메뉴 건너뛰기




Volumn 9, Issue 30, 2007, Pages 1-15

New targeted therapies for treatment of thrombosis in antiphospholipid syndrome

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ABCIXIMAB; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; APOLIPOPROTEIN E RECEPTOR 2; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA2 GLYCOPROTEIN 1; BLOOD CLOTTING FACTOR 5 LEIDEN; CD20 ANTIBODY; CYTOTOXIC AGENT; DILAZEP; DIPYRIDAMOLE; ENOXAPARIN; ESTROGEN; FLUINDOSTATIN; HEPARIN; HYDROXYCHLOROQUINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; LOW MOLECULAR WEIGHT HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PROTHROMBIN; RECEPTOR; RITUXIMAB; THROMBOPLASTIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN;

EID: 36348973956     PISSN: 14623994     EISSN: 14623994     Source Type: Journal    
DOI: 10.1017/S1462399407000506     Document Type: Review
Times cited : (28)

References (104)
  • 1
    • 0023434038 scopus 로고
    • Syndrome of the black swan
    • Harris, E.N. (1987) Syndrome of the black swan. Br J Rheumatol 26, 324-326
    • (1987) Br J Rheumatol , vol.26 , pp. 324-326
    • Harris, E.N.1
  • 2
    • 0033512274 scopus 로고    scopus 로고
    • International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop
    • Wilson, W.A. et al. (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop. Arthritis Rheum 42, 1309-1311
    • (1999) Arthritis Rheum , vol.42 , pp. 1309-1311
    • Wilson, W.A.1
  • 3
    • 0025332717 scopus 로고
    • 2 glycoprotein I (apolipoprotein H)
    • 2 glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A 87, 4120-4124
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 4120-4124
    • McNeil, H.P.1
  • 4
    • 0141957076 scopus 로고    scopus 로고
    • Clinical relevance of antiprothrombin antibodies
    • Atsumi, T. and Koike, T. (2002) Clinical relevance of antiprothrombin antibodies. Autoimmun Rev 1, 49-53
    • (2002) Autoimmun Rev , vol.1 , pp. 49-53
    • Atsumi, T.1    Koike, T.2
  • 5
    • 34248523994 scopus 로고    scopus 로고
    • 2glycoprotein I and the homologous catalytic domains of several serine proteases
    • 2glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 56, 1638-1647
    • (2007) Arthritis Rheum , vol.56 , pp. 1638-1647
    • Lin, X.S.1
  • 6
    • 34247153549 scopus 로고    scopus 로고
    • Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice
    • Chen, X.X. et al. (2007) Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice J Immunol 178, 5351-5356
    • (2007) J Immunol , vol.178 , pp. 5351-5356
    • Chen, X.X.1
  • 7
    • 33744481250 scopus 로고    scopus 로고
    • Autoantibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome
    • Cesarman-Maus, G. et al. (2006) Autoantibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome. Blood 107, 4375-7382
    • (2006) Blood , vol.107 , pp. 4375-7382
    • Cesarman-Maus, G.1
  • 8
    • 3142636662 scopus 로고
    • Thrombosis in SLE: Striking associations with the presence of circulating lupus anticoagulant
    • Boey, M.L. et al. (1983) Thrombosis in SLE: Striking associations with the presence of circulating lupus anticoagulant. Br Med J 287, 101-102
    • (1983) Br Med J , vol.287 , pp. 101-102
    • Boey, M.L.1
  • 9
    • 0026492990 scopus 로고
    • Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis
    • Ginsburg, K.S. et al. (1992) Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis, Ann Intern Med 117, 997-1002
    • (1992) Ann Intern Med , vol.117 , pp. 997-1002
    • Ginsburg, K.S.1
  • 10
    • 1842783797 scopus 로고    scopus 로고
    • The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
    • McClain, M.T. et al. (2004) The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 50, 1226-1232
    • (2004) Arthritis Rheum , vol.50 , pp. 1226-1232
    • McClain, M.T.1
  • 11
    • 9144234103 scopus 로고    scopus 로고
    • Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis
    • Moroni, G. et al. (2004) Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis. Am J Kidney Dis 43, 28-36
    • (2004) Am J Kidney Dis , vol.43 , pp. 28-36
    • Moroni, G.1
  • 12
    • 26944451361 scopus 로고    scopus 로고
    • The long-term prognosis of renal transplantation in patients with lupus nephritis
    • Moroni, G. et al. (2005) The long-term prognosis of renal transplantation in patients with lupus nephritis. Am J Kidney Dis 45, 903-911
