The Epidermal Growth Factor-like Domain of CD93 Is a Potent Angiogenic Factor

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Kao, Yuan Chung ^a,b   Jiang, Shinn Jong ^a,b   Pan, Wen An ^a,b   Wang, Kuan Chieh ^a,b   Chen, Po Ku ^a,b   Wei, Hsi Ju ^a,b   Chen, Wei Sheng ^a,b   Chang, Bi Ing ^a,b   Shi, Guey Yueh ^a,b   Wu, Hua Lin ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE A; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CD93; RECOMBINANT CD93D1; RECOMBINANT CD93D123; RECOMBINANT CD93D23; UNCLASSIFIED DRUG;

ANGIOGENESIS; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPIDERMAL GROWTH FACTOR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LAMININ; MEMBRANE GLYCOPROTEINS; MICE; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; RECEPTORS, COMPLEMENT; RETINAL DEGENERATION; SIGNAL TRANSDUCTION;

MUS;

EID: 84871303928     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051647     Document Type: Article

References (35)

1. Conway EM, Collen D, Carmeliet P, (2001) Molecular mechanisms of blood vessel growth. Cardiovasc Res 49: 507-521.
2. Kanno Y, Hirade K, Ishisaki A, Nakajima K, Suga H, et al. (2006) Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions. J Thromb Haemost 4: 1602-1610.
3. Jiang BH, Zheng JZ, Aoki M, Vogt PK, (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A 97: 1749-1753.
4. Chung BH, Cho YL, Kim JD, Jo HS, Won MH, et al. (2009) Promotion of direct angiogenesis in vitro and in vivo by Puerariae flos extract via activation of MEK/ERK-, PI3K/Akt/eNOS-, and Src/FAK-dependent pathways. Phytother Res.
5. Nepomuceno RR, Henschen-Edman AH, Burgess WH, Tenner AJ, (1997) cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity 6: 119-129.
6. Nepomuceno RR, Ruiz S, Park M, Tenner AJ, (1999) C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. J Immunol 162: 3583-3589.
7. Park M, Tenner AJ, (2003) Cell surface expression of C1qRP/CD93 is stabilized by O-glycosylation. J Cell Physiol 196: 512-522.
8. Nepomuceno RR, Tenner AJ, (1998) C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J Immunol 160: 1929-1935.
9. Fonseca MI, Carpenter PM, Park M, Palmarini G, Nelson EL, et al. (2001) C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J Leukoc Biol 70: 793-800.
10. Guan E, Robinson SL, Goodman EB, Tenner AJ, (1994) Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J Immunol 152: 4005-4016.
11. Danet GH, Luongo JL, Butler G, Lu MM, Tenner AJ, et al. (2002) C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc Natl Acad Sci U S A 99: 10441-10445.
12. Dean YD, McGreal EP, Akatsu H, Gasque P, (2000) Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. J Biol Chem 275: 34382-34392.
13. Petrenko O, Beavis A, Klaine M, Kittappa R, Godin I, et al. (1999) The molecular characterization of the fetal stem cell marker AA4. Immunity 10: 691-700.
14. Dean YD, McGreal EP, Gasque P, (2001) Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. Eur J Immunol 31: 1370-1381.
15. Carmeliet P, Jain RK, (2000) Angiogenesis in cancer and other diseases. Nature 407: 249-257.
16. Shi CS, Shi GY, Chang YS, Han HS, Kuo CH, et al. (2005) Evidence of human thrombomodulin domain as a novel angiogenic factor. Circulation 111: 1627-1636.
17. Greenlee MC, Sullivan SA, Bohlson SS, (2009) Detection and characterization of soluble CD93 released during inflammation. Inflammation research: official journal of the European Histamine Research Society [et al] 58: 909-919.
18. Malarstig A, Silveira A, Wagsater D, Ohrvik J, Backlund A, et al. (2011) Plasma CD93 concentration is a potential novel biomarker for coronary artery disease. Journal of internal medicine 270: 229-236.
19. Passaniti A, Taylor RM, Pili R, Guo Y, Long PV, et al. (1992) A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 67: 519-528.
20. Pieper JS, Hafmans T, van Wachem PB, van Luyn MJ, Brouwer LA, et al. (2002) Loading of collagen-heparan sulfate matrices with bFGF promotes angiogenesis and tissue generation in rats. J Biomed Mater Res 62: 185-194.
21. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, et al. (2009) Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nature protocols 4: 1565-1573.
22. Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, et al. (2004) Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. Journal of immunology 172: 3406-3414.
23. McGreal EP, Ikewaki N, Akatsu H, Morgan BP, Gasque P, (2002) Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol 168: 5222-5232.
24. Toker A, Cantley LC, (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387: 673-676.
25. Bohlson SS, Silva R, Fonseca MI, Tenner AJ, (2005) CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol 175: 1239-1247.
26. Ikewaki N, Tamauchi H, Inoko H, (2007) Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Microbiol Immunol 51: 1189-1200.
27. Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, et al. (1999) Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci U S A 96: 6235-6240.
28. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ, (1995) Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 376: 517-519.
29. Larsen AK, Ouaret D, El Ouadrani K, Petitprez A, (2011) Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacology & therapeutics 131: 80-90.
30. Garg P, Yang S, Liu A, Pallero MA, Buchsbaum DJ, et al. (2011) Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation. American journal of physiology Lung cellular and molecular physiology 301: L79-90.
31. Kuo CH, Chen PK, Chang BI, Sung MC, Shi CS, et al. (2012) The recombinant lectin-like domain of thrombomodulin inhibits angiogenesis through interaction with Lewis Y antigen. Blood 119: 1302-1313.
32. Maharjan S, Lee S, Agrawal V, Choi HJ, Maeng YS, et al. (2011) Sac-0601 prevents retinal vascular leakage in a mouse model of diabetic retinopathy. European journal of pharmacology 657: 35-40.
33. Park CC, Morel JC, Amin MA, Connors MA, Harlow LA, et al. (2001) Evidence of IL-18 as a novel angiogenic mediator. J Immunol 167: 1644-1653.
34. Koch AE, (2000) The role of angiogenesis in rheumatoid arthritis: recent developments. Ann Rheum Dis 59Suppl 1: i65-71.
35. Lee OH, Bae SK, Bae MH, Lee YM, Moon EJ, et al. (2000) Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis models. Br J Cancer 82: 385-391.