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Volumn 7, Issue 4, 2012, Pages

FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; OVALBUMIN; FC RECEPTOR; FC RECEPTOR, NEONATAL; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY;

EID: 84871130729     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036286     Document Type: Article
Times cited : (29)

References (46)
  • 1
    • 77951529848 scopus 로고    scopus 로고
    • Therapeutic antibodies for autoimmunity and inflammation
    • Chan AC, Carter PJ, (2010) Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 10: 301-316.
    • (2010) Nat Rev Immunol , vol.10 , pp. 301-316
    • Chan, A.C.1    Carter, P.J.2
  • 2
    • 78649681781 scopus 로고    scopus 로고
    • Therapeutic antibodies directed at G protein-coupled receptors
    • Hutchings CJ, Koglin M, Marshall FH, (2010) Therapeutic antibodies directed at G protein-coupled receptors. MAbs 2: 594-606.
    • (2010) MAbs , vol.2 , pp. 594-606
    • Hutchings, C.J.1    Koglin, M.2    Marshall, F.H.3
  • 3
    • 34548442070 scopus 로고    scopus 로고
    • Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment
    • Bender B, Bodrogi L, Mayer B, Schneider Z, Zhao Y, et al. (2007) Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment. Transgenic Res 16: 613-627.
    • (2007) Transgenic Res , vol.16 , pp. 613-627
    • Bender, B.1    Bodrogi, L.2    Mayer, B.3    Schneider, Z.4    Zhao, Y.5
  • 4
    • 80052579373 scopus 로고    scopus 로고
    • Recent Advances Using FcRn Overexpression in Transgenic Animals to Overcome Impediments of Standard Antibody Technologies
    • Kacskovics I, Cervenak J, Erdei A, Goldsby RA, Butler JE, (2011) Recent Advances Using FcRn Overexpression in Transgenic Animals to Overcome Impediments of Standard Antibody Technologies. mAbs 3: 431-439.
    • (2011) MAbs , vol.3 , pp. 431-439
    • Kacskovics, I.1    Cervenak, J.2    Erdei, A.3    Goldsby, R.A.4    Butler, J.E.5
  • 5
    • 84855654982 scopus 로고    scopus 로고
    • Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn
    • Catunda Lemos AP, Cervenak J, Bender B, Hoffmann OI, Baranyi M, et al. (2012) Characterization of the Rabbit Neonatal Fc Receptor (FcRn) and Analyzing the Immunophenotype of the Transgenic Rabbits That Overexpresses FcRn. PLoS One 7: e28869.
    • (2012) PLoS One , vol.7
    • Catunda Lemos, A.P.1    Cervenak, J.2    Bender, B.3    Hoffmann, O.I.4    Baranyi, M.5
  • 6
    • 0024529856 scopus 로고
    • An Fc receptor structurally related to MHC class I antigens
    • Simister NE, Mostov KE, (1989) An Fc receptor structurally related to MHC class I antigens. Nature 337: 184-187.
    • (1989) Nature , vol.337 , pp. 184-187
    • Simister, N.E.1    Mostov, K.E.2
  • 7
    • 0015421358 scopus 로고
    • The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat
    • Jones EA, Waldmann TA, (1972) The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest 51: 2916-2927.
    • (1972) J Clin Invest , vol.51 , pp. 2916-2927
    • Jones, E.A.1    Waldmann, T.A.2
  • 8
    • 69949115639 scopus 로고    scopus 로고
    • Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn
    • Ward ES, Ober RJ, (2009) Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn. Adv Immunol 103: 77-115.
    • (2009) Adv Immunol , vol.103 , pp. 77-115
    • Ward, E.S.1    Ober, R.J.2
  • 9
    • 0031685365 scopus 로고    scopus 로고
    • Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice
    • Borvak J, Richardson J, Medesan C, Antohe F, Radu C, et al. (1998) Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. Int Immunol 10: 1289-1298.