    • (2005) Am J Kidney Dis , vol.45 , pp. 903-911
    • Moroni, G.1
  • 13
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis, S. et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4, 295-306
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1
  • 14
    • 0027479513 scopus 로고
    • A comparison of cardiac valvular involvement in the primary antiphospholipid syndrome versus anticardiolipin negative systemic lupus erythematosus
    • Gleason, C.B. et al. (1993) A comparison of cardiac valvular involvement in the primary antiphospholipid syndrome versus anticardiolipin negative systemic lupus erythematosus. Am Heart J 125, 1123-1129
    • (1993) Am Heart J , vol.125 , pp. 1123-1129
    • Gleason, C.B.1
  • 15
    • 26844513345 scopus 로고    scopus 로고
    • Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholipid syndrome
    • Toubi, E. et al. (2005) Livedo reticularis is a marker for predicting multi-system thrombosis in antiphospholipid syndrome. Clin Exp Rheumatol 23, 499-504
    • (2005) Clin Exp Rheumatol , vol.23 , pp. 499-504
    • Toubi, E.1
  • 16
    • 23844440880 scopus 로고    scopus 로고
    • Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis
    • Atsumi, T. et al. (2005) Antiphospholipid antibody associated thrombocytopenia and the paradoxical risk of thrombosis. Lupus 14, 499-504
    • (2005) Lupus , vol.14 , pp. 499-504
    • Atsumi, T.1
  • 17
    • 33746714026 scopus 로고    scopus 로고
    • Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome
    • Levine, S.R. et al. (2000) Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am J Med 51, 169-185
    • (2000) Am J Med , vol.51 , pp. 169-185
    • Levine, S.R.1
  • 18
    • 0036068984 scopus 로고    scopus 로고
    • Transverse myelitis in patients with antiphospholipid antibodies - the importance of early diagnosis and treatment
    • Sherer, Y. et al. (2002) Transverse myelitis in patients with antiphospholipid antibodies - the importance of early diagnosis and treatment. Clin Rheumatol 21, 207-210
    • (2002) Clin Rheumatol , vol.21 , pp. 207-210
    • Sherer, Y.1
  • 19
    • 0034061349 scopus 로고    scopus 로고
    • Chorea as the presenting clinical feature of primary antiphospholipid syndrome in childhood
    • Al-Matar, M., Jaimes, J. and Malleson, P. (2000) Chorea as the presenting clinical feature of primary antiphospholipid syndrome in childhood. Neuropediatrics 2, 107-108
    • (2000) Neuropediatrics , vol.2 , pp. 107-108
    • Al-Matar, M.1    Jaimes, J.2    Malleson, P.3
  • 20
    • 0037294863 scopus 로고    scopus 로고
    • Migraine, memory loss, and "multiple sclerosis". Neurological features of the antiphospholipid (Hughes') syndrome
    • Hughes, G.R. (2003) Migraine, memory loss, and "multiple sclerosis". Neurological features of the antiphospholipid (Hughes') syndrome. Postgrad Med J 79, 81-83
    • (2003) Postgrad Med J , vol.79 , pp. 81-83
    • Hughes, G.R.1
  • 21
    • 0027266045 scopus 로고
    • Sneddon's syndrome and phospholipid antibodies
    • Mesa, H.A. et al. (1993) Sneddon's syndrome and phospholipid antibodies. Clin Rheumatol 12, 253-256
    • (1993) Clin Rheumatol , vol.12 , pp. 253-256
    • Mesa, H.A.1
  • 22
    • 3042727917 scopus 로고    scopus 로고
    • Features associated with epilepsy in the antiphospholipid syndrome
    • Shoenfeld, Y. et al. (2004) Features associated with epilepsy in the antiphospholipid syndrome. J Rheumatol 31, 1344-1348
    • (2004) J Rheumatol , vol.31 , pp. 1344-1348
    • Shoenfeld, Y.1
  • 23
    • 28044458991 scopus 로고    scopus 로고
    • Multiorgan failure and antiphospholipid antibodies: The catastrophic antiphospholipid (Asherson's) syndrome
    • Asherson, R.A. (2005) Multiorgan failure and antiphospholipid antibodies: The catastrophic antiphospholipid (Asherson's) syndrome. Immunobiology 210, 727-733
    • (2005) Immunobiology , vol.210 , pp. 727-733
    • Asherson, R.A.1
  • 24
    • 33144455336 scopus 로고    scopus 로고
    • Alveolar and serum antiphospholipid antibodies in acute respiratory distress syndrome associated with catastrophic antiphospholipid syndrome
    • Wiedermann, F.J. (2006) Alveolar and serum antiphospholipid antibodies in acute respiratory distress syndrome associated with catastrophic antiphospholipid syndrome. Ann Rheum Dis 65, 413
