Molecular chaperones in signal transduction

Handbook of Experimental Pharmacology

Volumn 172, Issue , 2006, Pages 93-109

  Gaestel, M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cell signaling; Chaperone; Protein kinase; Receptor; Transcription factor

Indexed keywords

EID: 84871043796     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/3-540-29717-0_4     Document Type: Article

References (97)

1. Abravaya K,MyersMP,Murphy SP,Morimoto RI (1992) The humanheat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev 6:1153-1164
2. Ali A, Bharadwaj S, OCarroll R, Ovsenek N (1998) HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes. Mol Cell Biol 18:4949-4960
3. BalerR,WelchWJ,VoellmyR(1992)Heat shock gene regulationby nascentpolypeptides and denatured proteins: hsp70 as a potential autoregulatory factor. J Cell Biol 117:1151-1159
4. Bardelli A, Longati P, Albero D, Goruppi S, Schneider C, Ponzetto C, Comoglio PM (1996) HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. Embo J 15:6205-6212
5. Bharadwaj S,Ali A,OvsenekN(1999)Multiple components of theHSP90 chaperone complex function in regulation of heat shock factor 1 In vivo. Mol Cell Biol 19:8033-8041
6. Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R (2004) DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci U S A 101:4100-4105. Epub 2004 Mar 4111
7. Bonvini P, Dalla Rosa H, Vignes N, Rosolen A (2004) Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylaminodemethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70- interacting protein. Cancer Res 64:3256-3264
8. Broemer M, Krappmann D, Scheidereit C (2004) Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. Oncogene 23:5378-5386
9. Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo AP, Kroemer G, Solary E, Garrido C (2000) Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2:645-652
10. Brugge JS, Erikson E, Erikson RL (1981) The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins. Cell 25:363-372
11. Catelli MG, Binart N, Jung-Testas I, Renoir JM, Baulieu EE, Feramisco JR,Welch WJ (1985) The common 90-kd protein component of non-transformed 8S steroid receptors is a heat-shock protein. EMBO J 4:3131-3135
12. Charette SJ, Lavoie JN, Lambert H, Landry J (2000) Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol 20:7602-7612
13. Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK (1996) Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem 271:30847-30857
14. Citri A, Gan J,MosessonY,Vereb G, Szollosi J,YardenY(2004) Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 5:1165-1170
15. CowanJL,Morley SJ (2004) The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12myoblasts and facilitates the association of hsp25 with the eIF4F complex. Eur J Biochem 271:3596-3611
16. CutforthT,RubinGM(1994)Mutations inHsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila. Cell 77:1027-1036
17. Dai Q, ZhangC,WuY,McDonoughH,WhaleyRA,GodfreyV, Li HH,Madamanchi N, XuW, Neckers L, CyrD, Patterson C (2003) CHIP activatesHSF1 and confers protection against apoptosis and cellular stress. EMBO J 22:5446-5458
18. Dai R, Frejtag W, He B, Zhang Y, Mivechi NF (2000) c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. J Biol Chem 275:18210-18218
19. De Carcer G (2004) Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner. Cancer Res 64:5106-5112
20. De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA, Scholz GM (2005) A central role for the Hsp90middle dotCdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. J Biol Chem 280:9813-9822. Epub 2005 Jan 9812
21. Den Engelsman J, Bennink EJ, Doerwald L, Onnekink C,Wunderink L, Andley UP, Kato K, de Jong WW, Boelens WC (2004) Mimicking phosphorylation of the small heat-shock protein alphaB-crystallin recruits the F-box protein FBX4 to nuclear SC35 speckles. Eur J Biochem 271:4195-4203
