New insights in the pathogenesis and treatment of normal tension glaucoma

Current Opinion in Pharmacology

Volumn 13, Issue 1, 2013, Pages 43-49

  Mozaffarieh, Maneli ^a   Flammer, Josef ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CARBONATE DEHYDRATASE INHIBITOR; ENDOTHELIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; MAGNESIUM; NITRIC OXIDE; PEROXYNITRITE;

ARTICLE; AUTOREGULATION; BLOOD PRESSURE REGULATION; DNA STRAND BREAKAGE; DOSE RESPONSE; EYE BLOOD FLOW; GINKGO BILOBA; HUMAN; INTRAOCULAR HYPERTENSION; LOW DRUG DOSE; LOW TENSION GLAUCOMA; OPTIC NERVE DISEASE; OXIDATIVE STRESS; PATHOGENESIS; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; REPERFUSION INJURY; RISK ASSESSMENT; RISK FACTOR; VENOUS PRESSURE;

EID: 84871344925     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2012.10.001     Document Type: Review

References (79)

1. K.T. Ma, C.Y. Kim, G.J. Seong, S.H. Lee, J.W. Park, S.J. Ha, B.J. Cho, J.A. Stewart, M.S. Kristoffersen, L.A. Nelson, and W.C. Stewart Intraocular pressure reduction in normal-tension glaucoma patients in South Korea Int Ophthalmol 31 2011 355 361
2. K.R. Sung, J.W. Cho, S. Lee, S.C. Yun, J. Choi, J.H. Na, Y. Lee, and M.S. Kook Characteristics of visual field progression in medically treated normal-tension glaucoma patients with unstable ocular perfusion pressure Invest Ophthalmol Vis Sci 52 2011 737 743
3. J. Flammer, and S. Orgul Optic nerve blood-flow abnormalities in glaucoma Prog Retin Eye Res 17 1998 267 289
4. J. Flammer, S. Orgul, V.P. Costa, N. Orzalesi, G.K. Krieglstein, L.M. Serra, J.P. Renard, and E. Stefansson The impact of ocular blood flow in glaucoma Prog Retin Eye Res 21 2002 359 393
5. D. Schmidl, G. Garhofer, and L. Schmetterer The complex interaction between ocular perfusion pressure and ocular blood flow-relevance for glaucoma Exp Eye Res 93 2011 141 155
6. H.J. Kaiser, A. Schoetzau, D. Stumpfig, and J. Flammer Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma Am J Ophthalmol 123 1997 320 327
7. J.E. Grunwald, J. Piltz, S.M. Hariprasad, and J. DuPont Optic nerve and choroidal circulation in glaucoma Invest Ophthalmol Vis Sci 39 1998 2329 2336
8. P. Gasser, and J. Flammer Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma Am J Ophthalmol 111 1991 585 588
9. M. Emre, S. Orgul, K. Gugleta, and J. Flammer Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation Br J Ophthalmol 88 2004 662 666
10. S.W. Oh, S. Lee, C. Park, and D.J. Kim Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome Diabetes Metab Res Rev 21 2005 434 440
11. M. Yoshida, M. Ishikawa, A. Kokaze, Y. Sekine, N. Matsunaga, Y. Uchida, and Y. Takashima Association of life-style with intraocular pressure in middle-aged and older Japanese residents Jpn J Ophthalmol 47 2003 191 198
12. P.R. Lichter, D.C. Musch, B.W. Gillespie, K.E. Guire, N.K. Janz, P.A. Wren, and R.P. Mills Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery Ophthalmology 108 2001 1943 1953
13. M. Nakabayashi Review of the ischemia hypothesis for ocular hypertension other than congenital glaucoma and closed-angle glaucoma Ophthalmologica 218 2004 344 349
14. N. Wang, S.K. Chintala, M.E. Fini, and J.S. Schuman Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype Nat Med 7 2001 304 309
15. J. Weber, W. Koll, and G.K. Krieglstein Intraocular pressure and visual field decay in chronic glaucoma Ger J Ophthalmol 2 1993 165 169
16. B. Schwartz, G. Tomita, and T. Takamoto Glaucoma-like discs with subsequent increased ocular pressures Ophthalmology 98 1991 41 49
