; 1: 1361-1363
    • (1975) Transplant Proc , vol.1 , pp. 1361-1363
    • Sneiderman, C.1    Wilson, J.2
  • 84
    • 0347407873 scopus 로고    scopus 로고
    • Successful pregnancy outcome following 19 consecutive miscarriages
    • Quenby S, Farquharson R, Young M, et al. Successful pregnancy outcome following 19 consecutive miscarriages. Hum Reprod. 2003 ; 18: 2562-2564
    • (2003) Hum Reprod , vol.18 , pp. 2562-2564
    • Quenby, S.1    Farquharson, R.2    Young, M.3
  • 85
    • 79959504067 scopus 로고    scopus 로고
    • First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss
    • Bramham K, Thomas M, Nelson-Piercy C, et al. First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. Blood. 2011 ; 117: 6948-6951
    • (2011) Blood , vol.117 , pp. 6948-6951
    • Bramham, K.1    Thomas, M.2    Nelson-Piercy, C.3
  • 86
    • 0030746019 scopus 로고    scopus 로고
    • Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss
    • Laskin CA, Bombardieri C, Hannah ME, et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med. 1997 ; 337: 148-153
    • (1997) N Engl J Med , vol.337 , pp. 148-153
    • Laskin, C.A.1    Bombardieri, C.2    Hannah, M.E.3
  • 87
    • 0030940457 scopus 로고    scopus 로고
    • Placental 11 beta-hydroxysteroid dehydrogenase: A key regulator of fetal glucocorticoid exposure
    • Benediktsson R, Calder A, Edwards C, et al. Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol [Oxf]. 1997 ; 46: 161-166
    • (1997) Clin Endocrinol [Oxf] , vol.46 , pp. 161-166
    • Benediktsson, R.1    Calder, A.2    Edwards, C.3
  • 88
    • 85027928073 scopus 로고    scopus 로고
    • In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage
    • Akther A, Faridi RM, Das V, et al. In vitro up-regulation of HLA-G using dexamethasone and hydrocortisone in first-trimester trophoblast cells of women experiencing recurrent miscarriage. Tissue Antigens 2012; 80: 126-135.
    • (2012) Tissue Antigens , vol.80 , pp. 126-135
    • Akther, A.1    Faridi, R.M.2    Das, V.3
  • 89
    • 79958140473 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy in rheumatic diseases
    • Bayry J, Negi VS. Intravenous immunoglobulin therapy in rheumatic diseases. Nat Rev Rheumatol. 2011 ; 7: 349-359
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 349-359
    • Bayry, J.1    Negi, V.S.2
  • 91
    • 42949130562 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion
    • Perricone R, De Carolis C, Kröegler B, et al. Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. Rheumatology. 2008 ; 47: 646-651
    • (2008) Rheumatology , vol.47 , pp. 646-651
    • Perricone, R.1    De Carolis, C.2    Kröegler, B.3
  • 92
    • 77249176999 scopus 로고    scopus 로고
    • Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome
    • Cervera R. Update on the diagnosis, treatment, and prognosis of the catastrophic antiphospholipid syndrome. Curr Rheumatol Rep. 2010 ; 12: 70-76
    • (2010) Curr Rheumatol Rep , vol.12 , pp. 70-76
    • Cervera, R.1
  • 93
    • 68249099717 scopus 로고    scopus 로고
    • Management of antiphospholipid syndrome
    • Tuthill J, Khamashta M. Management of antiphospholipid syndrome. J Autoimmun. 2009 ; 33: 92-98
    • (2009) J Autoimmun , vol.33 , pp. 92-98
    • Tuthill, J.1    Khamashta, M.2
  • 94
    • 0037334440 scopus 로고    scopus 로고
    • Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulins in the treatment of recurrent fetal loss associated with antiphospholipid antibodies
    • Triolo G, Ferrante A, Ciccia F, et al. Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulins in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis Rheum. 2003 ; 48: 728-731
    • (2003) Arthritis Rheum , vol.48 , pp. 728-731
    • Triolo, G.1    Ferrante, A.2    Ciccia, F.3
  • 95
    • 0033979270 scopus 로고    scopus 로고
    • A multicenter placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group
    • Branch D, Peaceman A, Druzin M, et al. A multicenter placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol. 2000 ; 182: 122-127
    • (2000) Am J Obstet Gynecol , vol.182 , pp. 122-127
    • Branch, D.1    Peaceman, A.2    Druzin, M.3
  • 96
    • 66549127166 scopus 로고    scopus 로고
    • Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome
