Pachastrissamine from Pachastrissa sp. inhibits melanoma cell growth by dual inhibition of Cdk2 and ERK-mediated FOXO3 downregulation

Phytotherapy Research

Volumn 26, Issue 12, 2012, Pages 1927-1933

  Yoo, Hyun ^a   Lee, Yun Sang ^a   Lee, Sukjin ^b   Kim, Sanghee ^b,c   Kim, Tae Yoon ^a  

^a The Catholic University of Korea   (South Korea)

^b Seoul National University   (South Korea)

^c Division of Life and Pharmaceutical Sciences   (South Korea)

Author keywords

apoptosis; ERK; FOXO3; melanoma; pachastrissamine (PA); phytosphingosine

Indexed keywords

CYCLIN DEPENDENT KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PACHASTRISSAMINE; PHYTOSPHINGOSINE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMELANOMA ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE REGULATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME REGULATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PACHASTRISSSA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN CANCER; TREATMENT RESPONSE;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAP KINASE SIGNALING SYSTEM; MELANOMA; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PORIFERA; SPHINGOSINE;

PACHASTRISSA;

EID: 84871308805     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4673     Document Type: Article

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