17. X.M. Duan, Y.H. Zou, X.L. Liu, F.R. Ai, and X.P. Liu Visual fields changes in chronic angle closure glaucoma patients after their intraocular pressures were well controlled Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26 2004 410 414
18. D.R. Anderson, S.M. Drance, and M. Schulzer Factors that predict the benefit of lowering intraocular pressure in normal tension glaucoma Am J Ophthalmol 136 2003 820 829
19. H.J. Kaiser, and J. Flammer Systemic hypotension: a risk factor for glaucomatous damage? Ophthalmologica 203 1991 105 108
20. H.J. Kaiser, J. Flammer, T. Graf, and D. Stumpfig Systemic blood pressure in glaucoma patients Graefes Arch Clin Exp Ophthalmol 231 1993 677 680
21. J. Flammer, and M. Mozaffarieh Autoregulation, a balancing act between supply and demand Can J Ophthalmol 43 2008 317 321
22. S. Orgul, C. Zawinka, K. Gugleta, and J. Flammer Therapeutic strategies for normal-tension glaucoma Ophthalmologica 219 2005 317 323
23. M. Pekmezci, B. Vo, A.K. Lim, D.R. Hirabayashi, G.H. Tanaka, R.N. Weinreb, and S.C. Lin The characteristics of glaucoma in Japanese Americans Arch Ophthalmol 127 2009 167 171
24. J. Flammer, I.O. Haefliger, S. Orgul, and T. Resink Vascular dysregulation: a principal risk factor for glaucomatous damage? J Glaucoma 8 1999 212 219
25. M.C. Leske, S.Y. Wu, B. Nemesure, and A. Hennis Incident open-angle glaucoma and ocular perfusion pressure Invest Ophthalmol Vis Sci 52 2011 7943
26. L. Quaranta, and I. Floriani The rate of progression and ocular perfusion pressure in the low-pressure Glaucoma Treatment Study Am J Ophthalmol 152 2011 880 881
27. O. Zeitz, P. Galambos, N. Matthiesen, L. Wagenfeld, W. Schillinger, A. Wiermann, G. Richard, and M. Klemm Effects of the systemic beta-adrenoceptor antagonist nebivolol on ocular hemodynamics in glaucoma patients Med Sci Monit 14 2008 CR268 CR275
28. A. Luksch, G. Rainer, D. Koyuncu, P. Ehrlich, T. Maca, M.E. Gschwandtner, C. Vass, and L. Schmetterer Effect of nimodipine on ocular blood flow and colour contrast sensitivity in patients with normal tension glaucoma Br J Ophthalmol 89 2005 21 25
29. B.C. Chauhan, T.L. LeVatte, C.A. Jollimore, P.K. Yu, H.A. Reitsamer, M.E. Kelly, D.Y. Yu, F. Tremblay, and M.L. Archibald Model of endothelin-1-induced chronic optic neuropathy in rat Invest Ophthalmol Vis Sci 45 2004 144 152
30. T. Haufschild, S.G. Shaw, J. Kesselring, and J. Flammer Increased endothelin-1 plasma levels in patients with multiple sclerosis J Neuroophthalmol 21 2001 37 38
31. M. Pache, H.J. Kaiser, N. Akhalbedashvili, C. Lienert, B. Dubler, L. Kappos, and J. Flammer Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis Eur Neurol 49 2003 164 168
32. P.L. Abegao, E. Vandewalle, C.E. De, C. Marques-Neves, and I. Stalmans Lack of spontaneous venous pulsation: possible risk indicator in normal tension glaucoma? Acta Ophthalmol 2012 Jul 9 1755 3786
33. S. Kain, W.H. Morgan, and D.Y. Yu New observations concerning the nature of central retinal vein pulsation Br J Ophthalmol 94 2010 854 857
34. W.H. Morgan, M.L. Hazelton, C. Balaratnasingamm, H. Chan, P.H. House, C.J. Barry, S.J. Cringle, and D.Y. Yu The association between retinal vein ophthalmodynamometric force change and optic disc excavation Br J Ophthalmol 93 2009 594 596
35. M. Mozaffarieh, G.P. Fontana, A. Schotzau, S. Orgul, J. Flammer, and K. Krauchi Thermal discomfort with cold extremities in relation to age, gender, and body mass index in a random sample of a Swiss urban population Popul Health Metr 8 2010 17