22. Diehl JA, Yang W, Rimerman RA, Xiao H, Emili A (2003) Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol 23:1764-1774
23. Donze O, Abbas-Terki T, Picard D (2001) The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. EMBO J 20:3771-3780
24. Evgrafov OV, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung CL, Schagina O, Verpoorten N, Van Impe K, Fedotov V, Dadali E, Auer-Grumbach M, Windpassinger C, Wagner K, Mitrovic Z, Hilton-Jones D, Talbot K, Martin JJ, Vasserman N, Tverskaya S, Polyakov A, Liem RK, Gettemans J, Robberecht W, De Jonghe P, Timmerman V (2004) Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Nat Genet 36:602-606. Epub 2004 May 2002
25. Freeman BC, Felts SJ, Toft DO, Yamamoto KR (2000) The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev 14:422-434
26. Freeman BC, Yamamoto KR (2002) Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296:2232-2235
27. Froesch BA, Takayama S, Reed JC (1998) BAG-1L protein enhances androgen receptor function. J Biol Chem 273:11660-11666
28. Grammatikakis N, Lin JH, Grammatikakis A, Tsichlis PN, Cochran BH (1999) p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol Cell Biol 19:1661-1672
29. Guay J, LambertH, Gingras-Breton G, Lavoie JN,Huot J, Landry J (1997) Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci 110:357-368
30. Guzey M, Takayama S, Reed JC (2000) BAG1L enhances trans-activation function of the vitamin D receptor. J Biol Chem 275:40749-40756
31. Herschlag D (1995) RNA chaperones and the RNA folding problem. J Biol Chem 270:20871-20874
32. Hjorth-Sorensen B, Hoffmann ER, Lissin NM, Sewell AK, Jakobsen BK (2001) Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins. Mol Microbiol 39:914-923
33. Hoffmann JH, Linke K, Graf PC, Lilie H, Jakob U (2004) Identification of a redox-regulated chaperone network. EMBO J 23:160-168. Epub 2003 Dec 2011
34. Hohfeld J, Jentsch S (1997)GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J 16:6209-6216
35. Holmberg CI, Hietakangas V,Mikhailov A, Rantanen JO, Kallio M,Meinander A,Hellman J, MorriceN,MacKintosh C,Morimoto RI, Eriksson JE, Sistonen L (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J 20:3800-3810
36. Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N, Michalik A, De Vriendt E, Jacobs A, Van Gerwen V, Vennekens K, Mazanec R, Tournev I, Hilton- Jones D, Talbot K, Kremensky I, Van Den Bosch L, RobberechtW, Van Vandekerckhove J, Broeckhoven C, Gettemans J, De Jonghe P, Timmerman V (2004) Hot-spot residue in small heat-shock protein 22 causes distalmotor neuropathy.Nat Genet 36:597-601. Epub 2004 May 2002
37. Ito H, Kamei K, Iwamoto I, Inaguma Y, Nohara D, Kato K (2001) Phosphorylation-induced change of the oligomerization state of alpha B-crystallin. J Biol Chem 276:5346-5352. Epub 2000 Nov 5328
38. Jakob U, Muse W, Eser M, Bardwell JC (1999) Chaperone activity with a redox switch. Cell 96:341-352
39. Kantorow M, Piatigorsky J (1994) Alpha-crystallin/small heat shock protein has autokinase activity. Proc Natl Acad Sci U S A 91:3112-3116
40. Kantorow M, Horwitz J, van Boekel MA, de Jong WW, Piatigorsky J (1995) Conversion from oligomers to tetramers enhances autophosphorylation by lens alpha A-crystallin. Specificity between alphaA- and alpha B-crystallin subunits. Alpha-crystallin/small heat shock protein has autokinase activity. J Biol Chem 270:17215-17220
41. Kato K, Ito H, Kamei K, Inaguma Y, Iwamoto I, Saga S (1998) Phosphorylation of alphaBcrystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation. J Biol Chem 273:28346-28354
42. Kim HJ, Song EJ, Lee YS, Kim E, Lee KJ (2005a) Human Fas-associated factor 1 interacts with heat shock protein 70 and negatively regulates chaperone activity. J Biol Chem 280:8125-8133. Epub 2004 Dec 8113
43. Kim J,Nueda A,Meng YH, DynanWS, Mivechi NF (1997) Analysis of the phosphorylation of human heat shock transcription factor-1 byMAP kinase familymembers. J Cell Biochem 67:43-54