    • Dendrinos S, Sakkas E, Makrakis E. Low-molecular-weight heparin versus intravenous immunoglobulin for recurrent abortion associated with antiphospholipid antibody syndrome. Int J Gynaecol Obstet. 2009 ; 104: 223-225
    • (2009) Int J Gynaecol Obstet , vol.104 , pp. 223-225
    • Dendrinos, S.1    Sakkas, E.2    Makrakis, E.3
  • 97
    • 84856019006 scopus 로고    scopus 로고
    • Antiphospholipid antibodies and recurrent implantation failure in in-vitro fertilization. The debate goes on
    • Lopera-Vallejo AF, Alijotas-Reig J. Antiphospholipid antibodies and recurrent implantation failure in in-vitro fertilization. The debate goes on. Med Clin [Barc]. 2011 ; 137: 697-701
    • (2011) Med Clin [Barc] , vol.137 , pp. 697-701
    • Lopera-Vallejo, A.F.1    Alijotas-Reig, J.2
  • 98
    • 1542347806 scopus 로고    scopus 로고
    • Combined therapy in pregnancy with primary antiphospholipid syndrome
    • Szodoray P, Bacskó G, Lakos G, et al. Combined therapy in pregnancy with primary antiphospholipid syndrome. Orv Hetil. 2003 ; 144: 2411-2413
    • (2003) Orv Hetil , vol.144 , pp. 2411-2413
    • Szodoray, P.1    Bacskó, G.2    Lakos, G.3
  • 99
    • 0035133651 scopus 로고    scopus 로고
    • Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: A comparative study of intravenous immunoglobulin versus prednisolone plus low-dose aspirin
    • Vaquero E, Lazzarin N, Valensise H, et al. Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisolone plus low-dose aspirin. Am J Reprod Immunol. 2001 ; 45: 174-179
    • (2001) Am J Reprod Immunol , vol.45 , pp. 174-179
    • Vaquero, E.1    Lazzarin, N.2    Valensise, H.3
  • 100
    • 37849033854 scopus 로고    scopus 로고
    • Intravenous immunoglobulin: Effect on infertility and recurrent pregnancy loss
    • Carp HJA. Intravenous immunoglobulin: effect on infertility and recurrent pregnancy loss. Israel Medical Association Journal (IMAJ). 2007 ; 9: 877-880
    • (2007) Israel Medical Association Journal (IMAJ) , vol.9 , pp. 877-880
    • Carp, H.J.A.1
  • 101
    • 84861934279 scopus 로고    scopus 로고
    • Intravenous immunoglobulin treatment increased live birth rate in a Spanish of women with recurrent reproductive failure and expanded CD56[+] cells
    • Moraru M, Carbone J, Alecsandru D, et al. Intravenous immunoglobulin treatment increased live birth rate in a Spanish of women with recurrent reproductive failure and expanded CD56[+] cells. Am J Reprod Immunol 2012; 68: 75-84.
    • (2012) Am J Reprod Immunol , vol.68 , pp. 75-84
    • Moraru, M.1    Carbone, J.2    Alecsandru, D.3
  • 102
    • 80051917173 scopus 로고    scopus 로고
    • A two-center study on the pharmacokinetics of intravenous immunoglobulin before and during pregnancy in healthy women with poor obstetrical histories
    • Ensom MH, Stephenson MD. A two-center study on the pharmacokinetics of intravenous immunoglobulin before and during pregnancy in healthy women with poor obstetrical histories. Hum Reprod. 2011 ; 26: 2283-228
    • (2011) Hum Reprod , vol.26 , pp. 2283-3228
    • Ensom, M.H.1    Stephenson, M.D.2
  • 103
    • 16444377894 scopus 로고    scopus 로고
    • Efficacy, tolerability and cost effectiveness of disease-modifying antirheumatic drugs and biologic agents in rheumatoid arthritis
    • Nurmohamed MT, Dijkmans BA. Efficacy, tolerability and cost effectiveness of disease-modifying antirheumatic drugs and biologic agents in rheumatoid arthritis. Drugs. 2005 ; 65: 661-694
    • (2005) Drugs , vol.65 , pp. 661-694
    • Nurmohamed, M.T.1    Dijkmans, B.A.2
  • 105
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, et al. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. Journal of American Medical Association (JAMA). 2006 ; 295: 2275-2285
    • (2006) Journal of American Medical Association (JAMA) , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3
  • 106
    • 58749115377 scopus 로고    scopus 로고
    • Exposition to anti-TNF drugs during pregnancy: Outcome of 15 cases and review of the literature
    • Berthelot JM, De Bandt M, Goupille P, et al. Exposition to anti-TNF drugs during pregnancy: outcome of 15 cases and review of the literature. Joint Bone Spine. 2009 ; 76: 28-34
    • (2009) Joint Bone Spine , vol.76 , pp. 28-34
    • Berthelot, J.M.1    De Bandt, M.2    Goupille, P.3
  • 107
    • 33746985526 scopus 로고    scopus 로고
    • Are we coming to terms with tumor necrosis factor inhibition in pregnancy?
