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Volumn 45, Issue 3, 2012, Pages 115-123

Overexpression of p53 protein in human tumors

Author keywords

Malignant tumor; P53; TP53

Indexed keywords

MUTANT PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; PROTEIN P63; PROTEIN P73;

EID: 84871423991     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-012-0575-6     Document Type: Review
Times cited : (29)

References (114)
  • 1
    • 0036258111 scopus 로고    scopus 로고
    • The IARC TP53 database: New online mutation analysis and recommendations to users
    • DOI 10.1002/humu.10081
    • Olivier M, Eeles R, Hollstein M, Khan MA, Harris CC, Hainaut P (2002) The IARC TP53 database: new online mutation analysis and recommendations to users. Hum Mutat 19:607-614 (Pubitemid 34556481)
    • (2002) Human Mutation , vol.19 , Issue.6 , pp. 607-614
    • Olivier, M.1    Eeles, R.2    Hollstein, M.3    Khan, M.A.4    Harris, C.C.5    Hainaut, P.6
  • 2
    • 0033992478 scopus 로고    scopus 로고
    • P53 and human cancer: The first ten thousand mutations
    • Hainaut P, Hollstein M (2000) p53 and human cancer: the fi rst ten thousand mutations. Adv Cancer Res 77:81-137 (Pubitemid 29439303)
    • (2000) Advances in Cancer Research , vol.77 , pp. 81-137
    • Hainaut, P.1    Hollstein, M.2
  • 4
    • 0025173845 scopus 로고
    • P53: Oncogene or anti-oncogene?
    • Lane DP, Benchimol S (1990) p53: oncogene or anti-oncogene? Genes Dev 4:1-8
    • (1990) Genes Dev , vol.4 , pp. 1-8
    • Lane, D.P.1    Benchimol, S.2
  • 5
    • 0025375355 scopus 로고
    • Structural aspects of the p53 protein in relation to gene evolution
    • Soussi T, Caron de Fromentel C, May P (1990) Structural aspects of the p53 protein in relation to gene evolution. Oncogene 5:945-952
    • (1990) Oncogene , vol.5 , pp. 945-952
    • Soussi, T.1    Caron De Fromentel, C.2    May, P.3
  • 6
    • 0021675797 scopus 로고
    • Participation of p53 cellular tumour antigen in transformation of normal embryonic cells
    • DOI 10.1038/312646a0
    • Eliyahu D, Raz A, Gruss P, Givol D, Oren M (1984) Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (Lond) 312:646-649 (Pubitemid 15218336)
    • (1984) Nature , vol.312 , Issue.5995 , pp. 646-649
    • Eliyahu, D.1    Raz, A.2    Gruss, P.3
  • 7
    • 0021676404 scopus 로고
    • Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
    • DOI 10.1038/312651a0
    • Jenkins JR, Rudge K, Currie GA (1984) Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53. Nature (Lond) 312:651-654 (Pubitemid 15218338)
    • (1984) Nature , vol.312 , Issue.5995 , pp. 651-654
    • Jenkins, J.R.1    Rudge, K.2    Currie, G.A.3
  • 8
    • 0021673319 scopus 로고
    • Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
    • DOI 10.1038/312649a0
    • Parada LF, Land H, Weinberg RA, Wolf D, Rotter V (1984) Cooperation between gene encoding p53 antigen and ras in cellular transformation. Nature (Lond) 312:649-651 (Pubitemid 15218337)
    • (1984) Nature , vol.312 , Issue.5995 , pp. 649-651
    • Parada, L.F.1    Land, H.2    Weinberg, R.A.3
  • 9
    • 0023261211 scopus 로고
    • Clonal analysis of human colorectal tumors
    • Fearon ER, Hamilton SR, Vogelstein B (1987) Clonal analysis of human colorectal tumors. Science 238:193-197 (Pubitemid 17139720)
    • (1987) Science , vol.238 , Issue.4824 , pp. 193-197
    • Fearon, E.R.1    Hamilton, S.R.2    Vogelstein, B.3
  • 13
    • 0024243847 scopus 로고
    • Allele loss on short arm of chromosome 17 in breast cancers
    • Mackay J, Steel CM, Elder PA, Forrest AP, Evans HJ (1988) Allele loss on short arm of chromosome 17 in breast cancer. Lancet 2:1384-1385 (Pubitemid 19004481)
    • (1988) Lancet , vol.2 , Issue.8625 , pp. 1384-1385
    • Mackay, J.1    Steel, C.M.2    Elder, P.A.3    Forrest, A.P.M.4    Evans, H.J.5
  • 16
    • 0024382760 scopus 로고
    • The p53 proto-oncogene can act as a suppressor of transformation
