Detailed characterization of the porcine MC4R gene in relation to fatness and growth

Animal Genetics

Volumn 40, Issue 4, 2009, Pages 401-409

  Fan, B ^a,b   Onteru, S K ^a   Plastow, G S ^c   Rothschild, M F ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Association; Haplotype; Melanocortin 4 receptor; Pig

Indexed keywords

MELANOCORTIN 4 RECEPTOR;

ANIMAL; ARTICLE; BODY COMPOSITION; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETICS; GENOME; GROWTH, DEVELOPMENT AND AGING; HAPLOTYPE; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SWINE;

ANIMALS; BODY COMPOSITION; GENETIC MARKERS; GENOME; HAPLOTYPES; LEAST-SQUARES ANALYSIS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RECEPTOR, MELANOCORTIN, TYPE 4; SWINE;

SUIDAE; SUS;

EID: 67849094562     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/j.1365-2052.2009.01853.x     Document Type: Article

References (34)

1. Adan R.A.H., Tiesjema B., Hillebrand J.J.G., la Fleur S.E., Kas M.J.H. de Krom M. (2006) The MC4R receptor and control of appetite. British Journal of Pharmacology 149, 815 27.
2. Barb C.R., Robertson A.S., Barrett J.B., Kraeling R.R. Houseknecht K.L. (2004) The role of melanocortin-3 and -4 receptor in regulating appetite, energy homeostasis and neuroendocrine function in the pig. Journal of Endocrinology 181, 39 52.
3. Barrett J.E., Fry B., Maller J. Daly M.J. (2005) haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263 5.
4. Bruun C.S., Jørgensen C.B., Nielsen V.H., Andersson L. Fredholm M. (2006) Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Animal Genetics 27, 359 62.
5. Challis B.G., Pritchard L.E., Creemers J.W.M. et al. (2002) A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Human Molecular Genetics 11, 1997 2004.
6. Chambers J.C., Elliott P., Zabaneh D. et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nature Genetics 40, 716 7.
7. D'Andrea M., Pilla F., Giuffra E., Waddington D. Archibald A.L. (2008) Structural analysis and haplotype diversity in swine LEP and MC4R gene. Journal of Animal Breeding and Genetics 125, 130 6.
8. Govaerts C., Srinivasah S., Shapiro A. et al. (2005) Obesity-associated mutations in the melanocortin-4 receptor provide novel insights into its function. Peptides 26, 1909 19.
9. Green P., Falls K. Crooks S. (1990) Documentation for crimap, version 2.4. Washington University School of Medicine, St Louis, MO.
10. Hernández-Sánchez J., Visscher P., Plastow G. Haley C. (2003) Candidate gene analysis for quantitative traits using the transmission disequilibrium test: the example of the melanocortin-4 receptor in pigs. Genetics 164, 637 44.
11. Hinney A., Bettecken T., Tarnow P. et al. (2006) Prevalence, spectrum, and functional characterization of melanocortin-4receptor gene mutations in a representative population-based sample and obese adults from Germany. Journal of Clinical Endocrinology and Metabolism 91, 1761 9.
12. Houston R.D., Cameron N.D. Rance K.A. (2004) A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected Large White pig populations. Animal Genetics 35, 386 90.
13. Huszar D., Lynch C.A., Fairchild-Huntress V. et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131 41.
14. Jokubka R., Maak S., Kerziene S. Swalve H.H. (2006) Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. Journal of Animal Breeding and Genetics 123, 17 22.
15. Kim K.S., Larsen N.J., Short T., Plastow G. Rothschild M.F. (2000a) A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mammalian Genome 11, 131 5.
16. Kim K.S., Larsen N.J. Rothschild M.F. (2000b) Linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene. Journal of Animal Science 78, 791 2.
