Plasma CD93 concentration is a potential novel biomarker for coronary artery disease

Journal of Internal Medicine

Volumn 270, Issue 3, 2011, Pages 229-236

  Malarstig A ^a   Silveira, A ^a   Wagsater D ^a   Ohrvik J ^a   Backlund A ^a   Samnegard A ^a,b   Khademi, M ^a   Hellenius, M L ^a   Leander, K ^c   Olsson, T ^a   Uhlen M ^d   de Faire, U ^a,c   Eriksson, P ^a   Hamsten, A ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Department of Medicine ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

Atherosclerosis; Biomarker; CD93; Expression; Genetics; Myocardial infarction

Indexed keywords

BIOLOGICAL MARKER; CD93 ANTIGEN; MEMBRANE PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; CASE CONTROL STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HEART INFARCTION; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MYOCARDIAL INFARCTION; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PROLINE; PROSPECTIVE STUDIES; RECEPTORS, COMPLEMENT; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; SERINE;

EID: 80051575522     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2011.02364.x     Document Type: Article

References (26)

1. Shiffman D, Kane JP, Louie JZ et al. Analysis of 17, 576 potentially functional SNPs in three case-control studies of myocardial infarction. PLoS ONE 2008; 3: e2895.
2. van der Net JB, Oosterveer DM, Versmissen J et al. Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia. Eur Heart J 2008; 29: 2195-201.
3. Christian S, Ahorn H, Koehler A et al. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J Biol Chem 2001; 276: 7408-14.
4. Nepomuceno RR, Henschen-Edman AH, Burgess WH, Tenner AJ. cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro. Immunity 1997; 6: 119-29.
5. Guan EN, Burgess WH, Robinson SL, Goodman EB, McTigue KJ, Tenner AJ. Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosis. J Biol Chem 1991; 266: 20345-55.
6. Greenlee MC, Sullivan SA, Bohlson SS. Detection and characterization of soluble CD93 released during inflammation. Inflamm Res 2009; 58: 909-19.
7. Ikewaki N, Tamauchi H, Inoko H. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Microbiol Immunol 2007; 51: 1189-200.
8. Maruyama H, Galvan M, Waffarn F, Tenner AJ. Human cord blood leukocyte innate immune responses to defense collagens. Pediatr Res 2003; 54: 724-31.
9. Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J et al. Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol 2004; 172: 3406-14.
10. Bohlson SS, Silva R, Fonseca MI, Tenner AJ. CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma. J Immunol 2005; 175: 1239-47.
11. Fonseca MI, Carpenter PM, Park M, Palmarini G, Nelson EL, Tenner AJ. C1qR(P), a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue. J Leukoc Biol 2001; 70: 793-800.
12. Nepomuceno RR, Tenner AJ. C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets. J Immunol 1998; 160: 1929-35.
13. Samnegard A, Silveira A, Lundman P et al. Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction. J Intern Med 2005; 258: 411-9.
14. Carlsson AC, Wandell PE, de Faire U, Hellenius ML. Prevalence of hypertension in immigrants and Swedish-born individuals, a cross-sectional study of 60-year-old men and women in Sweden. J Hypertens 2008; 26: 2295-302.
15. de Faire USJ, Hua X, Frostegård A et al. Low levels of IgM antibodies to phosphorylcholine predict cardiovascular disease in 60-year old men: effects on uptake of oxidized LDL in macrophages as a potential mechanism. J Autoimmun 2010; 34: 73-9.
16. Lundmark F, Duvefelt K, Iacobaeus E et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007; 39: 1108-13.
17. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-75.
18. Greenlee MC, Sullivan SA, Bohlson SS. CD93 and related family members: their role in innate immunity. Curr Drug Targets 2008; 9: 130-8.
19. Schrijvers DM, De Meyer GR, Herman AG, Martinet W. Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability. Cardiovasc Res 2007; 73: 470-80.
20. Cui D, Thorp E, Li Y et al. Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells. J Leukoc Biol 2007; 82: 1040-50.
21. Newby AC. Metalloproteinases and vulnerable atherosclerotic plaques. Trends Cardiovasc Med 2007; 17: 253-8.
22. Lutgens SP, Cleutjens KB, Daemen MJ, Heeneman S. Cathepsin cysteine proteases in cardiovascular disease. FASEB J 2007; 21: 3029-41.
23. Shi GP, Sukhova GK, Grubb A et al. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 1999; 104: 1191-7.
24. Eriksson P, Deguchi H, Samnegard A et al. Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease. Arterioscler Thromb Vasc Biol 2004; 24: 551-7.
25. Fritsche LG, Loenhardt T, Janssen A et al. Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet 2008; 40: 892-6.
26. Wu M, Jolicoeur N, Li Z et al. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis 2008; 29: 1710-6.