Management of obstetric antiphospholipid syndrome

Current Rheumatology Reports

Volumn 14, Issue 1, 2012, Pages 79-86

  De Jesus, Guilherme Ribeiro Ramires ^a   Dos Santos, Flavia Cunha ^a   Oliveira, Camila Souto ^a   Mendes Silva, Wallace ^a   De Jesus, Nilson Ramires ^a   Levy, Roger Abramino ^a  

^a UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO   (Brazil)

Author keywords

Anticoagulation; Antiphospholipid syndrome; APS; Fetal loss; Infertility; Lupus; Management of APS; Management of obstetric APS; Obstetric APS; Recurrent miscarriage; Thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CARDIOLIPIN ANTIBODY; ENOXAPARIN; HEPARIN; HYDROXYCHLOROQUINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LOW MOLECULAR WEIGHT HEPARIN; LUPUS ANTICOAGULANT; WARFARIN;

ANTIBODY TITER; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BREAST FEEDING; COMBINATION CHEMOTHERAPY; COUNSELING; DISEASE ASSOCIATION; DRUG ACTIVITY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FERTILIZATION IN VITRO; FETUS WASTAGE; GESTATIONAL AGE; HIGH RISK PREGNANCY; HUMAN; INFERTILITY; INTRAUTERINE GROWTH RETARDATION; LOW DRUG DOSE; MATERNAL CARE; MATERNAL MORTALITY; MONOTHERAPY; NONHUMAN; OBSTETRIC PROCEDURE; OVARY HYPERSTIMULATION; OVULATION INDUCTION; PRACTICE GUIDELINE; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PUERPERIUM; PULMONARY HYPERTENSION; RISK REDUCTION; SPONTANEOUS ABORTION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTOPENIA; THROMBOEMBOLISM; THROMBOSIS;

ANTIPHOSPHOLIPID SYNDROME; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 84856875872     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-011-0218-2     Document Type: Article

References (65)

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62. JH Rand XX Wu AS Quinn DJ Taatjes 2010 The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis Lupus 19 4 460 9 20353989 10.1177/0961203310361485 1:CAS:528:DC%2BC3cXmtVygsrY%3D This is a very interesting and original paper showing how the aPL-mediated reduction of annexin A5, a potent anticoagulant that shields phospholipid layers on placental villi, is responsible for fetal loss and thrombosis in APS animal models, and showing that HCQ can revert these aPL complexes, also helping in the formation of "patches" of annexin A5
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