Detraining Differentially Preserved Beneficial Effects of Exercise on Hypertension: Effects on Blood Pressure, Cardiac Function, Brain Inflammatory Cytokines and Oxidative Stress

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Agarwal, Deepmala ^a   Dange, Rahul B ^a   Vila, Jorge ^a   Otamendi, Arturo J ^a   Francis, Joseph ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DISEASE COURSE; ECHOCARDIOGRAPHY; EXERCISE INTENSITY; HEART FUNCTION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; KINESIOTHERAPY; MALE; MINIPUMP; NONHUMAN; OXIDATIVE STRESS; PARAVENTRICULAR THALAMIC NUCLEUS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SITTING; TELEMETRY; TRAINING; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD PRESSURE; BODY WEIGHT; BRAIN; CARDIOMEGALY; CYTOKINES; HEART FUNCTION TESTS; HYPERTENSION; INFLAMMATION MEDIATORS; MALE; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SUPEROXIDE DISMUTASE; TIME FACTORS;

RATTUS;

EID: 84871402217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052569     Document Type: Article

References (51)

1. Lehnen AM, Leguisamo NM, Pinto GH, Markoski MM, De Angelis K, et al. (2010) The beneficial effects of exercise in rodents are preserved after detraining: a phenomenon unrelated to GLUT4 expression. Cardiovasc Diabetol 9: 67.
2. Agarwal D, Welsch MA, Keller JN, Francis J, (2011) Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR. Basic Res Cardiol 106: 1069-1085.
3. Jennings JR, Zanstra Y, (2009) Is the brain the essential in hypertension? Neuroimage 47: 914-921.
4. Badoer E, (2010) Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure. Am J Physiol Renal Physiol 298: F839-846.
5. Coote JH, (2005) A role for the paraventricular nucleus of the hypothalamus in the autonomic control of heart and kidney. Exp Physiol 90: 169-173.
6. Shi P, Raizada MK, Sumners C, (2010) Brain cytokines as neuromodulators in cardiovascular control. Clin Exp Pharmacol Physiol 37: e52-57.
7. Kang YM, Ma Y, Zheng JP, Elks C, Sriramula S, et al. (2009) Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension. Cardiovasc Res 82: 503-512.
8. Xia H, Suda S, Bindom S, Feng Y, Gurley SB, et al. (2011) ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One 6: e22682.
9. Peeters AC, Netea MG, Janssen MC, Kullberg BJ, Van der Meer JW, et al. (2001) Pro-inflammatory cytokines in patients with essential hypertension. Eur J Clin Invest 31: 31-36.
10. Dorffel Y, Latsch C, Stuhlmuller B, Schreiber S, Scholze S, et al. (1999) Preactivated peripheral blood monocytes in patients with essential hypertension. Hypertension 34: 113-117.
11. Bai Y, Jabbari B, Ye S, Campese VM, Vaziri ND, (2009) Regional expression of NAD(P)H oxidase and superoxide dismutase in the brain of rats with neurogenic hypertension. Am J Nephrol 29: 483-492.
12. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL, (2004) Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res 95: 210-216.
13. Sirker A, Zhang M, Shah AM, (2011) NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies. Basic Res Cardiol 106: 735-747.
14. Mehta PK, Griendling KK, (2007) Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292: C82-97.
15. Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, et al. (2002) Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res 91: 1038-1045.
16. Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, et al. (2011) Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol 106: 527-538.
17. Agarwal D, Haque M, Sriramula S, Mariappan N, Pariaut R, et al. (2009) Role of proinflammatory cytokines and redox homeostasis in exercise-induced delayed progression of hypertension in spontaneously hypertensive rats. Hypertension 54: 1393-1400.
18. Agarwal D, Elks CM, Reed SD, Mariappan N, Majid DS, et al. (2012) Chronic exercise preserves renal structure and hemodynamics in spontaneously hypertensive rats. Antioxid Redox Signal 16: 139-152.
19. Vaziri ND, Lin CY, Farmand F, Sindhu RK, (2003) Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension. Kidney Int 63: 186-194.
20. Fujita M, Ando K, Nagae A, Fujita T, (2007) Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension. Hypertension 50: 360-367.
21. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, et al. (2011) Heart disease and stroke statistics-2011 update: a report from the American Heart Association. Circulation 123: e18-e209.
22. Ahmed N, Abdul Khaliq M, Shah SH, Anwar W, (2008) Compliance to antihypertensive drugs, salt restriction, exercise and control of systemic hypertension in hypertensive patients at Abbottabad. J Ayub Med Coll Abbottabad 20: 66-69.
23. Kump DS, Booth FW, (2005) Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary exercise. J Physiol 562: 829-838.
24. Neufer PD, Shinebarger MH, Dohm GL, (1992) Effect of training and detraining on skeletal muscle glucose transporter (GLUT4) content in rats. Can J Physiol Pharmacol 70: 1286-1290.
