-
1
-
-
67650511055
-
Considerations in sirolimus use in the early and late post-transplant periods
-
Patel SJ, Elliott EN, Knight RJ, Gaber LW, Gaber AO. Considerations in sirolimus use in the early and late post-transplant periods. Expert Opin Drug Saf 2009;8:421-34.
-
(2009)
Expert Opin Drug Saf
, vol.8
, pp. 421-434
-
-
Patel, S.J.1
Elliott, E.N.2
Knight, R.J.3
Gaber, L.W.4
Gaber, A.O.5
-
2
-
-
57449111076
-
mTOR pathway and mTOR inhibitors as agents for cancer therapy
-
Baldo P, Cecco S, Giacomin E, Lazzarini R, Ros B, Marastoni S. mTOR pathway and mTOR inhibitors as agents for cancer therapy. Curr Cancer Drug Targets 2008;8:647-65.
-
(2008)
Curr Cancer Drug Targets
, vol.8
, pp. 647-665
-
-
Baldo, P.1
Cecco, S.2
Giacomin, E.3
Lazzarini, R.4
Ros, B.5
Marastoni, S.6
-
3
-
-
73849101809
-
Key factors in mTOR regulation
-
Bai X, Jiang Y. Key factors in mTOR regulation. Cell Mol Life Sci 2010;67:239-53.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 239-253
-
-
Bai, X.1
Jiang, Y.2
-
4
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253-62.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
5
-
-
33745242315
-
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D, Desideri M, Cognetti F, Zupi G et al. Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006;66:5549-54.
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
-
7
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004;22:2954-63.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
8
-
-
33750072949
-
mTOR and cancer therapy
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006;25:6436-46.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
9
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, Logan TF, Dutcher JP, Hudes GR et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-18.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
Logan, T.F.4
Dutcher, J.P.5
Hudes, G.R.6
-
10
-
-
23944439945
-
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
Chan S, Scheulen ME, Johnston S, Mross K, Cardoso F, Dittrich C et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005;23:5314-22.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
Mross, K.4
Cardoso, F.5
Dittrich, C.6
-
11
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
12
-
-
77956839364
-
Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium
-
Hainsworth JD, Infante JR, Spigel DR, Peyton JD, Thompson DS, Lane CM et al. Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium. Cancer 2010;116:4122-9.
-
(2010)
Cancer
, vol.116
, pp. 4122-4129
-
-
Hainsworth, J.D.1
Infante, J.R.2
Spigel, D.R.3
Peyton, J.D.4
Thompson, D.S.5
Lane, C.M.6
-
13
-
-
77953100029
-
A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer
-
Armstrong AJ, Netto GJ, Rudek MA, Halabi S, Wood DP, Creel PA et al. A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer. Clin Cancer Res 2010;16:3057-66.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3057-3066
-
-
Armstrong, A.J.1
Netto, G.J.2
Rudek, M.A.3
Halabi, S.4
Wood, D.P.5
Creel, P.A.6
-
14
-
-
77951559617
-
A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma
-
Johnston PB, Inwards DJ, Colgan JP, Laplant BR, Kabat BF, Habermann TM et al. A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma. Am J Hematol 2010;85:320-4.
-
(2010)
Am J Hematol
, vol.85
, pp. 320-324
-
-
Johnston, P.B.1
Inwards, D.J.2
Colgan, J.P.3
Laplant, B.R.4
Kabat, B.F.5
Habermann, T.M.6
-
16
-
-
34548700597
-
Rapamycin: something old, something new, sometimes borrowed and now renewed
-
Hartford CM, Ratain MJ. Rapamycin: something old, something new, sometimes borrowed and now renewed. Clin Pharmacol Ther 2007;82:381-8.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 381-388
-
-
Hartford, C.M.1
Ratain, M.J.2
-
17
-
-
38649092279
-
Tuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779
-
Messina MP, Rauktys A, Lee L, Dabora SL. Tuberous sclerosis preclinical studies: timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779. BMC Pharmacol 2007;7:14.
-
(2007)
BMC Pharmacol
, vol.7
, pp. 14
-
-
Messina, M.P.1
Rauktys, A.2
Lee, L.3
Dabora, S.L.4
-
18
-
-
58149186098
-
Pilot study of rapamycin in patients with hormone-refractory prostate cancer
-
Amato RJ, Jac J, Mohammad T, Saxena S. Pilot study of rapamycin in patients with hormone-refractory prostate cancer. Clin Genitourin Cancer 2008;6:97-102.