    • (2006) Ann Rheum Dis , vol.65 , pp. 413
    • Wiedermann, F.J.1
  • 25
    • 0038006072 scopus 로고    scopus 로고
    • Unusual manifestations of the antiphospholipid syndrome
    • Asherson, R.A. and Cervera, R. (2003) Unusual manifestations of the antiphospholipid syndrome. Clin Rev Allergy Immunol 1, 61-78
    • (2003) Clin Rev Allergy Immunol , vol.1 , pp. 61-78
    • Asherson, R.A.1    Cervera, R.2
  • 26
    • 0036427762 scopus 로고    scopus 로고
    • Black swan in the kidney: Renal involvement in the antiphospholipid antibody syndrome
    • Nzerue, C.M. et al. (2002) "Black swan in the kidney": Renal involvement in the antiphospholipid antibody syndrome. Kidney 62, 733-744
    • (2002) Kidney , vol.62 , pp. 733-744
    • Nzerue, C.M.1
  • 27
    • 0037334595 scopus 로고    scopus 로고
    • Asyptomatic avascular necrosis in patients with primary antiphospholipid syndrome in the absence of corticosteroid use: A prospective study by magnetic resonance imaging
    • Tektonidou, M.G. et al. (2003) Asyptomatic avascular necrosis in patients with primary antiphospholipid syndrome in the absence of corticosteroid use: A prospective study by magnetic resonance imaging. Arthritis Rheum 48, 732-736
    • (2003) Arthritis Rheum , vol.48 , pp. 732-736
    • Tektonidou, M.G.1
  • 28
    • 0028908094 scopus 로고
    • The management of thrombosis in the antiphospholipid antibody syndrome
    • Khamashta, M.A. et al. (1995) The management of thrombosis in the antiphospholipid antibody syndrome. N Engl J Med 332, 993-997
    • (1995) N Engl J Med , vol.332 , pp. 993-997
    • Khamashta, M.A.1
  • 29
    • 0030924102 scopus 로고    scopus 로고
    • A retrospective review of 61 patients with antiphospholipid syndrome
    • Krnic-Barrie, S. et al. (1997) A retrospective review of 61 patients with antiphospholipid syndrome. Arch Intern Med 157, 2101-2108
    • (1997) Arch Intern Med , vol.157 , pp. 2101-2108
    • Krnic-Barrie, S.1
  • 30
    • 0141791073 scopus 로고    scopus 로고
    • A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
    • Crowther, M.A. et al. (2003) A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med 349, 1133-1138
    • (2003) N Engl J Med , vol.349 , pp. 1133-1138
    • Crowther, M.A.1
  • 31
    • 23844437705 scopus 로고    scopus 로고
    • A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)
    • Finazzi, G. et al. (2005) A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS). J Thromb Haemost 3, 848-853
    • (2005) J Thromb Haemost , vol.3 , pp. 848-853
    • Finazzi, G.1
  • 32
    • 36148929074 scopus 로고    scopus 로고
    • Garcia, D.A., Khamashta, M.A. and Crowther, M.A. (2007) How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: A case-based review. Blood [Epub ahead of print]
    • Garcia, D.A., Khamashta, M.A. and Crowther, M.A. (2007) How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: A case-based review. Blood [Epub ahead of print]
  • 33
    • 0036045796 scopus 로고    scopus 로고
    • A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome
    • Erkan, D. et al. (2002) A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford) 41, 924-929
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 924-929
    • Erkan, D.1
  • 34
    • 34547407889 scopus 로고    scopus 로고
    • Aspirin for primary thrombosis prevention in the antiphospholipid syndrome
    • Erkan, D. et al. (2007) Aspirin for primary thrombosis prevention in the antiphospholipid syndrome. Arthritis Rheum 56, 2382-2391
    • (2007) Arthritis Rheum , vol.56 , pp. 2382-2391
    • Erkan, D.1
  • 35
    • 32144435725 scopus 로고    scopus 로고
    • Rituximab treatment for resistant antiphospholipid syndrome
    • Rubenstein, E. et al. (2006) Rituximab treatment for resistant antiphospholipid syndrome. J Rheumatol 33, 355-357
    • (2006) J Rheumatol , vol.33 , pp. 355-357
    • Rubenstein, E.1
  • 36
    • 0025102933 scopus 로고
    • Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: A model for autoimmune fetal loss
    • Branch, D.W. et al. (1990) Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: A model for autoimmune fetal loss. Am J Obstet Gynecol 163, 210-216
    • (1990) Am J Obstet Gynecol , vol.163 , pp. 210-216
    • Branch, D.W.1
  • 37
    • 0026322836 scopus 로고
