-
1
-
-
12744262976
-
Cysteine proteases of malaria parasites
-
Rosenthal PJ. Cysteine proteases of malaria parasites. Int. J. Parasitol. 34(13-14), 1489-1499 (2004).
-
(2004)
Int. J. Parasitol
, vol.34
, Issue.13-14
, pp. 1489-1499
-
-
Rosenthal, P.J.1
-
2
-
-
0021193304
-
Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite plasmodium falciparum
-
Yayon A, Timberg R, Friedman S, Ginsburg H. Effects of chloroquine on the feeding mechanism of the intraerythrocytic human malarial parasite Plasmodium falciparum. J. Protozool 31(3), 367-372 (1984). (Pubitemid 14020760)
-
(1984)
Journal of Protozoology
, vol.31
, Issue.3
, pp. 367-372
-
-
Yayon, A.1
Timberg, R.2
Friedman, S.3
Ginsburg, H.4
-
3
-
-
23744478677
-
The key role of heme to trigger the antimalarial activity of trioxanes
-
DOI 10.1016/j.ccr.2004.12.022, PII S0010854505000093
-
Robert A, Benoit-Vical F, Meunier B. The key role of heme to trigger the antimalarial activity of trioxanes. Coord. Chem. Rev. 249(17-18), 1927-1936 (2005). (Pubitemid 41121959)
-
(2005)
Coordination Chemistry Reviews
, vol.249
, Issue.17-18 SPEC. ISSUE
, pp. 1927-1936
-
-
Robert, A.1
Benoit-Vical, F.2
Meunier, B.3
-
4
-
-
79952732772
-
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
-
Charman SA, Arbe-Barnes S, Bathurst IC et al. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl Acad. Sci. USA 108(11), 4400-4405 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, Issue.11
, pp. 4400-4405
-
-
Charman, S.A.1
Arbe-Barnes, S.2
Bathurst, I.C.3
-
5
-
-
2542640961
-
A medicinal chemistry perspective on artemisinin and related endoperoxides
-
DOI 10.1021/jm030571c
-
O'Neill PM, Posner GH. A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 47(12), 2945-2964 (2004). (Pubitemid 38702690)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.12
, pp. 2945-2964
-
-
O'Neill, P.M.1
Posner, G.H.2
-
6
-
-
58249143778
-
Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
-
Hartwig CL, Rosenthal AS, D'angelo J, Griffin CE, Posner GH, Cooper RA. Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. Biochem. Pharmacol. 77(3), 322-336 (2009).
-
(2009)
Biochem. Pharmacol
, vol.77
, Issue.3
, pp. 322-336
-
-
Hartwig, C.L.1
Rosenthal, A.S.2
D'Angelo, J.3
Griffin, C.E.4
Posner, G.H.5
Cooper, R.A.6
-
7
-
-
82555187385
-
Investigating the antimalarial action of 1 2,4-trioxolanes with fluorescent chemical probes
-
Hartwig CL, Lauterwasser EM, Mahajan SS, Hoke JM, Cooper RA, Renslo AR. Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes. J. Med. Chem. 54(23), 8207-8213 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, Issue.23
, pp. 8207-8213
-
-
Hartwig, C.L.1
Lauterwasser, E.M.2
Mahajan, S.S.3
Hoke, J.M.4
Cooper, R.A.5
Renslo, A.R.6
-
8
-
-
42049102584
-
Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials
-
DOI 10.1128/AAC.01033-07
-
Creek DJ, Charman WN, Chiu FC et al. Relationship between antimalarial activity and heme alkylation for spiro-and dispiro-1,2,4-trioxolane antimalarials. Antimicrob. Agents. Chemother. 52(4), 1291-1296 (2008). (Pubitemid 351521990)
-
(2008)
Antimicrobial Agents and Chemotherapy
, vol.52
, Issue.4
, pp. 1291-1296
-
-
Creek, D.J.1
Charman, W.N.2
Chiu, F.C.K.3
Prankerd, R.J.4
Dong, Y.5
Vennerstrom, J.L.6
Charman, S.A.7
-
9
-
-
38949125112
-
Hybrid molecules with a dual mode of action: Dream or reality?
-
Meunier B. Hybrid molecules with a dual mode of action: dream or reality? Acc. Chem. Res. 41(1), 69-77 (2008).
