Increased generation of CD8+ T cell clones in p53 mutant mice

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3957-3960

  Zhou, Xianzheng ^a   Wong, Stacey ^a   Walter, Jurgen ^a   Jacks, Tyler ^a,b   Eisen, Herman N ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CELL SPECIFICITY; CELL SURVIVAL; CYTOTOXIC T LYMPHOCYTE; GAMMA IRRADIATION; GENE MUTATION; GENOTYPE; INFLUENZA VIRUS; LYMPHOCYTE CLONE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENDAI VIRUS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CLONE CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033120112     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Fitch, F. W. 1981. T lymphocyte clones having defined immunological functions. Transplantation 32:171.
2. Ashwell, J. D., D. L. Longo, and S. H. Bridges. 1987. T-cell tumor elimination as a result of T-cell receptor-mediated activation. Science 237:61.
3. Russell, J. H., C. L. While, D. Y. Loh, and P. Meleedy-Rey. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA 88:2151.
4. Lenardo, M. J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353:858.
5. Lenardo, M. J. 1997. The molecular regulation of lymphocyte apoptosis. Semin. Immunol. 9:1.
6. Haffner, R., and M. Oren. 1995. Biochemical properties and biological effects of p53. Curr. Opin. Genes. Dev. 5:84.
7. Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323.
8. Jacks, T., R. Lee, B. O. Williams, E. M. Schmitt, S. Halachmi, R. T. Bronson, and R. A. Weinberg. 1994. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4:1.
9. Kast, W. M., L. Roux, J. Curren, H. J. J. Blom, A. C. Voordouw, R. H. Meloen, D. Kolakofsky, and C. J. M. Melief. 1991. Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natl. Acad. Sci. USA 88:2283.
10. Townsend, A. R., J. Rothbard, F. M. Gotch, G. Bahadur, D. Wraith, and A. J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell 44: 959.
11. Rotzschke, O., F. Falk, K. Deres, H. Schild, M. Norda, J. Metzger, G. Jung, and H.-G. Rammensee. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252.
12. Falk, K., O. Rotzschke, S. Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 355:290.
13. Kast, W. M., and C. J. M. Melief. 1991. Fine peptide specificity of cytotoxic T lymphocytes directed against adenovirus-induced tumors and peptide-MHC binding. Int. J. Cancer 6:90.
14. Ljunggren, H.-G., and K. Karre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants. J. Exp. Med. 162:1745.
15. + T cells specific for transporter associated with antigen processing-deficient cells. Proc. Natl. Acad. Sci. USA 94:11496.
16. Zhou, X., L. Berg, U. M. Motal, and M. Jondal. 1992. In vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides. J. Immunol. Methods 153:193.
17. Ljunggren, H.-G., N. J. Stam, C. Ohlen, J. J. Neefjes, P. Hoglund, M. T. Heemels, J. Batin, T. N. M. Schumacher, A. Townsend, K. Karre, and H. L. Ploegh. 1990. Empty class I molecules come out in the cold. Nature 346:476.
18. Sykulev, Y., A. Brunmark, T. J. Tsomides, S. Kageyama, M. Jackson, P. A. Peterson, and H. N. Eisen. 1995. High-affinity reactions between antigen-specific T-cell receptors and peplide associated with allogeneic and syngeneic major histocompatibility complex class I proteins. Proc. Natl. Acad. Sci. USA 91:11487.
19. Strasser, A., A. W. Harris, T. Jacks, and S. Cory. 1994. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79:329.
20. Tamura, T., M. Ishihara, M. S. Lamphler, N. Tanaka, I. Olshi, S. Alzawa, T. Matsuyama, T. W. Mark, S. Taki, and T. Taniguchi. 1995. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 376:596.
21. Boehme, S. A., and M. J. Lenardo. 1996. TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J. Immunol. 156:4075.
22. Yoon, S. T., U. Dianzani, K. Bottomly, and C. A. Janewsy, Jr. 1994. Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity 1:563.
23. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T-cell recognition of antigen. Nature 380:495.
24. Karlhofer, F. M., M. M. Orihuela, and W. M. Yokoyama.-1995. Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from p53-deficient mice. J. Exp. Med. 181:1785.
25. Palacios, R., C. Bucana, and X. Xie. 1996. Long-term culture of lymphohematopoietic stem cells. Proc. Natl. Acad. Sci. USA 93:5247.