    • DOI 10.1016/0092-8674(89)90045-7
    • Finlay CA, Hinds P, Levine A (1989) The p53 proto-oncogene can act as a suppressor of transformation. Cell 57:1083-1093 (Pubitemid 19169804)
    • (1989) Cell , vol.57 , Issue.7 , pp. 1083-1093
    • Finlay, C.A.1    Hinds, P.W.2    Levine, A.J.3
  • 17
    • 0025292735 scopus 로고
    • Wild type human p53 is antiproliferative in SV40-transformed hamster cells
    • Mercer WE, Amin M, Sauve GJ (1990) Wild type human p53 is antiproliferative in SV40-transformed hamster cells. Oncogene 5:973-980
    • (1990) Oncogene , vol.5 , pp. 973-980
    • Mercer, W.E.1    Amin, M.2    Sauve, G.J.3
  • 18
    • 0025265724 scopus 로고
    • Increased expression of mutant forms of p53 oncogene in primary lung cancer
    • DOI 10.1016/0140-6736(90)90801-B
    • Iggo R, Gatter K, Bartek J (1990) Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335:675-679 (Pubitemid 20089305)
    • (1990) Lancet , vol.335 , Issue.8691 , pp. 675-679
    • Iggo, R.1    Gatter, K.2    Bartek, J.3    Lane, D.4    Harris, A.L.5
  • 19
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specifi c for the mutant form
    • Gannon JV, Greaves R, Iggo R (1990) Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specifi c for the mutant form. EMBO J 9:1595-1602
    • (1990) EMBO J , vol.9 , pp. 1595-1602
    • Gannon, J.V.1    Greaves, R.2    Iggo, R.3
  • 21
    • 0022646788 scopus 로고
    • Localization of gene for human p53 tumour antigen to band 17p13
    • Isobe M, Emanuel BS, Givol D, Oren M, Croce CM (1986) Localization of gene for human p53 tumour antigen to band 17p13. Nature (Lond) 320:84-85 (Pubitemid 16105254)
    • (1986) Nature , vol.320 , Issue.6057 , pp. 84-85
    • Isobe, M.1    Emanuel, B.S.2    Givol, D.3
  • 23
    • 0022623436 scopus 로고
    • Human p53 gene localized to short arm of chromosome 17
    • Miller C, Mohandas T, Wolf D (1986) Human p53 gene localized to short arm of chromosome 17. Nature (Lond) 319:783-784 (Pubitemid 16145035)
    • (1986) Nature , vol.319 , Issue.6056 , pp. 783-784
    • Miller, C.1    Mohandas, T.2    Wolf, D.3
  • 24
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265:346-355 (Pubitemid 24259959)
    • (1994) Science , vol.265 , Issue.5170 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 26
    • 0026579237 scopus 로고
    • TP53 tumor suppressor gene: A model for investigating human mutagenesis
    • Caron de Fromentel C, Soussi T (1992) TP53 tumor suppressor gene: a model for investigating human mutagenesis. Genes Chromosomes Cancer 4:1-15
    • (1992) Genes Chromosomes Cancer , vol.4 , pp. 1-15
    • Caron De Fromentel, C.1    Soussi, T.2
  • 28
    • 0035496607 scopus 로고    scopus 로고
    • Rescuing the function of mutant p53
    • Bullock AN, Fersht AR (2001) Rescuing the function of mutant p53. Nat Rev Cancer 1:68-76 (Pubitemid 33741882)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.1 , pp. 68-76
    • Bullock, A.N.1    Fersht, A.R.2
  • 29
    • 0025024469 scopus 로고
    • Presence of a potent transcription activating sequence in the p53 protein
    • Fields S, Jang SK (1990) Presence of a potent transcription activating sequence in the p53 protein. Science 249:1046-1049
    • (1990) Science , vol.249 , pp. 1046-1049
    • Fields, S.1    Jang, S.K.2
  • 30
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutations of the p53 antioncogene
    • Raycroft L, Wu H, Lozano G (1990) Transcriptional activation by wild-type but not transforming mutations of the p53 antioncogene. Science 249:1049-1051
    • (1990) Science , vol.249 , pp. 1049-1051
    • Raycroft, L.1    Wu, H.2    Lozano, G.3
  • 32
    • 0027174586 scopus 로고
    • Use of the two-hybrid system to identify the domain of p53 involved in oligomerization
    • Iwabuchi K, Li B, Bartel P, Fields S (1993) Use of the two-hybrid to identify the domain of p53 involved in oligomerization. Oncogene 8:1693-1696 (Pubitemid 23189068)
    • (1993) Oncogene , vol.8 , Issue.6 , pp. 1693-1696