-
(2008)
Clin Genitourin Cancer
, vol.6
, pp. 97-102
-
-
Amato, R.J.1
Jac, J.2
Mohammad, T.3
Saxena, S.4
-
19
-
-
34548076410
-
In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites
-
Cai P, Tsao R, Ruppen ME. In vitro metabolic study of temsirolimus: preparation, isolation, and identification of the metabolites. Drug Metab Dispos 2007;35:1554-63.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1554-1563
-
-
Cai, P.1
Tsao, R.2
Ruppen, M.E.3
-
20
-
-
84871111017
-
-
A phase II study of RAD001 in men with hormone-refractory metastatic prostate cancer (HRPC). 2008 Genitourinary Cancers Symposium. Abstract 181.
-
George DJ, Armstrong AJ, Creel P, Morris K, Madden J, Turnbullet J et al. A phase II study of RAD001 in men with hormone-refractory metastatic prostate cancer (HRPC). 2008 Genitourinary Cancers Symposium. Abstract 181.
-
-
-
George, D.J.1
Armstrong, A.J.2
Creel, P.3
Morris, K.4
Madden, J.5
Turnbullet, J.6
-
21
-
-
0020638814
-
LNCaP model of human prostatic carcinoma
-
Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM et al. LNCaP model of human prostatic carcinoma. Cancer Res 1983;43:1809-18.
-
(1983)
Cancer Res
, vol.43
, pp. 1809-1818
-
-
Horoszewicz, J.S.1
Leong, S.S.2
Kawinski, E.3
Karr, J.P.4
Rosenthal, H.5
Chu, T.M.6
-
22
-
-
0034699378
-
Detection of dead cells and measurement of cell killing by flow cytometry
-
King MA. Detection of dead cells and measurement of cell killing by flow cytometry. J Immunol Methods 2000;243:155-66.
-
(2000)
J Immunol Methods
, vol.243
, pp. 155-166
-
-
King, M.A.1
-
23
-
-
0024308082
-
Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number
-
Ross DD, Joneckis CC, Ordóñez JV, Sisk AM, Wu RK, Hamburger AW et al. Estimation of cell survival by flow cytometric quantification of fluorescein diacetate/propidium iodide viable cell number. Cancer Res 1989;49:3776-82.
-
(1989)
Cancer Res
, vol.49
, pp. 3776-3782
-
-
Ross, D.D.1
Joneckis, C.C.2
Ordóñez, J.V.3
Sisk, A.M.4
Wu, R.K.5
Hamburger, A.W.6
-
25
-
-
45949105919
-
Measurement of apoptosis and other forms of cell death
-
Chapter 3:Unit 3.17
-
Muppidi J, Porter M, Siegel RM. Measurement of apoptosis and other forms of cell death. Curr Protoc Immunol 2004; Chapter 3:Unit 3.17
-
(2004)
Curr Protoc Immunol
-
-
Muppidi, J.1
Porter, M.2
Siegel, R.M.3
-
26
-
-
0003544950
-
-
4th edn. Wiley-Liss, New York, Chapter 10.2.
-
Shapiro HM. Practical Flow Cytometry, 4th edn. Wiley-Liss, New York, 2003; Chapter 10.2.
-
(2003)
Practical Flow Cytometry
-
-
Shapiro, H.M.1
-
27
-
-
77950517076
-
Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO
-
Mijatovic S, Maksimovic-Ivanic D, Timotijevic G, Miljkovic D, Donia M, Libra M et al. Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO. Free Radic Biol Med 2010;48:1090-9.
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 1090-1099
-
-
Mijatovic, S.1
Maksimovic-Ivanic, D.2
Timotijevic, G.3
Miljkovic, D.4
Donia, M.5
Libra, M.6
-
28
-
-
66849109073
-
The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt
-
Maksimovic-Ivanic D, Mijatovic S, Miljkovic D, Harhaji-Trajkovic L, Timotijevic G, Mojic M et al. The antitumor properties of a nontoxic, nitric oxide-modified version of saquinavir are independent of Akt. Mol Cancer Ther 2009;8:1169-78.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1169-1178
-
-
Maksimovic-Ivanic, D.1
Mijatovic, S.2
Miljkovic, D.3
Harhaji-Trajkovic, L.4
Timotijevic, G.5
Mojic, M.6
-
29
-
-
47149104693
-
Novel nitric oxide-donating compound (S, R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells
-
Mijatovic S, Maksimovic-Ivanic D, Mojic M, Malaponte G, Libra M, Cardile V et al. Novel nitric oxide-donating compound (S, R)-3-phenyl-4, 5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells. Nitric Oxide 2008;19:177-83.
-
(2008)
Nitric Oxide
, vol.19
, pp. 177-183
-
-
Mijatovic, S.1
Maksimovic-Ivanic, D.2
Mojic, M.3
Malaponte, G.4
Libra, M.5
Cardile, V.6
-
30
-
-
67549086078
-
The novel NO-donating compound GIT-27NO inhibits in vivo growth of human prostate cancer cells and prevents murine immunoinflammatory hepatitis
-
Donia M, Mijatovic S, Maksimovic-Ivanic D, Miljkovic D, Mangano K, Tumino S et al. The novel NO-donating compound GIT-27NO inhibits in vivo growth of human prostate cancer cells and prevents murine immunoinflammatory hepatitis. Eur J Pharmacol 2009;615:228-33.
