Telescoped flow process for the syntheses of N-aryl pyrazoles

Organic Process Research and Development

Volumn 16, Issue 12, 2012, Pages 2031-2035

  Li, Bryan ^a   Widlicka, Daniel ^a   Boucher, Steven ^a   Hayward, Cheryl ^a   Lucas, John ^a,b   Murray, John C ^a   O'Neil, Brian T ^a   Pfisterer, David ^a   Samp, Lacey ^a   Vanalsten, John ^a,c   Xiang, Yanqiao ^a   Young, Joseph ^a  

^a PFIZER INC   (United States)

^b AMGEN INC   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTINUOUS EXTRACTION; CONTINUOUS FLOWS; DEPROTECTION; DIAZONIUM SALTS; DIAZOTIZATION; FLOW PROCESS; HETEROGENEOUS REACTIONS; METHYL ETHERS; ORGANIC IMPURITIES; PRODUCTION SCALE; PYRAZOLES; SCALE-UP; TIN CHLORIDES;

ANILINE; CHLORINE COMPOUNDS; CHROMATOGRAPHY; ETHERS; HYDRAZINE; TIN;

TELESCOPES;

EID: 84871534962     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op300209p     Document Type: Article

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