Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells in Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis

Journal of Immunology

Volumn 172, Issue 6, 2004, Pages 3406-3414

  Norsworthy, Peter J ^a   Fossati Jimack, Liliane ^a   Cortes Hernandez, Josefina ^a   Taylor, Philip R ^b   Bygrave, Anne E ^a   Thompson, Richard D ^a   Nourshargh, Sussan ^a   Walport, Mark J ^a   Botto, Marina ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1QRP; FC RECEPTOR; INTERLEUKIN 1BETA; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; LEUKEMIA CELL LINE; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; THYMOCYTE;

EID: 1542619333     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.6.3406     Document Type: Article

References (32)

1. Tenner, A. J. 1998. C1q receptors: regulating specific functions of phagocytic cells. Immunobiology 199:250.
2. Ghiran, I., S. R. Tyagi, L. B. Klickstein, and A. Nicholson-Weller. 2002. Expression and function of C1q receptors and C1q binding proteins at the cell surface. Immunobiology 205:407.
3. Nepomuceno, R. R., S. Ruiz, M. Park, and A. J. Tenner. 1999. C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. J. Immunol. 162:3583.
4. Nepomuceno, R. R., A. H. Henschen-Edman, W. H. Burgess, and A. J. Tenner. 1997. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity 6:119.
5. Norsworthy, P. J., P. R. Taylor, M. J. Walport, and M. Botto. 1999. Cloning of the mouse homolog of the 126-kDa human C1q/MBL/SP-A receptor, C1qR(p). Mamm. Genome 10:789.
6. Kim, T. S., M. Park, R. R. Nepomuceno, G. Palmarini, S. Winokur, C. A. Cotman, U. Bengtsson, and A. J. Tenner. 2000. Characterization of the murine homolog of C1qR(P): identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qR(P). Mol. Immunol. 37:377.
7. Dean, Y. D., E. P. McGreal, H. Akatsu, and P. Gasque. 2000. Molecular and cellular properties of the rat AA4 antigen, a C-type lectin-like receptor with structural homology to thrombomodulin. J. Biol. Chem. 275:34382.
8. Lovik, G., J. T. Vaage, E. Dissen, C. Szpirer, J. C. Ryan, and B. Rolstad. 2000. Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. Eur. J. Immunol. 30:3355.
9. McGreal, E. P., N. Ikewaki, H. Akatsu, B. P. Morgan, and P. Gasque. 2002. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J. Immunol. 168:5222.
10. Steinberger, P., A. Szekeres, S. Wille, J. Stockl, N. Selenko, E. Prager, G. Staffler, O. Madic, H. Stockinger, and W. Knapp. 2002. Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning. J. Leukocyte Biol. 71:133.
11. Nepomuceno, R. R., and A. J. Tenner. 1998. C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J. Immunol. 160:1929.
12. Webster, S. D., M. Park, M. I. Fonseca, and A. J. Tenner. 2000. Structural and functional evidence for microglial expression of C1qR(P), the C1q receptor that enhances phagocytosis. J. Leukocyte Biol. 67:109.
13. Petrenko, O., A. Beavis, M. Klaine, R. Kittappa, I. Godin, and I. R. Lemischka. 1999. The molecular characterization of the fetal stem cell marker AA4. Immunity 10:691.
14. Dean, Y. D., E. P. McGreal, and P. Gasque. 2001. Endothelial cells, megakaryoblasts, platelets and alveolar epithelial cells express abundant levels of the mouse AA4 antigen, a C-type lectin-like receptor involved in homing activities and innate immune host defense. Eur. J. Immunol. 31:1370.
15. Fonseca, M. I., P. M. Carpenter, M. Park, G. Palmarini, E. L. Nelson, and A. J. Tenner. 2001. C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J. Leukocyte Biol. 70:793.
16. Rolink, A. G., J. Andersson, and F. Melchers. 1998. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur. J. Immunol. 28:3738.
17. Shibata, T., T. Berney, L. Reininger, Y. Chicheportiche, S. Ozaki, T. Shirai, and S. Izui. 1990. Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. Int. Immunol. 2:1133.
18. Azeredo da Silveira, S., S. Kikuchi, L. Fossati-Jimack, T. Moll, T. Saito, J. S. Verbeek, M. Botto, M. J. Walport, M. Carroll, and S. Izui. 2002. Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J. Exp. Med. 195:665.
19. Thompson, R. D., K. E. Noble, K. Y. Larbi, A. Dewar, G. S. Duncan, T. W. Mak, and S. Nourshargh. 2001. Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. Blood 97:1854.
20. Taylor, P. R., A. Carugati, V. A. Fadok, H. T. Cook, M. Andrews, M. C. Carroll, J. S. Savill, P. M. Henson, M. Botto, and M. J. Walport. 2000. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J. Exp. Med. 192:359.
21. Bobak, D. A., M. M. Frank, and A. J. Tenner. 1988. C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes. Eur. J. Immunol. 18:2001.
22. Botto, M., C. Dell'Agnola, A. E. Bygrave, E. M. Thompson, H. T. Cook, F. Petry, M. Loos, P. P. Pandolfi, and M. J. Walport. 1998. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19:56.
23. Park, S. Y., H. Arase, K. Wakizaka, N. Hirayama, S. Masaki, S. Sato. J. V. Ravetch, and T. Saito. 1995. Differential contribution of the FcRγ chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcRγ-deficient mice. Eur. J. Immunol. 25:2107.
24. Ezekowitz, R. A., R. B. Sim, M. Hill, and S. Gordon. 1984. Local opsonization by secreted macrophage complement components: role of receptors for complement in uptake of zymosan. J. Exp. Med. 159:244.
25. Guan, E., S. L. Robinson, E. B. Goodman, and A. J. Tenner. 1994. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J. Immunol. 152:4005.
26. Korb, L. C., and J. M. Ahearn. 1997. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J. Immunol. 158:4525.
27. Nicholson-Weller, A., and L. B. Klickstein. 1999. C1q-binding proteins and C1q receptors. Curr. Opin. Immunol. 11:42.
28. Nauta, A. J., L. A. Trouw, M. R. Daha, O. Tijsma, R. Nieuwland, W. J. Schwaeble, A. R. Gingras, A. Mantovani, E. C. Hack, and A. Roos. 2002. Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur. J. Immunol. 32:1726.
29. Savill, J., and V. Fadok. 2000. Corpse clearance defines the meaning of cell death. Nature 407:784.
30. Fadok, V. A., D. L. Bratton, and P. M. Henson. 2001. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J. Clin. Invest. 108:957.
31. Platt, N., H. Suzuki, T. Kodama, and S. Gordon. 2000. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal. J. Immunol. 164:4861.
32. Ogden, C. A., A. deCathelineau, P. R. Hoffmann, D. Bratton, B. Ghebrehiwet, V. A. Fadok, and P. M. Henson. 2001. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 194:781.