    • Iwabuchi, K.1    Li, B.2    Bartel, P.3    Fields, S.4
  • 33
    • 73949117703 scopus 로고    scopus 로고
    • Massively regulated genes: The example of TP53
    • Hollstein M, Hainaut P (2010) Massively regulated genes: the example of TP53. J Pathol 220:164-173
    • (2010) J Pathol , vol.220 , pp. 164-173
    • Hollstein, M.1    Hainaut, P.2
  • 34
    • 1242318518 scopus 로고    scopus 로고
    • P53 protein variants: Structural and functional similarities with p63 and p73 isoforms
    • DOI 10.1038/sj.onc.1206929
    • Courtois S, de Fromentel CC, Hainaut P (2004) p53 protein variants: structural and functional similarities with p63 and p73 isoforms. Oncogene 23:631-638 (Pubitemid 38241264)
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 631-638
    • Courtois, S.1    De Fromentel, C.C.2    Hainaut, P.3
  • 36
    • 59349099726 scopus 로고    scopus 로고
    • P53 isoforms - A conspiracy to kidnap p53 tumor suppressor activity?
    • Marcel V, Hainaut P (2009) p53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity? Cell Mol Life Sci 66:391-406
    • (2009) Cell Mol Life Sci , vol.66 , pp. 391-406
    • Marcel, V.1    Hainaut, P.2
  • 37
    • 0018348655 scopus 로고
    • T antigen is bound to a host protein in SV40 transformed cells
    • Lane DP, Crawford LV (1979) T-antigen is bound to host protein in SV40-transformed cells. Nature (Lond) 278:261-263 (Pubitemid 9129076)
    • (1979) Nature , vol.278 , Issue.5701 , pp. 261-263
    • Lane, D.P.1    Crawford, L.V.2
  • 38
    • 0018760324 scopus 로고
    • Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells
    • Linzer DIH, Levine AJ (1979) Characterization of a 54 K dalton cellular SV40 tumour antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells. Cell 17:43-52 (Pubitemid 9188209)
    • (1979) Cell , vol.17 , Issue.1 , pp. 43-52
    • Linzer, D.I.H.1    Levine, A.J.2
  • 39
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness BA, Levine AJ, Howley P (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.3
  • 41
    • 0020079972 scopus 로고
    • Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
    • Sarnow P, Ho YS, Williams J, Levine AJ (1982) Adenovirus E1b-58 kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28:387-394 (Pubitemid 12132769)
    • (1982) Cell , vol.28 , Issue.2 , pp. 387-394
    • Sarnow, P.1    Ho, Y.S.2    Williams, J.3    Levine, A.J.4
  • 42
    • 0027157304 scopus 로고
    • Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
    • Feitelson MA, Zhu M, Duan LX, London WT (1993) Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 8:1109-1117 (Pubitemid 23129832)
    • (1993) Oncogene , vol.8 , Issue.5 , pp. 1109-1117
    • Feitelson, M.A.1    Zhu, M.2    Duan, L.-X.3    London, W.T.4
  • 43
    • 0026058990 scopus 로고
    • Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53
    • Symonds H, Chen JD, Van Dyke T (1991) Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53. J Virol 65:5417-5424
    • (1991) J Virol , vol.65 , pp. 5417-5424
    • Symonds, H.1    Chen, J.D.2    Van Dyke, T.3
  • 44
    • 0022390692 scopus 로고
    • P53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors
    • Rogel A, Popliker M, Webb CG, Oren M (1985) p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol 5:2851-2855 (Pubitemid 15237110)
    • (1985) Molecular and Cellular Biology , vol.5 , Issue.10 , pp. 2851-2855
    • Rogel, A.1    Popliker, M.2    Webb, C.G.3    Oren, M.4
  • 45
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM (1990) The E6 oncoprotein encoded by human papilloma virus type 16 and 18 promotes degradation of p53. Cell 63:1129-1136 (Pubitemid 120035062)
    • (1990) Cell , vol.63 , Issue.6 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 47
    • 39749087530 scopus 로고    scopus 로고
    • SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
    • DOI 10.1016/j.stem.2008.01.002, PII S1934590908000039
