Subchronic effects of nasally instilled diesel exhaust particulates on the nasal and airway epithelia in mice

Inhalation Toxicology

Volumn 22, Issue 7, 2010, Pages 610-617

  Yoshizaki, K ^a   Brito, J M ^a   Toledo, A C ^a   Nakagawa, N K ^a   Piccin, V S ^a   Junqueira, M S ^a   Negri, E M ^a   Carvalho, A L N ^a   Ligeiro De Oliveira, A P ^a   Tavares De Lima, W ^a   Saldiva, P H N ^a   Mauad, T ^a   Macchione, Mariangela ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Air pollution; Diesel exhaust particulate; Hyperplasia; Interleukins; Lung; Muc5ac; Mucus; Nose epithelium

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; MUCIN 5AC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; GENE EXPRESSION PROFILING; LEUKOCYTE COUNT; LONG TERM EXPOSURE; LUNG LAVAGE; LYMPHOCYTE COUNT; MACROPHAGE; MALE; MOUSE; MUCUS SECRETION; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION;

ADMINISTRATION, INTRANASAL; AIR POLLUTANTS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; INFLAMMATION; INHALATION EXPOSURE; LUNG; MALE; MICE; MICE, INBRED BALB C; PARTICULATE MATTER; RESPIRATORY MUCOSA; VEHICLE EMISSIONS;

ANIMALIA; MUS;

EID: 77952831493     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958371003621633     Document Type: Article

References (46)

1. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, Boumghar A, Forastiere F, Forsberg B, Touloumi G, Schwartz J, Katsouyanni K. 2001. Acute effects of particulate air pollution on respiratory admissions: Results from APHEA 2 project. Air pollution and health: A European approach. Am J Respir Crit Care Med 164:1860-1866.
2. Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, Wilson SJ, Boman C, Cassee FR, Frew AJ, Kelly FJ, Sandstrom T, Blomberg A. 2006 Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J 27:359-365.
3. CETESB (Companhia de Tecnologia de Saneamento Ambiental). 2008. Relatório de qualidade do ar do estado de São Paulo 2008. Série Relatório- Secretaria do Estado do Meio Ambiente. São Paulo: CETESB. Available at: http//:www.cetesb.sp.gov.br/AR.
4. Clarke RW, Catalano PJ, Koutrakis P, Krishna Murthy CG, Sioutas C, Paulaskis J, Coull B, Ferguson S, Godleski JJ. 1999. Urban air particulate inhalation alters pulmonary function and induces pulmonary inflammation in a rodent model of chronic bronchitis. Inhal Toxicol 11:637-656.
5. de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT. 2007. Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am J Physiol Cell Physiol 293:C1120-C1128.
6. Devouassoux G, Brambilla C. 2002. Effect of diesel particles on allergic inflammatory response: Cellular targets and molecular mechanisms [review, in French]. Rev Mal Respir 19:467-479.
7. Diaz-Sanchez D, Tsien A, Casillas A, Dotson A, Saxon A. 1996. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J Allergy Clin Immunol 98:114-123.
8. Dockery DW, Pope CA III, Xu X, Spengler JD, Ware JH, Fay ME, Ferris BG Jr, Speizer FE. 1993. An association between air pollution and mortality in six US cities. N Engl J Med 329:1753-1759.
9. Hashimoto KI, Ishii Y, Uchida Y, Kimura T, Masuyama K, Morishima Y, Hirano K, Nomura A, Sakamoto T, Takano H, Sagai M, Sekizawa K. 2001. Exposure to diesel exhaust exacerbates allergen-induce airway responses in guinea pigs. Am J Respir Crit Care Med 164:1957-1963.
10. Henderson RF, Pickrell JA, Jones RK, Sun JD, Benson JM, Mauderly JL, Mcclellan RO. 1988. Response of rodents to inhaled diluted diesel exhaust: Biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue. Fundam Appl Toxicol 11:546-567.
11. Herbert RA, Leininger JR. 1999. Nose larynx and trachea. In: Maronpot RR, ed. Pathology of the Mouse: Reference and Atlas. Vienna, IL:Cache River Press, pp. 259-292.
12. Hyde DM, Ploper CG, Weir AJ. 1985. Peribronchial fibrosis in lung of cats chronically exposed to diesel exhaust. Lab Invest 52:195-206.
13. Hiura TS, Kaszubowski MP, Li N, Nel AE. 1999. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol 163:5582-5591.
14. Inoue KI, Takano T, Ichinose T, Tomura S, Yanagisawa R, Sakurai M, Sumi D, Cho AK, Hiyoshi K, Kumagai Y. 2007. Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice. Arch Toxicol 81:575-581.
15. Jaspers I, Sheridan PA, Zhang W, Brighton LE, Chason KD, Hua X, Tilley SL. 2009. Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection. Part Fibre Toxicol 6:22-32.
16. Jones R, Reid L. 1978. Secretory cells and their glycoproteins in health and disease. Br Med Bull 34:9-16.
17. Kampa M Castanas E. 2008. Human health effects of air pollution. Environ Pollut 151(2):362-367.
18. Kobayashi T, Ikeue T, Ikeda A. 1998. Four-week exposure to diesel exhaust induces nasal mucosal hyperresponsiveness to histamine in guinea pigs. Toxicol Sci 45:106-112.
19. Knowles MR, Boucher RC. 2002 Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109:571-577.
20. Laks D, Oliveira RC, André PA, Macchione M, Lemos M, Faffe D, Saldiva PHN, Zin WA. 2008. Composition of diesel particles influences acute pulmonary toxicity: Na experimental study in mice. Inhal Toxicol 20:1037-1042.
21. Lankford SM, Macchione M, Crews AL, McKane SA, Akley NJ, Martin LD. 2005. Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells. In Vitro Cell Dev Biol Anim 41:217-224.
22. Lehmann AD, Blank F, Baum O, Gehr P, Rothen-Rutishauser BM. 2009. Diesel exhaust particles modulate the tight junction protein occluding in lung cells in vitro. Part Fibre Toxicol 1:26-39.
23. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. 2003. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol 109:250-265.
24. Li R, Meng Z. 2007. Effects of SO2 derivatives on expressions of MUC5AC and IL-13 in human bronchial epithelial cells. Arch Toxicol 81:867-874. (Pubitemid 350198002)
25. Liang F, Lu M, Birch EB, Keener TC, Liu Z. 2006. Determination of polycyclic aromatic sulfur heterocycles in diesel particulate matter and diesel fuel by gas chromatography with atomic emission detection. J Chromatogr A 1114:145-153.
26. Maatz LF, Wood GJA, Rivero DHRF, Saldiva PHN. 2009. Tracheal instillation of urban PM2.5 suspension promotes acute cardiac polarization changes in rats. Br J Med Biol Res 42:207-213.
27. Nightingale J, Maggs R, Cullinan P, Donnelly LE, Rogers FD, Kinnersley R, Chung KF, Barnes PJ, Ashmore M, Newman-Taylor A. 2000. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med 162:161-166.
28. Pires-Neto RC, Lichtenfels AJ, Soares SR, Macchione M, Saldiva PHN, Dolhnikoff M. 2006. Effects of São Paulo air pollution on the upper airways of mice. Environ Res 101:356-361.
29. Pope CA III, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. 2004. Cardiovascular mortality and long-term exposure to particulate air pollution: Epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71-77.
30. Pourazar J, Frew AJ, Blomberg A, Helleday R, Kelly FJ, Wilson S, Sandstrom T. 2004. Diesel exhaust exposure enhances the expression of IL-13 in the bronchial epithelium of healthy subjects. Respir Med 98:821-825.
31. Riedl M, Diaz-Sanches D. 2005. Biology of diesel exhaust effects on respiratory function. J Allergy Clin Immunol 115:221-228.
32. Rogers DF. 2003 The airway goblet cell. Int J Biochem Cell Biol 35:1-6.
33. Rudell B, Blomberg A, Helleday R, Ledin MC, Lundback B, Stjernberg N, Horstedt P, Sandstrom T. 1999. Bronchoalveolar inflammation after exposure to diesel exhaust: Comparison between unfiltered and particle trap filtered exhaust. Occup Environ Med 56:527-534.
34. Sagai M, Furuyama A, Ichinose T. 1996. Biological effects of diesel exhaust particles (DEP), III: Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med 21:199-209.
35. Saldiva PHN, King M, Delmonte VLC, Macchione M, Parada MAC, Daliberto ML, Sakae RS, Criado PMP, Silveira PLP, Zin WA, Bohm GM. 1992. Respiratory alterations due to urban air pollution: An experimental study in rats. Environ Res 57:19-33.
36. Saldiva PH, Künzli N, Lippmann M. 2005. Ozone. In: WHO Regional Office for Europe: Air Quality Guidelines. 11:307-326.
37. Salvi S, Blomber A, Rudell B, Kelly F, Sandtrom T, Holgate ST, Frew A. 1999. Acute inflammatory responses in the airway and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702-709.
38. Sato H, Onose J, Toyoda H, Toida T, Imanari T, Sagai M, Nishimura N, Aoki Y. 2001. Quantitative changes in glycosaminoglycans in the lungs of rats exposed to diesel exhaust. Toxicology 166:119-128. (Pubitemid 32822793)
39. Schwartz J. 1994. What are the people dying of on high air pollution days? Environ Res 64:26-35.
40. Sydbom A, Blomberg A, Parnia S, Stenfors N, Sandstrom T, Dahlén S-E. 2001. Health effects of diesel exhaust emissions. Eur Respir J 17:733-746.
41. Takizawa H. 1998. Airway epithelial cells as regulator of airway inflammation. Int J Mol Med 1:367-378.
42. Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, Sagai M. 1997. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med 156:36-42.
43. Weibel ER, 1990. Morphometry: Stereological theory and practical methods. In: Gil J, ed. Models of Lung Disease, 1st ed. New York: Dekker, 199-252.
44. Wolff RK. 1986. Effects of airborne pollutants on mucociliary clearance. Environ Health Perspect 66:223-237.
45. Xia T, Korge P, Weiss JN, Li N, Venkatesen MI, Sioutas C, Nel A. 2004. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: Implications for ultrafine particle toxicity. Environ Health Perspect 112:1347-1358.
46. Zhao H, Ma JK, Barger MW, Mercer RR, Millecchia L, Schwegler-Berry D, Castranova V, Ma JY. 2009. Reactive oxygen species- and nitric oxide-mediated lunginflammation and mitochondrial dysfunction in wild-type and iNOS-deficient mice exposed to diesel exhaust particles. J Toxicol Environ Health A 72:560-570.