Progress and pitfalls in the identification of cancer stem cell-targeting therapies in head and neck squamous cell carcinoma

Current Medicinal Chemistry

Volumn 19, Issue 35, 2012, Pages 6056-6064

  Kiang, A ^a   Yu, M A ^a   Ongkeko, W M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cancer stem cells; Head and neck squamous cell carcinoma (HNSCC); Targeted therapy

Indexed keywords

ALDEHYDE DEHYDROGENASE; CARBOPLATIN; CD133 ANTIGEN; CD44V ANTIGEN; CETUXIMAB; CISPLATIN; CUCURBITACIN; MICRORNA; MICRORNA 107; MICRORNA 200C; NANOPARTICLE; QUERCETIN; SALINOMYCIN; UNTRANSLATED RNA;

ARTICLE; CANCER CHEMOTHERAPY; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER STEM CELL; CELL RENEWAL; CELL SUBPOPULATION; CLINICAL TRIAL (TOPIC); DRUG EFFICACY; EPITHELIAL MESENCHYMAL TRANSITION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; STEM CELL TRANSPLANTATION; TREATMENT PLANNING;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; GENETIC THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOTHERAPY; NANOPARTICLES; NEOPLASTIC STEM CELLS; RNA INTERFERENCE;

EID: 84871311663     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712804485827     Document Type: Article

References (43)

