Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis

Annals of Allergy, Asthma and Immunology

Volumn 99, Issue 6, 2007, Pages 549-554

  Hampel, Frank C ^a   Kittner, Barbara ^b   Van Bavel, Julius H ^c  

^a Central Texas Health Research   (United States)

^b SANOFI   (France)

^c Allergy and Asthma Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FEXOFENADINE; PLACEBO;

ALLERGIC RHINITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DEMOGRAPHY; DIARRHEA; DRUG SAFETY; DRUG TOLERABILITY; EAR DISEASE; ELECTROCARDIOGRAPHY; EYE INFLAMMATION; FEMALE; FEVER; FLATULENCE; GASTROENTERITIS; HUMAN; INFANT; INFECTION; INJURY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OTITIS MEDIA; PHYSICAL EXAMINATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; RHINITIS; STATISTICAL ANALYSIS; TREATMENT DURATION; UPPER RESPIRATORY TRACT INFECTION; VITAL SIGN; VOMITING;

EID: 37349114526     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60385-7     Document Type: Article

References (18)

1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet. 1998;351:1225-1232.
2. Berger WE. Allergic rhinitis in children: diagnosis and management strategies. Paediatr Drugs. 2004;6:233-250.
3. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics. 1994;94:895-901.
4. Blaiss MS. Allergic rhinitis and impairment issues in schoolchildren: a consensus report. Curr Med Res Opin. 2004;20:1937-1952.
5. Baena-Cagnani CE. Allergic rhinitis and asthma in children: disease management and outcomes. Curr Allergy Asthma Rep. 2001;1:515-522.
6. Casale TB, Blaiss MS, Gelfand E, et al. First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol. 2003;111(suppl 1):S835-S842.
7. Howarth PH, Stern MA, Roi L, Reynolds R, Bousquet J. Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. J Allergy Clin Immunol. 1999;104:927-933.
8. Van Cauwenberge P, Juniper EF. Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. Clin Exp Allergy. 2000;30:891-899.
9. Casale TB, Andrade C, Qu R. Safety and efficacy of once-daily fexofenadine HCl in the treatment of autumn seasonal allergic rhinitis. Allergy Asthma Proc. 1999;20:193-198.
10. Wahn U, Meltzer EO, Finn AF Jr, et al. Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis. J Allergy Clin Immunol. 2003;111:763-769.
11. Graft DF, Bernstein DI, Goldsobel A, Meltzer EO, Portnoy J, Long J. Safety of fexofenadine in children treated for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2001;87:22-26.
12. Meltzer E, Scheinmann P, Rosado Pinto JE, Bachert C, Finn AF Jr, Ruuth E. Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis: a pooled analysis of three studies. Pediatr Allergy Immunol. 2004;15:253-260.
13. Ngamphaiboon J, Direkwattanachai C, Visitsunthorn N, Vangveeravong M, Tiensuwan M. The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis. Asian Pac J Allergy Immunol. 2005;23:169-174.
14. Milgrom H, Kittner B, Lanier R, Hampel FC. Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. Ann Allergy Asthma Immunol. In press.
15. DuBuske LM. Second-generation antihistamines: the risk of ventricular arrhythmias. Clin Ther. 1999;21:281-295.
16. Taglialatela M, Castaldo P, Pannaccione A, et al. Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity. Clin Exp Allergy. 1999;29(suppl 3):182-189.
17. Meltzer EO. Quality of life in adults and children with allergic rhinitis. J Allergy Clin Immunol. 2001;108(suppl):S45-S53.
18. Lack G. Pediatric allergic rhinitis and comorbid disorders. J Allergy Clin Immunol. 2001;108(suppl):S9-S15.