    • Han MK, Song EK, Guo Y, Ou X, Mantel C, Broxmeyer HE (2008) SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2:241-251 (Pubitemid 351298591)
    • (2008) Cell Stem Cell , vol.2 , Issue.3 , pp. 241-251
    • Han, M.-K.1    Song, E.-K.2    Guo, Y.3    Ou, X.4    Mantel, C.5    Broxmeyer, H.E.6
  • 48
    • 0018854599 scopus 로고
    • Monoclonal antibodies against simian virus 40 T antigens: Evidence for distinct subclasses of large T antigen and for similarities among nonviral T antigens
    • Gurney EG, Harrison RO, Fennol J (1980) Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct subclasses of large T antigen and for similarities among nonviral T antigens. J Virol 34:752-763
    • (1980) J Virol , vol.34 , pp. 752-763
    • Gurney, E.G.1    Harrison, R.O.2    Fennol, J.3
  • 50
    • 0020653151 scopus 로고
    • P53 transformationrelated protein accumulates in the nucleus of transformed fi broblasts in association with the chromatin and is found in the cytoplasm of non-transformed fi broblasts
    • Rotter V, Abutbul H, Ben-Ze'ev A (1983) p53 transformationrelated protein accumulates in the nucleus of transformed fi broblasts in association with the chromatin and is found in the cytoplasm of non-transformed fi broblasts. EMBO J 2:1041-1047
    • (1983) EMBO J , vol.2 , pp. 1041-1047
    • Rotter, V.1    Abutbul, H.2    Ben-Ze'Ev, A.3
  • 51
    • 0022730596 scopus 로고
    • Evidence for free and metabolically stable p53 protein in nuclear subfractions of simian virus 40- transformed cells
    • Deppert W, Hang M (1986) Evidence for free and metabolically stable p53 protein in nuclear subfractions of simian virus 40- transformed cells. Mol Cell Biol 6:2233-2240
    • (1986) Mol Cell Biol , vol.6 , pp. 2233-2240
    • Deppert, W.1    Hang, M.2
  • 52
    • 0025203803 scopus 로고
    • Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells
    • Shaulsky G, Ben-Ze'ev A, Rotter V (1990) Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells. Oncogene 5:1707-1711 (Pubitemid 120034693)
    • (1990) Oncogene , vol.5 , Issue.11 , pp. 1707-1711
    • Shaulsky, G.1    Ben-Ze'ev, A.2    Rotter, V.3
  • 53
    • 0023711503 scopus 로고
    • Intranuclear distribution of SV40 large T-antigen and transformation- related protein p53 in abortively infected cells
    • Puvion E, Duthu A, Harper F, Ehrhart JC, Viron A, May P (1988) Intranuclear distribution of SV40 large T-antigen and transformation- related protein p53 in abortively infected cells. Exp Cell Res 177:73-89
    • (1988) Exp Cell Res , vol.177 , pp. 73-89
    • Puvion, E.1    Duthu, A.2    Harper, F.3    Ehrhart, J.C.4    Viron, A.5    May, P.6
  • 55
    • 33646807491 scopus 로고    scopus 로고
    • Transcriptional regulation by p53: One protein, many possibilities
    • Laptenko O, Prives C (2006) Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ 13:951-961
    • (2006) Cell Death Differ , vol.13 , pp. 951-961
    • Laptenko, O.1    Prives, C.2
  • 58
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • DOI 10.1128/MCB.20.9.3224-3233.2000
    • Ashcroft M, Taya Y, Vousden KH (2000) Stress signals utilize multiple pathways to stabilize p53. Mol Cel Biol 20:3224-3233 (Pubitemid 30215034)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.9 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 59
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • DOI 10.1016/S0092-8674(00)80416-X
    • Shieh SY, Ikeda M, Taya Y, Prives C (1997) DNA damage-induced phosphrylation of p53 alleviates inhibition by MDM2. Cell 91:325-334 (Pubitemid 27467963)
    • (1997) Cell , vol.91 , Issue.3 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 60
    • 0034142034 scopus 로고    scopus 로고
    • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate, p53 at multiple DNA damage-inducible sites
    • Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14:289-300 (Pubitemid 30106484)
    • (2000) Genes and Development , vol.14 , Issue.3 , pp. 289-300