44. Kim MV, Seit-Nebi AS, Gusev NB (2004a) The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8). Biochem Biophys Res Commun 325:649-652
45. Kim SA, Yoon JH, Lee SH, Ahn SG (2005b) Polo-like kinase 1 phosphorylates HSF1 and mediates its nuclear translocation during heat stress. J Biol Chem 20:20
46. Kim SW, Chao TH, Xiang R, Lo JF, CampbellMJ, Fearns C, Lee JD (2004b) Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. Cancer Res 64:7732-7739
47. Kimura Y, Rutherford SL,Miyata Y, Yahara I, Freeman BC, Yue L,Morimoto RI, Lindquist S (1997) Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes Dev 11:1775-1785
48. Kline MP, Morimoto RI (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol 17:2107-2115
49. Knauf U, Newton EM, Kyriakis J, Kingston RE (1996) Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev 10:2782-2793
50. Kosano H, Stensgard B, Charlesworth MC, McMahon N, Toft D (1998) The assembly of progesterone receptor-hsp90 complexes using purified proteins. J Biol Chem 273:32973-32979
51. Lambert H, Charette SJ, Bernier AF, Guimond A, Landry J (1999) HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus. J Biol Chem 274:9378-9385
52. Le Boeuf F, Houle F, Huot J (2004) Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. J Biol Chem 279:39175-39185. Epub 32004 Jul 39106
53. Lorsch JR (2002) RNA chaperones exist and DEAD box proteins get a life. Cell 109:797-800
54. Louvion JF, Abbas-Terki T, Picard D (1998) Hsp90 is required for pheromone signaling in yeast. Mol Biol Cell 9:3071-3083
55. Loyola A,AlmouzniG(2004)Histone chaperones, a supporting role in the limelight.Biochim Biophys Acta 1677:3-11
56. McMillanDR,Xiao X, Shao L,Graves K,Benjamin IJ (1998)Targeted disruptionof heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 273:7523-7528
57. Mikolajczyk M, Nelson MA (2004) Regulation of stability of cyclin-dependent kinase CDK11p110and a caspase-processed form, CDK11p46, byHsp90.BiochemJ 384:461-467
58. Miyata Y, Yahara I (1992) The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity. J Biol Chem 267:7042-7047
59. Miyata Y, Nishida E (2004) CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol 24:4065-4074
60. Morimoto RI (1993) Cells in stress: transcriptional activation of heat shock genes. Science 259:1409-1410
61. Morimoto RI (2002) Dynamic remodeling of transcription complexes by molecular chaperones. Cell 110:281-284
62. MuschMW,Kapil A,ChangEB(2004)Heat shockprotein 72 binds andprotects dihydrofolate reductase against oxidative injury. Biochem Biophys Res Commun 313:185-192
63. Nollen EA,Morimoto RI (2002) Chaperoning signaling pathways: molecular chaperones as stress-sensing heat shock proteins. J Cell Sci 115:2809-2816
64. Oppermann H, Levinson AD, Levintow L, Varmus HE, Bishop JM, Kawai S (1981) Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus. Virology 113:736-751
65. OzakiM, Deshpande SS, Angkeow P, Suzuki S, Irani K (2000) Rac1 regulates stress-induced, redox-dependent heat shock factor activation. J Biol Chem 275:35377-35383
66. Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantome A, Plenchette S, Khochbin S, Solary E, Garrido C (2003) HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation.Mol Cell Biol 23:5790-5802
67. Park KJ, Gaynor RB, Kwak YT (2003) Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem 278:35272-35278. Epub 32003 Jun 35225
68. Philpott A, Leno GH, Laskey RA (1991) Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin. Cell 65:569-578
69. Pontius BW, Berg P (1992) Rapid assembly and disassembly of complementaryDNA strands through an equilibrium intermediate state mediated by A1 hnRNP protein. J Biol Chem 267:13815-13818
70. Pratt WB, Galigniana MD, Harrell JM, DeFranco DB (2004) Role of hsp90 and the hsp90- binding immunophilins in signalling protein movement. Cell Signal 16:857-872
71. Rogalla T, Ehrnsperger M, Preville X, Kotlyarov A, Lutsch G, Ducasse C, Paul C,Wieske M, Arrigo AP, Buchner J, GaestelM(1999) Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem 274:18947-18956
