메뉴 건너뛰기




Volumn 11, Issue 24, 2012, Pages 4563-4569

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP

Author keywords

Apoptosis; p53; SAP; T cell homeostasis; X linked lymphoproliferative disease

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUTLIN 3; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; SIGNALING LYMPHOCYTE ACTIVATION MOLECULE ASSOCIATED PROTEIN;

EID: 84871475053     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.22810     Document Type: Article
Times cited : (23)

References (38)
  • 1
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the Light: The Growing Complexity of p53
    • PMID:19410540
    • Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009; 137:413-31; PMID:19410540; http://dx.doi.org/10.1016/j.cell. 2009.04.037.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 2
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • PMID:7926727
    • Lin J, Chen J, Elenbaas B, Levine AJ. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev 1994; 8:1235-46; PMID:7926727; http://dx.doi.org/10.1101/gad.8.10.1235.
    • (1994) Genes Dev , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 3
    • 0019476342 scopus 로고
    • X-linked lymphoproliferative syndrome. An immunodeficiency disorder with acquired agammaglobulinemia, fatal infectious mononucleosis, or malignant lymphoma
    • PMID:6894075
    • Purtilo DT. X-linked lymphoproliferative syndrome. An immunodeficiency disorder with acquired agammaglobulinemia, fatal infectious mononucleosis, or malignant lymphoma. Arch Pathol Lab Med 1981; 105:119-21; PMID:6894075.
    • (1981) Arch Pathol Lab Med , vol.105 , pp. 119-121
    • Purtilo, D.T.1
  • 4
    • 33244455863 scopus 로고    scopus 로고
    • Immune regulation by SLAM family receptors and SAP-related adaptors
    • PMID:16493427
    • Veillette A. Immune regulation by SLAM family receptors and SAP-related adaptors. Nat Rev Immunol 2006; 6:56-66; PMID:16493427; http://dx.doi.org/10. 1038/nri1761.
    • (2006) Nat Rev Immunol , vol.6 , pp. 56-66
    • Veillette, A.1
  • 5
    • 67749096266 scopus 로고    scopus 로고
    • The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
    • PMID:19570996
    • Nagy N, Matskova L, Kis LL, Hellman U, Klein G, Klein E. The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease. Proc Natl Acad Sci USA 2009; 106:11966-71; PMID:19570996; http://dx.doi.org/10.1073/pnas.0905691106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11966-11971
    • Nagy, N.1    Matskova, L.2    Kis, L.L.3    Hellman, U.4    Klein, G.5    Klein, E.6
  • 6
    • 0033179457 scopus 로고    scopus 로고
    • The abnormal gene in X-linked lymphoproliferative syndrome
    • PMID:10448142
    • Sullivan JL. The abnormal gene in X-linked lymphoproliferative syndrome. Curr Opin Immunol 1999; 11:431-4; PMID:10448142; http://dx.doi.org/10.1016/ S0952-7915(99)80072-7.
    • (1999) Curr Opin Immunol , vol.11 , pp. 431-434
    • Sullivan, J.L.1
  • 7
    • 9644275583 scopus 로고    scopus 로고
    • Wild-type p53 activates SAP expression in lymphoid cells
    • PMID:15378026
    • Nagy N, Takahara M, Nishikawa J, Bourdon JC, Kis LL, Klein G, et al. Wild-type p53 activates SAP expression in lymphoid cells. Oncogene 2004; 23:8563-70; PMID:15378026; http://dx.doi.org/10.1038/sj.onc.1207908.
    • (2004) Oncogene , vol.23 , pp. 8563-8570
    • Nagy, N.1    Takahara, M.2    Nishikawa, J.3    Bourdon, J.C.4    Kis, L.L.5    Klein, G.6
  • 8
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • PMID:15510160
    • Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4:793-805; PMID:15510160; http://dx.doi.org/10.1038/ nrc1455.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.2
  • 9
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • PMID:9733514
    • Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, et al. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998; 281:1674-7; PMID:9733514; http://dx.doi.org/10.1126/science.281.5383.1674.
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1    Moyal, L.2    Shieh, S.3    Taya, Y.4    Anderson, C.W.5    Chessa, L.6
  • 10
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • PMID:14704432
    • Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303:844-8; PMID:14704432; http://dx.doi.org/10.1126/science. 1092472.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3    Carvajal, D.4    Podlaski, F.5    Filipovic, Z.6
  • 11
    • 0033814931 scopus 로고    scopus 로고
    • SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines
    • PMID:11054674
    • Nagy N, Cerboni C, Mattsson K, Maeda A, Gogolák P, Sümegi J, et al. SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines. Int J Cancer 2000; 88:439-47; PMID:11054674; http://dx.doi.org/10.1002/ 1097-0215(20001101)88:3<439::AID-IJC17>3.0.CO;2-#.
    • (2000) Int J Cancer , vol.88 , pp. 439-447
    • Nagy, N.1    Cerboni, C.2    Mattsson, K.3    Maeda, A.4    Gogolák, P.5    Sümegi, J.6
  • 12
    • 0036681314 scopus 로고    scopus 로고
    • SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group i lines and is downregulated in parallel with immunoblastic transformation
    • PMID:12115526
    • Nagy N, Maeda A, Bandobashi K, Kis LL, Nishikawa J, Trivedi P, et al. SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation. Int J Cancer 2002; 100:433-40; PMID:12115526; http://dx.doi.org/10.1002/ijc.10498.
    • (2002) Int J Cancer , vol.100 , pp. 433-440
    • Nagy, N.1    Maeda, A.2    Bandobashi, K.3    Kis, L.L.4    Nishikawa, J.5    Trivedi, P.6
  • 13
    • 0034618065 scopus 로고    scopus 로고
    • X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    • PMID:10934222
    • Parolini S, Bottino C, Falco M, Augugliaro R, Giliani S, Franceschini R, et al. X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J Exp Med 2000; 192:337-46; PMID:10934222; http://dx.doi.org/10.1084/jem.192.3.337.
    • (2000) J Exp Med , vol.192 , pp. 337-346
    • Parolini, S.1    Bottino, C.2    Falco, M.3    Augugliaro, R.4    Giliani, S.5    Franceschini, R.6
  • 14
    • 79251578633 scopus 로고    scopus 로고
    • The role of SAP and SLAM family molecules in the humoral immune response
    • PMID:21091715
    • Ma CS, Deenick EK. The role of SAP and SLAM family molecules in the humoral immune response. Ann NY Acad Sci 2011; 1217:32-44; PMID:21091715; http://dx.doi.org/10.1111/j.1749-6632.2010.05824.x.
    • (2011) Ann NY Acad Sci , vol.1217 , pp. 32-44
    • Ma, C.S.1    Deenick, E.K.2
  • 15
    • 70349678683 scopus 로고    scopus 로고
    • Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency
    • PMID:19759517
    • Snow AL, Marsh RA, Krummey SM, Roehrs P, Young LR, Zhang K, et al. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest 2009; 119:2976-89; PMID:19759517.
    • (2009) J Clin Invest , vol.119 , pp. 2976-2989
    • Snow, A.L.1    Marsh, R.A.2    Krummey, S.M.3    Roehrs, P.4    Young, L.R.5    Zhang, K.6
  • 16
    • 17344372694 scopus 로고    scopus 로고
    • Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
    • PMID:9771704
    • Coffey AJ, Brooksbank RA, Brandau O, Oohashi T, Howell GR, Bye JM, et al. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet 1998; 20:129-35; PMID:9771704; http://dx.doi.org/10.1038/2424.
    • (1998) Nat Genet , vol.20 , pp. 129-135
    • Coffey, A.J.1    Brooksbank, R.A.2    Brandau, O.3    Oohashi, T.4    Howell, G.R.5    Bye, J.M.6
  • 17
    • 13144278345 scopus 로고    scopus 로고
    • Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome
    • PMID:9811875
    • Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci USA 1998; 95:13765-70; PMID:9811875; http://dx.doi.org/10.1073/pnas.95.23.13765.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13765-13770
    • Nichols, K.E.1    Harkin, D.P.2    Levitz, S.3    Krainer, M.4    Kolquist, K.A.5    Genovese, C.6
  • 18
    • 0032190081 scopus 로고    scopus 로고
    • The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
    • PMID:9774102
    • Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 1998; 395:462-9; PMID:9774102; http://dx.doi.org/ 10.1038/26683.
    • (1998) Nature , vol.395 , pp. 462-469
    • Sayos, J.1    Wu, C.2    Morra, M.3    Wang, N.4    Zhang, X.5    Allen, D.6
  • 19
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • PMID:7834749
    • Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-9; PMID:7834749; http://dx.doi.org/10.1016/0092-8674(95)90412-3.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 20
    • 0029003501 scopus 로고
    • Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
