Draize eye scores and eye irritation thresholds in man can be combined into one QSAR

Annals of the New York Academy of Sciences

Volumn 855, Issue , 1998, Pages 652-656

  Abraham, Michael H ^a   Kumarsingh, Rachel ^a   Cometto Muñiz, J Enrique ^b   Cain, William S ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEXADECANE;

ACIDITY; ATMOSPHERE; CONFERENCE PAPER; EYE IRRITATION; GAS; HYDROGEN BOND; PARTITION COEFFICIENT; PREDICTION; PRESSURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SCORING SYSTEM; SOLVATION; VAPOR;

EID: 0032461890     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10641.x     Document Type: Conference Paper

References (6)

1. 1. Abraham, M. H. et al. 1996. An analysis of nasal irritation thresholds using a new solvation equation. Fund. Appl. Toxicol. 31: 71-76.
2. 2. Cronin, M. T. D., D. A. Basketter & M. York. 1994. A quantitative structure-activity relationship (QSAR) investigation of a Draize eye irritation database. Toxicol. in Vitro 8: 21-28.
3. 3. Cometto-Muñiz, J. E. & W. S. Cain. 1995. Relative sensitivity of the ocular trigeminal, nasal trigeminal, and olfactory systems to airborne chemicals. Chem. Senses 20: 191-198.
4. 4. Abraham, M. H. 1994. Scales of solute hydrogen-bonding: Their construction and application to physicochemical and biochemical processes. Chem. Soc. Rev. 22: 73-83.
5. 5. Balls, M. et al. 1995. The EC/HO international validation study on alternatives to the Draize eye irritation test. Toxicol. in Vitro 9: 871-929.
6. 6. Cometto-Muñiz, J. E. et al. 1997. Sensory properties of selected terpenes: Threshold for odor, nasal pungency, nasal localization, and eye irritation. This volume.