Second-generation process research towards eletriptan: A fischer indole approach

Organic Process Research and Development

Volumn 15, Issue 1, 2011, Pages 98-103

  Ashcroft, Christopher P ^a   Hellier, Paul ^b   Pettman, Alan ^a   Watkinson, Simon ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLISATIONS; GENERATION PROCESS;

EID: 79251469074     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100251q     Document Type: Article

References (8)

1. Ogilvie, R. J. New Process for the Preparation of Anti-migraine Drug, Eletriptan; WO/2002/050063, 2002.
2. Fischer, E.; Jourdan, F. Chem. Ber. 1883, 16, 2241
3. Li, J.-J.; Johnson, D. S.; Roth, B. D.; Sliskovic, D. R. Contemporary Drug Syntheses; John Wiley and Sons: Chichester, 2004.
4. Robinson, B. The Fischer Indole Synthesis; John Wiley and Sons: Chichester, 1982.
5. Brittain, J. M.; Jones, R. A.; Arques, J. S.; Saliente, T. A. Synth. Commun. 1982, 12, 231
6. Spangler, C. W.; McCoy, R. K. Synth. Commun. 1988, 18, 51
7. Lambert, J. F.; Norris, T. Preparation of N-(5-cyclopropyl-1-quinolin-5- yl-1H-pyrazole-4-carbonyl)guanidine and other sodium-hydrogen exchanger type-1 (NHE-1) inhibitors, with improved product color, via an improved preparation of arylhydrazines using ascorbic acid reduction; WO/2002/044133, 2002.
8. Ashcroft, P. C. Modified Fischer Indole Synthesis of Eletriptan; WO/2005/103035, 2005.