    • Induction of antiphospholipid syndrome in naïve mice with mouse lupus monoclonal and human polyclonal anticardiolipin antibodies
    • Blank, M. et al. (1991) Induction of antiphospholipid syndrome in naïve mice with mouse lupus monoclonal and human polyclonal anticardiolipin antibodies. Proc Natl Acad Sci USA 88, 3069-3073
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3069-3073
    • Blank, M.1
  • 38
    • 0033586656 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    • Pierangeli, S.S. et al. (1999) Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 99, 1997-2000
    • (1999) Circulation , vol.99 , pp. 1997-2000
    • Pierangeli, S.S.1
  • 39
    • 0037217897 scopus 로고    scopus 로고
    • 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
    • 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster. Blood 101, 157-162
    • (2003) Blood , vol.101 , pp. 157-162
    • Jankowski, M.1
  • 40
    • 0031762606 scopus 로고    scopus 로고
    • Mechanisms of autoantibody-mediated thrombosis
    • Roubey, R.A.S. (1998) Mechanisms of autoantibody-mediated thrombosis. Lupus 7, S114-119
    • (1998) Lupus , vol.7
    • Roubey, R.A.S.1
  • 41
    • 0037148520 scopus 로고    scopus 로고
    • C3 activation is required for anti-phospholipid antibody-induced fetal loss
    • Holers, V.M. et al. (2002) C3 activation is required for anti-phospholipid antibody-induced fetal loss. J Exp Med 195, 211-220
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1
  • 42
    • 0036839070 scopus 로고    scopus 로고
    • Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis
    • Salmon, J.E., Girardi, G. and Holers, V.M. (2002) Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 61, 46-50
    • (2002) Ann Rheum Dis , vol.61 , pp. 46-50
    • Salmon, J.E.1    Girardi, G.2    Holers, V.M.3
  • 43
    • 22244485396 scopus 로고    scopus 로고
    • Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    • Pierangeli, S.S. et al. (2005) Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 52, 2120-2124
    • (2005) Arthritis Rheum , vol.52 , pp. 2120-2124
    • Pierangeli, S.S.1
  • 44
    • 27144494245 scopus 로고    scopus 로고
    • 2 glycoprotein I is complement-dependent and requires a priming factor
    • 2 glycoprotein I is complement-dependent and requires a priming factor. Blood 106, 2340-2346
    • (2005) Blood , vol.106 , pp. 2340-2346
    • Fischetti, F.1
  • 45
    • 0023678887 scopus 로고
    • Immune mediated mechanism for thrombosis: Antiphospholipid antibody binding to platelet membranes
    • Khamashta, M.A. et al. (1988) Immune mediated mechanism for thrombosis: antiphospholipid antibody binding to platelet membranes. Ann Rheum Dis 47, 849-854
    • (1988) Ann Rheum Dis , vol.47 , pp. 849-854
    • Khamashta, M.A.1
  • 46
    • 0028959014 scopus 로고
    • Comparison of the effect of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation
    • Campbell, A.L. et al. (1995) Comparison of the effect of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. Thromb Haemost 73, 529-534
    • (1995) Thromb Haemost , vol.73 , pp. 529-534
    • Campbell, A.L.1
  • 47
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    • Espinola, R.G. et al. (2002) Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies. Thromb Haemost 87, 518-522
    • (2002) Thromb Haemost , vol.87 , pp. 518-522
    • Espinola, R.G.1
  • 48
    • 0031442025 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice
    • Edwards, M.H. et al. (1997) Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice. Circulation 96, 4380-4384
    • (1997) Circulation , vol.96 , pp. 4380-4384
    • Edwards, M.H.1
  • 49
    • 0027375161 scopus 로고
    • Antiphospholipid Antibodies enhance thrombin-induced platelet activation and thromboxane formation
    • Martinuzzo, M.E. et al. (1993) Antiphospholipid Antibodies enhance thrombin-induced platelet activation and thromboxane formation. Thromb Haemost 70, 667-671
    • (1993) Thromb Haemost , vol.70 , pp. 667-671
    • Martinuzzo, M.E.1
  • 50
    • 0031594156 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: Association with increased excretion of platelet-derived thromboxane urinary metabolites
    • 2glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. Thromb Haemost 79, 42-45
    • (1998) Thromb Haemost , vol.79 , pp. 42-45
    • Forastiero, R.1
  • 51
    • 0031594519 scopus 로고    scopus 로고
