Evidence-based management of chronic urticaria in children

Pediatric, Allergy, Immunology, and Pulmonology

Volumn 25, Issue 4, 2012, Pages 198-207

  Pavić, Ivan ^a   Hojsak, Iva ^a   Čepin Bogović, Jasna ^a  

^a Alergologiju I Reumatologiju S Klini kom Imunologijom   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIVASTINE; AMINOCAPROIC ACID; ASTEMIZOLE; BILASTINE; CETIRIZINE; CHLORPHENIRAMINE; CLEMASTINE; CORTICOSTEROID; CYCLOSPORIN; DAPSONE; DESLORATADINE; DIPHENHYDRAMINE; EBASTINE; EMEDASTINE; FAMOTIDINE; FEXOFENADINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HYDROXYZINE; LEVOCETIRIZINE; LORATADINE; MIZOLASTINE; MONTELUKAST; OMALIZUMAB; OXATOMIDE; PLACEBO; RANITIDINE; RUPATADINE; TERFENADINE; UNINDEXED DRUG; ZAFIRLUKAST;

ADD ON THERAPY; ADOLESCENT; ANTIINFLAMMATORY ACTIVITY; CASE REPORT; CHRONIC URTICARIA; DIET; DRUG DOSE INCREASE; EVIDENCE BASED PRACTICE; FEMALE; FOLLOW UP; HUMAN; MENTAL STRESS; MONOTHERAPY; PEDIATRICS; PRIORITY JOURNAL; PRURITUS; PSEUDOALLERGEN DIET; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RELAPSE; REVIEW; TREATMENT DURATION; URTICARIA;

EID: 84871098228     PISSN: 2151321X     EISSN: 21513228     Source Type: Journal    
DOI: 10.1089/ped.2012.0149     Document Type: Review

References (122)

1. Grattan CE, Humphreys F. Guidelines for evaluation and management of urticaria in adults and children. Br J Dermatol 2007; 157:1116-1123. (Pubitemid 350115711)
2. Kaplan AP. Clinical practice. Chronic urticaria and angioedema. N Engl J Med 2002; 346:175-179. (Pubitemid 34438884)
3. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, et al. BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy 2007; 37:631-650. (Pubitemid 46643051)
4. Maurer M, Weller K, Bindslev-Jensen C, Gimenez-Arnau A, Bousquet PJ, Bousquet J, et al. Unmet clinical needs in chronic spontaneous urticaria. A GA(2)LEN task force report. Allergy 2011; 66:317-330.
5. Dodig S, Richter D. Chronic autoimmune urticaria in children. Acta Dermatovenerol Croat 2008; 16:65-71. (Pubitemid 351879798)
6. Volonakis M, Katsarou-Katsari A, Stratigos J. Etiologic factors in childhood chronic urticaria. Ann Allergy 1992; 69:61-65.
7. Brunetti L, Francavilla R, Miniello VL, Platzer MH, Rizzi D, Lospalluti ML, et al. High prevalence of autoimmune urticaria in children with chronic urticaria. J Allergy Clin Immunol 2004; 114:922-927. (Pubitemid 39330267)
8. Papadopoulou N, Kalogeromitros D, Staurianeas NG, Tiblalexi D, Theoharides TC. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria. J Invest Dermatol 2005; 125:952-955.
9. Kaplan AP. Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol 2004; 114:465-474; quiz 475. (Pubitemid 39194914)
10. Poonawalla T, Kelly B. Urticaria: a review. Am J Clin Dermatol 2009; 10:9-21.
11. Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 2006; 155:145-151. (Pubitemid 43876407)
12. Sahiner UM, Civelek E, Tuncer A, Yavuz ST, Karabulut E, Sackesen C, et al. Chronic urticaria: etiology and natural course in children. Int Arch Allergy Immunol 2011; 156:224-230.
13. Gregoriou S, Rigopoulos D, Katsambas A, Katsarou A, Papaioannou D, Gkouvi A, et al. Etiologic aspects and prognostic factors of patients with chronic urticaria: nonrandomized, prospective, descriptive study. J Cutan Med Surg 2009; 13: 198-203.
14. Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A. Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol 2012; 129:1307-1313.
15. van der Valk PG, Moret G, Kiemeney LA. The natural history of chronic urticaria and angioedema in patients visiting a tertiary referral centre. Br J Dermatol 2002; 146:110-113. (Pubitemid 34158417)
16. Kozel MM, Mekkes JR, Bossuyt PM, Bos JD. The effectiveness of a history-based diagnostic approach in chronic urticaria and angioedema. Arch Dermatol 1998; 134:1575-1580. (Pubitemid 29009259)
17. The diagnosis and management of urticaria: a practice parameter part I: acute urticaria/angioedema part II: chronic urticaria/angioedema. Joint Task Force on Practice Parameters. Ann Allergy Asthma Immunol 2000; 85(6 Pt 2):521-544.
18. Oxford Centre for Evidence-Based Medicine. www.cebm.net/index.aspx?o = 1025
19. Zuberbier T, Asero R, Bindslev-Jensen C, Walter Canonica G, Church MK, Gimenez-Arnau AM, et al. EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy 2009; 64:1427-1443.
20. Church MK, Maurer M, Simons FE, Bindslev-Jensen C, van Cauwenberge P, Bousquet J, et al. Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy 2010; 65:459-466.
21. Sharfstein JM, North M, Serwint JR. Over the counter but no longer under the radar-pediatric cough and cold medications. N Engl J Med 2007; 357:2321-2324. (Pubitemid 350223385)
22. Jauregui I, Ferrer M, Montoro J, Davila I, Bartra J, del Cuvillo A, et al. Antihistamines in the treatment of chronic urticaria. J Investig Allergol Clin Immunol 2007; 17 Suppl 2:41-52. (Pubitemid 351252754)
23. Simons FE. Prevention of acute urticaria in young children with atopic dermatitis. J Allergy Clin Immunol 2001; 107: 703-706. (Pubitemid 32397760)
24. Spicak V, Dab I, Hulhoven R, Desager JP, Klanova M, de Longueville M, et al. Pharmacokinetics and pharmacodynamics of cetirizine in infants and toddlers. Clin Pharmacol Ther 1997; 61:325-330. (Pubitemid 27145434)
25. www.drugs.com/pro/cetirizine.html
26. Simons FE. H1-antihistamine treatment in young atopic children: effect on urticaria. Ann Allergy Asthma Immunol 2007; 99:261-266. (Pubitemid 47417228)
27. Hampel F, Ratner P, Haeusler JM. Safety and tolerability of levocetirizine dihydrochloride in infants and children with allergic rhinitis or chronic urticaria. Allergy Asthma Proc 2010; 31:290-295.
28. Lutsky BN, Schuller JL, Cerio R, Chieira ML, Giannetti A, Goncalves HM, et al. Comparative study of the efficacy and safety of loratadine syrup and terfenadine suspension in the treatment of chronic allergic skin diseases in a pediatric population. Arzneimittelforschung 1993; 43:1196-1199. (Pubitemid 23350284)
29. Anthes JC, Gilchrest H, Richard C, Eckel S, Hesk D, West RE, Jr., et al. Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. Eur J Pharmacol 2002; 449:229-237.
30. Monroe EW. Desloratidine for the treatment of chronic urticaria. Skin Ther Lett 2002; 7:1-2, 5.
31. Bloom M, Staudinger H, Herron J. Safety of desloratadine syrup in children. Curr Med Res Opin 2004; 20:1959-1965. (Pubitemid 40179635)
32. www.drugs.com/pro/fexofenadine.html
33. Finn AF, Jr., Kaplan AP, Fretwell R, Qu R, Long J. A doubleblind, placebo-controlled trial of fexofenadine HCl in the treatment of chronic idiopathic urticaria. J Allergy Clin Immunol 1999; 104:1071-1078. (Pubitemid 29532131)
34. Spector SL, Shikiar R, Harding G, Meeves S, Leahy MJ. The effect of fexofenadine hydrochloride on productivity and quality of life in patients with chronic idiopathic urticaria. Cutis 2007; 79:157-162.
