The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 43116-43125

  Gang, Toh B ^a   Hammond, David J ^a   Singh, Sanjay K ^a   Ferguson, Donald A ^a   Mishra, Vinod K ^b   Agrawal, Alok ^a  

^a East Tennessee State University   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; MAMMALS; PROTEINS;

BINDING POCKETS; C-REACTIVE PROTEINS; COMPLEMENT SYSTEMS; PHOSPHOCHOLINE; PHOSPHOETHANOLAMINE; PNEUMOCOCCAL CELLS; PROTEIN BINDS; PROTEIN MUTANTS; STREPTOCOCCUS PNEUMONIAE; WILD TYPES;

AFFINITY CHROMATOGRAPHY;

C REACTIVE PROTEIN; PHOSPHORYLCHOLINE; SEPHAROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTEREMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; INFECTION PREVENTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS INHIBITION; WILD TYPE;

EID: 84871139320     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427310     Document Type: Article

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