    • 2glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the Antiphospholipid syndrome
    • 2glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the Antiphospholipid syndrome. J Rheumatol 25, 51-56
    • (1998) J Rheumatol , vol.25 , pp. 51-56
    • Robbins, D.L.1
  • 52
    • 12244286755 scopus 로고    scopus 로고
    • 2glycoprotein I induced synthesis of human platelet thromboxane A2 in vitro
    • 2glycoprotein I induced synthesis of human platelet thromboxane A2 in vitro. J Rheumatol 30, 55-59
    • (2003) J Rheumatol , vol.30 , pp. 55-59
    • Opara, E.1    Robbins, D.L.2    Ziboh, V.A.3
  • 53
    • 4444273214 scopus 로고    scopus 로고
    • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    • Vega-Ostertag, M., Harris, E.N. and Pierangeli, S.S. (2004) Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. Arthritis Rheum 50, 2911-2919
    • (2004) Arthritis Rheum , vol.50 , pp. 2911-2919
    • Vega-Ostertag, M.1    Harris, E.N.2    Pierangeli, S.S.3
  • 54
    • 0141445991 scopus 로고    scopus 로고
    • 2glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′
    • 2glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem 278, 33831-33838
    • (2003) J Biol Chem , vol.278 , pp. 33831-33838
    • Lutters, B.C.1
  • 55
    • 33747023522 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies in complex with β2 glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib/IX-V
    • 2glycoprotein I antibodies in complex with β2 glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib/IX-V. Arthritis Rheum 54, 2558-2567
    • (2006) Arthritis Rheum , vol.54 , pp. 2558-2567
    • Shi, T.1
  • 56
    • 0028883356 scopus 로고
    • Activation of cultured vascular endothelial cells by antiphospholipid antibodies
    • Simantov, E. et al. (1995) Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 96, 2211-2219
    • (1995) J Clin Invest , vol.96 , pp. 2211-2219
    • Simantov, E.1
  • 57
    • 0035793334 scopus 로고    scopus 로고
    • Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    • Pierangeli, S.S. et al. (2001) Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 88, 245-250
    • (2001) Circ Res , vol.88 , pp. 245-250
    • Pierangeli, S.S.1
  • 58
    • 0142166253 scopus 로고    scopus 로고
    • E-selectin mediated pathogenic effects of antiphospholipid antibodies
    • Espinola, R.G. et al. (2002) E-selectin mediated pathogenic effects of antiphospholipid antibodies. J Thromb Haemost 1, 843-848
    • (2002) J Thromb Haemost , vol.1 , pp. 843-848
    • Espinola, R.G.1
  • 59
    • 0034085616 scopus 로고    scopus 로고
    • Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: Correlations with the severity of thrombosis
    • Kaplanski, G. et al. (2000) Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: Correlations with the severity of thrombosis. Arthritis Rheum 43, 55-64
    • (2000) Arthritis Rheum , vol.43 , pp. 55-64
    • Kaplanski, G.1
  • 60
    • 0023851758 scopus 로고
    • Tissue factor and hemostasis
    • Nemerson, Y. (1988) Tissue factor and hemostasis. Blood 71, 1-8
    • (1988) Blood , vol.71 , pp. 1-8
    • Nemerson, Y.1
  • 61
    • 0030857363 scopus 로고    scopus 로고
    • Tissue factor in health and disease
    • Semerato, N. and Colucci, M. (1997) Tissue factor in health and disease. Thromb Haemost 78, 759-764
    • (1997) Thromb Haemost , vol.78 , pp. 759-764
    • Semerato, N.1    Colucci, M.2
  • 62
    • 0028365677 scopus 로고
    • Induction of tissue factor-like activity in monocyes by anti-cardiolipin antibodies
    • Kornberg, A. et al. (1994) Induction of tissue factor-like activity in monocyes by anti-cardiolipin antibodies. J Immunol 153, 1328-1332
    • (1994) J Immunol , vol.153 , pp. 1328-1332
    • Kornberg, A.1
  • 63
    • 1842413134 scopus 로고    scopus 로고
    • Thrombosis in primary antiphospholipid syndrome: A pivotal role for monocyte tissue factor expression
    • Cuadrado, M.J. et al. (1997) Thrombosis in primary antiphospholipid syndrome: A pivotal role for monocyte tissue factor expression. Arthritis Rheum 40, 834-841
    • (1997) Arthritis Rheum , vol.40 , pp. 834-841
    • Cuadrado, M.J.1
  • 64
    • 0031886679 scopus 로고    scopus 로고
    • The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome
    • Amengual, O. et al. (1998) The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb Haemost 79, 276-281
