Tempol attenuates excitatory actions of angiotensin II in the rostral ventrolateral medulla during emotional stress

Hypertension

Volumn 44, Issue 1, 2004, Pages 101-106

  Mayorov, Dmitry N ^a   Head, Geoffrey A ^a   De Matteo, Robert ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Angiotensin II; Blood pressure; Brain; Nitric oxide; Rabbits; Stress

Indexed keywords

3 CARBAMOYLPROXYL; ANGIOTENSIN; ENZYME ACTIVATOR; GLUTAMIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL; TIRON; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; EMOTIONAL STRESS; EXCITATION; HORMONE ACTION; MEDULLA OBLONGATA; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR BLOCKING; SYMPATHETIC TONE; TACHYCARDIA;

ANGIOTENSIN II; ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; BRAIN; CARDIOVASCULAR PHYSIOLOGY; CYCLIC N-OXIDES; FREE RADICAL SCAVENGERS; HEMODYNAMIC PROCESSES; HYPERTENSION; NITRIC OXIDE; RABBITS; SPIN LABELS; STRESS; STRESS, PSYCHOLOGICAL; SUPEROXIDES; SYMPATHETIC NERVOUS SYSTEM;

EID: 3042631056     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000131290.12255.04     Document Type: Article

References (28)

1. Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol. 1998;10: 248-253.
2. Griendling KK, Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept. 2000;91:21-27.
3. Kawazoe T, Kosaka H, Yoneyama H, Hata Y. Acute production of vascular superoxide by angiotensin II but not by catecholamines. J Hypertens. 2000;18:179-185.
4. Shastri S, Gopalakrishnan V, Poduri R, Di Wang H. Tempol selectively attenuates angiotensin II evoked vasoconstrictor responses in spontaneously hypertensive rats. J Hypertens. 2002;20:1381-1391.
5. Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res. 2002;91:1038-1045.
6. Dampney RAL. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev. 1994;74:323-364.
7. Allen AM, Moeller I, Jenkins TA, Zhuo J, Aldred GP, Chai SY, Mendelsohn FA. Angiotensin receptors in the nervous system. Brain Res Bull. 1998;47:17-28.
8. Fontes MAP, Baltatu O, Caligiorne SM, Campagnole-Santos MJ, Ganten D, Bader M, Santos RAS. Angiotensin peptides acting at rostral ventrolateral medulla contribute to hypertension of TGR(MREN2)27 rats. Physiol Genomics. 2000;2:137-142.
9. Ito S, Komatsu K, Tsukamoto K, Kanmatsuse K, Sved AF. Ventrolateral medulla AT1 receptors support blood pressure in hypertensive rats. Hypertension. 2002;40:552-559.
10. Mayorov DN, Head GA. AT1-receptors in the RVLM mediate pressor responses to emotional stress in rabbits. Hypertension. 2003;41:1168-1173.
11. Mayorov DN, Head GA. Influence of rostral ventrolateral medulla on renal sympathetic baroreflex in conscious rabbits. Am J Physiol Regul Integr Comp Physiol. 2001;280:R577-R587.
12. Watanabe T, Fujioka T, Hashimoto M, Nakamura S. Stress and brain angiotensin II receptors. Crit Rev Neurobiol. 1998;12:305-317.
13. Krishna MC, Grahame DA, Samuni A, Mitchell JB, Russo A. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc Natl Acad Sci U S A. 1992;89:5537-5541.
14. Mayorov DN, Head GA. Glutamate receptors in RVLM modulate sympathetic baroreflex in conscious rabbits. Am J Physiol Regul Integr Comp Physiol. 2003;284:R511-R519.
15. Mok JS, Paisley K, Martin W. Inhibition of nitrergic neurotransmission in the bovine retractor penis muscle by an oxidant stress: effects of superoxide dismutase mimetics. Br J Pharmacol. 1998;124:111-118.
16. Yamada J, Yoshimura S, Yamakawa H, Sawada M, Nakagawa M, Hara S, Kaku Y, Iwama T, Naganawa T, Banno Y, Nakashima S, Sakai N. Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation. Neurosci Res. 2003; 45:1-8.
17. Morimoto S, Sasaki S, Miki S, Kawa T, Nakamura K, Itoh H, Nakata T, Takeda K, Nakagawa M, Fushiki S. Nitric oxide is an excitatory modulator in the rostral ventrolateral medulla in rats. Am J Hypertens. 2000; 13:1125-1134.
18. Schnackenberg CG, Welch WJ, Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension. 1998;32:59-64.
19. Nishiyama A, Fukui T, Fujisawa Y, Rahman M, Tian RX, Kimura S, Abe Y. Systemic and regional hemodynamic responses to tempol in angiotensin II- infused hypertensive rats. Hypertension. 2001;37:77-83.
20. Shokoji T, Nishiyama A, Fujisawa Y, Hitomi H, Kiyomoto H, Takahashi N, Kimura S, Kohno M, Abe Y. Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension. 2003;41: 266-273.
21. Hahn SM, Sullivan FJ, DeLuca AM, Bacher JD, Liebmann J, Krishna MC, Coffin D, Mitchell JB. Hemodynamic effect of the nitroxide superoxide dismutase mimics. Free Radic Biol Med. 1999;27:529-535.
22. Xu H, Fink GD, Chen A, Watts S, Galligan JJ. Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats. Am J Physiol Heart Circ Physiol. 2001;281: H975-H980.
23. Muscoli C, Cuzzocrea S, Riley DP, Zweier JL, Thiemermann C, Wang ZQ, Salvemini D. On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies. Br J Pharmacol. 2003; 140:445-460.
24. Zanzinger J, Czachurski J. Chronic oxidative stress in the RVLM modulates sympathetic control of circulation in pigs. Pflugers Arch. 2000; 439:489-494.
25. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest. 1996;97:1916-1923.
26. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem. 1992; 267:24173-24176.
27. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494-501.
28. Atlante A, Calissano P, Bobba A, Giannattasio S, Marra E, Passarella S. Glutamate neurotoxicity, oxidative stress and mitochondria. FEBS Lett. 2001;497:1-5.