    • Shieh, S.-Y.1    Ahn, J.2    Tamai, K.3    Taya, Y.4    Prives, C.5
  • 61
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • DOI 10.1046/j.1432-1327.2001.02225.x
    • Appella E, Anderson CW (2001) Post-translational modifi cations and activation of p53 by genotoxic stresses. Eur J Biochem 268:2764-2772 (Pubitemid 32862957)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.10 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 64
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse JP, Gu W (2009) Modes of p53 regulation. Cell 137:609- 622
    • (2009) Cell , vol.137 , pp. 609-622
    • Kruse, J.P.1    Gu, W.2
  • 65
    • 33845656738 scopus 로고    scopus 로고
    • Acetylation of the p53 DNA-Binding Domain Regulates Apoptosis Induction
    • DOI 10.1016/j.molcel.2006.11.026, PII S1097276506008215
    • Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB (2006) Acethylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24:841-851 (Pubitemid 44960096)
    • (2006) Molecular Cell , vol.24 , Issue.6 , pp. 841-851
    • Sykes, S.M.1    Mellert, H.S.2    Holbert, M.A.3    Li, K.4    Marmorstein, R.5    Lane, W.S.6    McMahon, S.B.7
  • 67
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • DOI 10.1016/S0955-0674(03)00003-6
    • Books CL, Gu W (2003) Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 15:164-171 (Pubitemid 36332191)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.2 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 68
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation Is Indispensable for p53 Activation
    • DOI 10.1016/j.cell.2008.03.025, PII S0092867408004418
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008) Acetylation is indispensable for p53 activation. Cell 133:612-626 (Pubitemid 351636297)
    • (2008) Cell , vol.133 , Issue.4 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gu, W.5
  • 69
    • 0025858631 scopus 로고
    • Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
    • Bargonetti J, Friedman PN, Kern SE, Vogelstein B, Prives C (1991) Wild-type but not mutant p53 immunopurifi ed proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65:1083-1091 (Pubitemid 121001696)
    • (1991) Cell , vol.65 , Issue.6 , pp. 1083-1091
    • Bargonetti, J.1    Friedman, P.N.2    Kern, S.E.3    Vogelstein, B.4    Prives, C.5
  • 70
    • 43949107925 scopus 로고    scopus 로고
    • SnapShot: P53 posttranslational modifi cations
    • 930
    • Kruse JP, Gu W (2008) SnapShot: p53 posttranslational modifi cations. Cell 133:930-930, e1
    • (2008) Cell , vol.133 , Issue.930
    • Kruse, J.P.1    Gu, W.2
  • 71
    • 61449190667 scopus 로고    scopus 로고
    • Modifi cations of p53: Competing for the lysines
    • Carter S, Vousden KH (2009) Modifi cations of p53: competing for the lysines. Curr Opin Genet Dev 19:18-24
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 18-24
    • Carter, S.1    Vousden, K.H.2
  • 72
    • 34047198167 scopus 로고    scopus 로고
    • Transcription regulation by mutant p53
    • DOI 10.1038/sj.onc.1210294, PII 1210294
    • Weisz L, Oren M, Rotter V (2007) Transcription regulation by mutant p53. Oncogene 26:2202-2211 (Pubitemid 46536644)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2202-2211
    • Weisz, L.1    Oren, M.2    Rotter, V.3
  • 73
    • 0020339943 scopus 로고
    • Radioimmunoassay of the cellular protein p53 in mouse and human cell lines
    • Benchimol S, Pim D, Crawford L (1982) Radioimmunoassay of the cellular protein p53 in mouse and human cell lines. EMBO J 7:1055-1062
    • (1982) EMBO J , vol.7 , pp. 1055-1062
    • Benchimol, S.1    Pim, D.2    Crawford, L.3
  • 74
    • 0026547319 scopus 로고
    • Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fi xed, embedded tissue
    • Porter PL, Gown AM, Kramp SG, Coltrera MD (1992) Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fi xed, embedded tissue. Am J Pathol 140:145-153
    • (1992) Am J Pathol , vol.140 , pp. 145-153