    • PMID:7539102
    • Owen-Schaub LB, Zhang W, Cusack JC, Angelo LS, Santee SM, Fujiwara T, et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol 1995; 15:3032-40; PMID:7539102.
    • (1995) Mol Cell Biol , vol.15 , pp. 3032-3040
    • Owen-Schaub, L.B.1    Zhang, W.2    Cusack, J.C.3    Angelo, L.S.4    Santee, S.M.5    Fujiwara, T.6
  • 21
    • 0030930366 scopus 로고    scopus 로고
    • A model for p53-induced apoptosis
    • PMID:9305847
    • Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997; 389:300-5; PMID:9305847; http://dx.doi.org/10.1038/38525.
    • (1997) Nature , vol.389 , pp. 300-305
    • Polyak, K.1    Xia, Y.2    Zweier, J.L.3    Kinzler, K.W.4    Vogelstein, B.5
  • 22
    • 70349929531 scopus 로고    scopus 로고
    • The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease
    • PMID:19738428
    • Nagy N, Matskova L, Hellman U, Klein G, Klein E. The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease. Cell Cycle 2009; 8:3086-90; PMID:19738428; http://dx.doi.org/10.4161/cc.8.19.9636.
    • (2009) Cell Cycle , vol.8 , pp. 3086-3090
    • Nagy, N.1    Matskova, L.2    Hellman, U.3    Klein, G.4    Klein, E.5
  • 23
    • 79955991034 scopus 로고    scopus 로고
    • Mechanism-specific signatures for small-molecule p53 activators
    • PMID:21490429
    • van Leeuwen IM, Higgins M, Campbell J, Brown CJ, McCarthy AR, Pirrie L, et al. Mechanism-specific signatures for small-molecule p53 activators. Cell Cycle 2011; 10:1590-8; PMID:21490429; http://dx.doi.org/10.4161/cc.10.10.15519.
    • (2011) Cell Cycle , vol.10 , pp. 1590-1598
    • Van Leeuwen, I.M.1    Higgins, M.2    Campbell, J.3    Brown, C.J.4    McCarthy, A.R.5    Pirrie, L.6
  • 24
    • 9244247272 scopus 로고    scopus 로고
    • Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms
    • PMID:15459902
    • Okamoto S, Ji H, Howie D, Clarke K, Gullo C, Manning S, et al. Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms. Eur J Immunol 2004; 34:3176-86; PMID:15459902; http://dx.doi.org/10.1002/eji.200324755.
    • (2004) Eur J Immunol , vol.34 , pp. 3176-3186
    • Okamoto, S.1    Ji, H.2    Howie, D.3    Clarke, K.4    Gullo, C.5    Manning, S.6
  • 25
    • 0025300037 scopus 로고
    • Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: Regulatory role for the protooncogene ETS1
    • PMID:2187191
    • Bhat NK, Thompson CB, Lindsten T, June CH, Fujiwara S, Koizumi S, et al. Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proc Natl Acad Sci USA 1990; 87:3723-7; PMID:2187191; http://dx.doi.org/10.1073/pnas.87.10.3723.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3723-3727
    • Bhat, N.K.1    Thompson, C.B.2    Lindsten, T.3    June, C.H.4    Fujiwara, S.5    Koizumi, S.6
  • 26
    • 0031216743 scopus 로고    scopus 로고
    • Expression of protooncogenes during lymphocyte activation by growth factors
    • Mosc PMID:9457764
    • Bulanova EG, Budagyan VM, Yarilin AA, Mazurenko NN. Expression of protooncogenes during lymphocyte activation by growth factors. Biochemistry (Mosc) 1997; 62:1021-5; PMID:9457764.
    • (1997) Biochemistry , vol.62 , pp. 1021-1025
    • Bulanova, E.G.1    Budagyan, V.M.2    Yarilin, A.A.3    Mazurenko, N.N.4
  • 27
    • 0025879338 scopus 로고
    • Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells
    • PMID:1906503
    • Terada N, Lucas JJ, Gelfand EW. Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells. J Immunol 1991; 147:698-704; PMID:1906503.
    • (1991) J Immunol , vol.147 , pp. 698-704
    • Terada, N.1    Lucas, J.J.2    Gelfand, E.W.3
  • 28
    • 0031958676 scopus 로고    scopus 로고
    • Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans
    • PMID:9620358
    • VanAman SE, Whisler RL. Differential expression of p53 tumor suppressor protein and IL-2 in activated T cells from elderly humans. J Interferon Cytokine Res 1998; 18:315-20; PMID:9620358; http://dx.doi.org/10.1089/jir.1998.18.315.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 315-320
    • VanAman, S.E.1    Whisler, R.L.2
  • 29
    • 0028795758 scopus 로고
    • Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
    • PMID:7530335
    • Dhein J, Walczak H, Bäumler C, Debatin KM, Krammer PH. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 1995; 373:438-41; PMID:7530335; http://dx.doi.org/10.1038/373438a0.
