A novel functional brain imaging endophenotype of autism: The neural response to facial expression of emotion

Translational Psychiatry

Volumn 1, Issue , 2011, Pages

  Spencer, M D ^a   Holt, R J ^a   Chura, L R ^a   Suckling, J ^b   Calder, A J ^c   Bullmore, E T ^b   Baron Cohen, S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Autism; Endophenotype; fMRI; Genetic; Sibling

Indexed keywords

BIOLOGICAL MARKER;

ADOLESCENT; ARTICLE; AUTISM; BRAIN; CHILD; COMPARATIVE STUDY; EMOTION; ENDOPHENOTYPE; FACIAL EXPRESSION; FEMALE; GENETICS; HUMAN; INSTRUMENTATION; MALE; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK; SIBLING;

ADOLESCENT; AUTISTIC DISORDER; BIOLOGICAL MARKERS; BRAIN; CHILD; EMOTIONS; ENDOPHENOTYPES; FACIAL EXPRESSION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; RISK; SIBLINGS;

EID: 79960371705     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.18     Document Type: Article

References (41)

1. Constantino JN, Zhang Y, Frazier T, Abbacchi AM, Law P. Sibling recurrence and the genetic epidemiology of autism. Am J Psychiatry 2010;167:1349-1356.
2. Ritvo ER, Jorde LB, Mason-Brothers A, Freeman BJ, Pingree C, Jones MB et al. The UCLA-University of Utah epidemiologic survey of autism: recurrence risk estimates and genetic counseling. Am J Psychiatry 1989;146:1032-1036. (Pubitemid 19197982)
3. Lauritsen MB, Pedersen CB, Mortensen PB. Effects of familial risk factors and place of birth on the risk of autism: a nationwide register-based study. J Child Psychol Psychiatry 2005;46:963-971. (Pubitemid 44192664)
4. Bolton P, Macdonald H, Pickles A, Rios P, Goode S, Crowson M et al. A case-control family history study of autism. J Child Psychol Psychiatry 1994;35:877-900. (Pubitemid 24213267)
5. Baron-Cohen S, Ring H, Chitnis X, Wheelwright S, Gregory L, Williams S et al. fMRI of parents of children with Asperger syndrome: a pilot study. Brain Cogn 2006;61:122-130. (Pubitemid 43732438)
6. Piven J. The broad autism phenotype: a complementary strategy for molecular genetic studies of autism. Am J Med Genet 2001;105:34-35.
7. Losh M, Adolphs R, Poe MD, Couture S, Penn D, Baranek GT et al. Neuropsychological profile of autism and the broad autism phenotype. Arch Gen Psychiatry 2009;66:518-526.
8. Dalton KM, Nacewicz BM, Alexander AL, Davidson RJ. Gaze-fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism. Biol Psychiatry 2007;61:512-520. (Pubitemid 46185335)
9. Kaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM et al. Neural signatures of autism. Proc Natl Acad Sci USA 2010;107:21223-21228.
10. Belmonte MK, Gomot M, Baron-Cohen S. Visual attention in autism families: 'unaffected' sibs share atypical frontal activation. J Child Psychol Psychiatry 2010;51:259-276.
11. John B, Lewis KR. Chromosome variability and geographic distribution in insects. Science 1966;152:711-721.
12. Gottesman II, Shields J. Genetic theorizing and schizophrenia. Br J Psychiatry 1973;122:15-30.
13. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003;160:636-645. (Pubitemid 41079594)
14. Happe F, Ronald A, Plomin R. Time to give up on a single explanation for autism. Nat Neurosci 2006;9:1218-1220. (Pubitemid 44454258)
15. Kendler KS, Neale MC. Endophenotype: a conceptual analysis. Mol Psychiatry 2010;15:789-797.
16. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, 4th edn. American Psychiatric Association: Washington, DC, 1994.
17. Dawson G, Carver L, Meltzoff AN, Panagiotides H, McPartland J, Webb SJ. Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development. Child Dev 2002;73:700-717. (Pubitemid 41692433)
18. Bailey AJ, Braeutigam S, Jousmaki V, Swithenby SJ. Abnormal activation of face processing systems at early and intermediate latency in individuals with autism spectrum disorder: a magnetoencephalographic study. Eur J Neurosci 2005;21:2575-2585. (Pubitemid 40813939)
