Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin

Archives of Toxicology

Volumn 86, Issue 12, 2012, Pages 1851-1859

  Val, Stéphanie ^a   Belade, Esther ^b,c   George, Isabelle ^a   Boczkowski, Jorge ^b,c,d,e   Baeza Squiban, Armelle ^a  

^a Groupe Hospitalier Pitié Salpêtrière   (France)

^b INSERM   (France)

^c FACULTÉ DE MÉDECINE   (France)

^d CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

^e HENRI MONDOR HOSPITAL   (France)

Author keywords

Atmospheric particle; EGFR pathway; Lung; Mucin; Pro inflammatory cytokine

Indexed keywords

AMPHIREGULIN; AMPHIREGULIN ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; INTERLEUKIN 8; MESSENGER RNA; METALLOPROTEINASE INHIBITOR; MUCIN 5AC; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; BRONCHUS MUCOSA; CONTROLLED STUDY; CULTURE MEDIUM; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUSPENDED PARTICULATE MATTER; TRACHEA; URBAN AREA;

ANIMALS; AUTOCRINE COMMUNICATION; CELL LINE; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GLYCOPROTEINS; INJECTIONS, SPINAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-8; LUNG; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MUCIN 5AC; PARTICLE SIZE; PARTICULATE MATTER; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA;

MUS;

EID: 84871195734     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0903-6     Document Type: Article

References (30)

1. Auger F, Gendron MC, Chamot C, Marano F, Dazy AC (2006) Responses of well-differentiated nasal epithelial cells exposed to particles: role of the epithelium in airway inflammation. Toxicol Appl Pharmacol 215(3):285-294.
2. Baulig A, Poirault JJ, Ausset P, Schins R, Shi T, Baralle D, Dorlhene P, Meyer M, Lefevre R, Baeza-Squiban A, Marano F (2004) Physicochemical characteristics and biological activities of seasonal atmospheric particulate matter sampling in two locations of Paris. Environ Sci Technol 38(22):5985-5992.
3. Blanchet S, Ramgolam K, Baulig A, Marano F, Baeza-Squiban A (2004) Fine particulate matter induces amphiregulin secretion by bronchial epithelial cells. Am J Respir Cell Mol Biol 30(4): 421-427.
4. Bonner JC (2002) The epidermal growth factor receptor at the crossroads of airway remodeling. Am J Physiol Lung Cell Mol Physiol 283(3):L528-L530.
5. Burgel PR, Nadel JA (2008) Epidermal growth factor receptormediated innate immune responses and their roles in airway diseases. Eur Respir J 32(4):1068-1081.
6. Churg A, Brauer M, Avila-Casado MD, Fortoul TI, Wright JL (2003) Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 111(5):714-718.
7. de Boer WI, Hau CM, van Schadewijk A, Stolk J, van Krieken JH, Hiemstra PS (2006) Expression of epidermal growth factors and their receptors in the bronchial epithelium of subjects with chronic obstructive pulmonary disease. Am J Clin Pathol 125(2): 184-192.
8. Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y (2009) Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack. J Allergy Clin Immunol 124(5): 913-920.e911-917.
9. Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E (2004) Effects of concentrated ambient particles on normal and hypersecretory airways in rats. Res Rep Health Eff Inst 120:1-68; (discussion 69-79).
10. Kim KW, Jee HM, Park YH, Choi BS, Sohn MH, Kim KE (2009) Relationship between amphiregulin and airway inflammation in children with asthma and eosinophilic bronchitis. Chest 136(3): 805-810.
11. Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK (2011) Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol 300(3):L414-L421.
12. Li N, Hao M, Phalen R, Hinds W, Nel A (2003) Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol 109(3): 250-265.
13. Longphre M, Li D, Li J, Matovinovic E, Gallup M, Samet JM, Basbaum CB (2000) Lung mucin production is stimulated by the air pollutant residual oil fly ash. Toxicol Appl Pharmacol 162(2): 86-92.
14. Mazzoli-Rocha F, Fernandes S, Einicker-Lamas M, Zin W (2010) Roles of oxidative stress in signaling and inflammation induced by particulate matter. Cell Biol Toxicol 26(5):481-498.
15. Newland N, Richter A (2008) Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells. Toxicol in Vitro 22(7):1782-1788.
16. Pope CA, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, Thun MJ (2009) Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 120(11):941-948.
17. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE (2000) Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 14(10):1362-1374.
18. Ramgolam K, Hamel R, Rumelhard M, Marano F, Baeza-Squiban A (2012) Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells. Arch Toxicol.
19. Robinson CL, Baumann LM, Romero K, Combe JM, Gomez A, Gilman RH, Cabrera L, Gonzalvez G, Hansel NN, Wise RA, Barnes KC, Breysse PN, Checkley W (2011) Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting. Thorax 66(12):1051-1057.
20. Rogers DF (2007) Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 52(9):1134-1146; (discussion 1146-1139).
21. Rumelhard M, Ramgolam K, Auger F, Dazy AC, Blanchet S, Marano F, Baeza-Squiban A (2007a) Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells. Toxicol Lett 168(2):155-164.
22. Rumelhard M, Ramgolam K, Hamel R, Marano F, Baeza-Squiban A (2007b) Expression and role of EGFR ligands induced in airway cells by PM2.5 and its components. Eur Respir J 30(6): 1064-1073.
23. Shao MX, Nadel JA (2005) Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNFalpha- converting enzyme. J Immunol 175(6):4009-4016.
24. Shao MX, Ueki IF, Nadel JA (2003) Tumor necrosis factor alphaconverting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci USA 100(20):11618-11623.
25. Shao MX, Nakanaga T, Nadel JA (2004) Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alphaconverting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol 287(2):L420-L427.
26. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA (1999) Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 96(6):3081-3086.
27. Val S, Martinon L, Cachier H, Yahyaoui A, Marfaing H, Baeza- Squiban A (2011) Role of size and composition of traffic and agricultural aerosols in the molecular responses triggered in airway epithelial cells. Inhal Toxicol 23(11):627-640.
28. Vestbo J (2005) Chronic mucus hypersecretion, exacerbations and natural history of COPD. Exp Lung Res 31(Suppl 1):63-65.
29. Yoshizaki K, Brito JM, Toledo AC, Nakagawa NK, Piccin VS, Junqueira MS, Negri EM, Carvalho AL, Oliveira AP, Lima WT, Saldiva PH, Mauad T, Macchione M (2010) Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice. Inhal Toxicol 22(7):610-617.
30. Yoshizaki K, Brito JM, Toledo AC, Nakagawa NK, Piccin VS, Junqueira MS, Negri EM, Carvalho AL, Oliveira AP, Lima WT, Saldiva PH, Mauad T, Macchione M (2010) Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice. Inhal Toxicol 22(7):610-617.