36. M. Mozaffarieh, R. Osusky, A. Schotzau, and J. Flammer Relationship between optic nerve head and finger blood flow Eur J Ophthalmol 20 2010 136 141
37. A. Prunte-Glowazki, and J. Flammer Ocular vasospasm. 4: clinical examples Klin Monatsbl Augenheilkd 198 1991 415 418
38. J.F. Beltrame, S. Sasayama, and A. Maseri Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients J Am Coll Cardiol 33 1999 1442 1452
39. J. Mocco, E.R. Ransom, R.J. Komotar, W.J. Mack, P.B. Sergot, S.M. Albert, and E.S. Connolly Jr. Racial differences in cerebral vasospasm: a systematic review of the literature Neurosurgery 58 2006 305 314
40. N. Harada, A. Ueda, and S. Takegata Prevalence of Raynaud's phenomenon in Japanese males and females J Clin Epidemiol 44 1991 649 655
41. U. Guthauser, J. Flammer, and F. Mahler The relationship between digital and ocular vasospasm Graefes Arch Clin Exp Ophthalmol 226 1988 224 226
42. B. Teuchner, S. Orgul, H. Ulmer, T. Haufschild, and J. Flammer Reduced thirst in patients with a vasospastic syndrome Acta Ophthalmol Scand 82 2004 738 740
43. S. Orgul, H.J. Kaiser, J. Flammer, and P. Gasser Systemic blood pressure and capillary blood-cell velocity in glaucoma patients: a preliminary study Eur J Ophthalmol 5 1995 88 91
44. P. Gasser, and O. Meienberg Finger microcirculation in classical migraine. A video-microscopic study of nailfold capillaries Eur Neurol 31 1991 168 171
45. K. Wunderlich, C. Zimmerman, H. Gutmann, B. Teuchner, J. Flammer, and J. Drewe Vasospastic persons exhibit differential expression of ABC-transport proteins Mol Vis 9 2003 756 761
46. M. Mozaffarieh, D. Hauenstein, A. Schoetzau, K. Konieczka, and J. Flammer Smell perception in normal tension glaucoma patients Mol Vis 16 2010 506 510
47. K. Gugleta, A. Kochkorov, R. Katamay, A. Husner, A. Welge-Lussen, J. Flammer, and S. Orgul Olfactory function in primary open-angle glaucoma patients Klin Monbl Augenheilkd 227 2010 277 279
48. M. Pache, K. Krauchi, C. Cajochen, A. Wirz-Justice, B. Dubler, J. Flammer, and H.J. Kaiser Cold feet and prolonged sleep-onset latency in vasospastic syndrome Lancet 358 2001 125 126
49. J. Flammer Innovative glaucoma therapy Ophthalmologe 98 2001 923 924
50. K. Gugleta, C. Zawinka, I. Rickenbacher, A. Kochkorov, R. Katamay, J. Flammer, and S. Orgul Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity Invest Ophthalmol Vis Sci 47 2006 4034 4041
51. A. Kochkorov, K. Gugleta, C. Zawinka, R. Katamay, J. Flammer, and S. Orgul Short-term retinal vessel diameter variability in relation to the history of cold extremities Invest Ophthalmol Vis Sci 47 2006 4026 4033
52. K. Gugleta, S. Orgul, P.W. Hasler, T. Picornell, D. Gherghel, and J. Flammer Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma Invest Ophthalmol Vis Sci 44 2003 1573 1580
53. K. Gugleta, A. Kochkorov, R. Katamay, C. Zawinka, J. Flammer, and S. Orgul On pulse-wave propagation in the ocular circulation Invest Ophthalmol Vis Sci 47 2006 4019 4025
54. J. Flammer Glaucomatous optic neuropathy: a reperfusion injury Klin Monatsbl Augenheilkd 218 2001 290 291
55. M. Mozaffarieh, M.C. Grieshaber, and J. Flammer Oxygen and blood flow: players in the pathogenesis of glaucoma Mol Vis 14 2008 224 233
56. M. Mozaffarieh, A. Schoetzau, M. Sauter, M. Grieshaber, S. Orgul, O. Golubnitschaja, and J. Flammer Comet assay analysis of single-stranded DNA breaks in circulating leukocytes of glaucoma patients Mol Vis 14 2008 1584 1588
57. M. Cellini, E. Strobbe, C. Gizzi, N. Balducci, P.G. Toschi, and E.C. Campos Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma Life Sci 2012
