Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat

Gene Therapy

Volumn 16, Issue 3, 2009, Pages 383-391

  Nomoto, T ^a,b   Okada, T ^a,c   Shimazaki, K ^a   Yoshioka, T ^a   Nonaka Sarukawa, M ^a   Ito, T ^a   Takeuchi, K ^a   Katsura, K J ^b   Mizukami, H ^a   Kume, A ^a   Ookawara, S ^a   Ikeda, U ^d   Katayama, Y ^b   Ozawa, K ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^d SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; PARVOVIRUS VECTOR; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; BRAIN BLOOD VESSEL; CELL INFILTRATION; CONTROLLED STUDY; DISEASE MODEL; DRUG DOSE COMPARISON; EMBRYO; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY BLOOD VESSEL; MACROPHAGE; MALE; MALIGNANT HYPERTENSION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAT; STROKE; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; SURVIVAL RATE; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; VASCULAR RESISTANCE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; BLOOD PRESSURE; BRAIN; CAROTID ARTERIES; DEPENDOVIRUS; GENE THERAPY; GENETIC VECTORS; HYPERTENSION; INTERLEUKIN-10; KIDNEY DISEASES; MALE; RATS; RATS, INBRED SHR; STROKE; SURVIVAL ANALYSIS; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; ANIMALIA; RATTUS;

EID: 62549155340     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2008.151     Document Type: Article

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