-
(2008)
Acc. Chem. Res
, vol.41
, Issue.1
, pp. 69-77
-
-
Meunier, B.1
-
10
-
-
26444465676
-
The antimalarial drug artemisinin alkylates heme in infected mice
-
DOI 10.1073/pnas.0500972102
-
Robert A, Benoit-Vical F, Claparols C, Meunier B. The antimalarial drug artemisinin alkylates heme in infected mice. Proc. Natl Acad. Sci. USA 102(38), 13676-13680 (2005). (Pubitemid 41420907)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.38
, pp. 13676-13680
-
-
Robert, A.1
Benoit-Vical, F.2
Claparols, C.3
Meunier, B.4
-
11
-
-
48749099910
-
The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice
-
Bousejra-El Garah F, Claparols C, Benoit-Vical F, Meunier B, Robert A. The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice. Antimicrob. Agents Chemother. 52(8), 2966-2969 (2008).
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, Issue.8
, pp. 2966-2969
-
-
Bousejra-El Garah, F.1
Claparols, C.2
Benoit-Vical, F.3
Meunier, B.4
Robert, A.5
-
12
-
-
79955528674
-
Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni
-
Pradines V, Portela J, Boissier J, Cosledan F, Meunier B, Robert A. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni. Antimicrob. Agents Chemother. 55(5), 2403-2405 (2011).
-
(2011)
Antimicrob. Agents Chemother
, vol.55
, Issue.5
, pp. 2403-2405
-
-
Pradines, V.1
Portela, J.2
Boissier, J.3
Cosledan, F.4
Meunier, B.5
Robert, A.6
-
13
-
-
79960683200
-
Antimalarial mannoxanes: Hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action
-
Chadwick J, Amewu RK, Marti F et al. Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem 6(8), 1357-1361 (2011).
-
(2011)
ChemMedChem
, vol.6
, Issue.8
, pp. 1357-1361
-
-
Chadwick, J.1
Amewu, R.K.2
Marti, F.3
-
14
-
-
79959568292
-
Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on beta-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum
-
Feng TS, Guantai EM, Nell M et al. Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on beta-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum. Biochem. Pharmacol. 82(3), 236-247 (2011).
-
(2011)
Biochem. Pharmacol
, vol.82
, Issue.3
, pp. 236-247
-
-
Feng, T.S.1
Guantai, E.M.2
Nell, M.3
-
15
-
-
80052865308
-
Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy
-
Capela R, Cabal GG, Rosenthal PJ et al. Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob. Agents Chemother. 55(10), 4698-4706 (2011).
-
(2011)
Antimicrob. Agents Chemother
, vol.55
, Issue.10
, pp. 4698-4706
-
-
Capela, R.1
Cabal, G.G.2
Rosenthal, P.J.3
-
16
-
-
84857752407
-
Antimalarial peroxides: Advances in drug discovery and design
-
Slack RD, Jacobine AM, Posner GH. Antimalarial peroxides: advances in drug discovery and design. MedChemComm 3(3), 281-297 (2012).
-
(2012)
MedChemComm
, vol.3
, Issue.3
, pp. 281-297
-
-
Slack, R.D.1
Jacobine, A.M.2
Posner, G.H.3
-
17
-
-
79952095966
-
A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite
-
Mahajan SS, Deu E, Lauterwasser EM et al. A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite. ChemMedChem 6(3), 415-419 (2011).
-
(2011)
ChemMedChem
, vol.6
, Issue.3
, pp. 415-419
-
-
Mahajan, S.S.1
Deu, E.2
Lauterwasser, E.M.3
-
18
-
-
4544263432
-
Design and synthesis of endoperoxide antimalarial prodrug models
-
DOI 10.1002/anie.200453859
-
O'Neill PM, Stocks PA, Pugh MD et al. Design and synthesis of endoperoxide antimalarial prodrug models. Angew. Chem. Int. Ed. Engl. 43(32), 4193-4197 (2004). (Pubitemid 39257436)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.32
, pp. 4193-4197
-
-
O'Neill, P.M.1
Stocks, P.A.2
Pugh, M.D.3
Araujo, N.C.4
Korshin, E.E.5
Bickley, J.F.6
Ward, S.A.7
Bray, P.G.8
Pasini, E.9
Davies, J.10
Verissimo, E.11
Bachi, M.D.12
-
19
-
-
4544268106
-
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore
-
DOI 10.1021/ol0492142
-
O'Neill PM, Mukhtar A, Ward SA et al. Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. Org. Lett. 6(18), 3035-3038 (2004). (Pubitemid 39233113)
-
(2004)
Organic Letters
, vol.6
, Issue.18
