Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ

Journal of Biological Chemistry

Volumn 287, Issue 50, 2012, Pages 41651-41666

  Hammond, Victoria J ^a   Morgan, Alwena H ^a   Lauder, Sarah ^a   Thomas, Christopher P ^a   Brown, Sarah ^c,d   Freeman, Bruce A ^b   Lloyd, Clare M ^c   Davies, Jane ^d   Bush, Andrew ^d   Levonen, Anna Liisa ^e   Kansanen, Emilia ^e   Villacorta, Luis ^f   Chen, Y Eugene ^f   Porter, Ned ^g   Garcia Diaz, Yoel M ^g   Schopfer, Francisco J ^b   O'Donnell, Valerie B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

^e UNIVERSITY OF EASTERN FINLAND   (Finland)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^g VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY ACTION; BRONCHOALVEOLAR LAVAGE FLUID; CALCIUM MOBILIZATION; CYSTIC FIBROSIS; DOSE-DEPENDENT MANNER; EICOSANOIDS; GLUTATHIONES; HUMAN MONOCYTES; IN-VIVO; MICHAEL ADDITIONS; MONOCYTIC CELLS; MURINE PERITONEAL MACROPHAGES; OXIDIZED PHOSPHOLIPIDS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR;

ADDITION REACTIONS; AMINO ACIDS; BODY FLUIDS; CYTOLOGY; ENDOTHELIAL CELLS; PHOSPHOLIPIDS;

MACROPHAGES;

15 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 15 KETOEICOSATETRAENOIC ACID; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID DERIVATIVE; CYSTEINE; GLUTATHIONE; INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; CYSTIC FIBROSIS; ELECTROPHILICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG LAVAGE; MACROPHAGE; MICHAEL ADDITION; MONOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; PERITONEUM MACROPHAGE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; REPORTER GENE;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACIDS; CYSTIC FIBROSIS; FEMALE; HUMANS; MACROPHAGES, ALVEOLAR; MACROPHAGES, PERITONEAL; MALE; MICE; MONOCYTES; PHOSPHATIDYLETHANOLAMINES; PPAR GAMMA;

MURINAE; MUS;

EID: 84871332422     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.405407     Document Type: Article

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