Empathy and emotion recognition in people with autism, first-degree relatives, and controls

Neuropsychologia

Volumn 51, Issue 1, 2013, Pages 98-105

  Sucksmith, E ^a   Allison, C ^b   Baron Cohen, S ^b   Chakrabarti, B ^b,c   Hoekstra, R A ^a  

^a OPEN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF READING   (United Kingdom)

Author keywords

Autism; Broader autism phenotype; Emotion; Empathy; Endophenotype

Indexed keywords

ADULT; ARTICLE; AUTISM; CHILD; CONTROLLED STUDY; EMOTION; EMPATHY; ENDOPHENOTYPE; FACIAL EXPRESSION; FAMILY RELATION; FATHER; FEMALE; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MOTHER; PATTERN RECOGNITION; PHENOTYPE; QUANTITATIVE ANALYSIS; RECOGNITION; SELF REPORT; SEX DIFFERENCE; TASK PERFORMANCE;

ADULT; AUTISTIC DISORDER; EMPATHY; FAMILY; FEMALE; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; PERSONALITY DISORDERS; PHOTIC STIMULATION; PSYCHIATRIC STATUS RATING SCALES;

EID: 84870980849     PISSN: 00283932     EISSN: 18733514     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2012.11.013     Document Type: Article

References (70)