-
(2009)
Eur J Pharmacol
, vol.615
, pp. 228-233
-
-
Donia, M.1
Mijatovic, S.2
Maksimovic-Ivanic, D.3
Miljkovic, D.4
Mangano, K.5
Tumino, S.6
-
31
-
-
0028262128
-
Determination of lymphocyte division by flow cytometry
-
Lyons AB, Parish CR. Determination of lymphocyte division by flow cytometry. J Immunol Methods 1994;171:131-7.
-
(1994)
J Immunol Methods
, vol.171
, pp. 131-137
-
-
Lyons, A.B.1
Parish, C.R.2
-
32
-
-
41649090964
-
Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo
-
Maksimovic-Ivanic D, Mijatovic S, Harhaji L, Miljkovic D, Dabideen D, Fan Cheng K et al. Anticancer properties of the novel nitric oxide-donating compound (S, R)-3-phenyl-4, 5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo. Mol Cancer Ther 2008;7:510-20.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 510-520
-
-
Maksimovic-Ivanic, D.1
Mijatovic, S.2
Harhaji, L.3
Miljkovic, D.4
Dabideen, D.5
Fan Cheng, K.6
-
33
-
-
9644268056
-
Heterogeneous cell response to topotecan in a CFSE-based proliferation test
-
Matera G, Lupi M, Ubezio P. Heterogeneous cell response to topotecan in a CFSE-based proliferation test. Cytometry A 2004;62:118-28.
-
(2004)
Cytometry A
, vol.62
, pp. 118-128
-
-
Matera, G.1
Lupi, M.2
Ubezio, P.3
-
34
-
-
37649024139
-
Antiproliferative activity of cisplatin detected by CFSE in p53-proficient and p53-deficient cells
-
Ubezio P, Lupi M, Matera G. Antiproliferative activity of cisplatin detected by CFSE in p53-proficient and p53-deficient cells. Immunol Invest 2007;36:847-59.
-
(2007)
Immunol Invest
, vol.36
, pp. 847-859
-
-
Ubezio, P.1
Lupi, M.2
Matera, G.3
-
35
-
-
72149105604
-
Comparison of temsirolimus pharmacokinetics in patients with renal cell carcinoma not receiving dialysis and those receiving hemodialysis: a case series
-
Lunardi G, Armirotti A, Nicodemo M, Cavallini L, Damonte G, Vannozzi MO et al. Comparison of temsirolimus pharmacokinetics in patients with renal cell carcinoma not receiving dialysis and those receiving hemodialysis: a case series. Clin Ther 2009;31:1812-9.
-
(2009)
Clin Ther
, vol.31
, pp. 1812-1819
-
-
Lunardi, G.1
Armirotti, A.2
Nicodemo, M.3
Cavallini, L.4
Damonte, G.5
Vannozzi, M.O.6
-
36
-
-
53849125004
-
mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work?
-
Le Tourneau C, Faivre S, Serova M, Raymond E. mTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br J Cancer 2008;99:1197-203.
-
(2008)
Br J Cancer
, vol.99
, pp. 1197-1203
-
-
Le Tourneau, C.1
Faivre, S.2
Serova, M.3
Raymond, E.4
-
37
-
-
37549070324
-
Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma
-
North American Brain Tumor Consortium and the National Cancer Institute.
-
Kuhn JG, Chang SM, Wen PY, Cloughesy TF, Greenberg H, Schiff D et al. North American Brain Tumor Consortium and the National Cancer Institute. Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma. Clin Cancer Res 2007;13:7401-6.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7401-7406
-
-
Kuhn, J.G.1
Chang, S.M.2
Wen, P.Y.3
Cloughesy, T.F.4
Greenberg, H.5
Schiff, D.6
-
38
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond E, Alexandre J, Faivre S, Vera K, Materman E, Boni J et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004;22:2336-47.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
-
39
-
-
34147146014
-
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
-
Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C et al. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 2007;109:3509-12.
-
(2007)
Blood
, vol.109
, pp. 3509-3512
-
-
Zeng, Z.1
Sarbassov dos, D.2
Samudio, I.J.3
Yee, K.W.4
Munsell, M.F.5
Ellen Jackson, C.6
-
40
-
-
38649121421
-
mTOR: the mammalian target of replication
-
Cohen EE. mTOR: the mammalian target of replication. J Clin Oncol 2008;26:348-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 348-349
-
-
Cohen, E.E.1
|