1. Ferlay, J.; Shin, H. R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D. M., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 2010, 127, (12), 2893-2917.
2. Gupta, S.; Kong, W.; Peng, Y.; Miao, Q.; Mackillop, W. J., Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States. Int J Cancer, 2009, 125, (9), 2159-2165.
3. Bonnet, D.; Dick, J. E., Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med, 1997, 3, (7), 730-737.
4. Visvader, J. E.; Lindeman, G. J., Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer, 2008, 8, (10), 755-768.
5. Prince, M. E.; Sivanandan, R.; Kaczorowski, A.; Wolf, G. T.; Kaplan, M. J.; Dalerba, P.; Weissman, I. L.; Clarke, M. F.; Ailles, L. E., Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A, 2007, 104, (3), 973-978.
6. Al-Hajj, M.; Wicha, M. S.; Benito-Hernandez, A.; Morrison, S. J.; Clarke, M. F., Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A, 2003, 100, (7), 3983-3988.
7. Chen, Y. C.; Chang, C. J.; Hsu, H. S.; Chen, Y. W.; Tai, L. K.; Tseng, L. M.; Chiou, G. Y.; Chang, S. C.; Kao, S. Y.; Chiou, S. H.; Lo, W. L., Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1. Oral Oncol, 2010, 46, (3), 158-165.
8. Bourguignon, L. Y.; Zhu, H.; Shao, L.; Chen, Y. W., CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration. J Biol Chem, 2000, 275, (3), 1829-1838.
9. Tanabe, K. K.; Saya, H., The CD44 adhesion molecule and metastasis. Crit Rev Oncog, 1994, 5, (2-3), 201-212.
10. Charafe-Jauffret, E.; Ginestier, C.; Iovino, F.; Wicinski, J.; Cervera, N.; Finetti, P.; Hur, M. H.; Diebel, M. E.; Monville, F.; Dutcher, J.; Brown, M.; Viens, P.; Xerri, L.; Bertucci, F.; Stassi, G.; Dontu, G.; Birnbaum, D.; Wicha, M. S., Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res, 2009, 69, (4), 1302-1313.
11. Chen, Y. C.; Chen, Y. W.; Hsu, H. S.; Tseng, L. M.; Huang, P. I.; Lu, K. H.; Chen, D. T.; Tai, L. K.; Yung, M. C.; Chang, S. C.; Ku, H. H.; Chiou, S. H.; Lo, W. L., Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun, 2009, 385, (3), 307-313.
12. Clay, M. R.; Tabor, M.; Owen, J. H.; Carey, T. E.; Bradford, C. R.; Wolf, G. T.; Wicha, M. S.; Prince, M. E., Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck, 2010, 32, (9), 1195-1201.
13. Sophos, N. A.; Vasiliou, V., Aldehyde dehydrogenase gene superfamily: the 2002 update. Chem Biol Interact, 2003, 143-144, 5-22.
14. Collins, A. T.; Berry, P. A.; Hyde, C.; Stower, M. J.; Maitland, N. J., Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res, 2005, 65, (23), 10946-10951.
15. Singh, S. K.; Clarke, I. D.; Terasaki, M.; Bonn, V. E.; Hawkins, C.; Squire, J.; Dirks, P. B., Identification of a cancer stem cell in human brain tumors. Cancer Res, 2003, 63, (18), 5821-5828.
16. Wei, X. D.; Zhou, L.; Cheng, L.; Tian, J.; Jiang, J. J.; Maccallum, J., In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line. Head Neck, 2009, 31, (1), 94-101.
17. Zhang, Q.; Shi, S.; Yen, Y.; Brown, J.; Ta, J. Q.; Le, A. D., A subpopulation of CD133 (+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. Cancer Lett, 2010, 289, (2), 151-160.
18. Mizrak, D.; Brittan, M.; Alison, M. R., CD133: molecule of the moment. J Pathol, 2008, 214, (1), 3-9.
19. Bonner, J. A.; Harari, P. M.; Giralt, J.; Azarnia, N.; Shin, D. M.; Cohen, R. B.; Jones, C. U.; Sur, R.; Raben, D.; Jassem, J.; Ove, R.; Kies, M. S.; Baselga, J.; Youssoufian, H.; Amellal, N.; Rowinsky, E. K.; Ang, K. K., Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med, 2006, 354, (6), 567-578.
20. Vermorken, J. B.; Mesia, R.; Rivera, F.; Remenar, E.; Kawecki, A.; Rottey, S.; Erfan, J.; Zabolotnyy, D.; Kienzer, H. R.; Cupissol, D.; Peyrade, F.; Benasso, M.; Vynnychenko, I.; De Raucourt, D.; Bokemeyer, C.; Schueler, A.; Amellal, N.; Hitt, R., Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med, 2008, 359, (11), 1116-1127.
21. Vermorken, J. B.; Trigo, J.; Hitt, R.; Koralewski, P.; Diaz-Rubio, E.; Rolland, F.; Knecht, R.; Amellal, N.; Schueler, A.; Baselga, J., Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol, 2007, 25, (16), 2171-2177.
22. Abhold, E. L.; Kiang, A.; Rahimy, E.; Kuo, S. Z.; Wang-Rodriguez, J.; Lopez, J. P.; Blair, K. J.; Yu, M. A.; Haas, M.; Brumund, K. T.; Altuna, X.; Patel, A.; Weisman, R. A.; Ongkeko, W. M., EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells. PLoS One, 2012, 7, (2), e32459.
23. Chen, J. S.; Pardo, F. S.; Wang-Rodriguez, J.; Chu, T. S.; Lopez, J. P.; Aguilera, J.; Altuna, X.; Weisman, R. A.; Ongkeko, W. M., EGFR regulates the side population in head and neck squamous cell carcinoma. Laryngoscope, 2006, 116, (3), 401-406.
