The beneficial effects of exercise in rodents are preserved after detraining: A phenomenon unrelated to GLUT4 expression

Cardiovascular Diabetology

Volumn 9, Issue , 2010, Pages

  Lehnen, Alexandre M ^a   Leguisamo, Natalia M ^a   Pinto, Graziela H ^a,b   Markoski, Melissa M ^a   De Angelis, Kátia ^c   Machado, Ubiratan F ^d   Schaan, Beatriz ^a,e  

^a Instituto de Cardiologia do Rio Grande do Sul Fundação   (Brazil)

^b UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^c SÃO JUDAS TADEU UNIVERSITY   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; SLC2A4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; EXERCISE; EXERCISE TEST; GASTROCNEMIUS MUSCLE; HEART; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERTANT; RODENT; SPONTANEOUSLY HYPERTENSIVE RAT; TAIL; TREADMILL; VELOCITY; WESTERN BLOTTING; WHITE ADIPOSE TISSUE; ADAPTATION; ANIMAL; DISEASE MODEL; EXERCISE TOLERANCE; HEART MUSCLE; HYPERTENSION; INSULIN RESISTANCE; METABOLISM; PATHOPHYSIOLOGY; SKELETAL MUSCLE; TIME; WISTAR KYOTO RAT;

ADAPTATION, PHYSIOLOGICAL; ADIPOSE TISSUE, WHITE; ANIMALS; BLOOD PRESSURE; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; EXERCISE TOLERANCE; GLUCOSE TRANSPORTER TYPE 4; HYPERTENSION; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; MYOCARDIUM; PHYSICAL EXERTION; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TIME FACTORS;

EID: 77958558386     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-9-67     Document Type: Article

References (35)

1. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002, 360:1903-1913. 10.1016/S0140-6736(02)11911-8, 12493255.
2. Fuchs F, Gus M, Moreira W, Moreira L, Moraes R, Rosito G, Sorucco A, Atanázio P, Machado R. Blood pressure effects of antihypertensive drugs and changes in lifestyle in a Brazilian hypertensive cohort. Journal of Hypertension 1997, 15(7):783-792. 10.1097/00004872-199715070-00011, 9222947.
3. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007, 115(4):450-458. 10.1161/CIRCULATIONAHA.106.637793, 17190864.
4. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981, 30(12):1000-1007.
5. Ploug T, Van Deurs B, Ai H, Cushman S, Ralston E. Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are recruited by insulin and muscle contractions. J Cell Biol 1998, 142:1429-1446. 10.1083/jcb.142.6.1429, 2141761, 9744875.
6. Thorens B, Charron MJ, Lodish HF. Molecular physiology of glucose transporters. Diabetes Care 1990, 13(3):209-218. 10.2337/diacare.13.3.209, 2407476.
7. Jolly K, Taylor R, Lip GY, Greenfield S, Raftery J, Mant J, Lane D, Jones M, Lee KW, Stevens A. The Birmingham Rehabilitation Uptake Maximisation Study (BRUM). Home-based compared with hospital-based cardiac rehabilitation in a multi-ethnic population: cost-effectiveness and patient adherence. Health Technol Assess 2007, 11(35):1-118.
8. Pavlik G. Effects of physical training and detraining on resting cardiovascular parameters in albino rats. Acta Physiol Hung 1985, 66(1):27-37.
9. Kump D, Booth F. Alterations in insulin receptor signalling in the rat epitrochlearis muscle upon cessation of voluntary excercise. J Physiol 2005, 562(3):829-838. 10.1113/jphysiol.2004.073593, 1665545, 15550465.
10. Neufer P, Shinebarger M, Dohm G. Effect of training and detraining on skeletal muscle glucose transporter (GLUT4) content in rats. Can J Physiol Pharmacol 1992, 70(9):1286-1290.
11. Katayama S, Inaba M, Maruno Y, Morita T, Awata T, Oka Y. Glucose intolerance in spontaneously hypertensive and wistar-kyoto rats: enhanced gene expression and synthesis of skeletal muscle glucose transporter 4. Hypertens Res 1997, 20:279-286. 10.1291/hypres.20.279, 9453263.
12. NIH Guide for the Care and Use of Laboratory Animals. 1996, Washingtion, DC: National Academy Press, NIH.
13. Geloneze B, Tambascia M. Laboratorial evaluation and diagnosis of insulin resistance. Arq Bras Endocrinol Metabol 2006, 50(2):208-215.
14. Brito JO, Ponciano K, Figueroa D, Bernardes N, Sanches IC, Irigoyen MC, De Angelis K. Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats. Braz J Med Biol Res 2008, 41(9):804-808. 10.1590/S0100-879X2008005000030, 18833640.
15. Cartee GD, Young DA, Sleeper MD, Zierath J, Wallberg-Henriksson H, Holloszy JO. Prolonged increase in insulin-stimulated glucose transport in muscle after exercise. Am J Physiol 1989, 256(4 Pt 1):E494-499.
16. Rodrigues B, Figueroa D, Mostarda C, Heeren M, Irigoyen M, De Angelis K. Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats. Cardiovasc Diabetol 2007, 6(1):38. 10.1186/1475-2840-6-38, 2222609, 18078520.
17. Host H, Hansen P, Nolte L, Chen M, Holloszy J. Rapid reversal of adaptive increases in muscle GLUT4 and glucose transport capacity after cessation of training. J Appl Physiol 1998, 84:798-802.
18. Machado U, Shimizu I, Saito M. Reduced content and preserved translocation of glucose transporter (GLUT 4) in white adipose tissue of obese mice. Physiology & Behavior 1994, 55(4):621-625.
19. Tipton C, Sebastian L, Overton J, Woodman C, Williams S. Chronic exercise and its hemodynamic influences on resting blood pressure of hypertensive rats. J Appl Physiol 1991, 71:2206-2210.
20. Negrão C, Moreira E, Brum P, Denadai M, Krieger EM. Vagal and sympathetic controls of the heart rate during exercise in sedentary and trained rats. Braziliam Journal of Medical and Biological Reserch 1992, 25:1045-1052.
21. Melo R, Martinho E, Michelini L. Training-Induced, Pressure-Lowering Effect in SHR Wide Effects on Circulatory Profile of Exercised and Nonexercised Muscles. Hypertension 2003, 42(2):851-857. 10.1161/01.HYP.0000086201.27420.33, 12913057.
22. Graham D, Rush J. Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 2004, 96(6):2088-2096. 10.1152/japplphysiol.01252.2003, 14752124.
23. Kemi O, Haram P, Wisloff U, Ellingsen O. Aerobic fitness is associated with cardiomyocyte contractile capacity and endothelial function in exercise training and detraining. Circulation 2004, 109:2897-2904. 10.1161/01.CIR.0000129308.04757.72, 15173028.
24. Mostarda C, Rogow A, Silva I, De La Fuente R, Jorge L, Rodrigues B, Heeren M, Caldini E, De Angelis K, Irigoyen M. Benefits of exercise training in diabetic rats persist after three weeks of detraining. Auton Neurosci 2009, 28(145):11-16.
25. Bocalini DS, Carvalho EV, de Sousa AF, Levy RF, Tucci PJ. Exercise training-induced enhancement in myocardial mechanics is lost after 2 weeks of detraining in rats. Eur J Appl Physiol 2010, 109(5):909-914. 10.1007/s00421-010-1406-x, 20300769.
26. Wisloff U, Helgerud J, Kemi OJ, Ellingsen O. Intensity-controlled treadmill running in rats: VO(2 max) and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 2001, 280(3):H1301-1310.
27. Marini M, Falcieri E, Margonato V, Treré D, Lapalombella R, di Tullio S, Marchionni C, Burattini S, Samaja M, Esposito F, et al. Partial persistence of exercise-induced myocardial angiogenesis following 4-week detraining in the rat. Histochem Cell Biol 2008, 129(4):479-487. 10.1007/s00418-007-0373-8, 18172661.
28. Hayashi T, Hirshman M, Kurth E, Winder W, Goodyear L. Evidence for 5'AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 1998, 47:1369-1373. 10.2337/diabetes.47.8.1369, 9703344.
29. Sparling D, Griesel B, Weems J, Olson A. GLUT4 Enhancer Factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 Promoter in adipocytes. Journal of Biological Chemistry 2008, 282(12):7429-7447.
30. Rose AJ, Frosig C, Kiens B, Wojtaszewski JF, Richter EA. Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans. J Physiol 2007, 583(Pt 2):785-795. 10.1113/jphysiol.2007.138529, 2277010, 17627985.
31. van den Brom CE, Huisman MC, Vlasblom R, Boontje NM, Duijst S, Lubberink M, Molthoff CF, Lammertsma AA, van der Velden J, Boer C, et al. Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovasc Diabetol 2009, 8:39. 10.1186/1475-2840-8-39, 2722582, 19624828.
32. Reynolds T, Brozinick J, Larkin L, Cushman S. Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training. J Appl Physiol 2000, 88:2240-2245. 10.1063/1.1287758, 2754275, 10846041.
33. Furuya DT, Poletto AC, Favaro RR, Martins JO, Zorn TM, Machado UF. Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. Metabolism 2010, 59(3):395-399. 10.1016/j.metabol.2009.08.011, 19800637.
34. Shehata MF. Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats. Cardiovasc Diabetol 2008, 7:19. 10.1186/1475-2840-7-19, 2459151, 18570670.
35. Okamoto MM, Sumida DH, Carvalho CR, Vargas AM, Heimann JC, Schaan BD, Machado UF. Changes in dietary sodium consumption modulate GLUT4 gene expression and early steps of insulin signaling. Am J Physiol Regul Integr Comp Physiol 2004, 286(4):R779-785.