25. Cardinale JP, Sriramula S, Mariappan N, Agarwal D, Francis J, (2012) Angiotensin II-Induced Hypertension Is Modulated by Nuclear Factor-kappaB in the Paraventricular Nucleus. Hypertension 59: 113-121.
26. Boissiere J, Eder V, Machet MC, Courteix D, Bonnet P, (2008) Moderate exercise training does not worsen left ventricle remodeling and function in untreated severe hypertensive rats. J Appl Physiol 104: 321-327.
27. Sun MW, Qian FL, Wang J, Tao T, Guo J, et al. (2008) Low-intensity voluntary running lowers blood pressure with simultaneous improvement in endothelium-dependent vasodilatation and insulin sensitivity in aged spontaneously hypertensive rats. Hypertens Res 31: 543-552.
28. Pellett AA, Tolar WG, Merwin DG, Kerut EK, (2004) The Tei index: methodology and disease state values. Echocardiography 21: 669-672.
29. Gao L, Wang W, Li YL, Schultz HD, Liu D, et al. (2005) Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin II type 1 receptors and NAD(P)H oxidase. Circulation 112: 1763-1770.
30. Kobayashi S, Inoue N, Azumi H, Seno T, Hirata K, et al. (2002) Expressional changes of the vascular antioxidant system in atherosclerotic coronary arteries. J Atheroscler Thromb 9: 184-190.
31. Allen AM, Zhuo J, Mendelsohn FA, (2000) Localization and function of angiotensin AT1 receptors. Am J Hypertens 13: 31S-38S.
32. Qi J, Zhang DM, Suo YP, Song XA, Yu XJ, et al. (2012) Renin-Angiotensin System Modulates Neurotransmitters in the Paraventricular Nucleus and Contributes to Angiotensin II-Induced Hypertensive Response. Cardiovasc Toxicol.
33. Sriramula S, Cardinale JP, Lazartigues E, Francis J, (2011) ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension. Cardiovasc Res 92: 401-408.
34. Veras-Silva AS, Mattos KC, Gava NS, Brum PC, Negrao CE, et al. (1997) Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol 273: H2627-2631.
35. Chicco AJ, McCune SA, Emter CA, Sparagna GC, Rees ML, et al. (2008) Low-intensity exercise training delays heart failure and improves survival in female hypertensive heart failure rats. Hypertension 51: 1096-1102.
36. Graham DA, Rush JW, (2004) Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 96: 2088-2096.
37. Law M, Wald N, Morris J, (2003) Lowering blood pressure to prevent myocardial infarction and stroke: a new preventive strategy. Health Technol Assess 7: 1-94.
38. Bocalini DS, Carvalho EV, de Sousa AF, Levy RF, Tucci PJ, (2010) Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats. Eur J Appl Physiol 109: 909-914.
39. Pavlik G, (1985) Effects of physical training and detraining on resting cardiovascular parameters in albino rats. Acta Physiol Hung 66: 27-37.
40. Mostarda C, Rogow A, Silva IC, De La Fuente RN, Jorge L, et al. (2009) Benefits of exercise training in diabetic rats persist after three weeks of detraining. Auton Neurosci 145: 11-16.
41. Kimura T, Yamamoto T, Ota K, Shoji M, Inoue M, et al. (1993) Central effects of interleukin-1 on blood pressure, thermogenesis, and the release of vasopressin, ACTH, and atrial natriuretic peptide. Ann N Y Acad Sci 689: 330-345.
42. Kannan H, Tanaka Y, Kunitake T, Ueta Y, Hayashida Y, et al. (1996) Activation of sympathetic outflow by recombinant human interleukin-1 beta in conscious rats. Am J Physiol 270: R479-485.
43. Lu Y, Chen J, Yin X, Zhao H, (2009) Angiotensin II receptor 1 involved in the central pressor response induced by interleukin-1 beta in the paraventricular nucleus. Neurol Res 31: 420-424.
44. Murray PJ, (2005) The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci U S A 102: 8686-8691.
45. Nonaka-Sarukawa M, Okada T, Ito T, Yamamoto K, Yoshioka T, et al. (2008) Adeno-associated virus vector-mediated systemic interleukin-10 expression ameliorates hypertensive organ damage in Dahl salt-sensitive rats. J Gene Med 10: 368-374.
46. Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, et al. (2009) Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat. Gene Ther 16: 383-391.
47. Mayorov DN, Head GA, De Matteo R, (2004) Tempol attenuates excitatory actions of angiotensin II in the rostral ventrolateral medulla during emotional stress. Hypertension 44: 101-106.
48. Campos RR, (2009) Oxidative stress in the brain and arterial hypertension. Hypertens Res 32: 1047-1048.
49. Sun C, Sellers KW, Sumners C, Raizada MK, (2005) NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II. Circ Res 96: 659-666.
50. Kohno H, Furukawa S, Naito H, Minamitani K, Ohmori D, et al. (2002) Contribution of nitric oxide, angiotensin II and superoxide dismutase to exercise-induced attenuation of blood pressure elevation in spontaneously hypertensive rats. Jpn Heart J 43: 25-34.
51. Kar S, Gao L, Zucker IH, (2010) Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure. J Appl Physiol 108: 923-932.