1. Abrahams B.S., Geschwind D.H. Advances in autism genetics: On the threshold of a new neurobiology. Nature Reviews Genetics 2008, 9(6):341-355.
2. Adolphs R., Sears L., Piven J. Abnormal processing of social information from faces in autism. Journal of Cognitive Neuroscience 2001, 13(2):232-240.
3. Allison C., Baron-Cohen S., Wheelwright S.J., Stone M.H., Muncer S.J. Psychometric analysis of the empathy quotient (EQ). Personality and Individual Differences 2011, 51:829-835.
4. Amercian Psychiatric Association Diagnostic and statistical manual of mental disorders 4th Edn.-Text revision (DSM-IV-TR) 2000, American Psychiatric Association, Washington, DC.
5. Ashwin C., Chapman E., Colle L., Baron-Cohen S. Impaired recognition of negative basic emotions in autism: A test of the amygdala theory. Social Neuroscience 2006, 1(3-4):349-363.
6. Baron-Cohen S. Autism and symbolic play. British Journal of Developmental Psychology 1987, 5:139-148.
7. Baron-Cohen S. Mindblindess: An essay on autism and theory of mind 1995, MIT Press/Bradford Books, Boston.
8. Baron-Cohen S. The extreme male brain theory of autism. Trends in Cognitive Sciences 2002, 6:248-254.
9. Baron-Cohen S. Autism: The empathizing-systemizing (E-S) theory. Year in Cognitive Neuroscience 2009, Annals of the New York Academy of Sciences 2009, 1156:68-80.
10. Baron-Cohen S., Hammer J. Parents of children with asperger syndrome: What is the cognitive phenotype?. Journal of Cognitive Neuroscience 1997, 9(4):548-554.
11. Baron-Cohen S., Leslie A.M., Frith U. Does the autistic child have a 'theory of mind'?. Cognition 1985, 21:37-46.
12. Baron-Cohen S., Wheelwright S. The Empathy Quotient: An investigation of adults with asperger syndrome or high functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders 2004, 34(2):163-175.
13. Baron-Cohen S., Wheelwright S., Skinner R., Martin J., Clubley E. The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders 2001, 31(1):5-17.
14. Bartels M., Boomsma D.I., Hudziak J.J., van Beijsterveldt T.C.E.M., van den Oord E.J.C.G. Twins and the study of rater (dis)agreement. Psychological Methods 2007, 12(4):451-466.
15. Belmonte M.K., Gomot M., Baron-Cohen S. Visual attention in autism families: 'Unaffected' sibs share atypical frontal activation. The Journal of Child Psychology and Psychiatry 2010, 51(3):259-276.
16. Bölte S., Duketis E., Poustka F., Holtmann M. Sex differences in cognitive domains and their clinical correlates in higher-functioning autism spectrum disorders. Autism 2011, 15(4):497-511.
17. Bölte S., Poustka F. The recognition of facial affect in autistic and schizophrenic subjects and their first-degree relatives. Psychological Medicine 2003, 33:907-915.
18. Bolton P., Macdonald H., Pickles A., Rios P., Goode S., Crowson M., et al. A case-control family history study of autism. Journal of Child Psychology and Psychiatry 1994, 35(5):877-900.
19. Brothers L. The social brain: A project for integrating primate behaviour and neurophysiology in a new domain. Concepts in Neuroscience 1990, 1:27-51.
20. Calder A.J., Keane J., Manly T., Sprengelmeyer R., Scott S., Nimmo-Smith I., et al. Facial expression recognition across the adult life span. Neuropsychologia 2003, 41:195-202.
21. Capps L., Sigman M., Yirmiya N. Self-competence and emotional understanding in high-functioning children with autism. Development and Psychopathology 1995, 7:137-149.
22. Chakrabarti B., Baron-Cohen S. Empathizing: Neurocognitive developmental mechanisms and individual differences. Progress in Brain Research 2006, 156:403-417.
23. Chakrabarti B., Bullmore E., Baron-Cohen S. Empathizing with basic emotions: Common and discrete neural substrates. Social Neuroscience 2006, 1(3-4):364-384.
24. Chakrabarti B., Dudbridge F., Kent L., Wheelwright S., Hill-Cawthorne G., Allison C., et al. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and asperger syndrome. Autism Research 2009, 2(3):157-177.
25. Constantino J.N., Lajonchere C., Lutz M., Gray T., Abbacchi A., McKenna K., et al. Autistic social impairment in the siblings of children with pervasive developmental disorders. American Journal of Psychiatry 2006, 163:294-296.
26. Darwin C. The expression of the emotions in man and animals 2009, Harper Collins Publishers, (original work published 1872).
27. Decety J., Moriguchi Y. The empathic brain and its dysfunction in psychiatric populations: Implications for intervention across different clinical conditions. BioPsychoSocial Medicine 2007, 1:22.
28. Ekman P., Friesen W.V. Constants across cultures in the face and emotion. Journal of Personality and Social Psychology 1971, 17:124-129.
29. Field T.M., Woodson R., Greenberg R., Cohen D. Discrimination and imitation of facial expressions by neonates. Science 1982, 281:179-181.
30. Freitag C.M., Staal W., Klauck S.M., Duketis E., Waltes R. Genetics of autistic disorders: Review and clinical implications. European Child & Adolescent Psychiatry 2010, 19(3):169-178.
31. Giola J.V., Brosgole L. Visual and auditory affect recognition in singly diagnosed mentally retarded patients, mentally retarded patients with autism and normal young children. International Journal of Neuroscience 1988, 43:149-163.
32. Goeleven E., De Raedt R., Leyman L., Verschuere B. The Karolinska directed emotional faces: A validation study. Cognition and Emotion 2008, 22(6):1094-1118.
33. Golan O., Baron-Cohen S., Hill J.J. The Cambridge mindreading face-voice battery: Testing complex emotion recognition in adults with and without asperger syndrome. Journal of Autism and Developmental Disorders 2006, 36:169-183.
34. Gosling S.D., Vazire S., Srivastava S., John O.P. Should we trust web-based studies? A comparative analysis of six preconceptions about internet questionnaires. American Psychologist 2004, 59(2):93-104.
35. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry; etymology and strategic intentions. The American Journal of Psychiatry 2003, 160(4):636-645.
36. Happé F., Briskman J., Frith U. Exploring the cognitive phenotype of autism: weak 'central coherence' in parents and siblings of children with autism: I. Experimental tests. Journal of Child Psychology and Psychiatry 2001, 42:299-307.