35. Kaplan AP, Spector SL, Meeves S, Liao Y, Varghese ST, Georges G. Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebocontrolled study. Ann Allergy Asthma Immunol 2005; 94: 662-669. (Pubitemid 40847153)
36. Nelson HS, Reynolds R, Mason J. Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria. Ann Allergy Asthma Immunol 2000; 84:517-522. (Pubitemid 30365414)
37. Hampel FC, Kittner B, van Bavel JH. Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis. Ann Allergy Asthma Immunol 2007; 99:549-554. (Pubitemid 350308755)
38. Zitelli KB, Cordoro KM. Evidence-based evaluation and management of chronic urticaria in children. Pediatr Dermatol 2011; 28:629-639.
39. Staevska M, Popov TA, Kralimarkova T, Lazarova C, Kraeva S, Popova D, et al. The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol 2010; 125:676-682.
40. Siebenhaar F, Degener F, Zuberbier T, Martus P, Maurer M. High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standarddose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. J Allergy Clin Immunol 2009; 123:672-679.
41. Gimenez-Arnau A, Izquierdo I, Maurer M. The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo-controlled treatment with rupatadine 10 and 20 mg. J Eur Acad Dermatol Venereol 2009; 23:1088-1091.
42. Bleehen SS, Thomas SE, Greaves MW, Newton J, Kennedy CT, Hindley F, et al. Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study. Br J Dermatol 1987; 117:81-88. (Pubitemid 17096140)
43. Monroe EW, Cohen SH, Kalbfleisch J, Schulz CI. Combined H1 and H2 antihistamine therapy in chronic urticaria. Arch Dermatol 1981; 117:404-407. (Pubitemid 11075329)
44. Simons FE, Sussman GL, Simons KJ. Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria. J Allergy Clin Immunol 1995; 95:685-693.
45. Paul E, Bodeker RH. Treatment of chronic urticaria with terfenadine and ranitidine. A randomized double-blind study in 45 patients. Eur J Clin Pharmacol 1986; 31:277-280. (Pubitemid 17021626)
46. www.fda.gov/downloads/ScienceResearch/SpecialTopics/ PediatricTherapeuticsResearch/UCM163159.pdf
47. Vena GA, Cassano N, Buquicchio R, Ventura MT. Antiinflammatory effects of H1-antihistamines: clinical and immunological relevance. Curr Pharm Des 2008; 14:2902-2911.
48. Erbagci Z. The leukotriene receptor antagonist montelukast in the treatment of chronic idiopathic urticaria: a single-blind, placebo-controlled, crossover clinical study. J Allergy Clin Immunol 2002; 110:484-488.
49. Nettis E, Colanardi MC, Paradiso MT, Ferrannini A. Desloratadine in combination with montelukast in the treatment of chronic urticaria: a randomized, double-blind, placebocontrolled study. Clin Exp Allergy 2004; 34:1401-1407. (Pubitemid 39233695)
50. Di Lorenzo G, Pacor ML, Mansueto P, Esposito Pellitteri M, Lo Bianco C, Ditta V, et al. Randomized placebo-controlled trial comparing desloratadine and montelukast in monotherapy and desloratadine plus montelukast in combined therapy for chronic idiopathic urticaria. J Allergy Clin Immunol 2004; 114:619-625. (Pubitemid 39194938)
51. Wan KS. Efficacy of leukotriene receptor antagonist with an anti-H1 receptor antagonist for treatment of chronic idiopathic urticaria. J Dermatolog Treat 2009; 20:194-197.
52. Kosnik M, Subic T. Add-on montelukast in antihistamineresistant chronic idiopathic urticaria. Respir Med 2011; 105 Suppl 1:S84-S88.
