Expression levels of candidate genes for intramuscular fat deposition in two Banna mini-pig inbred lines divergently selected for fatness traits

Genetics and Molecular Biology

Volumn 35, Issue 4, 2012, Pages 783-789

  Zhao, Su Mei ^a   Li, Wei Zhen ^a   Pan, Hong Bin ^a   Huang, Ying ^a   Yang, Ming Hua ^a   Wei, Hong Jiang ^a   Gao, Shi Zheng ^a  

^a YUNNAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Banna mini pig inbred line (BMIL); Expression levels; Intramuscular fat (IMF)

Indexed keywords

DIACYLGLYCEROL ACYLTRANSFERASE 1; FATTY ACID; FATTY ACID BINDING PROTEIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ARTICLE; CONTROLLED STUDY; DIACYLGLYCEROL ACYLTRANSFERASE 1 GENE; FATTY ACID ANALYSIS; FATTY ACID BINDING PROTEIN GENE; FATTY ACID BLOOD LEVEL; GENE; GENE EXPRESSION REGULATION; INBREEDING; LEPTIN RECEPTOR GENE; LIPID STORAGE; MELANOCORTIN 4 RECEPTOR GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C GENE; TRIACYLGLYCEROL BLOOD LEVEL;

SUIDAE;

EID: 84871533658     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572012005000079     Document Type: Article

References (47)

