Involvement of FKHRL1 in melanoma cell survival and death

Pigment Cell and Melanoma Research

Volumn 21, Issue 2, 2008, Pages 139-146

  Hilmi, C ^a,b   Larribere, L ^a,b   Deckert, M ^a,b   Rocchi, S ^a,b   Giuliano, S ^a,b   Bille, K ^a,b   Ortonne, J P ^a,b,c   Ballotti, R ^a,b   Bertolotto, C ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

FKHRL1; IGF1; Melanoma; Survivin

Indexed keywords

PROTEIN KINASE B; SOMATOMEDIN C; SURVIVIN; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MELANOMA; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 42249088750     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2008.00440.x     Document Type: Article

References (32)

1. Accili, D. Arden, K.C. (2004). FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421 426.
2. Birkenkamp, K.U., Essafi, A., Van Der Vos, K.E., Da Costa, M., Hui, R.C., Holstege, F., Koenderman, L., Lam, E.W. Coffer, P.J. (2007). FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J. Biol. Chem. 282, 2211 2220.
3. Brose, M.S., Volpe, P., Feldman, M. et al. (2002). BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 62, 6997 7000.
4. Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J. Greenberg, M.E. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 96, 857 868.
5. Burgering, B.M. Medema, R.H. (2003). Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J. Leukoc. Biol. 73, 689 701.
6. Chawla-Sarkar, M., Bae, S.I., Reu, F.J., Jacobs, B.S., Lindner, D.J. Borden, E.C. (2004). Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 11, 915 923.
7. Davies, H., Bignell, G.R., Cox, C. et al. (2002). Mutations of the BRAF gene in human cancer. Nature 417, 949 954.
8. Essers, M.A., Weijzen, S., De Vries-Smits, A.M., Saarloos, I., De Ruiter, N.D., Bos, J.L. Burgering, B.M. (2004). FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 23, 4802 4812.
9. Fernandez De Mattos, S., Essafi, A., Soeiro, I. et al. (2004). FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol. Cell. Biol. 24, 10058 10071.
10. Grimberg, A. (2003). Mechanisms by which IGF-I may promote cancer. Cancer Biol. Ther. 2, 630 635.
11. Hilmi, C., Larribere, L., Giuliano, S., Bille, K., Ortonne, J.P., Ballotti, R. Bertolotto, C. 2007). IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of Bcl2, BclX(L) and survivin. J. Invest. Dermatol., in press.
12. Kaestner, K.H., Knochel, W. Martinez, D.E. (2000). Unified nomenclature for the winged helix/forkhead transcription factors. Genes Dev. 14, 142 146.
13. Kau, T.R., Schroeder, F., Ramaswamy, S., Wojciechowski, C.L., Zhao, J.J., Roberts, T.M., Clardy, J., Sellers, W.R. Silver, P.A. (2003). A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 4, 463 476.
14. Khaled, M., Larribere, L., Bille, K., Ortonne, J.P., Ballotti, R. Bertolotto, C. (2003). Microphthalmia associated transcription factor (MITF) is a target of the PI3K pathway. J. Invest. Dermatol. 121, 831 836.
15. Kops, G.J., Dansen, T.B., Polderman, P.E., Saarloos, I., Wirtz, K.W., Coffer, P.J., Huang, T.T., Bos, J.L., Medema, R.H. Burgering, B.M. (2002a). Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316 321.
16. Kops, G.J., Medema, R.H., Glassford, J., Essers, M.A., Dijkers, P.F., Coffer, P.J., Lam, E.W. Burgering, B.M. (2002b). Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol. Cell. Biol. 22, 2025 2036.
17. Larribere, L., Khaled, M., Tartare-Deckert, S. et al. (2004). PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes. Cell Death Differ. 11, 1084 1091.
18. Larribere, L., Hilmi, C., Khaled, M., Gaggioli, C., Bille, K., Auberger, P., Ortonne, J.P., Ballotti, R. Bertolotto, C. (2005). The cleavage of microphthalmia associated transcription factor, MITF, by caspases plays an essential role in melanocyte and melanoma cell apoptosis. Genes Dev. 19, 1980 1985.
19. Li, F. Ling, X. (2006). Survivin study: an update of "What is the next wave?". J. Cell. Physiol. 197, 8 29.
20. Modur, V., Nagarajan, R., Evers, B.M. Milbrandt, J. (2002). FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem. 277, 47928 47937.
21. Rena, G., Guo, S., Cichy, S.C., Unterman, T.G. Cohen, P. (1999). Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 274, 17179 17183.
22. Robertson, G.P. (2005). Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev. 24, 273 285.
23. Schmidt, M., Fernandez De Mattos, S., Van Der Horst, A., Klompmaker, R., Kops, G.J., Lam, E.W., Burgering, B.M. Medema, R.H. (2002). Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol. Cell. Biol. 22, 7842 7852.
24. Slipicevic, A., Holm, R., Nguyen, M.T., Bohler, P.J., Davidson, B. Florenes, V.A. (2005). Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. Am. J. Clin. Pathol. 124, 528 536.
25. Soengas, M.S. Lowe, S.W. (2003). Apoptosis and melanoma chemoresistance. Oncogene 22, 3138 3151.
26. Stahl, J.M., Cheung, M., Sharma, A., Trivedi, N.R., Shanmugam, S. Robertson, G.P. (2003). Loss of PTEN promotes tumor development in malignant melanoma. Cancer Res. 63, 2881 2890.
27. Stahl, J.M., Sharma, A., Cheung, M., Zimmerman, M., Cheng, J.Q., Bosenberg, M.W., Kester, M., Sandirasegarane, L. Robertson, G.P. (2004). Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res. 64, 7002 7010.
28. Takeuchi, H., Morton, D.L., Elashoff, D. Hoon, D.S. (2005). Survivin expression by metastatic melanoma predicts poor disease outcome in patients receiving adjuvant polyvalent vaccine. Int. J. Cancer 117, 1032 1038.
29. Tran, H., Brunet, A., Grenier, J.M., Datta, S.R., Fornace Jr., A.J., Distefano, P.S., Chiang, L.W. Greenberg, M.E. (2002). DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530 534.
30. Van Der Heide, L.P., Hoekman, M.F. Smidt, M.P. (2004). The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem. J. 380, 297 309.
31. Yeh, A.H., Bohula, E.A. Macaulay, V.M. (2006). Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs. Oncogene 25, 6574 6581.
32. Zhao, H.H., Herrera, R.E., Coronado-Heinsohn, E. et al. (2001). Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. J. Biol. Chem. 276, 27907 27912.