Saucerneol F, a new lignan isolated from Saururus chinensis, attenuates degranulation via phospholipase Cγ1 inhibition and eicosanoid generation by suppressing MAP kinases in mast cells

Biomolecules and Therapeutics

Volumn 20, Issue 6, 2012, Pages 526-531

  Lu, Yue ^a   Son, Jong Keun ^a   Chang, Hyeun Wook ^a  

^a Yeungnam University   (South Korea)

Author keywords

Degranulation; Leukotriene C4; Mast cells; Mitogen activated protein kinase; Prostaglandin D2; Saucerneol F

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CALCIUM ION; CYCLOOXYGENASE 2; LEUKOTRIENE C4; LICOFELONE; LIGNAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE C GAMMA1; PROSTAGLANDIN D2; SAUCERNEOL F; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; INFLAMMATION; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SAURURACEAE; SAURURUS CHINENSIS;

SAURURUS CHINENSIS;

EID: 84870940679     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2012.20.6.526     Document Type: Article

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