Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells

American Journal of Surgery

Volumn 204, Issue 6, 2012, Pages 868-873

  Kaushik, Gaurav ^a   Ramalingam, Satish ^a,b   Subramaniam, Dharmalingam ^a,b   Rangarajan, Parthasarthy ^a,b   Protti, Piero ^a   Rammamoorthy, Prabhu ^a,b   Anant, Shrikant ^a,b   Mammen, Joshua M V ^a,b  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS CANCER CENTER   (United States)

Author keywords

secretase; AKT; Cell cycle arrest; Cyclin D1; Melanoma; mTOR

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CYCLIN D1; GAMMA SECRETASE; HONOKIOL; MAMMALIAN TARGET OF RAPAMYCIN; NOTCH RECEPTOR; PROTEIN KINASE B;

ARTICLE; AUTOPHAGOSOME; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL CYCLE ARREST; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MAGNOLIACEAE; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AUTOPHAGY; BIPHENYL COMPOUNDS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; IMMUNOBLOTTING; LIGNANS; MELANOMA; MICE; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR MARKERS, BIOLOGICAL;

EID: 84871009996     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2012.09.001     Document Type: Article

References (33)

1. A. Jemal, M.J. Thun, L.A. Ries Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control J Natl Cancer Inst 100 2008 1672 1694
2. E. Linos, S.M. Swetter, M.G. Cockburn Increasing burden of melanoma in the United States J Invest Dermatol 129 2009 1666 1674
3. H. Davies, G.R. Bignell, C. Cox Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
4. J.A. Curtin, J. Fridlyand, T. Kageshita Distinct sets of genetic alterations in melanoma N Engl J Med 353 2005 2135 2147
5. K. Satyamoorthy, G. Li, M.R. Gerrero Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation Cancer Res 63 2003 756 759
6. H. Wu, V. Goel, F.G. Haluska PTEN signaling pathways in melanoma Oncogene 22 2003 3113 3122
7. J. Liang, J. Zubovitz, T. Petrocelli PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest Nat Med 8 2002 1153 1156
8. C.F. Welsh, K. Roovers, J. Villanueva Timing of cyclin D1 expression within G1 phase is controlled by Rho Nat Cell Biol 3 2001 950 957
9. D. Fulton, J.P. Gratton, T.J. McCabe Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature 399 1999 597 601
10. W. Zundel, C. Schindler, D. Haas-Kogan Loss of PTEN facilitates HIF-1-mediated gene expression Genes Dev 14 2000 391 396
11. A. Schulze, K. Lehmann, H.B. Jefferies Analysis of the transcriptional program induced by Raf in epithelial cells Genes Dev 15 2001 981 994
12. B.K. Park, X. Zeng, R.I. Glazer AKT1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells Cancer Res 61 2001 7647 7653
13. E. Liu, A.A. Thant, F. Kikkawa The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1 Cancer Res 60 2000 2361 2364
14. U. Benbow, G.B. Tower, C.A. Wyatt High levels of MMP-1 expression in the absence of the 2G single nucleotide polymorphism is mediated by p38 and ERK1/2 mitogen-activated protein kinases in VMM5 melanoma cells J Cell Biochem 86 2002 307 319
15. C.J. Vlahos, W.F. Matter, K.Y. Hui A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) J Biol Chem 269 1994 5241 5248
16. D. Massi, F. Tarantini, A. Franchi Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma Mod Pathol 19 2006 246 254
17. C. Ronchini, A.J. Capobianco Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic) Mol Cell Biol 21 2001 5925 5934
18. S. Ponnurangam, J.M. Mammen, S. Ramalingam Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells Mol Cancer Ther 11 2012 963 972
19. U. Landegren Measurement of cell numbers by means of the endogenous enzyme hexosaminidase Applications to detection of lymphokines and cell surface antigens J Immunol Methods 67 1984 379 388
20. L.E. Fried, J.L. Arbiser Honokiol, a multifunctional antiangiogenic and antitumor agent Antioxid Redox Signal 11 2009 1139 1148
21. R. Donnellan, R. Chetty Cyclin D1 and human neoplasia J Clin Pathol Mol Pathol 51 1998 1 7
22. E.R. Sauter, U.C. Yeo, A. von Stemm Cyclin D1 is a candidate oncogene in cutaneous melanoma Cancer Res 62 2002 3200 3206
23. J. Hu, L.J. Chen, L. Liu Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity Exp Mol Med 40 2008 617 628
24. A. Platz, S. Egyhazi, U. Ringborg Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site Mol Oncol 1 2008 395 405
25. M. Cheung, A. Sharma, S.V. Madhunapantula AKT3 and mutant V600E B-Raf cooperate to promote early melanoma development Cancer Res 68 2008 3429 3439
26. B. Bedogni, M.S. O'Neill, S.M. Welford Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/AKT and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice Cancer Res 64 2004 2552 2560
27. M.F. Favata, K.Y. Horiuchi, E.J. Manos Identification of a novel inhibitor of mitogen-activated protein kinase kinase J Biol Chem 273 1998 18623 18632
28. S.P. Davies, H. Reddy, M. Caivano Specificity and mechanism of action of some commonly used protein kinase inhibitors Biochem J 351 2000 95 105
29. S.S. Sikandar, K.T. Pate, S. Anderson NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer Cancer Res 70 2010 1469 1478
30. M. Kondratyev, A. Kreso, R.M. Hallett Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer Oncogene 31 2012 93 103
31. S.Y. Lee, D.Y. Yuk, H.S. Song Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB Eur J Pharmacol 582 2008 17 25
32. S. Arora, A. Bhardwaj, S.K. Srivastava Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells PLoS One 6 2011 e21573
33. L. Bello, G. Carrabba, C. Giussani Low-dose chemotherapy combined with an antiangiogenic drug reduces human glioma growth in vivo Cancer Res 61 2001 7501 7506