    • Porter, P.L.1    Gown, A.M.2    Kramp, S.G.3    Coltrera, M.D.4
  • 77
    • 10944236962 scopus 로고    scopus 로고
    • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
    • DOI 10.1016/j.cell.2004.11.004, PII S0092867404010463
    • Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T (2004) Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119:847-860 (Pubitemid 40017690)
    • (2004) Cell , vol.119 , Issue.6 , pp. 847-860
    • Olive, K.P.1    Tuveson, D.A.2    Ruhe, Z.C.3    Yin, B.4    Willis, N.A.5    Bronson, R.T.6    Crowley, D.7    Jacks, T.8
  • 78
    • 34247329362 scopus 로고    scopus 로고
    • P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
    • DOI 10.1038/ncb1571, PII NCB1571
    • Song H, Hollstein M, Xu Y (2007) p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 9:573-580 (Pubitemid 46696539)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 573-580
    • Song, H.1    Hollstein, M.2    Xu, Y.3
  • 80
    • 0032526426 scopus 로고    scopus 로고
    • How p53 binds DNA as a tetramer
    • DOI 10.1093/emboj/17.12.3342
    • McLure KG, Lee PW (1998) How p53 binds DNA as a tetramer. EMBO J 17:3342-3350 (Pubitemid 28279508)
    • (1998) EMBO Journal , vol.17 , Issue.12 , pp. 3342-3350
    • McLure, K.G.1    Lee, P.W.K.2
  • 81
    • 0025731379 scopus 로고
    • Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
    • Milner J, Medcalf AJ (1991) Co-translation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 65:765-774 (Pubitemid 121001308)
    • (1991) Cell , vol.65 , Issue.5 , pp. 765-774
    • Milner, J.1    Medcalf, E.A.2
  • 82
    • 0024535277 scopus 로고
    • Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
    • Hinds P, Finlay C, Levine AJ (1989) Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation. J Virol 63:739-746 (Pubitemid 19057240)
    • (1989) Journal of Virology , vol.63 , Issue.2 , pp. 739-746
    • Hinds, P.1    Finlay, C.2    Levine, A.J.3
  • 83
    • 0031038701 scopus 로고    scopus 로고
    • A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene
    • Varley JM, Thorncroft M, McGown G, Appleby J, Kelsey AM, Tricker KJ, Evans DGR, Birch JM (1997) A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li- Fraumeni patients carrying a mutation to the TP53 gene. Oncogene 14:865-871 (Pubitemid 27100031)
    • (1997) Oncogene , vol.14 , Issue.7 , pp. 865-871
    • Varley, J.M.1    Thorncroft, M.2    McGown, G.3    Appleby, J.4    Kelsey, A.M.5    Tricker, K.J.6    Evans, D.7    Birch, J.M.8
  • 84
    • 0032473823 scopus 로고    scopus 로고
    • TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer
    • Erber R, Conradt C, Homann N, Enders C, Finck M, Dietz A, Weidauer H, Bosch FX (1998) TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer. Oncogene 16:1671-1679 (Pubitemid 28175048)
    • (1998) Oncogene , vol.16 , Issue.13 , pp. 1671-1679
    • Erber, R.1    Conradt, C.2    Homann, N.3    Enders, C.4    Finckh, M.5    Dietz, A.6    Weidauer, H.7    Bosch, F.X.8
  • 85
    • 0032480248 scopus 로고    scopus 로고
    • Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome
    • Birch JM, Blair V, Kelsey AM, Evans DG, Harris M, Tricker KJ, Varley JM (1998) Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome. Oncogene 17:1061-1068 (Pubitemid 28444590)
    • (1998) Oncogene , vol.17 , Issue.9 , pp. 1061-1068
    • Birch, J.M.1    Blair, V.2    Kelsey, A.M.3    Evans, D.G.4    Harris, M.5    Tricker, K.J.6    Varley, J.M.7
  • 86
    • 33645321175 scopus 로고    scopus 로고
    • DNA damage: A trigger of innate immunity but a requirement for adaptive immune homeostasis
    • Xu Y (2006) DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Nat Rev Immunol 6:261-270
    • (2006) Nat Rev Immunol , vol.6 , pp. 261-270
    • Xu, Y.1
  • 87
    • 0021403035 scopus 로고
    • Abelson murine leukemia virustransformed cells that lack p53 protein synthesis express aberrant p53 mRNA species