    • (1998) Int Immunol , vol.10 , pp. 1289-1298
    • Borvak, J.1    Richardson, J.2    Medesan, C.3    Antohe, F.4    Radu, C.5
  • 10
    • 39549088649 scopus 로고    scopus 로고
    • Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism
    • Akilesh S, Christianson GJ, Roopenian DC, Shaw AS, (2007) Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism. J Immunol 179: 4580-4588.
    • (2007) J Immunol , vol.179 , pp. 4580-4588
    • Akilesh, S.1    Christianson, G.J.2    Roopenian, D.C.3    Shaw, A.S.4
  • 11
    • 62449200475 scopus 로고    scopus 로고
    • Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
    • Montoyo HP, Vaccaro C, Hafner M, Ober RJ, Mueller W, et al. (2009) Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice. Proc Natl Acad Sci U S A 106: 2788-2793.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 2788-2793
    • Montoyo, H.P.1    Vaccaro, C.2    Hafner, M.3    Ober, R.J.4    Mueller, W.5
  • 12
    • 35048814454 scopus 로고    scopus 로고
    • Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice
    • Lu W, Zhao Z, Zhao Y, Yu S, Zhao Y, et al. (2007) Over-expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice. Immunology 122: 401-408.
    • (2007) Immunology , vol.122 , pp. 401-408
    • Lu, W.1    Zhao, Z.2    Zhao, Y.3    Yu, S.4    Zhao, Y.5
  • 15
    • 71849083999 scopus 로고    scopus 로고
    • Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments
    • Mi W, Wanjie S, Lo ST, Gan Z, Pickl-Herk B, et al. (2008) Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments. J Immunol 181: 7550-7561.
    • (2008) J Immunol , vol.181 , pp. 7550-7561
    • Mi, W.1    Wanjie, S.2    Lo, S.T.3    Gan, Z.4    Pickl-Herk, B.5
  • 16
    • 79955024081 scopus 로고    scopus 로고
    • The Neonatal FcR-Mediated Presentation of Immune-Complexed Antigen Is Associated with Endosomal and Phagosomal pH and Antigen Stability in Macrophages and Dendritic Cells
    • Liu X, Lu L, Yang Z, Palaniyandi S, Zeng R, et al. (2011) The Neonatal FcR-Mediated Presentation of Immune-Complexed Antigen Is Associated with Endosomal and Phagosomal pH and Antigen Stability in Macrophages and Dendritic Cells. J Immunol 186: 4674-4686.
    • (2011) J Immunol , vol.186 , pp. 4674-4686
    • Liu, X.1    Lu, L.2    Yang, Z.3    Palaniyandi, S.4    Zeng, R.5
  • 18
    • 79251577108 scopus 로고    scopus 로고
    • Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice
    • Cervenak J, Bender B, Schneider Z, Magna M, Carstea BV, et al. (2011) Neonatal FcR Overexpression Boosts Humoral Immune Response in Transgenic Mice. J Immunol 186: 959-968.
    • (2011) J Immunol , vol.186 , pp. 959-968
    • Cervenak, J.1    Bender, B.2    Schneider, Z.3    Magna, M.4    Carstea, B.V.5
  • 19
    • 79954419216 scopus 로고    scopus 로고
    • Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity
    • Schneider Z, Cervenak J, Baranyi M, Papp K, Prechl J, et al. (2011) Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity. Immunology Letters 137: 62-69.
    • (2011) Immunology Letters , vol.137 , pp. 62-69
    • Schneider, Z.1    Cervenak, J.2    Baranyi, M.3    Papp, K.4    Prechl, J.5
  • 20
    • 85052274878 scopus 로고    scopus 로고
    • FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen
    • Vegh A, Cervenak J, Jankovics I, Kacskovics I, (2011) FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen. mAbs 3: 173-180.
    • (2011) MAbs , vol.3 , pp. 173-180
    • Vegh, A.1    Cervenak, J.2    Jankovics, I.3    Kacskovics, I.4
  • 21
    • 0021930547 scopus 로고
    • The mouse Ly-17 locus identifies a polymorphism of the Fc receptor
    • Hibbs ML, Hogarth PM, McKenzie IF, (1985) The mouse Ly-17 locus identifies a polymorphism of the Fc receptor. Immunogenetics 22: 335-348.