53. Bagenstose SE, Levin L, Bernstein JA. The addition of zafirlukast to cetirizine improves the treatment of chronic urticaria in patients with positive autologous serum skin test results. J Allergy Clin Immunol 2004; 113:134-140. (Pubitemid 38096173)
54. Pacor ML, Di Lorenzo G, Corrocher R. Efficacy of leukotriene receptor antagonist in chronic urticaria. A double-blind, placebo-controlled comparison of treatment with montelukast and cetirizine in patients with chronic urticaria with intolerance to food additive and/or acetylsalicylic acid. Clin Exp Allergy 2001; 31:1607-1614. (Pubitemid 32939469)
55. Reimers A, Pichler C, Helbling A, Pichler WJ, Yawalkar N. Zafirlukast has no beneficial effects in the treatment of chronic urticaria. Clin Exp Allergy 2002; 32:1763-1768. (Pubitemid 35463863)
56. Nettis E, Pannofino A, Cavallo E, Ferrannini A, Tursi A. Efficacy of montelukast, in combination with loratadine, in the treatment of delayed pressure urticaria. J Allergy Clin Immunol 2003; 112:212-213. (Pubitemid 36819832)
57. Vita D, Passalacqua G, Caminiti L, Barberio G, Pajno GB. Successful combined therapy for refractory chronic urticaria in a 10-year-old boy. Allergy 2004; 59:1021-1022. (Pubitemid 39141426)
58. Kanani A, Schellenberg R, Warrington R. Urticaria and angioedema. Allergy Asthma Clin Immunol 2011; 7 Suppl 1:S9.
59. Liu AH, Covar RA, Spahn JD, Leung DYM. Childhood asthma. In: Kliegman RM, Behrman RE, Stanton BF, St. Geme J, Schor N, eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: Elsevier Saunders Co, 2011.
60. Kozel MM, Sabroe RA. Chronic urticaria: aetiology, management and current and future treatment options. Drugs 2004; 64:2515-2536. (Pubitemid 39587219)
61. Doshi DR, Weinberger MM. Experience with cyclosporine in children with chronic idiopathic urticaria. Pediatr Dermatol 2009; 26:409-413.
62. Giuliodori K, Ganzetti G, Campanati A, Simonetti O, Marconi B, Offidani A. A non-responsive chronic autoimmune urticaria in a 12-year-old autistic girl treated with cyclosporin. J Eur Acad Dermatol Venereol 2009; 23:619-620.
63. Zhu YI, Stiller MJ. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol 2001; 45:420-434. (Pubitemid 32800500)
64. Cassano N, D'Argento V, Filotico R, Vena GA. Low-dose dapsone in chronic idiopathic urticaria: preliminary results of an open study. Acta Derm Venereol 2005; 85:254-255. (Pubitemid 40695172)
65. Engin B, Ozdemir M. Prospective randomized non-blinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria. J Eur Acad Dermatol Venereol 2008; 22:481-486. (Pubitemid 351436921)
66. Criado RF, Criado PR, Martins JE, Valente NY, Michalany NS, Vasconcellos C. Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features. J Dermatolog Treat 2008; 19:92-96. (Pubitemid 351891545)
67. Gurcan H, Mabrouk D, Razzaque Ahmed A. Management of pemphigus in pediatric patients.Minerva Pediatr 2011; 63:279-291.
68. Oliver JM, Tarleton CA, Gilmartin L, Archibeque T, Qualls CR, Diehl L, et al. Reduced FcepsilonRI-mediated release of asthmapromoting cytokines and chemokines from human basophils during omalizumab therapy. Int Arch Allergy Immunol 2010; 151:275-284.
69. Saini S, Rosen KE, Hsieh HJ, Wong DA, Conner E, Kaplan A, et al. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistaminerefractory chronic idiopathic urticaria. J Allergy Clin Immunol 2011; 128:567-573.e1.
70. Spector SL, Tan RA. Therapeutic alternatives for chronic urticaria: additional reports on omalizumab. Ann Allergy Asthma Immunol 2008; 101:647.
71. Spector SL, Tan RA. Effect of omalizumab on patients with chronic urticaria. Ann Allergy Asthma Immunol 2007; 99:190-193. (Pubitemid 47264781)
72. Kaplan AP, Joseph K, Maykut RJ, Geba GP, Zeldin RK. Treatment of chronic autoimmune urticaria with omalizumab. J Allergy Clin Immunol 2008; 122:569-573.