    • (1998) Thromb Haemost , vol.79 , pp. 276-281
    • Amengual, O.1
  • 65
    • 0032700453 scopus 로고    scopus 로고
    • Increased levels of TF mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome
    • Dobado-Barrios, M. (1999) Increased levels of TF mRNA in mononuclear blood cells of patients with primary antiphospholipid syndrome. Thromb Haemost 82, 1578-1582
    • (1999) Thromb Haemost , vol.82 , pp. 1578-1582
    • Dobado-Barrios, M.1
  • 66
    • 0029949753 scopus 로고    scopus 로고
    • Antiphospholipid antibodies (aPL) increase the potential monocyte procoagulant activity in patients with systemic lupus erythematosus
    • Martini, F. et al. (1996) Antiphospholipid antibodies (aPL) increase the potential monocyte procoagulant activity in patients with systemic lupus erythematosus. Lupus 5, 206-211
    • (1996) Lupus , vol.5 , pp. 206-211
    • Martini, F.1
  • 67
    • 0031876263 scopus 로고    scopus 로고
    • Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes
    • Reverter, J.C. (1998) Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes. Arthritis Rheum 41, 1420-1427
    • (1998) Arthritis Rheum , vol.41 , pp. 1420-1427
    • Reverter, J.C.1
  • 68
    • 14744275911 scopus 로고    scopus 로고
    • Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies
    • Forastiero, R.R., Martinuzzo, M.E. and De Larranaga, G. (2005) Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies. Lupus 14, 129-136
    • (2005) Lupus , vol.14 , pp. 129-136
    • Forastiero, R.R.1    Martinuzzo, M.E.2    De Larranaga, G.3
  • 69
    • 3242697048 scopus 로고    scopus 로고
    • Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    • Zhou, H., Wolberg, A.S. and Roubey, R.A. (2004) Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep. Blood 104, 2353-2358
    • (2004) Blood , vol.104 , pp. 2353-2358
    • Zhou, H.1    Wolberg, A.S.2    Roubey, R.A.3
  • 70
    • 33750091036 scopus 로고    scopus 로고
    • Vascular endotelial growth factor expresión in monocytes from patients with primary antiphospholipid síndrome
    • Cuadrado, M.J. et al. (2006) Vascular endotelial growth factor expresión in monocytes from patients with primary antiphospholipid síndrome. J Thromb Haemost 4, 2461-2469
    • (2006) J Thromb Haemost , vol.4 , pp. 2461-2469
    • Cuadrado, M.J.1
  • 71
    • 0033694198 scopus 로고    scopus 로고
    • Systemic endothelial cell markers in primary antiphospholipid syndrome
    • Williams, F.M. et al. (2000) Systemic endothelial cell markers in primary antiphospholipid syndrome. J Thromb Haemost 84, 742-746
    • (2000) J Thromb Haemost , vol.84 , pp. 742-746
    • Williams, F.M.1
  • 72
    • 18244398919 scopus 로고    scopus 로고
    • NF-kappa B activation plays a role in superoxide-mediated cerebral endothelial dysfunction after hypoxia/reoxygenation
    • Xie, H., Ray, P.E. and Short, B.L. (2005) NF-kappa B activation plays a role in superoxide-mediated cerebral endothelial dysfunction after hypoxia/reoxygenation. Stroke 36, 1047-1052
    • (2005) Stroke , vol.36 , pp. 1047-1052
    • Xie, H.1    Ray, P.E.2    Short, B.L.3
  • 73
    • 0037208149 scopus 로고    scopus 로고
    • Nuclear factor kappa B mediates a procoagulant response in monocytes during extracorporeal circulation
    • Morgan, E.N. et al. (2003) Nuclear factor kappa B mediates a procoagulant response in monocytes during extracorporeal circulation. J Thorac Cardiovasc Surg 125, 165-171
    • (2003) J Thorac Cardiovasc Surg , vol.125 , pp. 165-171
    • Morgan, E.N.1
  • 74
    • 0032900439 scopus 로고    scopus 로고
    • New insights into the role of nuclear factor-κB, aubiquitous transcription factor in the initiation of diseases
    • Chen, F. et al. (1999) New insights into the role of nuclear factor-κB, aubiquitous transcription factor in the initiation of diseases. Clin Chem 45, 7-17
    • (1999) Clin Chem , vol.45 , pp. 7-17
    • Chen, F.1
  • 75
    • 0036143654 scopus 로고    scopus 로고
    • p38-dependent marking of inflammatory genes for increasing NF-kappa B recruitment
    • Saccani, S., Pantano, S. and Natoli, G. (2002) p38-dependent marking of inflammatory genes for increasing NF-kappa B recruitment. Nat Immunol 3, 69-75
    • (2002) Nat Immunol , vol.3 , pp. 69-75
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 76