    • Wolf D, Admon S, Oren M (1984) Abelson murine leukemia virustransformed cells that lack p53 protein synthesis express aberrant p53 mRNA species. Mol Cell Biol 4:552-558
    • (1984) Mol Cell Biol , vol.4 , pp. 552-558
    • Wolf, D.1    Admon, S.2    Oren, M.3
  • 89
    • 0028131554 scopus 로고
    • Transcriptional activation by p53 correlates with suppression of growth but not transformation
    • DOI 10.1016/0092-8674(94)90071-X
    • Crook T, Marston NJ, Sara EA, Vousden KH (1994) Transcriptional activation by p53 correlates with suppression of growth but not transformation. Cell 79:817-827 (Pubitemid 24371972)
    • (1994) Cell , vol.79 , Issue.5 , pp. 817-827
    • Crook, T.1    Marston, N.J.2    Sara, E.A.3    Vousden, K.H.4
  • 90
    • 0021746318 scopus 로고
    • Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene
    • Wolf D, Harris N, Rotter V (1984) Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene. Cell 38:119-126 (Pubitemid 15216541)
    • (1984) Cell , vol.38 , Issue.1 , pp. 119-126
    • Wolf, D.1    Harris, N.2    Rotter, V.3
  • 93
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplifi cation in cells with mutant p53 alleles
    • Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM (1992) Wild-type p53 restores cell cycle control and inhibits gene amplifi cation in cells with mutant p53 alleles. Cell 70:937-948
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 94
    • 0026452949 scopus 로고
    • Defects in a cell cycle checkpoint
    • may be responsible for the genomic instability of cancer cells
    • Hartwell L (1992) Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71:543-546
    • (1992) Cell , vol.71 , pp. 543-546
    • Hartwell, L.1
  • 95
    • 0032951530 scopus 로고    scopus 로고
    • P73 Function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como CJ, Gaiddon C, Prives C (1999) p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol Cell Biol 19:1438-1449 (Pubitemid 29046885)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.2 , pp. 1438-1449
    • Di Como, C.J.1    Gaiddon, C.2    Prives, C.3
  • 96
    • 0035131701 scopus 로고    scopus 로고
    • A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
    • DOI 10.1128/MCB.21.5.1874-1887.2001
    • Gaiddon C, Lokshin M, Ahn J, Zhang T, Prives C (2001) A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain. Mol Cell Biol 21:1874-1887 (Pubitemid 32156407)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.5 , pp. 1874-1887
    • Gaiddon, C.1    Lokshin, M.2    Ahn, J.3    Zhang, T.4    Prives, C.5
  • 97
    • 34547753615 scopus 로고    scopus 로고
    • P63 and p73 in human cancer: Defining the network
    • DOI 10.1038/sj.onc.1210337, PII 1210337
    • Deyoung MP, Ellisen LW (2007) p63 and p73 in human cancer: defi ning the network. Oncogene 26:5169-5183 (Pubitemid 47237632)
    • (2007) Oncogene , vol.26 , Issue.36 , pp. 5169-5183
    • DeYoung, M.P.1    Ellisen, L.W.2
  • 98
    • 34047198167 scopus 로고    scopus 로고
    • Transcription regulation by mutant p53
    • DOI 10.1038/sj.onc.1210294, PII 1210294
    • Weisz L, Oren M, Rotter V (2007) Transcription regulation by mutant p53. Oncogene 26:2202-2211 (Pubitemid 46536644)
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2202-2211
    • Weisz, L.1    Oren, M.2    Rotter, V.3
  • 99
    • 22744458985 scopus 로고    scopus 로고
    • Transcriptional activities of mutant p53: When mutations are more than a loss
    • DOI 10.1002/jcb.20271
    • Kim E, Deppert W (2004) Transcriptional activities of mutant p53: when mutations are more than a loss. J Cell Biochem 93: 878-886 (Pubitemid 44264143)
    • (2004) Journal of Cellular Biochemistry , vol.93 , Issue.5 , pp. 878-886
    • Kim, E.1    Deppert, W.2
  • 101
    • 33748211158 scopus 로고    scopus 로고
    • Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    • DOI 10.1016/j.ccr.2006.08.013, PII S1535610806002534
