Selective targeting of distinct active site nucleophiles by irreversible Src-family kinase inhibitors

Journal of the American Chemical Society

Volumn 134, Issue 50, 2012, Pages 20214-20217

  Gushwa, Nathan N ^a   Kang, Sumin ^b   Chen, Jing ^b   Taunton, Jack ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC LYSINE; CHEMICAL PROBES; CLINICAL USE; DISTINCT ACTIVE SITES; ELECTROPHILES; HUMAN PHYSIOLOGY; INTACT CELLS; KINASE TARGETS; LIVING CELL; SRC-FAMILY KINASE; TYROSINE KINASE;

ACETYLENE; AMINO ACIDS; CHEMICAL COMPOUNDS; PROBES;

ENZYMES;

5' FLUOROSULFONYLBENZOATE; 5' VINYLSULFONATE; BENZOIC ACID DERIVATIVE; CYSTEINE; LYSINE; NUCLEOPHILE; PONATINIB; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN COS7; CHEMICAL REACTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVE SITE;

ANIMALS; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; COS CELLS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; SRC-FAMILY KINASES;

EID: 84871397454     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja310659j     Document Type: Article

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