Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery

Biomaterials

Volumn 34, Issue 7, 2013, Pages 1772-1780

  Huang, Xinglu ^a   Zhang, Fan ^a,b   Wang, Hui ^a   Niu, Gang ^a   Choi, Ki Young ^a   Swierczewska, Magdalena ^a   Zhang, Guofeng ^a   Gao, Haokao ^a   Wang, Zhe ^a   Zhu, Lei ^a,b   Choi, Hak Soo ^c   Lee, Seulki ^a   Chen, Xiaoyuan ^a  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b XIAMEN UNIVERSITY   (China)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cell engineering; Mesenchymal stem cells (MSCs); Mesoporous silica nanoparticles (MSNs); Multimodal imaging; Targeted delivery

Indexed keywords

CELL PRODUCTS; CELL-BASED; CELLULAR UPTAKE; GLIOBLASTOMAS; IN-VIVO; MESENCHYMAL STEM CELL; MESOPOROUS SILICA NANOPARTICLES; MULTI-FUNCTIONALIZATION; MULTIMODAL IMAGING; ORTHOTOPIC; PROOF OF CONCEPT; RETENTION TIME; TARGETED DELIVERY; TUMOR TARGETED DELIVERY; TUMOR UPTAKE;

CELL ENGINEERING; DIAGNOSIS; DISEASE CONTROL; FLOWCHARTING; MOLECULAR BIOLOGY; STEM CELLS; TUMORS;

CELL CULTURE;

COPPER 64; FLUORESCEIN ISOTHIOCYANATE; MESOPOROUS SILICA NANOPARTICLE; NANOPARTICLE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ENGINEERING; GLIOBLASTOMA; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ANIMALS; BRAIN NEOPLASMS; FEMALE; GLIOBLASTOMA; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, NUDE; NANOPARTICLES; SILICON DIOXIDE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871082798     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.11.032     Document Type: Article

References (42)