    • 4043106414 scopus 로고    scopus 로고
    • NF-κB: Holy grail for rheumatoid arthritis
    • Firestein, G.S. (2004) NF-κB: Holy grail for rheumatoid arthritis. Arthritis Rheum 50, 2381-2386
    • (2004) Arthritis Rheum , vol.50 , pp. 2381-2386
    • Firestein, G.S.1
  • 77
    • 0030783156 scopus 로고    scopus 로고
    • The search for physiological substrates ofMAPand SAP kinases in mammalian cells
    • Cohen, P. (1997) The search for physiological substrates ofMAPand SAP kinases in mammalian cells. Trends Cell Biol 7, 353-358
    • (1997) Trends Cell Biol , vol.7 , pp. 353-358
    • Cohen, P.1
  • 78
    • 0036636018 scopus 로고    scopus 로고
    • Monocyte adhesion and transmigration induce tissue-factor expression: Role of the mitogen-activated protein kinases
    • McGilvray, I.D. et al. (2002) Monocyte adhesion and transmigration induce tissue-factor expression: Role of the mitogen-activated protein kinases. Shock 18, 51-57
    • (2002) Shock , vol.18 , pp. 51-57
    • McGilvray, I.D.1
  • 80
    • 8344267910 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies
    • 2glycoprotein I antibodies. Int Immunol 16, 1632-1641
    • (2004) Int Immunol , vol.16 , pp. 1632-1641
    • Bohgaki, M.1
  • 81
    • 18644361988 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    • Vega-Ostertag, M. et al. (2005) Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 52, 1545-1554
    • (2005) Arthritis Rheum , vol.52 , pp. 1545-1554
    • Vega-Ostertag, M.1
  • 82
    • 31044449865 scopus 로고    scopus 로고
    • Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway
    • López-Pedrera, C. et al. (2006) Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 54, 301-311
    • (2006) Arthritis Rheum , vol.54 , pp. 301-311
    • López-Pedrera, C.1
  • 83
    • 17644365392 scopus 로고    scopus 로고
    • Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
    • Simoncini, S. et al. (2004) Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 17, 489-500
    • (2004) Int Immunol , vol.17 , pp. 489-500
    • Simoncini, S.1
  • 84
    • 34548079756 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation
    • Vega-Ostertag, M.E. et al. (2007) Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation. J Thromb Haemost 5, 1828-1834
    • (2007) J Thromb Haemost , vol.5 , pp. 1828-1834
    • Vega-Ostertag, M.E.1
  • 85
    • 34948875756 scopus 로고    scopus 로고
    • In vivo effects of an inhibitor of nuclear factor-kappa (κ) B on thrombogenic properties of Antiphospholipid antibodies
    • Montiel-Manzano, G. et al. (2007) In vivo effects of an inhibitor of nuclear factor-kappa (κ) B on thrombogenic properties of Antiphospholipid antibodies. Ann NY Acad Sci 1108, 540-553
    • (2007) Ann NY Acad Sci , vol.1108 , pp. 540-553
    • Montiel-Manzano, G.1
  • 86
    • 0035673283 scopus 로고    scopus 로고
    • 2glycoprotein I) antibodies: Effect on the proadhesive and proinflammatory phenotype
    • 2glycoprotein I) antibodies: Effect on the proadhesive and proinflammatory phenotype. Arthritis Rheum 44, 2870-2878
    • (2001) Arthritis Rheum , vol.44 , pp. 2870-2878
    • Meroni, P.L.1
  • 87
    • 0242721975 scopus 로고    scopus 로고
    • Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    • Ferrara, D.E. et al. (2003) Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. Arthritis Rheum 48, 3272-3279
    • (2003) Arthritis Rheum , vol.48 , pp. 3272-3279
    • Ferrara, D.E.1
  • 88
    • 7244237671 scopus 로고    scopus 로고
    • Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
    • Ferrara, D.E. et al. (2004) Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. J Thromb Haemost 2, 1558-1563
    • (2004) J Thromb Haemost , vol.2 , pp. 1558-1563
    • Ferrara, D.E.1
  • 89
    • 0033214106 scopus 로고    scopus 로고
    • 2glycoprotein I to phospholipids based on its crystal structure
    • 2glycoprotein I to phospholipids based on its crystal structure. EMBO J 18, 5166-5174
    • (1999) EMBO J , vol.18 , pp. 5166-5174
    • Bouma, B.1
  • 90
    • 36348953247 scopus 로고    scopus 로고
    • 2glycoprotein I ameliorates thrombosis induced by antiphospholipid antibodies in mice
    • Abstract
    • 2glycoprotein I ameliorates thrombosis induced by antiphospholipid antibodies in mice. Arthritis Rheum 54 (suppl), S559 (Abstract)
    • (2006) Arthritis Rheum , vol.54 , Issue.SUPPL.