1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
2. Bruun CS, Jørgensen CB, Nielsen VH, Andersson L and Fredholm M (2006) Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Anim Genet 37:359-362
3. Cánovas A, Quintanilla R, AmillsMand Pena RN (2010) Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits. BMC Genomics 11:372-387
4. Chen J, Yang XJ, Xia D, Chen J, Wegner J, Jiang Z and Zhao RQ (2008) Sterol regulatory element binding transcription factor 1 expression and genetic polymorphism significantly affect intramuscular fat deposition in the longissimus muscle of Erhualian and Sutai pigs. J Anim Sci 86:57-63
5. Chmurzynska A (2006) The multigene family of fatty acidbinding proteins (FABPs): Function, structure and polymorphism. J Appl Genet 47:39-48
6. Coleman RA and Lee DP (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 43:134-176
7. Damon M, Louveau I, Lefaucheur L, Lebret B, Vincent A, Leroy P, Sanchez MP, Herpin P and Gondret F (2006) Number of intramuscular adipocytes and fatty acid binding protein-4 content are significant indicators of intramuscular fat level in crossbred Large White x Duroc pigs. J Anim Sci 84:1083-1092
8. Ding ST, Schinckel AP, Weber TE and Mersmann HJ (2000) Expression of porcine transcription factors and genes related to fatty acid metabolism in different tissues and genetic populations. J Anim Sci 78:2127-2134
9. Fan B, Lkhagvadorj S, Cai W, Young J, Smith RM, Dekkers JC, Huff-Lonergan E, Lonergan SM and Rothschild MF (2010) Identification of genetic markers associated with residual feed intake and meat quality traits in the pig. Meat Sci 84:645-650
10. Fan B, Onteru SK, Plastow GS and Rothschild MF (2009) Detailed characterization of the porcine MC4R gene in relation to fatness and growth. Anim Genet 40:401-409
11. Fernandez X, Monin G, Talmant A, Mourot J and Lebret B (1999) Influence of intramuscular fat content on the quality of pig meat-1. Composition of the lipid fraction and sensory characteristics of m. longissimus lumborum. Meat Sci 53:59-65
12. Gao SZ and Zhao SM (2009) Physiology, affecting factors and strategies for control of pig meat intramuscular fat. Recent Pat Food Nutr Agric 1:59-74
13. Gardan D, Louveau I and Gondret F (2007) Adipocyte-and heart-type fatty acid binding proteins are both expressed in subcutaneous and intramuscular porcine (Sus scrofa) adipocytes. Comp Biochem Physiol B 148:14-19
14. Gerbens F, Rettenberger G, Lenstra JA, Veerkamp JH and te Pas MFW (1997) Characterization, chromosomal localization, and genetic variation of the porcine heart fatty acid-binding protein. Mamm Genome 8:328-331
15. Gerbens F, Jansen A, van Erp AJM, Harders F, Meuwissen THE, Rettenberger G, Veerkamp JH and te Pas MF (1998) The adipocyte fatty acid-binding protein locus: Characterization and association with intramuscular fat content in pigs. Mamm Genome 9:1022-1026
16. Gerbens F, van Erp AJM, Harders FL, Verburg FJ, Meuwissen THE, Veerkamp JH and te Pas MFW (1999) Effect of genetic variants of the heart fatty acid-binding protein gene on intramuscular fat and performance traits in pigs. J Anim Sci 77:846-852
17. Gerbens F, de Koning DJ, Harders FL, Meuwissen THE, Janss LLG, Groenen MA, Veerkamp JH, Van Arendonk JA and te Pas MF (2000) The effect of adipocyte and heart fatty acid-binding protein genes on intramuscular fat and backfat content in Meishan crossbred pigs. J Anim Sci 78:552-559
18. Glatz JF, Schaap FG and Binas B (2003) Cytoplasmic fatty acidbinding protein facilitates fatty acid utilization by skeletal muscle. Acta Physiol Scand 178:367-371
19. Guo X, Xia X, Tang R, Zhou J, Zhao H and Wang K (2008) Development of a real-time PCR method for Firmicutes and Bacteroidetes in faeces and its application to quantify intestinal population of obese and lean pigs. Lett Appl Microbiol 47:367-373
20. Halaas JL and Friedman JM (1997) Leptin and its receptor. J Endocrinol 155:215-216
21. Hauser N, Mourot J, De Clercq L, Genart C and Remacle C (1997) The cellularity of developing adipose tissues in Pietrain and Meishan pigs. Reprod Nutr Dev 37:617-625
22. Houseknecht KL and Portocarrero CP (1998) Leptin and its receptors: Regulators of whole body energy homeostasis. Domest Anim Endocrinol 15:457-475
23. Huo J, Huo H, Wang P, Zeng Y and Xiao H (2012) The Association of MC1R gene with coat color of Banna Mini-Pig Inbred Line (BMIL). J Anim Vet Adv 1:503-508
24. Jokubka R, Maak S, Kerziene S and Swalve HH (2006) Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. J Anim Breed Genet 123:17-22
25. Kim KS, Lee JJ, Shin HY, Choi BH, Lee CK, Kim JJ, Cho BW and Kim TH (2006) Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits. Anim Genet 37:419-421
26. Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Liana C, Terayama K, Naylor S, Rao M, Hubbard B and Farese RV (2010) DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation. J Clin Invest 120:756-767
27. Larkina TA, Sazanova AL, Fomichev KA, Barkova Olu, Sazanova AA, Malwski T and JaszczakK(2011) Expression profiling of candidate genes for abdominal fat mass in domestic chicken Gallus gallus. Genetika 47:1140-1144
28. Li B, Zerby HN and Lee K (2007) Heart fatty acid binding protein is upregulated during porcine adipocyte development. J Anim Sci 85:1651-1659
29. Li X, Kim SW, Choi JS, Lee YM, Lee CK, Choi BH, Kim TH, Choi YI, Kim JJ and Kim KS (2010) Investigation of porcine FABP3 and LEPR gene polymorphisms and mRNA expression for variation in intramuscular fat content. Mol Biol Rep 37:3931-3939
30. Liu J, Damon M, Gutton N, Guisle I, Ecolan P, Vincent A, Cherel P and Gondret F (2009) Differentially-expressed genes in pig longissimus muscles with contrasting levels of fat, as identified by combined transcriptomic, reverse transcription PCR, and proteomic analyses. J Agric Food Chem 57:3808-3817
31. Mackowski M, Szymoniak K, Szydlowski M, Kamyczek M, Eckert R, RozyckiMand SwitonskiM(2005) Missense mutations in exon 4 of the porcine LEPR gene encoding extracellular domain and their association with fatness traits. Anim Genet 36:135-137
32. Magana MM, Koo SH, Towle HC and Osborne TF (2000) Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase. J Biol Chem 275:4726-4733
33. Mourot J and Kouba M (1998) Lipogenic enzyme activities in muscles of growing Large White and Meishan pigs. Livest Prod Sci 55:127-133
34. Ovilo C, Fernández A, Noguera JL, Barragán C, Letón R, Rodríguez C, Mercadé A, Alves E, Folch JM and Varona L (2005) Fine mapping of porcine chromosome 6 QTL and LEPR effects on body composition in multiple generations of an Iberian by Landrace intercross. Genet Res 85:57-67
35. Piórkowska K, Tyra M, Rogoz M, Ropka-Molik K, OczkowiczM and RózyckiM(2010) Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland. Meat Sci 85:297-301
36. Schwab CR, Mote BE, Du ZQ, Amoako R, Baas TJ and Rothschild MF (2009) An evaluation of four candidate genes for use in selection programmes aimed at increased intramuscular fat in Duroc swine. J Anim Breed Genet 126:228-236
37. Stinckens A, Luyten T, Van den Maagdenberg K, Janssens S, De Smet S, GeorgesMand Buys N (2009) Interactions between genes involved in growth and muscularity in pigs: IGF-2, myostatin, ryanodine receptor 1, and melanocortin-4 receptor. Domest Anim Endocrinol 37:227-235
38. Switonski M, Stachowiak M, Cieslak J, Bartz M and Grzes M (2010) Genetics of fat tissue accumulation in pigs: A comparative approach. J Appl Genet 51:153-168
39. Tyra M, Ropka-Molik K, Eckert R, Piorkowska K and Oczkowicz M (2011) H-FABP and LEPR gene expression profile in skeletal muscles and liver during ontogenesis in various breeds of pigs. Domest Anim Endocrinol 40:147-154
40. Wangsness PJ, James LG and SherrittGW(1980) Feeding behavior of lean and obese pigs. Physiol Behav 24:407-410
41. Wardlaw SL (2001) Obesity as a neuroendocrine disease: Lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men. J Clin Endocrinol Metabol 86:1442-1446
42. Wood JD, Enser M, Fisher AV, Nute GR, Sheard PR, Richardson RI, Hughes SI and Whittington FM (2008) Fat depositon, fatty acid composition and meat quality: A review. Meat Sci 78:343-358
43. Yen CL, Stone SJ, Koliwad S, Harris C and Farese RV (2008) Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res 49:2283-2301
44. Yeo GS, Farooqi IS, Challis BG, Jackson RS and O'Rahilly S (2000) The role of melanocortin signalling in the control of body weight: Evidence from human and murine genetic models. QJM 2000 93:7-14
45. Zhao SM, Liu LY, Zhang X, Ge CR, Liu YG and Gao SZ (2009) Effects of monoclonal antibody on fat tissue development, carcass composition, growth performance and fat metabolism of pigs by subcutaneous injection. Livest Sci 122:8-15
46. Zhao SM, Ren LJ, Chen L, Zhang X, Cheng ML, Li WZ, Zhang YY and Gao SZ (2009) Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition. Lipids 44:1029-1037
47. Zhuang Y, Yin L and Hillgartner FB (2003) SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium chain fatty acids on ACC alpha transcription in hepatocytes. J Lipid Res 44:356-368