A Novel Melanocortin-4 Receptor Mutation MC4R-P272L Associated with Severe Obesity Has Increased Propensity To Be Ubiquitinated in the ER in the Face of Correct Folding

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Granell, Susana ^a   Serra Juhé, Clara ^b   Martos Moreno, Gabriel Á ^c   Díaz, Francisca ^c   Pérez Jurado, Luis A ^b   Baldini, Giulia ^a   Argente, Jesús ^c,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CYCLIC AMP; MELANOCORTIN 4 RECEPTOR; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; INTRACELLULAR SIGNALING; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; MORBID OBESITY; NERVE CELL; ONSET AGE; PRESCHOOL CHILD; PROTEIN FOLDING; UBIQUITINATION; WILD TYPE;

ALLELES; CELL LINE; CHILD; CHILD, PRESCHOOL; CYCLIC AMP; DNA MUTATIONAL ANALYSIS; ENDOPLASMIC RETICULUM; FEMALE; GENE FREQUENCY; HUMANS; MALE; MUTATION; OBESITY; PROTEIN FOLDING; RECEPTOR, MELANOCORTIN, TYPE 4; TRANSFECTION; UBIQUITIN; UBIQUITINATION;

EID: 84871226608     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050894     Document Type: Article

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