Structure-based design of potent and selective CK1γ inhibitors

ACS Medicinal Chemistry Letters

Volumn 3, Issue 12, 2012, Pages 1059-1064

  Huang, Hongbing ^a   Acquaviva, Lisa ^a   Berry, Virginia ^a   Bregman, Howard ^a   Chakka, Nagasree ^a   O'Connor, Anne ^a   Dimauro, Erin F ^a   Dovey, Jennifer ^a   Epstein, Oleg ^a   Grubinska, Barbara ^a   Goldstein, Jon ^a   Gunaydin, Hakan ^a   Hua, Zihao ^a   Huang, Xin ^a   Huang, Liyue ^a   Human, Jason ^a   Long, Alex ^a   Newcomb, John ^a   Patel, Vinod F ^a,b   Saffran, Doug ^a   Serafino, Randy ^a   Schneider, Steve ^a   Strathdee, Craig ^a   Tang, Jin ^a   Turci, Susan ^a   White, Ryan ^a   Yu, Violeta ^a   Zhao, Huilin ^a   Wilson, Cindy ^a   Martin, Matthew W ^a   more..

^a AMGEN INC   (United States)

^b Sanofi Aventis   (United States)

Author keywords

cancer; CK1?; pyridyl pyrrolopyridinone; Wnt pathway

Indexed keywords

CASEIN KINASE 1 GAMMA; CASEIN KINASE 1 GAMMA INHIBITOR; CASEIN KINASE I; DOXYCYCLINE; ISOENZYME; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; WNT PROTEIN;

AREA UNDER THE CURVE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TUMOR MODEL;

EID: 84871207557     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300278f     Document Type: Article

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