    • Ioannou, J.1
  • 91
    • 0006722561 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies
    • 2glycoprotein I antibodies. J Immunol 160, 5572-5578
    • (1998) J Immunol , vol.160 , pp. 5572-5578
    • Del Papa, N.1
  • 92
    • 33745861703 scopus 로고    scopus 로고
    • 2glycoprotein I reverses antiphospholipid-mediated thrombosis in mice
    • 2glycoprotein I reverses antiphospholipid-mediated thrombosis in mice. Lupus 15, 358-365
    • (2006) Lupus , vol.15 , pp. 358-365
    • Vega Ostertag, M.1
  • 93
    • 0034685886 scopus 로고    scopus 로고
    • 2glycoprotein I to human endothelial cells is mediated by Annexin II
    • 2glycoprotein I to human endothelial cells is mediated by Annexin II. J Biol Chem 275, 15541-15548
    • (2000) J Biol Chem , vol.275 , pp. 15541-15548
    • Ma, K.1
  • 94
    • 14944367961 scopus 로고    scopus 로고
    • 2Glycoprotein I antibodies
    • 2Glycoprotein I antibodies. Blood 105, 1964-1969
    • (2005) Blood , vol.105 , pp. 1964-1969
    • Zhang, J.1    McCrae, K.R.2
  • 95
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. and Kaisho, T. (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2, 675-680
    • (2001) Nat Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 96
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi, E. et al. (2003) Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 101, 3495-3500
    • (2003) Blood , vol.101 , pp. 3495-3500
    • Raschi, E.1
  • 97
    • 34250721890 scopus 로고    scopus 로고
    • Toll like receptor 4 is involved in Antiphospholipid-mediated thrombosis: In vivo studies
    • Epub ahead of print
    • Pierangeli, S.S. et al. (2007) Toll like receptor 4 is involved in Antiphospholipid-mediated thrombosis: In vivo studies. Ann Rheum Dis [Epub ahead of print]
    • (2007) Ann Rheum Dis
    • Pierangeli, S.S.1
  • 98
    • 0028787634 scopus 로고
    • Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome
    • Pierangeli, S.S. et al. (1995) Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the antiphospholipid syndrome. Thromb Haemost 74, 1361-1367
    • (1995) Thromb Haemost , vol.74 , pp. 1361-1367
    • Pierangeli, S.S.1
  • 99
    • 0030784716 scopus 로고    scopus 로고
    • Anticardiolipin IgG subclasses: Association with IgG2 with arterial and/or venous thrombosis
    • Sammaritano, L.R. et al. (1997) Anticardiolipin IgG subclasses: association with IgG2 with arterial and/or venous thrombosis. Arthritis Rheum 40, 1998-2006
    • (1997) Arthritis Rheum , vol.40 , pp. 1998-2006
    • Sammaritano, L.R.1
  • 100
    • 34948885608 scopus 로고    scopus 로고
    • C5a receptor-deficient micer are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies
    • Romay-Penabad, Z. et al. (2007) C5a receptor-deficient micer are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies. Ann NY Acad Sci 1108, 554-566
    • (2007) Ann NY Acad Sci , vol.1108 , pp. 554-566
    • Romay-Penabad, Z.1
  • 101
    • 0034100612 scopus 로고    scopus 로고
    • Detection of complement-fixing antiphospholipid antibodies in association with thrombosis
    • Munakata, Y. et al. (2000) Detection of complement-fixing antiphospholipid antibodies in association with thrombosis. Thromb Haemost 83, 728-731
    • (2000) Thromb Haemost , vol.83 , pp. 728-731
    • Munakata, Y.1
  • 102
    • 0033009331 scopus 로고    scopus 로고
    • Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss
    • Carbone, J. et al. (1999) Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss. Lupus 8, 274-278
    • (1999) Lupus , vol.8 , pp. 274-278
    • Carbone, J.1
  • 103
    • 0026706529 scopus 로고
    • Antiphospholipid antibodies and complement activation in patients with cerebral ischemia
    • Davis, W.D. and Brey, R.L. (1992) Antiphospholipid antibodies and complement activation in patients with cerebral ischemia. Clin Exp Immunol 10, 455-460
    • (1992) Clin Exp Immunol , vol.10 , pp. 455-460
    • Davis, W.D.1    Brey, R.L.2
  • 104
    • 32644434384 scopus 로고    scopus 로고
    • Gene-expression patterns predict phenotypes of immune-mediated thrombosis
    • Potti, A. et al. (2006) Gene-expression patterns predict phenotypes of immune-mediated thrombosis. Blood 107, 1391-1396
    • (2006) Blood , vol.107 , pp. 1391-1396
    • Potti, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.