Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4α transcriptional activity

Biochemical Journal

Volumn 394, Issue 2, 2006, Pages 379-387

  Guo, Hongtao ^a   Gao, Chengjiang ^a   Mi, Zhiyong ^a   Wai, Philip Y ^a   Kuo, Paul C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hepatocyte nuclear factor 4 ; Inducible nitric oxide synthase (iNOS); Inflammatory redox; Oxidative stress; p38 mitogen activated protein kinase (MAPK); Phosphorylation

Indexed keywords

DNA; ENZYME KINETICS;

HEPATOCYTE NUCLEAR FACTORΑ; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INFLAMMATORY REDOX; OXIDATIVE STRESS;

NITROGEN OXIDES;

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHOPEPTIDE; PROTEIN KINASE C INHIBITOR; SERINE; THREONINE; TRANSCRIPTION FACTOR; DNA; HEPATOCYTE NUCLEAR FACTOR 4; HNF4A PROTEIN, HUMAN; INTERLEUKIN 1; PHOSPHOSERINE;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LIVER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CERCOPITHECUS; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; UPREGULATION;

ANIMALIA;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; HYDROGEN PEROXIDE; INFLAMMATION; INTERLEUKIN-1; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 33644773582     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051730     Document Type: Article

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