, pp. 3035-3038
-
-
O'Neill, P.M.1
Mukhtar, A.2
Ward, S.A.3
Bickley, J.F.4
Davies, J.5
Bachi, M.D.6
Stocks, P.A.7
-
20
-
-
4344630762
-
Identification of an antimalarial synthetic trioxolane drug development candidate
-
DOI 10.1038/nature02779
-
Vennerstrom JL, Arbe-Barnes S, Brun R et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430(7002), 900-904 (2004). (Pubitemid 39119218)
-
(2004)
Nature
, vol.430
, Issue.7002
, pp. 900-904
-
-
Vennerstrom, J.L.1
Arbe-Barnes, S.2
Brun, R.3
Charman, S.A.4
Chiu, F.C.K.5
Chollet, J.6
Dong, Y.7
Dorn, A.8
Hunziker, D.9
Matile, H.10
McIntosh, K.11
Padmanilayam, M.12
Santo Tomas, J.13
Scheurer, C.14
Scorneaux, B.15
Tang, Y.16
Urwyler, H.17
Wittlin, S.18
Charman, W.H.19
-
21
-
-
34548293148
-
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
-
DOI 10.1002/anie.200604697
-
Stocks PA, Bray PG, Barton VE et al. evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angew. Chem. Int. Ed. Engl. 46(33), 6278-6283 (2007). (Pubitemid 47329416)
-
(2007)
Angewandte Chemie - International Edition
, vol.46
, Issue.33
, pp. 6278-6283
-
-
Stocks, P.A.1
Bray, P.G.2
Barton, V.E.3
Al-Helal, M.4
Jones, M.5
Araujo, N.C.6
Gibbons, P.7
Ward, S.A.8
Hughes, R.H.9
Biagini, G.A.10
Davies, J.11
Amewu, R.12
Mercer, A.E.13
Ellis, G.14
O'Neill, P.M.15
-
22
-
-
0024208917
-
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
-
Rosenthal PJ, Mckerrow JH, Aikawa M, Nagasawa H, Leech JH. A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J. Clin. Invest. 82(5), 1560-1566 (1988). (Pubitemid 19007759)
-
(1988)
Journal of Clinical Investigation
, vol.82
, Issue.5
, pp. 1560-1566
-
-
Rosenthal, P.J.1
McKerrow, J.H.2
Aikawa, M.3
Nagasawa, H.4
Leech, J.H.5
-
23
-
-
0037226491
-
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones
-
DOI 10.1128/AAC.47.1.154-160.2003
-
Shenai BR, Lee BJ, Alvarez-Hernandez A et al. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrob. Agents Chemother. 47(1), 154-160 (2003). (Pubitemid 36070357)
-
(2003)
Antimicrobial Agents and Chemotherapy
, vol.47
, Issue.1
, pp. 154-160
-
-
Shenai, B.R.1
Lee, B.J.2
Alvarez-Hernandez, A.3
Chong, P.Y.4
Emal, C.D.5
Neitz, R.J.6
Roush, W.R.7
Rosenthal, P.J.8
-
24
-
-
54349106665
-
Activity-based probes as a tool for functional proteomic analysis of proteases
-
Fonovic M, Bogyo M. Activity-based probes as a tool for functional proteomic analysis of proteases. Expert Rev. Proteomics 5(5), 721-730 (2008).
-
(2008)
Expert Rev. Proteomics
, vol.5
, Issue.5
, pp. 721-730
-
-
Fonovic, M.1
Bogyo, M.2
-
25
-
-
77953631133
-
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
-
Johnson DS, Weerapana E, Cravatt BF. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Future Med. Chem. 2(6), 949-964 (2010).
-
(2010)
Future Med. Chem
, vol.2
, Issue.6
, pp. 949-964
-
-
Johnson, D.S.1
Weerapana, E.2
Cravatt, B.F.3
-
26
-
-
77956051319
-
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase i using small molecule inhibitors and active site probes
-
Deu E, Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M. Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes. Chem. Biol. 17(8), 808-819 (2010).
-
(2010)
Chem. Biol
, vol.17
, Issue.8
, pp. 808-819
-
-
Deu, E.1
Leyva, M.J.2
Albrow, V.E.3
Rice, M.J.4
Ellman, J.A.5
Bogyo, M.6
-
27
-
-
84860012591
-
Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates
-
Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. Proc. Natl Acad. Sci. USA 109, 6211-6216 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 6211-6216
-
-
Santi, D.V.1
Schneider, E.L.2
Reid, R.3
Robinson, L.4
Ashley, G.W.5
-
28
-
-
78649526279
-
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: Toward combination chemotherapy of malaria through a single chemical entity
-
Gibbons P, Verissimo E, Araujo NC et al. Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J. Med. Chem. 53(22), 8202-8206 (2010).
-
(2010)
J. Med. Chem
, vol.53
, Issue.22
, pp. 8202-8206
-
-
Gibbons, P.1
Verissimo, E.2
Araujo, N.C.3
|