    • Di Agostino S, Strano S, Emilliozzi V, Zerbini V, Mottolese M, Sacchi A, Blandino G, Piaggio G (2006) Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 10:191-202 (Pubitemid 44311070)
    • (2006) Cancer Cell , vol.10 , Issue.3 , pp. 191-202
    • Di Agostino, S.1    Strano, S.2    Emiliozzi, V.3    Zerbini, V.4    Mottolese, M.5    Sacchi, A.6    Blandino, G.7    Piaggio, G.8
  • 102
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 94: 23-28
    • (1976) Science , vol.94 , pp. 23-28
    • Nowell, P.C.1
  • 103
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein BA (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.A.2
  • 105
    • 0018343201 scopus 로고
    • Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977
    • Auerbach O, Hammond E, Carfi nkel L (1979) Changes in bronchial epitheium in relation to cigarette smoking, 1955-1960 vs.970-1977. N Engl J Med 300:381-386 (Pubitemid 9134282)
    • (1979) New England Journal of Medicine , vol.300 , Issue.8 , pp. 381-386
    • Auerbach, O.1    Cuyler Hammond, E.2    Garfinkel, L.3
  • 107
    • 0029841088 scopus 로고    scopus 로고
    • Overexpression of MDM2 and p53 protein is infrequently but significantly associated with progression of human prostatic adenocarcinoma
    • Yamasaki I, Furihata M, Ohtsuki Y, Yamashita M, Morioka M, Shuin T (1996) Overexpression of MDM2 and p53 protein is infrequently but signifi cantly associated with progression of human prostatic adenocarcinoma. Oncol Rep 3:925-929 (Pubitemid 26323754)
    • (1996) Oncology Reports , vol.3 , Issue.5 , pp. 925-929
    • Yamasaki, I.1    Furihata, M.2    Ohtsuki, Y.3    Yamashita, M.4    Morioka, M.5    Shuin, T.6
  • 108
    • 16244396938 scopus 로고    scopus 로고
    • Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors
    • Matsumoto M, Furihata M, Kurabayashi A, Ohtsuki Y (2004) Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors. Oncol Rep 12:1039-1043
    • (2004) Oncol Rep , vol.12 , pp. 1039-1043
    • Matsumoto, M.1    Furihata, M.2    Kurabayashi, A.3    Ohtsuki, Y.4
  • 109
    • 8344287553 scopus 로고    scopus 로고
    • Prognostic signifi cance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma
    • DOI 10.1159/000081001
    • Matsumoto M, Furihata M, Kurabayashi A, Sasaguri S, Araki K, Hayashi H, Ohtsuki Y (2004) Prognostic signifi cance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma. Oncology 67:143-150 (Pubitemid 39482683)
    • (2004) Oncology , vol.67 , Issue.2 , pp. 143-150
    • Matsumoto, M.1    Furihata, M.2    Kurabayashi, A.3    Sasaguri, S.4    Araki, K.5    Hayashi, H.6    Ohtsuki, Y.7
  • 110
    • 0027443691 scopus 로고
    • High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder
    • Furihata M, Inoue K, Ohtsuki Y, Hashimoto H, Terao N, Fujita Y (1993) High-risk human papillomavirus infections and overexpression of p53 protein as prognostic indicators in transitional cell carcinoma of the urinary bladder. Cancer Res 53:4823-4827 (Pubitemid 23326173)
    • (1993) Cancer Research , vol.53 , Issue.20 , pp. 4823-4827
    • Furihata, M.1    Inoue, K.2    Ohtsuki, Y.3    Hashimoto, H.4    Terao, N.5    Fujita, Y.6
  • 113
    • 40749144468 scopus 로고    scopus 로고
    • Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival
    • DOI 10.1158/1078-0432.CCR-07-1192
    • Bartel F, Jung J, Böhnke A, Gradhand E, Zeng K, Thomssen C, Hauptmann S (2008) Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival. Clin Cancer Res 14:89-96 (Pubitemid 351377982)
    • (2008) Clinical Cancer Research , vol.14 , Issue.1 , pp. 89-96
    • Bartel, F.1    Jung, J.2    Bohnke, A.3    Gradhand, E.4    Zeng, K.5    Thomssen, C.6    Hauptmann, S.7
  • 114
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: News from the mutant p53 fi eld
    • Brosh R, Rotter V (2009) When mutants gain new powers: news from the mutant p53 fi eld. Cancer (Phila) 9:701-713
    • (2009) Cancer (Phila , vol.9 , pp. 701-713
    • Brosh, R.1    Rotter, V.2


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