73. Magerl M, Staubach P, Altrichter S, Ardelean E, Krause K, Metz M, et al. Effective treatment of therapy-resistant chronic spontaneous urticaria with omalizumab. J Allergy Clin Immunol 2010; 126:665-666.
74. Buyukozturk S, Gelincik A, Demirturk M, Kocaturk E, Colakoglu B, Dal M. Omalizumab markedly improves urticaria activity scores and quality of life scores in chronic spontaneous urticaria patients: a real life survey. J Dermatol 2012; 39:439-442.
75. Milgrom H, Fowler-Taylor A, Vidaurre CF, Jayawardene S. Safety and tolerability of omalizumab in children with allergic (IgE-mediated) asthma. Curr Med Res Opin 2011; 27:163-169.
76. Charlesworth EN. Chronic urticaria: background, evaluation, and treatment. Curr Allergy Asthma Rep 2001; 1:342-347.
77. Zuberbier T, Chantraine-Hess S, Hartmann K, Czarnetzki BM. Pseudoallergen-free diet in the treatment of chronic urticaria. A prospective study. Acta Derm Venereol 1995; 75:484-487. (Pubitemid 26053290)
78. Guida B, De Martino CD, De Martino SD, Tritto G, Patella V, Trio R, et al. Histamine plasma levels and elimination diet in chronic idiopathic urticaria. Eur J Clin Nutr 2000; 54:155-158. (Pubitemid 30162887)
79. Di Lorenzo G, Pacor ML, Mansueto P, Martinelli N, Esposito-Pellitteri M, Lo Bianco C, et al. Food-additive-induced urticaria: a survey of 838 patients with recurrent chronic idiopathic urticaria. Int Arch Allergy Immunol 2005; 138:235-242. (Pubitemid 41540682)
80. Haustein UF. Pseudoallergen-free diet in the treatment of chronic urticaria. Acta Derm Venereol 1996; 76:498-499.
81. Magerl M, Pisarevskaja D, Scheufele R, Zuberbier T, Maurer M. Effects of a pseudoallergen-free diet on chronic spontaneous urticaria: a prospective trial. Allergy 2010; 65:78-83.
82. Hong JB, Lee HC, Hu FC, Chu CY. A randomized, doubleblind, active-controlled, parallel-group pilot study to compare the efficacy and sedative effects of desloratadine 5mg with levocetirizine 5mg in the treatment of chronic idiopathic urticaria. J Am Acad Dermatol 2010; 63:e100-e102.
83. Zuberbier T, Oanta A, Bogacka E, Medina I, Wesel F, Uhl P, et al. Comparison of the efficacy and safety of bilastine 20mg vs levocetirizine 5mg for the treatment of chronic idiopathic urticaria: a multi-centre, double-blind, randomized, placebocontrolled study. Allergy 2010; 65:516-528.
84. Grob JJ, Auquier P, Dreyfus I, Ortonne JP. How to prescribe antihistamines for chronic idiopathic urticaria: desloratadine daily vs PRN and quality of life. Allergy 2009; 64:605-612.
85. Bachert C, Kuna P, Sanquer F, Ivan P, Dimitrov V, Gorina MM, et al. Comparison of the efficacy and safety of bilastine 20mg vs desloratadine 5mg in seasonal allergic rhinitis patients. Allergy 2009; 64:158-165.
86. Potter PC, Kapp A, Maurer M, Guillet G, Jian AM, Hauptmann P, et al. Comparison of the efficacy of levocetirizine 5mg and desloratadine 5mg in chronic idiopathic urticaria patients. Allergy 2009; 64:596-604.
87. Grob JJ, Auquier P, Dreyfus I, Ortonne JP. Quality of life in adults with chronic idiopathic urticaria receiving desloratadine: a randomized, double-blind, multicentre, placebo-controlled study. J Eur Acad Dermatol Venereol 2008; 22:87-93.