19. Hall GB, Szechtman H, Nahmias C. Enhanced salience and emotion recognition in Autism: a PET study. Am J Psychiatry 2003;160:1439-1441. (Pubitemid 41070919)
20. Pierce K, Muller RA, Ambrose J, Allen G, Courchesne E. Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI. Brain 2001;124(Part 10):2059-2073. (Pubitemid 32945904)
21. Baron-Cohen S, Ring HA, Wheelwright S, Bullmore ET, Brammer MJ, Simmons A et al. Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci 1999;11:1891-1898. (Pubitemid 29240553)
22. Brothers L. The social brain: a project for integrating primate behaviour and neurophysiology in a new domain. Concepts Neurosci 1990;1:27-51.
23. Frith U, Frith CD. Development and neurophysiology of mentalizing. Philos Trans R Soc Lond B Biol Sci 2003;358:459-473. (Pubitemid 36386247)
24. von dem Hagen EA, Nummenmaa L, Yu R, Engell AD, Ewbank MP, Calder AJ. Autism spectrum traits in the typical population predict structure and function in the posterior superior temporal sulcus. Cereb Cortex 2011;21:493-500.
25. Kanwisher N, McDermott J, Chun MM. The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci 1997;17:4302-4311. (Pubitemid 27220621)
26. Piven J, Palmer P, Jacobi D, Childress D, Arndt S. Broader autism phenotype: evidence from a family history study of multiple-incidence autism families. Am J Psychiatry 1997;154:185-190. (Pubitemid 27053723)
27. Lord C, Rutter M, Le Couteur A. Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994;24:659-685. (Pubitemid 24309810)
28. Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L et al. Autism diagnostic observation schedule: a standardized observation of communicative and social behavior. J Autism Dev Disord 1989;19:185-212. (Pubitemid 19176529)
29. Berument SK, Rutter M, Lord C, Pickles A, Bailey A. Autism screening questionnaire: diagnostic validity. Br J Psychiatry 1999;175:444-451.
30. Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI). Psychological Corporation: London, 1999.
31. Ekman P, Friesen WV. Pictures of Facial Affect. Consulting Psychologists Press: Palo Alto, California, 1976.
32. Cusack R, Mitchell DJ, Duncan J. Discrete object representation, attention switching, and task difficulty in the parietal lobe. J Cogn Neurosci 2009;22:32-47.
33. Evans AC, Collins DL, Milner B. An MRI-based stereotactic brain atlas from 300 young normal subjects. Proc 22nd Annu Symp Soc Neurosci, Anaheim, CA 1992, 408.
34. Brett M, Anton J, Valabregue R, Poline J. Region of interest analysis using an SPM toolbox. Neuroimage 2002;16:S497.
35. Rorden C, Brett M. Stereotaxic display of brain lesions. Behav Neurol 2000;12:191-200. (Pubitemid 32843166)
36. Vollm BA, Taylor AN, Richardson P, Corcoran R, Stirling J, McKie S et al. Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 2006;29:90-98. (Pubitemid 41828033)
37. Schulte-Ruther M, Markowitsch HJ, Fink GR, Piefke M. Mirror neuron and theory of mind mechanisms involved in face-to-face interactions: a functional magnetic resonance imaging approach to empathy. J Cogn Neurosci 2007;19:1354-1372. (Pubitemid 47204076)
38. Olson IR, Plotzker A, Ezzyat Y. The enigmatic temporal pole: a review of findings on social and emotional processing. Brain 2007;130(Part 7):1718-1731. (Pubitemid 47343791)
39. Ashwin C, Wheelwright S, Baron-Cohen S. Finding a face in the crowd: testing the anger superiority effect in Asperger syndrome. Brain Cogn 2006;61:78-95.
40. Kanner L. Autistic disturbances of affective contact. Nervous Child 1943;2:217-250.
41. Bailey A, Palferman S, Heavey L, Le Couteur A. Autism: the phenotype in relatives. J Autism Dev Disord 1998;28:369-392. (Pubitemid 29101854)