Quantifying high-affinity binding of hydrophobic ligands by isothermal titration calorimetry

Analytical Chemistry

Volumn 84, Issue 24, 2012, Pages 10715-10722

  Krainer, Georg ^a,b,c   Broecker, Jana ^a   Vargas, Carolyn ^a   Fanghänel, Jörg ^d   Keller, Sandro ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d Bayer HealthCare Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AQUEOUS BUFFER; BINDING ENTHALPIES; BINDING THERMODYNAMICS; COMPOUND LIBRARIES; DILUTE MIXTURES; DISPLACEMENT ASSAY; DISSOCIATION CONSTANT; DRUG DISCOVERY; HIGH AFFINITY LIGANDS; HIGH CONCENTRATION; HYDROPHOBIC LIGAND; INTERMOLECULAR INTERACTIONS; ISOTHERMAL TITRATION CALORIMETRY; METAL-ION CHELATION; PROTEIN BINDING; QUANTITATIVE CHARACTERIZATION; RECEPTOR-LIGAND INTERACTIONS; SMALL MOLECULES; THERMODYNAMIC DESCRIPTION; WATER SOLUBLE COMPOUNDS;

BIOCHEMISTRY; CALORIMETERS; CALORIMETRY; DISSOCIATION; HYDROPHOBICITY; ISOTHERMS; METAL IONS; ORGANIC SOLVENTS; TITRATION;

LIGANDS;

CELL RECEPTOR; LIGAND;

ARTICLE; CALORIMETRY; CHEMICAL PHENOMENA; CHEMISTRY; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN BINDING;

CALORIMETRY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84871265987     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac3025575     Document Type: Article

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