88. Dubertret L, Zalupca L, Cristodoulo T, Benea V, Medina I, Fantin S, et al. Once-daily rupatadine improves the symptoms of chronic idiopathic urticaria: a randomised, double-blind, placebo-controlled study. Eur J Dermatol 2007; 17:223-228. (Pubitemid 46847786)
89. Gimenez-Arnau A, Pujol RM, Ianosi S, Kaszuba A, Malbran A, Poop G, et al. Rupatadine in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled multicentre study. Allergy 2007; 62:539-546. (Pubitemid 46608361)
90. Ortonne JP, Grob JJ, Auquier P, Dreyfus I. Efficacy and safety of desloratadine in adults with chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, multicenter trial. Am J Clin Dermatol 2007; 8:37-42. (Pubitemid 46998562)
91. Pons-Guiraud A, Nekam K, Lahovsky J, Costa A, Piacentini A. Emedastine difumarate versus loratadine in chronic idiopathic urticaria: a randomized, double-blind, controlled European multicentre clinical trial. Eur J Dermatol 2006; 16:649-654. (Pubitemid 46202963)
92. Kapp A, Pichler WJ. Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study. Int J Dermatol 2006; 45:469-474.
93. Nettis E, Colanardi MC, Barra L, Ferrannini A, Vacca A, Tursi A. Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. Br J Dermatol 2006; 154:533-538. (Pubitemid 43382664)
94. Handa S, Dogra S, Kumar B. Comparative efficacy of cetirizine and fexofenadine in the treatment of chronic idiopathic urticaria. J Dermatolog Treat 2004; 15:55-57. (Pubitemid 38252098)
95. Monroe E, Finn A, Patel P, Guerrero R, Ratner P, Bernstein D. Efficacy and safety of desloratadine 5mg once daily in the treatment of chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial. J Am Acad Dermatol 2003; 48:535-541. (Pubitemid 36397016)
96. La Rosa M, Leonardi S, Marchese G, Corrias A, Barberio G, Oggiano N, et al. Double-blind multicenter study on the efficacy and tolerability of cetirizine compared with oxatomide in chronic idiopathic urticaria in preschool children. Ann Allergy Asthma Immunol 2001; 87:48-53. (Pubitemid 32678334)
97. Ring J, Hein R, Gauger A. Desloratadine in the treatment of chronic idiopathic urticaria. Allergy 2001; 56 Suppl 65:28-32. (Pubitemid 32156195)
98. Leynadier F, Duarte-Risselin C, Murrieta M. Comparative therapeutic effect and safety of mizolastine and loratadine in chronic idiopathic urticaria. URTILOR study group. Eur J Dermatol 2000; 10:205-211. (Pubitemid 30186559)
99. Dubertret L, Murrieta Aguttes M, Tonet J. Efficacy and safety of mizolastine 10mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR Study. J Eur Acad Dermatol Venereol 1999; 12:16-24. (Pubitemid 29132981)
100. Breneman DL. Cetirizine versus hydroxyzine and placebo in chronic idiopathic urticaria.Ann Pharmacother 1996; 30:1075-1079. (Pubitemid 26332861)
101. Brostoff J, Fitzharris P, Dunmore C, Theron M, Blondin P. Efficacy of mizolastine, a new antihistamine, compared with placebo in the treatment of chronic idiopathic urticaria. Allergy 1996; 51:320-325. (Pubitemid 26232824)
102. Kalis B. Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs 1996; 52 Suppl 1:30-34. (Pubitemid 26290227)
103. Breneman D, Bronsky EA, Bruce S, Kalivas JT, Klein GL, Roth HL, et al. Cetirizine and astemizole therapy for chronic idiopathic urticaria: a double-blind, placebo-controlled, comparative trial. J Am Acad Dermatol 1995; 33(2 Pt 1):192-198.
104. Andri L, Senna GE, Betteli C, Givanni S, Andri G, Lombardi C, et al. A comparison of the efficacy of cetirizine and terfenadine. A double-blind, controlled study of chronic idiopathic urticaria. Allergy 1993; 48:358-365. (Pubitemid 23214685)
105. Abu Shareeah AM. Comparative efficacy of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. Int J Dermatol 1992; 31:355-356.