    • Salmon JE, Alpert D. Are we coming to terms with tumor necrosis factor inhibition in pregnancy?. Arthritis Rheum. 2006 ; 54: 2353-235
    • (2006) Arthritis Rheum , vol.54 , pp. 2353-3235
    • Salmon, J.E.1    Alpert, D.2
  • 108
    • 34548281182 scopus 로고    scopus 로고
    • Pregnancy in rheumatology patients exposed to anti-tumor [TNF]-alpha therapy
    • Rosner I, Haddad A, Boulman N, et al. Pregnancy in rheumatology patients exposed to anti-tumor [TNF]-alpha therapy. Rheumatology. 2007 ; 46: 1508-1509
    • (2007) Rheumatology , vol.46 , pp. 1508-1509
    • Rosner, I.1    Haddad, A.2    Boulman, N.3
  • 109
    • 16344365796 scopus 로고    scopus 로고
    • Unexpected dramatic clinical response of psoriasis lesions and unexpected pregnancy in an infertile patient in response to treatment with anti-tumor necrosis factor monoclonal antibody for Crohn's disease
    • Bank LHB. Unexpected dramatic clinical response of psoriasis lesions and unexpected pregnancy in an infertile patient in response to treatment with anti-tumor necrosis factor monoclonal antibody for Crohn's disease. Am J Gastroenterol. 2002 ; 97 (Abstract). S260 - S260
    • (2002) Am J Gastroenterol , vol.97 , Issue.ABSTRACT
    • Bank, L.H.B.1
  • 110
    • 72149112759 scopus 로고    scopus 로고
    • Autoimmune diseases induced by biological agents: A double-edged sword?
    • Ramos-Casals M, Roberto-Perez-Alvarez , Diaz-Lagares C, et al. Autoimmune diseases induced by biological agents: a double-edged sword?. Autoimmun Rev. 2010 ; 9: 188-193
    • (2010) Autoimmun Rev , vol.9 , pp. 188-193
    • Ramos-Casals, M.1    Roberto-Perez-Alvarez2    Diaz-Lagares, C.3
  • 111
    • 58249141891 scopus 로고    scopus 로고
    • Treatment with Adalimumab [HumiraR] and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF
    • Winger EE, Reed JL, Ashoush S, et al. Treatment with Adalimumab [HumiraR] and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol. 2009 ; 61: 113-120
    • (2009) Am J Reprod Immunol , vol.61 , pp. 113-120
    • Winger, E.E.1    Reed, J.L.2    Ashoush, S.3
  • 112
    • 45349107145 scopus 로고    scopus 로고
    • Treatment with tumor necrosis factor inhibitors and intravenous immunoglobulin improves live birth rates in women with recurrent spontaneous abortion
    • Winger EE, Reed JL. Treatment with tumor necrosis factor inhibitors and intravenous immunoglobulin improves live birth rates in women with recurrent spontaneous abortion. Am J Reprod Immunol. 2008 ; 60: 8-16
    • (2008) Am J Reprod Immunol , vol.60 , pp. 8-16
    • Winger, E.E.1    Reed, J.L.2
  • 113
    • 58249133221 scopus 로고    scopus 로고
    • Th-1/Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options
    • Beer AE. Th-1/Th-2 natural killer cell activation systemically and locally in the endometrium and therapeutic options. Am J Reprod Immunol. 2001 ; 45: 23-23
    • (2001) Am J Reprod Immunol , vol.45 , pp. 23-23
    • Beer, A.E.1
  • 114
    • 58249144381 scopus 로고    scopus 로고