37. Harms M., Martin A., Wallace G.L. Facial emotion recognition in autism spectrum disorders: A review of behavioral and neuroimaging studies. Neuropsychology Review 2010, 20:290-322.
38. Holt R., Monaco A.P. Links between genetics and pathophysiology in the autism spectrum disorders. Molecular Medicine 2011, 3:438-450.
39. Howard M.A., Cowell P.E., Boucher J., Broks P., Mayes A., Farrant A., et al. Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport 2000, 11(13):2931-2935.
40. Isler J.R., Martien K.M., Grieve P.G., Stark R.I., Herbert M.R. Reduced functional connectivity in visual evoked potentials in children with autism spectrum disorder. Clinical Neurophysiology 2010, 121:2035-2043.
41. Lai M.-C., Lombardo M.V., Pasco G., Ruigrok A.N.V., Wheelwright S.J., Sadek S.A., et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS One 2011, 6(6):e20835. 10.1371/journal.pone.0020835.
42. Law Smith M.J., Montagne B., Perrett D.I., Gill M., Gallagher L. Detecting subtle facial emotion recognition deficits in high-functioning autism using dynamic stimuli of varying intensities. Neuropsychologia 2010, 48:2777-2781.
43. Lawrence E.J., Shaw P., Baker D., Baron-Cohen S., David A.S. Measuring empathy: Reliability and validity of the empathy quotient. Psychological Medicine 2004, 34(5):911-919.
44. Lee H., Marvin A.R., Watson T., Piggot J., Law J.K., Law P.A. Accuracy of phenotyping of autistic children based on internet implemented parent report. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2010, 153B(6):1119-1126.
45. Leslie A.M. Pretense and representation: the origins of 'theory of mind'. Psychological Review 1987, 94:412-426.
46. Leslie A.M., Frith U. Autistic children's understanding of seeing, knowing and believing. British Journal of Developmental Psychology 1988, 6:315-324.
47. Lord C., Risi S., Lambrecht L., Cook E.H., Leventhal B.L., DiLavore P.C., et al. The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders 2000, 30(3):205-223.
48. Losh M., Adolphs R., Poe M.D., Couture S., Penn D., Baranek G.T., et al. Neuropsychological profile of autism and the broad autism phenotype. Archives of General Psychiatry 2009, 66(5):518-526.
49. Loveland K.A., TunaliKotoski B., Chen Y.R., Ortegon J., Pearson D.A., Brelsford K.A., et al. Emotion recognition in autism: Verbal and non-verbal information. Development and Psychopathology 1997, 9(3):579-593.
50. Lundqvist D., Flykt A., Ohman A. The Karolinska directed emotional faces-KDEF 1998, Department of Clinical Neuroscience, Psychology Section, Karolinska Institutet, Stockholm, Sweden.
51. Mevorach C., Humphreys G.W., Shalev L. Opposite biases in salience-based selection for the left and right posterior parietal cortex. Nature Neuroscience 2006, 9(6):740-742.
52. Minshew N.J., Williams D.L. The new neurobiology of autism: Cortex, connectivity and neuronal organisation. Archives of Neurology 2007, 64(7):945-950.
53. Montagne B., Kessels R.P.C., De Haan E.H.F., Perrett D.I. The emotion recognition task: A paradigm to measure the perception of facial emotional expressions at different intensities. Perceptual and Motor Skills 2007, 104(2):589-598.
54. Palermo M.T., Pasqualetti P., Barbati G., Intelligente F., Rossini P.M. Recognition of schematic facial displays of emotion in parents of children with autism. Autism 2006, 10(4):353-364.
55. Pellicano E. Psychological models of autism: An overview. Researching the autism spectrum: Contemporary perspectives 2011, 219-265. Cambridge University Press. I. Roth, P. Rezaie (Eds.).
56. Pelphrey K.A., Sasson N.J., Reznick J.S., Paul G., Goldman B.D., Piven J. Visual scanning of faces in autism. Journal of Autism and Developmental Disorders 2002, 32(4):249-261.
57. Perner J., Frith U., Leslie A.M., Leekam S.R. Exploration of the autistic child's theory of mind: Knowledge, belief, and communication. Child Development 1989, 60:689-700.
58. Phillips W., Baron-Cohen S., Rutter M. Understanding intention in normal development and in autism. British Journal of Developmental Psychology 1998, 16:337-348.
59. Raven J.C., Court J.H., Raven J. Manual for Raven's progressive matrices and vocabulary scales 1996, Oxford University Press, Oxford.
60. Rutherford M.D., Towns A.M. Scan path differences and similarities during emotion perception in those with and without autism spectrum disorders. Journal of Autism and Developmental Disorders 2008, 38(7):1371-1381.
61. Scott F., Baron-Cohen S. Imagining real and unreal objects: An investigation of imagination in autism. Journal of Cognitive Neuroscience 1996, 8:400-411.
62. Smalley S.L., Asarnow R.F. Cognitive subclinical markers in autism. Journal of Autism and Developmental Disorders 1990, 20(2):271-278.
63. Spencer M.D., Holt R.J., Chura L.R., Suckling J., Calder A.J., Bullmore E.T., et al. A novel functional brain imaging endophenotype of autism: The neural response to facial expression of emotion. Translational Psychiatry 2011, 1:e19.
64. Sucksmith E., Roth I., Hoekstra R.A. Autistic traits below the clinical threshold: re-examining the broader autism phenotype in the 21st century. Neuropsychology Review 2011, 21(4):360-389.
65. Sutherland A., Crewther D.P. Magnocellular visual evoked potential delay with high autism spectrum quotient yields a neural mechanism for altered perception. Brain 2010, 133:2089-2097.
66. Walden T.A., Ogan T.A. The development of social referencing. Child Development 1988, 59(5):1230-1240.
67. Walker-Andrews A.S. Infants perception of expressive behaviours: Differentiation of multi-modal information. Psychological Bulletin 1997, 121:437-456.
68. Wallace S., Sebastian C., Pellicano E., Parr J., Bailey A. Face processing abilities in relatives of individuals with ASD. Autism Research 2010, 3(6):345-349.
69. Wheelwright S., Auyeung B., Allison C., Baron-Cohen S. Defining the broader, medium and narrow autism phenotype among parents using the autism spectrum quotient (AQ). Molecular Autism 2010, 1:1-10.
70. World Health Organisation Mental disorders: A glossary and guide to their classification in accordance with the 10th revision of the international classification of diseases: Research Diagnostic Criteria (ICD-10) 1993, WHO, Geneva.