24. Basu, D.; Montone, K. T.; Wang, L. P.; Gimotty, P. A.; Hammond, R.; Diehl, J. A.; Rustgi, A. K.; Lee, J. T.; Rasanen, K.; Weinstein, G. S.; Herlyn, M., Detecting and targeting mesenchymal-like subpopulations within squamous cell carcinomas. Cell Cycle, 2011, 10, (12), 2008-2016.
25. Gupta, P. B.; Onder, T. T.; Jiang, G.; Tao, K.; Kuperwasser, C.; Weinberg, R. A.; Lander, E. S., Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell, 2009, 138, (4), 645-659.
26. Jo, M.; Eastman, B. M.; Webb, D. L.; Stoletov, K.; Klemke, R.; Gonias, S. L., Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res, 2010, 70, (21), 8948-8958.
27. Chang, W. W.; Hu, F. W.; Yu, C. C.; Wang, H. H.; Feng, H. P.; Lan, C.; Tsai, L. L.; Chang, Y. C., Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck, 2012.
28. Piao, L.; Zhang, M.; Datta, J.; Xie, X.; Su, T.; Li, H.; Teknos, T. N.; Pan, Q., Lipid-based Nanoparticle Delivery of Pre-miR-107 Inhibits the Tumorigenicity of Head and Neck Squamous Cell Carcinoma. Mol Ther, 2012.
29. Lo, W. L.; Yu, C. C.; Chiou, G. Y.; Chen, Y. W.; Huang, P. I.; Chien, C. S.; Tseng, L. M.; Chu, P. Y.; Lu, K. H.; Chang, K. W.; Kao, S. Y.; Chiou, S. H., MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol, 2011, 223, (4), 482-495.
30. Yu, C. C.; Chen, Y. W.; Chiou, G. Y.; Tsai, L. L.; Huang, P. I.; Chang, C. Y.; Tseng, L. M.; Chiou, S. H.; Yen, S. H.; Chou, M. Y.; Chu, P. Y.; Lo, W. L., MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. Oral Oncol, 2011, 47, (3), 202-210.
31. Waldron, N. N.; Kaufman, D. S.; Oh, S.; Inde, Z.; Hexum, M. K.; Ohlfest, J. R.; Vallera, D. A., Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer. Mol Cancer Ther, 2011, 10, (10), 1829-1838.
32. Visus, C.; Wang, Y.; Lozano-Leon, A.; Ferris, R. L.; Silver, S.; Szczepanski, M. J.; Brand, R. E.; Ferrone, C. R.; Whiteside, T. L.; Ferrone, S.; De Leo, A. B.; Wang, X., Targeting ALDH (bright) human carcinoma-initiating cells with ALDH1A1-specific CD8 T cells. Clin Cancer Res, 2011, 17, (19), 6174-6184.
33. Krishnamurthy, S.; Dong, Z.; Vodopyanov, D.; Imai, A.; Helman, J. I.; Prince, M. E.; Wicha, M. S.; Nor, J. E., Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res, 2010, 70, (23), 9969-9978.
34. Covello, K. L.; Kehler, J.; Yu, H.; Gordan, J. D.; Arsham, A. M.; Hu, C. J.; Labosky, P. A.; Simon, M. C.; Keith, B., HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev, 2006, 20, (5), 557-570.
35. Keith, B.; Simon, M. C., Hypoxia-inducible factors, stem cells, and cancer. Cell, 2007, 129, (3), 465-472.
36. Yoshida, Y.; Takahashi, K.; Okita, K.; Ichisaka, T.; Yamanaka, S., Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell, 2009, 5, (3), 237-241.
37. Gibb, E. A.; Enfield, K. S.; Stewart, G. L.; Lonergan, K. M.; Chari, R.; Ng, R. T.; Zhang, L.; MacAulay, C. E.; Rosin, M. P.; Lam, W. L., Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncol, 2011, 47, (11), 1055-1061.
38. Dinger, M. E.; Amaral, P. P.; Mercer, T. R.; Pang, K. C.; Bruce, S. J.; Gardiner, B. B.; Askarian-Amiri, M. E.; Ru, K.; Solda, G.; Simons, C.; Sunkin, S. M.; Crowe, M. L.; Grimmond, S. M.; Perkins, A. C.; Mattick, J. S., Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Res, 2008, 18, (9), 1433-1445.
39. Gupta, R. A.; Shah, N.; Wang, K. C.; Kim, J.; Horlings, H. M.; Wong, D. J.; Tsai, M. C.; Hung, T.; Argani, P.; Rinn, J. L.; Wang, Y.; Brzoska, P.; Kong, B.; Li, R.; West, R. B.; Van De Vijver, M. J.; Sukumar, S.; Chang, H. Y., Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature, 2010, 464, (7291), 1071-1076.
40. Lo, W. L.; Chien, Y.; Chiou, G. Y.; Tseng, L. M.; Hsu, H. S.; Chang, Y. L.; Lu, K. H.; Chien, C. S.; Wang, M. L.; Chen, Y. W.; Huang, P. I.; Hu, F. W.; Yu, C. C.; Chu, P. Y.; Chiou, S. H., Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells. Biomaterials, 2012, 33, (14), 3693-3709.
41. Hirsch, H. A.; Iliopoulos, D.; Tsichlis, P. N.; Struhl, K., Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res, 2009, 69, (19), 7507-7511.
42. Wu, M. J.; Jan, C. I.; Tsay, Y. G.; Yu, Y. H.; Huang, C. Y.; Lin, S. C.; Liu, C. J.; Chen, Y. S.; Lo, J. F.; Yu, C. C., Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer, 2010, 9, 283.
43. Chen, Y. W.; Chen, K. H.; Huang, P. I.; Chen, Y. C.; Chiou, G. Y.; Lo, W. L.; Tseng, L. M.; Hsu, H. S.; Chang, K. W.; Chiou, S. H., Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma-derived CD44 (+) ALDH1 (+) cells. Mol Cancer Ther, 2010, 9, (11), 2879-2892.