    • (1985) Immunogenetics , vol.22 , pp. 335-348
    • Hibbs, M.L.1    Hogarth, P.M.2    McKenzie, I.F.3
  • 24
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research 29: e45.
    • (2001) Nucleic Acids Research , vol.29
    • Pfaffl, M.W.1
  • 25
    • 35848941169 scopus 로고    scopus 로고
    • Cephalin as an efficient fusogen in hybridoma technology: can it replace poly ethylene glycol?
    • Golestani R, Pourfathollah AA, Moazzeni SM, (2007) Cephalin as an efficient fusogen in hybridoma technology: can it replace poly ethylene glycol? Hybridoma 26: 296-301.
    • (2007) Hybridoma , vol.26 , pp. 296-301
    • Golestani, R.1    Pourfathollah, A.A.2    Moazzeni, S.M.3
  • 26
    • 0022556005 scopus 로고
    • Factors affecting production of monoclonal antibodies
    • Westerwoudt RJ, (1986) Factors affecting production of monoclonal antibodies. Methods in enzymology 121: 3-18.
    • (1986) Methods in Enzymology , vol.121 , pp. 3-18
    • Westerwoudt, R.J.1
  • 27
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger JA, Kipps TJ, (2006) CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767.
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 28
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, Berger EA, (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 29
    • 84871124865 scopus 로고    scopus 로고
    • Efficient production of CXCR4 specific monoclonal antibodies using transgenic mice that overexpress the bovine neonatal Fc receptor (bFcRn)
    • mAbs submitted
    • Onisk D, Brown M, Keter D, Chambers R, Moriango J, et al. (2011) Efficient production of CXCR4 specific monoclonal antibodies using transgenic mice that overexpress the bovine neonatal Fc receptor (bFcRn). mAbs submitted.
    • (2011)
    • Onisk, D.1    Brown, M.2    Keter, D.3    Chambers, R.4    Moriango, J.5
  • 30
    • 0031975540 scopus 로고    scopus 로고
    • Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity
    • Hesselgesser J, Liang M, Hoxie J, Greenberg M, Brass LF, et al. (1998) Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity. The Journal of Immunology 160: 877-883.
    • (1998) The Journal of Immunology , vol.160 , pp. 877-883
    • Hesselgesser, J.1    Liang, M.2    Hoxie, J.3    Greenberg, M.4    Brass, L.F.5
  • 31
    • 0019426596 scopus 로고
    • The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response
    • Kunkl A, Klaus GG, (1981) The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response. Immunology 43: 371-378.
    • (1981) Immunology , vol.43 , pp. 371-378
    • Kunkl, A.1    Klaus, G.G.2
  • 32
    • 0015121213 scopus 로고
    • Early and enhanced germinal center formation and antibody responses in mice after primary stimulation with antigen-isologous antibody complexes as compared with antigen alone
    • Laissue J, Cottier H, Hess MW, Stoner RD, (1971) Early and enhanced germinal center formation and antibody responses in mice after primary stimulation with antigen-isologous antibody complexes as compared with antigen alone. J Immunol 107: 822-831.
    • (1971) J Immunol , vol.107 , pp. 822-831
    • Laissue, J.1    Cottier, H.2    Hess, M.W.3    Stoner, R.D.4
  • 33
    • 0022370483 scopus 로고
    • Enhancement of IgG anti-carrier responses by IgG2 anti-hapten antibodies in mice
    • Coulie PG, Van Snick J, (1985) Enhancement of IgG anti-carrier responses by IgG2 anti-hapten antibodies in mice. Eur J Immunol 15: 793-798.
    • (1985) Eur J Immunol , vol.15 , pp. 793-798
    • Coulie, P.G.1    Van Snick, J.2
  • 34
    • 33644681606 scopus 로고    scopus 로고
    • How antibodies act as natural adjuvants
    • Getahun A, Heyman B, (2006) How antibodies act as natural adjuvants. Immunology letters 104: 38-45.