    • Etanercept and immune treatment in multiple IVF failures
    • Mangubat CP, Thaker PP, Cavalcante M, et al. Etanercept and immune treatment in multiple IVF failures. Am J Reprod Immunol. 2001 ; 45: 24-24
    • (2001) Am J Reprod Immunol , vol.45 , pp. 24-24
    • Mangubat, C.P.1    Thaker, P.P.2    Cavalcante, M.3
  • 115
    • 12444342763 scopus 로고
    • IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau
    • Chaouat G, Assal-Meliani A, Martal J, et al. IL-10 prevents naturally occurring fetal loss in the CBAxDBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol. 1995 ; 154: 426-428
    • (1995) J Immunol , vol.154 , pp. 426-428
    • Chaouat, G.1    Assal-Meliani, A.2    Martal, J.3
  • 116
    • 44049099283 scopus 로고    scopus 로고
    • Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice
    • Zhong XH, Shi WY, Ma AT, et al. Effects of Radix scutellariae and Rhizoma atractylodis on LPS-induced abortion and the uterine IL-10 contents in mice. Am J Chin Med. 2008 ; 36: 141-148
    • (2008) Am J Chin Med , vol.36 , pp. 141-148
    • Zhong, X.H.1    Shi, W.Y.2    Ma, A.T.3
  • 117
    • 64549101645 scopus 로고    scopus 로고
    • Immunological mechanisms of pentoxifylline in chronic heart failure
    • Shaw SM, Shah MKH, Williams SG, et al. Immunological mechanisms of pentoxifylline in chronic heart failure. Eur J Cardiol. 2009 ; XX: 113-118
    • (2009) Eur J Cardiol , vol.20 , pp. 113-118
    • Shaw, S.M.1    Shah, M.K.H.2    Williams, S.G.3
  • 119
    • 47649110500 scopus 로고    scopus 로고
    • Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: A preliminary trial
    • Creus M, Fabregues F, Carmona F, et al. Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial. Hum Reprod. 2008 ; 23: 1910-1916
    • (2008) Hum Reprod , vol.23 , pp. 1910-1916
    • Creus, M.1    Fabregues, F.2    Carmona, F.3
  • 120
    • 0034779270 scopus 로고    scopus 로고
    • Antiphospholipid thrombosis syndromes
    • Bick RL. Antiphospholipid thrombosis syndromes. Clin Appl Thromb Hemost. 2001 ; 7: 241-258
    • (2001) Clin Appl Thromb Hemost , vol.7 , pp. 241-258
    • Bick, R.L.1
  • 121
    • 0037307282 scopus 로고    scopus 로고
    • Successful pregnancies after combined pentoxifylline-tocopherol treatment in women with premature ovarian failure who are resistant to hormone replacement therapy
    • Letur-Konirsch H, Delanian S. Successful pregnancies after combined pentoxifylline-tocopherol treatment in women with premature ovarian failure who are resistant to hormone replacement therapy. Fertil Steril. 2003 ; 79: 439-441
    • (2003) Fertil Steril , vol.79 , pp. 439-441
    • Letur-Konirsch, H.1    Delanian, S.2
  • 122
    • 84862496402 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in antiphospholipid syndrome: Implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment
    • Perez-Sanchez C, Ruiz-Limon P, Aguirre MA, et al. Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment. Blood 2012; 119: 5859-5870.