58. Y.Z. Shoshani, A. Harris, M.M. Shoja, D. Rusia, B. Siesky, Y. Arieli, and B. Wirostko Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma Curr Eye Res 37 2012 1 11
59. O. Golubnitschaja, K. Yeghiazaryan, R. Liu, H. Monkemann, D. Leppert, H. Schild, I.O. Haefliger, and J. Flammer Increased expression of matrix metalloproteinases in mononuclear blood cells of normal-tension glaucoma patients J Glaucoma 13 2004 66 72
60. K. Wunderlich, O. Golubnitschaja, M. Pache, A.N. Eberle, and J. Flammer Increased plasma levels of 20S proteasome alpha-subunit in glaucoma patients: an observational pilot study Mol Vis 8 2002 431 435
61. J. Flammer, and M. Mozaffarieh What is the present pathogenetic concept of glaucomatous optic neuropathy? Surv Ophthalmol 52 Suppl 2 2007 S162 S173
62. B. Liu, H. Chen, T.G. Johns, and A.H. Neufeld Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury J Neurosci 26 2006 7532 7540
63. G. Prasanna, R. Krishnamoorthy, A.F. Clark, R.J. Wordinger, and T. Yorio Human optic nerve head astrocytes as a target for endothelin-1 Invest Ophthalmol Vis Sci 43 2002 2704 2713
64. T. Taniguchi, M. Shimazawa, M. Sasaoka, A. Shimazaki, and H. Hara Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve Curr Neurovasc Res 3 2006 81 88
65. A.H. Neufeld, M.R. Hernandez, and M. Gonzalez Nitric oxide synthase in the human glaucomatous optic nerve head Arch Ophthalmol 115 1997 497 503
66. N. Gupta, L.C. Ang, T.L. Noel de, L. Bidaisee, and Y.H. Yucel Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex Br J Ophthalmol 90 2006 674 678
67. C.F. Burgoyne A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma Exp Eye Res 93 2011 120 132
68. M.C. Grieshaber, T. Terhorst, and J. Flammer The pathogenesis of optic disc splinter haemorrhages: a new hypothesis Acta Ophthalmol.Scand 84 2006 62 68
69. M. Mozaffarieh, and J. Flammer A novel perspective on natural therapeutic approaches in glaucoma therapy Expert Opin Emerg Drugs 12 2007 195 198
70. M. Mozaffarieh, and J. Flammer Is there more to glaucoma treatment than lowering IOP? Surv Ophthalmol 52 Suppl 2 2007 S174 S179
71. M. Mozaffarieh, M.C. Grieshaber, S. Orgul, and J. Flammer The potential value of natural antioxidative treatment in glaucoma Surv Ophthalmol 53 2008 479 505
72. K. Gugleta, S. Orgul, D. Stumpfig, B. Dubler, and J. Flammer Fludrocortisone in the treatment of systemic hypotension in primary open-angle glaucoma patients Int Ophthalmol 23 1999 25 30
73. E.S. Dettmann, T.F. Luscher, J. Flammer, and I.O. Haefliger Modulation of endothelin-1-induced contractions by magnesium/calcium in porcine ciliary arteries Graefes Arch Clin Exp Ophthalmol 236 1998 47 51
74. M. Mozaffarieh, K. Konieczka, and J. Flammer Calcium channel blockers: their use in normal tension glaucoma Expert Rev Ophthalmol 5 2010 617 625
75. F. Michalk, G. Michelson, J. Harazny, U. Werner, W.G. Daniel, and D. Werner Single-dose nimodipine normalizes impaired retinal circulation in normal tension glaucoma J Glaucoma 13 2004 158 162
76. A.K. Cybulska-Heinrich, M. Mozaffarieh, and J. Flammer Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma Mol Vis 18 2012 390 402
77. J. Lee, S.W. Sohn, and C. Kee Effect of Ginkgo biloba extract on visual field progression in normal tension glaucoma J Glaucoma 2012
78. S.H. Shim, J.M. Kim, C.Y. Choi, C.Y. Kim, and K.H. Park Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma J Med Food 15 2012 818 823
79. L. Quaranta, S. Bettelli, M.G. Uva, F. Semeraro, R. Turano, and E. Gandolfo Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma Ophthalmology 110 2003 359 362