106. Monroe EW, Bernstein DI, Fox RW, Grabiec SV, Honsinger RW, Kalivas JT, et al. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria. Arzneimittelforschung 1992; 42:1119-1121.
107. Sussman G, Jancelewicz Z. Controlled trial of H1 antagonists in the treatment of chronic idiopathic urticaria. Ann Allergy 1991; 67:433-439.
108. Monroe EW. Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria and atopic dermatitis. Clin Ther 1992; 14:17-21.
109. Goh CL, Wong WK, Lim J. Cetirizine vs placebo in chronic idiopathic urticaria-a double blind randomised cross-over study. Ann Acad Med Singapore 1991; 20:328-330.
110. Kalivas J, Breneman D, Tharp M, Bruce S, Bigby M. Urticaria: clinical efficacy of cetirizine in comparison with hydroxyzine and placebo. J Allergy Clin Immunol 1990; 86(6 Pt 2):1014-1018.
111. Alomar A, De La C, Fernandez J. Cetirizine vs astemizole in the treatment of chronic idiopathic urticaria. J Int Med Res 1990; 18:358-365. (Pubitemid 20361362)
112. Belaich S, Bruttmann G, DeGreef H, Lachapelle JM, Paul E, Pedrali P, et al. Comparative effects of loratadine and terfenadine in the treatment of chronic idiopathic urticaria. Ann Allergy 1990; 64(2 Pt 2):191-194. (Pubitemid 20067099)
113. Boggs PB, Ellis CN, Grossman J, Washburne WF, Gupta AK, Ball R, et al. Double-blind, placebo-controlled study of terfenadine and hydroxyzine in patients with chronic idiopathic urticaria. Ann Allergy 1989; 63(6 Pt 2):616-620. (Pubitemid 20022761)
114. Leyh F, Harvey SG, Gibson JR, Manna VK. A comparison of acrivastine versus clemastine and placebo in the treatment of patients with chronic idiopathic urticaria. J Int Med Res 1989; 17 Suppl 2:22B-24B. (Pubitemid 19194186)
115. Salo OP, Harvey SG, Calthrop JG, Gibson JR. A comparison of acrivastine versus hydroxyzine and placebo in the treatment of chronic idiopathic urticaria. J Int Med Res 1989; 17 Suppl 2: 18B-21B. (Pubitemid 19194185)
116. van Joost T, Blog FB, Westerhof W, Jansen FC, Starink TM, den Boer MS, et al. A comparison of acrivastine versus terfenadine and placebo in the treatment of chronic idiopathic urticaria. J Int Med Res 1989; 17 Suppl 2:14B-17B. (Pubitemid 19194184)
117. Juhlin L, Arendt C. Treatment of chronic urticaria with cetirizine dihydrochloride a non-sedating antihistamine. Br J Dermatol 1988; 119:67-71.
118. Grant JA, Bernstein DI, Buckley CE, Chu T, Fox RW, Rocklin RE, et al. Double-blind comparison of terfenadine, chlorpheniramine, and placebo in the treatment of chronic idiopathic urticaria. J Allergy Clin Immunol 1988; 81:574-579. (Pubitemid 18089939)
119. Fox RW, Lockey RF, Bukantz SC, Serbousek D. The treatment of mild to severe chronic idiopathic urticaria with astemizole: double-blind and open trials. J Allergy Clin Immunol 1986; 78:1159-1166. (Pubitemid 17227462)
120. Cainelli T, Seidenari S, Valsecchi R, Mosca M. Double-blind comparison of astemizole and terfenadine in the treatment of chronic urticaria. Pharmatherapeutica 1986; 4:679-686. (Pubitemid 17231102)
121. Ferguson J, MacDonald KJ, Kenicer KJ. Terfenadine and placebo compared in the treatment of chronic idiopathic urticaria: a randomised double-blind study. Br J Clin Pharmacol 1985; 20:639-641. (Pubitemid 16184104)
122. Godse KV. Oral montelukast monotherapy is ineffective in chronic idiopathic urticaria: a comparison with oral cetirizine. Indian J Dermatol Venereol Leprol 2006; 72:312-314.