    • (2006) Immunology Letters , vol.104 , pp. 38-45
    • Getahun, A.1    Heyman, B.2
  • 35
  • 36
    • 79952704589 scopus 로고    scopus 로고
    • Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    • Calabro S, Tortoli M, Baudner BC, Pacitto A, Cortese M, et al. (2011) Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine 29: 1812-1823.
    • (2011) Vaccine , vol.29 , pp. 1812-1823
    • Calabro, S.1    Tortoli, M.2    Baudner, B.C.3    Pacitto, A.4    Cortese, M.5
  • 37
    • 79251559088 scopus 로고    scopus 로고
    • CCR7 is involved in the migration of neutrophils to lymph nodes
    • Beauvillain C, Cunin P, Doni A, Scotet M, Jaillon S, et al. (2011) CCR7 is involved in the migration of neutrophils to lymph nodes. Blood 117: 1196-1204.
    • (2011) Blood , vol.117 , pp. 1196-1204
    • Beauvillain, C.1    Cunin, P.2    Doni, A.3    Scotet, M.4    Jaillon, S.5
  • 38
    • 70350032189 scopus 로고    scopus 로고
    • An elegant defense: how neutrophils shape the immune response
    • Soehnlein O, (2009) An elegant defense: how neutrophils shape the immune response. Trends Immunol 30: 511-512.
    • (2009) Trends Immunol , vol.30 , pp. 511-512
    • Soehnlein, O.1
  • 39
    • 0035284906 scopus 로고    scopus 로고
    • MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    • Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, et al. (2001) MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol 166: 3266-3276.
    • (2001) J Immunol , vol.166 , pp. 3266-3276
    • Zhu, X.1    Meng, G.2    Dickinson, B.L.3    Li, X.4    Mizoguchi, E.5
  • 41
    • 33645780182 scopus 로고    scopus 로고
    • Identification of memory B cells using a novel transgenic mouse model
    • Chappell CP, Jacob J, (2006) Identification of memory B cells using a novel transgenic mouse model. J Immunol 176: 4706-4715.
    • (2006) J Immunol , vol.176 , pp. 4706-4715
    • Chappell, C.P.1    Jacob, J.2
  • 42
    • 33846828273 scopus 로고    scopus 로고
    • Epitope characterization of ovalbumin in BALB/c mice using different entry routes
    • Mine Y, Yang M, (2007) Epitope characterization of ovalbumin in BALB/c mice using different entry routes. Biochimica et biophysica acta 1774: 200-212.
    • (2007) Biochimica Et Biophysica Acta , vol.1774 , pp. 200-212
    • Mine, Y.1    Yang, M.2
  • 43
    • 0030266699 scopus 로고    scopus 로고
    • B cell responses to a peptide epitope. I. The cellular basis for restricted recognition
    • Agarwal A, Sarkar S, Nazabal C, Balasundaram G, Rao KV, (1996) B cell responses to a peptide epitope. I. The cellular basis for restricted recognition. Journal of immunology 157: 2779-2788.
    • (1996) Journal of Immunology , vol.157 , pp. 2779-2788
    • Agarwal, A.1    Sarkar, S.2    Nazabal, C.3    Balasundaram, G.4    Rao, K.V.5
  • 44
    • 0031180974 scopus 로고    scopus 로고
    • Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope
    • Garrity RR, Rimmelzwaan G, Minassian A, Tsai WP, Lin G, et al. (1997) Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope. Journal of immunology 159: 279-289.
    • (1997) Journal of Immunology , vol.159 , pp. 279-289
    • Garrity, R.R.1    Rimmelzwaan, G.2    Minassian, A.3    Tsai, W.P.4    Lin, G.5
  • 45
    • 80054967006 scopus 로고    scopus 로고
    • Developing strategies to enhance and focus humoral immune responses using filamentous phage as a model antigen
    • Henry KA, Murira A, van Houten NE, Scott JK, (2011) Developing strategies to enhance and focus humoral immune responses using filamentous phage as a model antigen. Bioengineered bugs 2: 275-283.
    • (2011) Bioengineered Bugs , vol.2 , pp. 275-283
    • Henry, K.A.1    Murira, A.2    van Houten, N.E.3    Scott, J.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.