    • (2012) Blood , vol.119 , pp. 5859-5870
    • Perez-Sanchez, C.1    Ruiz-Limon, P.2    Ma, A.3
  • 123
    • 34548150136 scopus 로고    scopus 로고
    • Vitamin D and autoimmunity: New aetiological and therapeutic considerations
    • Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007 ; 66: 1137-1142
    • (2007) Ann Rheum Dis , vol.66 , pp. 1137-1142
    • Arnson, Y.1    Amital, H.2    Shoenfeld, Y.3
  • 124
    • 78650676621 scopus 로고    scopus 로고
    • Vitamin D: An instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression
    • Agmon-Levin N, Blank M, Zandman-Goddard G, et al. Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis. 2011 ; 70: 145-150
    • (2011) Ann Rheum Dis , vol.70 , pp. 145-150
    • Agmon-Levin, N.1    Blank, M.2    Zandman-Goddard, G.3
  • 125
    • 34247130470 scopus 로고    scopus 로고
    • Hughes syndrome: The antiphospholipid syndrome -a clinical overview
    • Hughes G. Hughes syndrome: the antiphospholipid syndrome -a clinical overview. Clin Rev Allergy Immunol. 2007 ; 32: 3-12
    • (2007) Clin Rev Allergy Immunol , vol.32 , pp. 3-12
    • Hughes, G.1
  • 126
    • 36348973956 scopus 로고    scopus 로고
    • New targeted therapies for treatment of thrombosis in antiphospholipid syndrome
    • Pierangeli SS, Vega-Ostertag ME, Gonzalez EB. New targeted therapies for treatment of thrombosis in antiphospholipid syndrome. Expert Rev Mol Med. 2007 ; 9: 1-15
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-15
    • Pierangeli, S.S.1    Vega-Ostertag, M.E.2    Gonzalez, E.B.3
  • 127
    • 84871541493 scopus 로고    scopus 로고
    • Toll-like receptors: Another player in the pathogenesis of the antiphospholipid syndrome
    • Raschi E, Borghi MO, Grossi C, et al. Toll-like receptors: another player in the pathogenesis of the antiphospholipid syndrome. Lupus. 2008 ; 87: 214-220
    • (2008) Lupus , vol.87 , pp. 214-220
    • Raschi, E.1    Borghi, M.O.2    Grossi, C.3
  • 128
    • 32944464959 scopus 로고    scopus 로고
    • Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns
    • Sadeghi K, Wessner B, Laggner U, et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006 ; 36: 361-370
    • (2006) Eur J Immunol , vol.36 , pp. 361-370
    • Sadeghi, K.1    Wessner, B.2    Laggner, U.3
  • 129
    • 0036303892 scopus 로고    scopus 로고
    • Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: Involvement of the A3 adenosine receptor
    • Broussas M, Cornillet- Levefre P, Potron G, et al. Adenosine inhibits tissue factor expression by LPS-stimulated human monocytes: involvement of the A3 adenosine receptor. Thromb Haemost. 2002 ; 88: 123-130
    • (2002) Thromb Haemost , vol.88 , pp. 123-130
    • Broussas, M.1    Cornillet- Levefre, P.2    Potron, G.3
  • 130
    • 0036732005 scopus 로고    scopus 로고
    • Treatment of catastrophic antiphospholipid syndrome with defibrotide: A proposed vascular endothelial cell modulator
    • Burcuglu-O'Ral A, Erkan D, Asherson R. Treatment of catastrophic antiphospholipid syndrome with defibrotide: a proposed vascular endothelial cell modulator. J Rheumatol. 2002 ; 29: 2006-2011
    • (2002) J Rheumatol , vol.29 , pp. 2006-2011
    • Burcuglu-O'Ral, A.1    Erkan, D.2    Asherson, R.3
  • 131
    • 0033960710 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes
    • Napoleone E, Di Santo A, Camera M, et al. Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes. Circ Res. 2002 ; 86: 139-143
    • (2002) Circ Res , vol.86 , pp. 139-143
    • Napoleone, E.1    Di Santo, A.2    Camera, M.3
  • 132
    • 35348974994 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress TF-KappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes
    • J, Mahmud SA, Bitterman PB, et al. Histone deacetylase inhibitors suppress TF-KappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. J Biol Chem. 2007 ; 282: 24-408-24418
    • (2007) J Biol Chem , vol.282 , pp. 24408-24418
    • Mahmud, S.A.J.1    Bitterman, P.B.2
  • 133
    • 59649088107 scopus 로고    scopus 로고
    • Tissue factor in the antiphospholipid syndrome
    • Kinev AV, Roubey RAS. Tissue factor in the antiphospholipid syndrome. Lupus. 2008 ; 17: 952-958
    • (2008) Lupus , vol.17 , pp. 952-958
    • Kinev, A.V.1    Roubey, R.A.S.2
  • 134
    • 58849090583 scopus 로고    scopus 로고
    • Toll-like receptors: Another player in the pathogenesis of the anti-phospholipid syndrome
    • Raschi E, Borghi MO, Grossi C, et al. Toll-like receptors: another player in the pathogenesis of the anti-phospholipid syndrome. Lupus. 2008 ; 17: 937-942
    • (2008) Lupus , vol.17 , pp. 937-942
    • Raschi, E.1    Borghi, M.O.2    Grossi, C.3
  • 135
    • 84863197776 scopus 로고    scopus 로고
    • Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies
    • Lockhin MD, Kim M, Laskin CA, et al. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum. 2012 ; 64: 2311-2318
    • (2012) Arthritis Rheum , vol.64 , pp. 2311-2318
    • Lockhin, M.D.1    Kim, M.2    Laskin, C.A.3


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