    • (1995) Nature , vol.373 , pp. 438-441
    • Dhein, J.1    Walczak, H.2    Bäumler, C.3    Debatin, K.M.4    Krammer, P.H.5
  • 30
    • 0038819110 scopus 로고    scopus 로고
    • Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis
    • PMID:12586632
    • Luiten RM, Péne J, Yssel H, Spits H. Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 2003; 101:4512-9; PMID:12586632; http://dx.doi.org/10.1182/blood-2002-07-2018.
    • (2003) Blood , vol.101 , pp. 4512-4519
    • Luiten, R.M.1    Péne, J.2    Yssel, H.3    Spits, H.4
  • 31
    • 0041743240 scopus 로고    scopus 로고
    • Telomerase levels control the lifespan of human T lymphocytes
    • PMID:12689947
    • Roth A, Yssel H, Pene J, Chavez EA, Schertzer M, Lansdorp PM, et al. Telomerase levels control the lifespan of human T lymphocytes. Blood 2003; 102:849-57; PMID:12689947; http://dx.doi.org/10.1182/blood-2002-07-2015.
    • (2003) Blood , vol.102 , pp. 849-857
    • Roth, A.1    Yssel, H.2    Pene, J.3    Chavez, E.A.4    Schertzer, M.5    Lansdorp, P.M.6
  • 32
    • 0034048726 scopus 로고    scopus 로고
    • Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription
    • PMID:10778946
    • Kanaya T, Kyo S, Hamada K, Takakura M, Kitagawa Y, Harada H, et al. Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin Cancer Res 2000; 6:1239-47; PMID:10778946.
    • (2000) Clin Cancer Res , vol.6 , pp. 1239-1247
    • Kanaya, T.1    Kyo, S.2    Hamada, K.3    Takakura, M.4    Kitagawa, Y.5    Harada, H.6
  • 33
    • 0034718769 scopus 로고    scopus 로고
    • Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells
    • PMID:11064449
    • Xu D, Wang Q, Gruber A, Björkholm M, Chen Z, Zaid A, et al. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene 2000; 19:5123-33; PMID:11064449; http://dx.doi.org/10.1038/sj.onc.1203890.
    • (2000) Oncogene , vol.19 , pp. 5123-5133
    • Xu, D.1    Wang, Q.2    Gruber, A.3    Björkholm, M.4    Chen, Z.5    Zaid, A.6
  • 34
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • PMID:1552940
    • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr., Butel JS, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356:215-21; PMID:1552940; http://dx.doi.org/ 10.1038/356215a0.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3    McArthur, M.J.4    Montgomery Jr., C.A.5    Butel, J.S.6
  • 35
    • 0028862865 scopus 로고
    • Effects of genetic background on tumorigenesis in p53-deficient mice
    • PMID:7546219
    • Donehower LA, Harvey M, Vogel H, McArthur MJ, Montgomery CA Jr., Park SH, et al. Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog 1995; 14:16-22; PMID:7546219; http://dx.doi.org/10.1002/mc. 2940140105.
    • (1995) Mol Carcinog , vol.14 , pp. 16-22
    • Donehower, L.A.1    Harvey, M.2    Vogel, H.3    McArthur, M.J.4    Montgomery Jr., C.A.5    Park, S.H.6
  • 36
    • 0033120112 scopus 로고    scopus 로고
    • Increased generation of CD8+ T cell clones in p53 mutant mice
    • PMID:10201915
    • Zhou X, Wong S, Walter J, Jacks T, Eisen HN. Increased generation of CD8+ T cell clones in p53 mutant mice. J Immunol 1999; 162:3957-60; PMID:10201915.
    • (1999) J Immunol , vol.162 , pp. 3957-3960
    • Zhou, X.1    Wong, S.2    Walter, J.3    Jacks, T.4    Eisen, H.N.5
  • 37
    • 10244237695 scopus 로고    scopus 로고
    • Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: Functional inactivation of p53 in developing T cells
    • PMID:15319293
    • Gimeno R, Weijer K, Voordouw A, Uittenbogaart CH, Legrand N, Alves NL, et al. Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells. Blood 2004; 104:3886-93; PMID:15319293; http://dx.doi.org/10.1182/blood-2004-02-0656.
    • (2004) Blood , vol.104 , pp. 3886-3893
    • Gimeno, R.1    Weijer, K.2    Voordouw, A.3    Uittenbogaart, C.H.4    Legrand, N.5    Alves, N.L.6
  • 38
    • 0030092024 scopus 로고    scopus 로고
    • Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues
    • PMID:8774137
    • Fredersdorf S, Milne AW, Hall PA, Lu X. Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues. Am J Pathol 1996; 148:825-35; PMID:8774137.
    • (1996) Am J Pathol , vol.148 , pp. 825-835
    • Fredersdorf, S.1    Milne, A.W.2    Hall, P.A.3    Lu, X.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.