72. Sanchez ER, Toft DO, Schlesinger MJ, Pratt WB (1985) Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein. J Biol Chem 260:12398-12401
73. Satyal SH, Chen D, Fox SG, Kramer JM,Morimoto RI (1998) Negative regulation of the heat shock transcriptional response by HSBP1. Genes Dev 12:1962-1974
74. Schneikert J, Hubner S, Martin E, Cato AC (1999) A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. J Cell Biol 146:929-940
75. Shi Y, Mosser DD, Morimoto RI (1998) Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev 12:654-666
76. Silverstein AM, Galigniana MD, Chen MS, Owens-Grillo JK, Chinkers M, Pratt WB (1997) Protein phosphatase 5 is a major component of glucocorticoid receptor hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem 272:16224-16230
77. Sitia R,Molteni SN(2004) Stress, protein (mis)folding, and signaling: the redox connection. Sci STKE 2004: pe27
78. Smith CC, Yu YX, Kulka M, Aurelian L (2000) A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. J Biol Chem 275:25690-25699
79. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, Sacks DB, Calderwood SK (2003) Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun 303:700-706
80. Song J,Takeda M,Morimoto RI (2001) Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nat Cell Biol 3:276-282
81. Stokoe D, Engel K, Campbell DG, Cohen P, Gaestel M (1992) Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett 313:307-313
82. Suzuki A, Sugiyama Y, Hayashi Y, Nyu-i N, Yoshida M, Nonaka I, Ishiura S, Arahata K, Ohno S (1998) MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase. J Cell Biol 140:1113-1124
83. Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC (1997) BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J 16:4887-4896
84. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 80:279-284
85. Wang HG, Takayama S, Rapp UR, Reed JC (1996) Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A 93:7063-7068
86. Wang X, Grammatikakis N, Siganou A, Stevenson MA, Calderwood SK (2004) Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem 279:49460-49469. Epub 42004 Sep 49410
87. WinklerW,Nahvi A, Breaker RR (2002) Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Nature 419:952-956. Epub 2002 Oct 2016
88. Winklhofer KF, Reintjes A, Hoener MC, Voellmy R, Tatzelt J (2001) Geldanamycin restores a defective heat shock response in vivo. J Biol Chem 276:45160-45167. Epub 42001 Sep 45126
89. Xia W, Voellmy R, Spector NL (2000) Sensitization of tumor cells to fas killing through overexpression of heat-shock transcription factor 1. J Cell Physiol 183:425-431
90. XuW, Mimnaugh E, RosserMF,Nicchitta C,MarcuM, Yarden Y,Neckers L (2001) Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276:3702-3708. Epub 2000 Nov 3708
91. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP (1997) Sequence-specific and phosphorylation- dependent proline isomerization: a potential mitotic regulatory mechanism. Science 278:1957-1960
92. YanLJ,Christians ES,LiuL,Xiao X, Sohal RS,Benjamin IJ (2002)Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. EMBO J 21:5164-5172
93. Young JC, Hartl FU (2002) Chaperones and transcriptional regulation by nuclear receptors. Nat Struct Biol 9:640-642
94. Zeiner M, Gehring U (1995) A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. Proc Natl Acad Sci U S A 92:11465-11469
95. Zeiner M, Niyaz Y, Gehring U (1999) The hsp70-associating protein Hap46 binds to DNA and stimulates transcription. Proc Natl Acad Sci U S A 96:10194-10199
96. Zeke T, Morrice N, Vazquez-Martin C, Cohen PT (2005) Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. Biochem J 385:45-56
97. Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (1998) Repression of heat shock transcription factorHSF1 activation byHSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94:471-480