17. Kim K.S., Reecy J.M., Hsu W.H., Andersson L.L. Rothschild M.F. (2004a) Function and phylogenetic analysis of a melanocortin-4 receptor mutation in domestic pigs. Domestic Animal Endocrinology 26, 75 86.
18. Kim K.S., Thomsen H., Bastiaansen J., Nguyen N.T., Dekkers J.C.M., Plastow G.S. Rothshild M.F. (2004b) Investigation of obesity candidate genes on porcine fat deposition quantitative trait loci regions. Obesity Research 12, 1981 94.
19. Loos R.J.F., Lindgren C.M., Li S.X. et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nature Genetics 40, 768 75.
20. Lubrano-Berthelier C., Cavazos M., Dubern B. et al. (2003a) Molecular genetics of human obesity-associated MC4R mutations. Annals of the New York Academy of Sciences 994, 49 57.
21. Lubrano-Berthelier C., Cavazos M., Le Stunff C., Haas K., Shapiro A., Zhang S., Bougneres P. Vaisse C. (2003b) The human MC4R promoter characterization and role in obesity. Diabetes 52, 2669 3000.
22. Malek M., Dekkers J.C.M., Lee H.K., Baas T.J. Rothschild M.F. (2001) A molecular genome scan analysis to identify chromosomal regions influencing economic traits in the pig. I. Growth and body composition. Mammalian Genome 12, 630 6.
23. 2 Mangalitsa × Piėtrain pigs. Animal Genetics 37, 245 7.
24. Óvilo C., Fernández A., Rodríguez M.C., Nieto M. Silió L. (2006) Association of MC4R gene variants with growth, carcass composition and meat and fat quality traits in heavy pig. Meat Science 73, 42 7.
25. Park H.B., Carlborg Ö., Marklund S. Andersson L. (2002) Melanocortin-4 receptor (MC4R) genotypes have no effect on fatness in a Large White × Wild Boar intercross. Animal Genetics 33, 155 7.
26. Seaton G., Hernandez J., Grunchec J.A., White I., Allen J., De Koning D.J., Wei W., Berry D., Haley C. Knott S. (2006) GridQTL: A Grid Portal for QTL Mapping of Compute Intensive Datasets. In : Proceedings of the 8th World Congress on Genetics Applied to Livestock Production. Belo Horizonte, Brazil.
27. Stachowiak M., Szydlowski M., Obarzanek-Fojt M. Switonski M. (2005) An effect of a missense mutation in the porcine melanocortin-4 receptor (MC4R) gene on population traits in Polish pig breeds is doubtful. Animal Genetics 37, 55 7.
28. Stäubert C., Tarnow P., Brumm H. et al. (2007) Evolutionary aspects in evaluating mutations in the melanocortin-4 receptor. Endocrinology 148, 4642 8.
29. Ste Marie L., Miura G.I., Marsh D.J., Yagaloff K. Palmiter R.D. (2000) A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proceedings of the National Academy of Sciences of the United States of America 97, 12339 44.
30. Stephens M., Smith N. Donnelly P. (2001) A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics 69, 978 89.
31. Tao Y.X. (2005) Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Molecular and Cellular Endocrinology 239, 1 14.
32. Valli-Jaakola K., Palvimo J.J., Lipsanen-Nyman M., Salomaa V., Peltonen L., Kontula K. Schalin-Jäntti C. (2006) A two-base deletion -439delGC in the melanocortin-4 receptor promoter associated with early-onset obesity. Hormone Research 66, 70 2.
33. Van den Maagdenberg K., Stinckens A., Claeys E., Seynaeve M., Clinquart A., Georges M., Buys N. De Smet S. (2007) The p.Asp298Asn missense mutation in the porcine melanocortin-4 receptor (MC4R) gene can be used to affect growth and carcass traits without an effect on meat quality. Animal 1, 1089 98.
34. Zhao H., Rothschild M.F., Fernando R.L. Dekkers J.C.M. (2003) Tests of candidate genes in breed cross populations for QTL mapping in livestock. Mammalian Genome 14, 472 82.