1. Chauhan V.P., Stylianopoulos T., Martin J.D., Popovic Z., Chen O., Kamoun W.S., et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat Nanotechnol 2012, 7(6):383-388.
2. Smith B.R., Kempen P., Bouley D., Xu A., Liu Z., Melosh N., et al. Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation. Nano Lett 2012, 12(7):3369-3377.
3. Zhang F., Huang X., Zhu L., Guo N., Niu G., Swierczewska M., et al. Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles. Biomaterials 2012, 33(21):5414-5422.
4. Sasportas L.S., Kasmieh R., Wakimoto H., Hingtgen S., van de Water J.A., Mohapatra G., et al. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A 2009, 106(12):4822-4827.
5. Gutova M., Najbauer J., Frank R.T., Kendall S.E., Gevorgyan A., Metz M.Z., et al. Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors. Stem Cells 2008, 26(6):1406-1413.
6. Chung T.H., Hsiao J.K., Hsu S.C., Yao M., Chen Y.C., Wang S.W., et al. Iron oxide nanoparticle-induced epidermal growth factor receptor expression in human stem cells for tumor therapy. ACS Nano 2011, 5(12):9807-9816.
7. Studeny M., Marini F.C., Champlin R.E., Zompetta C., Fidler I.J., Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002, 62(13):3603-3608.
8. Hu Y.L., Fu Y.H., Tabata Y., Gao J.Q. Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy. J Control Release 2010, 147(2):154-162.
9. Stephan M.T., Moon J.J., Um S.H., Bershteyn A., Irvine D.J. Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Nat Med 2010, 16(9):1035-1041.
10. Li L., Guan Y., Liu H., Hao N., Liu T., Meng X., et al. Silica nanorattle-doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy. ACS Nano 2011, 5(9):7462-7470.
11. Cheng H., Kastrup C.J., Ramanathan R., Siegwart D.J., Ma M., Bogatyrev S.R., et al. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano 2010, 4(2):625-631.
12. Roger M., Clavreul A., Venier-Julienne M.C., Passirani C., Sindji L., Schiller P., et al. Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors. Biomaterials 2010, 31(32):8393-8401.
13. Lin X., Xie J., Niu G., Zhang F., Gao H., Yang M., et al. Chimeric ferritin nanocages for multiple function loading and multimodal imaging. Nano Lett 2011, 11(2):814-819.
14. Law W.C., Mahajan S.D., Kopwitthaya A., Reynolds J.L., Liu M., Liu X., et al. Gene silencing of human neuronal cells for drug addiction therapy using anisotropic nanocrystals. Theranostics 2012, 2(7):695-704.
15. Ruan J., Song H., Li C., Bao C., Fu H., Wang K., et al. DiR-labeled embryonic stem cells for targeted imaging of in vivo gastric cancer cells. Theranostics 2012, 2(6):618-628.
16. Huang N.F., Okogbaa J., Babakhanyan A., Cooke J.P. Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration. Theranostics 2012, 2(4):346-354.
17. Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. Theranostics 2012, 2(4):335-345.
18. Huang X., Swierczewska M., Choi K.Y., Zhu L., Bhirde A., Park J., et al. Multiplex imaging of an intracellular proteolytic cascade by using a broad-spectrum nanoquencher. Angew Chem Int Ed Engl 2012, 51(7):1625-1630.
19. Huang X., Zhang F., Lee S., Swierczewska M., Kiesewetter D.O., Lang L., et al. Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes. Biomaterials 2012, 33(17):4370-4378.
20. Choi K.Y., Chung H., Min K.H., Yoon H.Y., Kim K., Park J.H., et al. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 2010, 31(1):106-114.
21. Wang H., Cao F., De A., Cao Y., Contag C., Gambhir S.S., et al. Trafficking mesenchymal stem cell engraftment and differentiation in tumor-bearing mice by bioluminescence imaging. Stem Cells 2009, 27(7):1548-1558.
22. Xie J., Chen K., Huang J., Lee S., Wang J., Gao J., et al. PET/NIRF/MRI triple functional iron oxide nanoparticles. Biomaterials 2010, 31(11):3016-3022.
23. Huang X., Li L., Liu T., Hao N., Liu H., Chen D., et al. The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo. ACS Nano 2011, 5(7):5390-5399.
24. Khaldoyanidi S. Directing stem cell homing. Cell Stem Cell 2008, 2(3):198-200.
25. Huang X., Teng X., Chen D., Tang F., He J. The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. Biomaterials 2010, 31(3):438-448.
26. Mickler F.M., Mockl L., Ruthardt N., Ogris M., Wagner E., Brauchle C. Tuning nanoparticle uptake: live-cell imaging reveals two distinct endocytosis mechanisms mediated by natural and artificial EGFR targeting ligand. Nano Lett 2012, 12(7):3417-3423.
27. Vacha R., Martinez-Veracoechea F.J., Frenkel D. Receptor-mediated endocytosis of nanoparticles of various shapes. Nano Lett 2011, 11(12):5391-5395.
28. Fulci G., Chiocca E.A. The status of gene therapy for brain tumors. Expert Opin Biol Ther 2007, 7(2):197-208.
29. Liu S., Liu H., Ren G., Kimura R.H., Cochran J.R., Cheng Z. PET imaging of integrin positive tumors using 18F labeled knottin peptides. Theranostics 2011, 1:403-412.
30. Upadhyay K.K., Bhatt A.N., Mishra A.K., Dwarakanath B.S., Jain S., Schatz C., et al. The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(gamma-benzyl l-glutamate)-b-hyaluronan polymersomes. Biomaterials 2010, 31(10):2882-2892.
31. Liu T.W., Chen J., Burgess L., Cao W., Shi J., Wilson B.C., et al. Multimodal bacteriochlorophyll theranostic agent. Theranostics 2011, 1:354-362.
32. Sordi V. Mesenchymal stem cell homing capacity. Transplantation 2009, 87(9 Suppl.):S42-S45.
33. Yu M.K., Park J., Jon S. Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy. Theranostics 2012, 2(1):3-44.
34. Bardhan R., Chen W., Bartels M., Perez-Torres C., Botero M.F., McAninch R.W., et al. Tracking of multimodal therapeutic nanocomplexes targeting breast cancer in vivo. Nano Lett 2010, 10(12):4920-4928.
35. Cai W., Shin D.W., Chen K., Gheysens O., Cao Q., Wang S.X., et al. Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett 2006, 6(4):669-676.
36. Guo J., Gao X., Su L., Xia H., Gu G., Pang Z., et al. Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery. Biomaterials 2011, 32(31):8010-8020.
37. Xie J., Liu G., Eden H.S., Ai H., Chen X. Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy. Acc Chem Res 2011, 44(10):883-892.
38. Huang X., Lee S., Chen X. Design of " smart" probes for optical imaging of apoptosis. Am J Nucl Med Mol Imaging 2011, 1(1):3-17.
39. Azarin S.M., Lian X., Larson E.A., Popelka H.M., de Pablo J.J., Palecek S.P. Modulation of Wnt/beta-catenin signaling in human embryonic stem cells using a 3-D microwell array. Biomaterials 2012, 33(7):2041-2049.
40. Hsiao W.C., Sung S.Y., Liao C.H., Wu H.C., Hsieh C.L. Vitamin D3-inducible mesenchymal stem cell-based delivery of conditionally replicating adenoviruses effectively targets renal cell carcinoma and inhibits tumor growth. Mol Pharm 2012, 9(5):1396-1408.
41. Liu H., Chen D., Li L., Liu T., Tan L., Wu X., et al. Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. Angew Chem Int Ed Engl 2011, 50(4):891-895.
42. Ferris D.P., Lu J., Gothard C., Yanes R., Thomas C.R., Olsen J.C., et al. Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells. Small 2011, 7(13):1816-1826.